Aliases &
Descriptions
for PIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| prolactin-induced protein1 2 3 | | Gross cystic disease fluid protein 152 3 | | GPIP41 2 3 | | SABP2 3 | | GCDFP-151 2 3 | | prolactin-inducible protein2 | | GCDFP151 2 3 | | gp173 | | Secretory actin-binding protein2 3 | | |
Export aliases for PIP gene to outside databasesPrevious GC identifers: GC07P141155 GC07P142221 GC07P142300 GC07P142346 GC07P142539 GC07P142829 |
Summaries
for PIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for PIP (Prolactin-induced protein) |
Genomic Views
for PIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PIP gene promoter:
STAT5A p53 FOXL1 TBP MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for PIP
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q32-qterPIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P137167: view genomic region
(about GC identifiers)
Start:
|
137,167,318 bp from pter |
End:
|
137,174,970 bp from pter |
Size:
|
7,653 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+ 142,829,170-142,836,839 |
RefSeq DNA sequence:- NC_000007.13 NT_007914.15 NT_079596.2
|
Proteins
for PIP gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PIP_HUMAN, P12273 (See
protein sequence)Recommended Name: Prolactin-inducible protein precursor Size: 146 amino acids; 16572 Da
Subunit: Monomer. Interacts with AZGP1
Subcellular location: Secreted
PDB structures from  and Proteopedia  :3ES6 (3D)
Secondary accessions: A0A963 A0A9C3 A0A9F3 A4D2I1Explore the universe of human proteins at neXtProt for PIP: NX_P12273
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002643.1
ENSEMBL proteins: ENSP00000291009
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
NAS | -- |
About this table
PIP for ontologies About GeneDecksing
Antibodies for PIP:
Assays for PIP: |
Protein
Domains/
Families
for PIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PIP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P12273ProtoNet protein and cluster: P12273 UniProtKB/Swiss-Prot: PIP_HUMAN, P12273Similarity: Belongs to the PIP family |
Gene Function
for PIP gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PIP_HUMAN, P12273Induction: By prolactin and androgen; inhibited by estrogen
Genatlas biochemistry entry for PIP:prolactin-induced protein2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
PIP for ontologies About GeneDecksing
|
Pathways & Interactions
for PIP gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for PIP
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIP
2 Interacting proteins for PIP (ENSP000002910093 P122731) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
About this table
PIP for ontologies About GeneDecksing
|
Drugs & Compounds
for PIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
PIP for compounds About GeneDecksing
 Browse Tocris compounds for PIP
10/14  Novoseek chemical compound relationships for PIP gene (see all 14)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| progesterone |
62.8 |
23 |
10672061 (1), 11447997 (1), 15365364 (1), 10576657 (1) (see all 20) |
| estrogen |
62.6 |
37 |
20173733 (3), 2269395 (2), 9426521 (2), 11117786 (2) (see all 28) |
| b 723 |
61.3 |
13 |
17004974 (5), 1370877 (2), 1556271 (1), 11940224 (1) |
| mucicarmine |
53.8 |
1 |
9870855 (1) |
| progestins |
40.5 |
6 |
2142871 (1), 1446056 (1), 1551135 (1) |
| bicalutamide |
35.9 |
1 |
10402478 (1) |
| tamoxifen |
31.7 |
3 |
1930624 (3) |
| dihydrotestosterone |
30.2 |
7 |
7927949 (2), 7558422 (2), 10402478 (1) |
| testosterone |
19.2 |
11 |
1955075 (3), 9111629 (1), 10402478 (1), 9831198 (1) (see all 5) |
| androstenedione |
8.73 |
1 |
9111629 (1) |
About this table
|
Transcripts
for PIP gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PIP gene: NM_002652.2 Additional cDNA sequence: AK312227.1 BC010950.1 BC010951.1 J03460.1 Y10179.1 6 DOTS entries: DT.99946855 DT.408915 DT.100678499 DT.100717527 DT.75156109 DT.91667251 5 AceView cDNA sequences: Y10179 NM_002652 J03460 BC010950 BC010951
 highest scoring ESTs for PIP:Y10179 BC010950 BC010951 CA946476 J03460 AA532383 AA564296 AA916110 AI420470 AI535656 Unigene Cluster for PIP: Prolactin-induced protein Hs.99949 [show with all ESTs]Unigene Representative Sequence: BF965123
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000291009(uc003wcf.1)
|
Expression
for PIP gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PIP expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching PIP gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 325_s_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.99 |
0.97 |
HG1763-HT1780 |
0.20 |
1.00 |
0.72 |
1 |
| 41094_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.99 |
1.05 |
Y10179 |
1.00 |
1.00 |
1.00 |
1 |
| 206509_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_002652 |
0.60 |
1.00 |
0.82 |
1 |
| 206509_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PIP for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTTAAAAAAA
SOURCE GeneReport for Unigene cluster: Hs.99949
Expression variation in blood from EXPOLDB for PIP UniProtKB/Swiss-Prot: PIP_HUMAN, P12273Tissue specificity: Expressed in pathological conditions of the mammary gland and in several exocrine tissues, such asthe lacrimal, salivary, and sweat glands
SABiosciences Custom PCR Arrays for PIP
|
Orthologs
for PIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PIP gene from 5 species
About this table Species with no ortholog for PIP
ENSEMBL Gene Tree for PIP (if available) |
Paralogs
for PIP gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for PIP gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PIP (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PIP
3 CNVs: 52136 52135 52137 | | QIAGEN SeqTarget long-range PCR primers for resequencing PIP |
|
Disorders & Mutations
for PIP gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PIP for disorders About GeneDecksing
OMIM: 176720
10/33 Novoseek disease relationships for PIP gene (see all 33)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carcinoma lobular |
76.4 |
5 |
10672061 (3), 19556822 (1), 1592388 (1) |
| breast carcinoma |
75.7 |
52 |
19217055 (5), 17145637 (4), 18251583 (4), 7722013 (4) (see all 26) |
| fibrocystic breast disease |
75.3 |
9 |
7829219 (2), 2357014 (1), 7850069 (1), 2058763 (1) (see all 6) |
| extramammary pagets disease |
74.1 |
1 |
8599433 (1) |
| breast cysts |
73.4 |
2 |
11992405 (1), 11029771 (1) |
| carcinoma ductal |
72.2 |
2 |
15569980 (1), 18753974 (1) |
| carcinoma |
61.6 |
39 |
16045781 (7), 17004974 (3), 18339419 (3), 8248106 (3) (see all 15) |
| ductal breast carcinoma |
60.9 |
1 |
8248106 (1) |
| breast cancer |
60.1 |
56 |
11029771 (5), 7558422 (3), 11992405 (2), 10576657 (2) (see all 27) |
| metastatic carcinoma |
59.7 |
5 |
18251583 (2), 7945916 (1), 7722013 (1) |
About this table
Genetic Association Database (GAD): PIP
Human Genome Epidemiology (HuGE) Navigator: PIP (7 documents)
Export disorders and mutations for PIP gene to outside databases
|
Medical News
for PIP gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for PIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/185 PubMed articles for PIP gene, integrated from 7 sources (see all 185):
(articles sorted by number of sources associating them with PIP)- The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation. (PubMed id 1955075)1, 2, 3, 7 Myal Y....Shiu R.P. (1991)
- Crystal structure of the novel complex formed between zinc alpha2- glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma. (PubMed id 18930737)1, 2, 7 Hassan M.I....Singh T.P. (2008)
- Primary structure of a new actin-binding protein from human seminal plasma. (PubMed id 2013294)1, 2, 7 Schaller J.... Rickli E.E. (1991)
- Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Isolation from a human seminal vesicle library of the cDNA for gp17, a CD4 binding factor. (PubMed id 9218538)1, 2 Autiero M.... Piatier-Tonneau D. (1997)
- The gene for prolactin-inducible protein (PIP), uniquely expressed in exocrine organs, maps to chromosome 7. (PubMed id 2727805)1, 3 Myal Y....Shiu R.P. (1989)
- Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP). Regulation of PIP gene expression in the human breast cancer cell line, T-47D. (PubMed id 3667631)1, 2 Murphy L.C.... Shiu R.P.C. (1987)
- Differential antibody reactivity and CD4 binding of the mammary tumor marker protein GCDFP-15 from breast cyst and its counterparts from exocrine epithelia. (PubMed id 9724097)1, 7 Caputo E....Guardiola J. (1998)
|
External Searches for PIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PIP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PIP gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PIP gene:
Search GeneIP for patents involving PIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PIP gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for PIP |
| |  |  |  |  | | | | | Antibodies for PIP |
| |
 | | | ELISAs and CLIAs for PIP |
| |
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