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PIP5KL1 Gene

protein-coding GIFtS: 49

GC09M100300

phosphatidylinositol-4-phosphate 5-kinase-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
phosphatidylinositol-4-phosphate 5-kinase-like 1¹ ²		PIPKH² ⁵
MGC46424¹ ²		phosphatidylinositol-4-phosphate 5-kinase-like protein 1²
bA203J24.5¹ ²		phosphatidylinositol phosphate kinase homolog²
PtdIns(4)P-5-kinase-like protein 1² ³		EC 2.7.1.68³
PI(4)P 5-kinase-like protein 1² ³

External Ids:	HGNC: 28711¹	Entrez Gene: 138429²	Ensembl: ENSG00000167103⁷	UniProtKB: Q5T9C9³

Export aliases for PIP5KL1 gene to outside databases

Previous GC identifers: GC09M126060 GC09M127763 GC09M129723 GC09M130683

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIP5KL1:

PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I

PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 (PubMed

14701839)).(supplied by OMIM)

UniProtKB/Swiss-Prot: PI5L1_HUMAN, Q5T9C9

Function: May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the

cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to

PI(3,4,5)P3 (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PIP5KL1 gene promoter:
         MEF-2A
         Other transcription factors

Search SABiosciences Chromatin IP Primers for PIP5KL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PIP5KL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.13

PIP5KL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIP5KL1 gene location

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M100300: view genomic region (about GC identifiers)

Start:	100,300,746 bp from pter
End:	100,310,021 bp from pter
Size:	9,276 bases
Orientation:	minus strand

1 alternative location:

Chr9- 130,683,158-130,693,076

RefSeq DNA sequence:

NC_000009.11 NT_008470.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PI5L1_HUMAN, Q5T9C9 (See protein sequence)

Recommended Name: Phosphatidylinositol-4-phosphate 5-kinase-like protein 1

Size: 394 amino acids; 44572 Da

Subunit: Heterodimerizes with other type I phosphatidylinositol-4-phosphate 5-kinase (By similarity)

Subcellular location: Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures (By similarity)

Caution: It is unsure if the enzyme has intrinsic kinase activity

Secondary accessions: Q8IVS3

Alternative splicing: 2 isoforms: Q5T9C9-1 Q5T9C9-2

Explore the universe of human proteins at neXtProt for PIP5KL1: NX_Q5T9C9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001128691.1 NP_775763.1

ENSEMBL proteins:

ENSP00000373398 ENSP00000373399 ENSP00000300432

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PIP5KL1
	GenScript Custom Purified and Recombinant Proteins Services for PIP5KL1
	Novus Biologicals Protein for PIP5KL1
	Novus Biologicals Lysate for PIP5KL1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0016020	membrane	IEA	--
GO:0042995	cell projection	IEA	--

About this table

PIP5KL1 for ontologies About GeneDecksing

Antibodies for PIP5KL1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PIP5KL1
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for PIP5KL1
	Browse antibodies at Epitomics

Assays for PIP5KL1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PIP5KL1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PIP5KL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PIP5KL1 for domains About GeneDecksing

1 InterPro domain/family:

IPR002498 PInositol-4-P-5-kinase_core

Graphical View of Domain Structure for InterPro Entry Q5T9C9

ProtoNet protein and cluster: Q5T9C9

1 Blocks protein family: IPB002498 Phosphatidylinositol-4-phosphate 5-kinase

UniProtKB/Swiss-Prot: PI5L1_HUMAN, Q5T9C9

Similarity: Contains 1 PIPK domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: PI5L1_HUMAN, Q5T9C9

Function: May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the

cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to

PI(3,4,5)P3 (By similarity)

Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol

4,5-bisphosphate

Enzyme Number (IUBMB): EC 2.7.1.68

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PIP5KL1 Sigma-Aldrich shRNA Panels and shRNA for PIP5KL1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PIP5KL1 OriGene shRNA RFP (see all 2): PIP5KL1 OriGene basic RS shRNA (see all 2): PIP5KL1 OriGene siRNA (see all 2): PIP5KL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PIP5KL1

miRNA:		Sigma-Aldrich microRNA Mimics for PIP5KL1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PIP5KL1
		2 SABiosciences Assays for microRNAs that regulate PIP5KL1:
		hsa-miR-137 hsa-miR-338-3p

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PIP5KL1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PIP5KL1 OriGene untagged cDNA clones in CMV expression vector: PIP5KL1 OriGene 3'-UTR clone (see all 2): PIP5KL1 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: PIP5KL1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for PIP5KL1

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016301	kinase activity	IEA	--
GO:0016307	phosphatidylinositol phosphate kinase activity	--	--

About this table

PIP5KL1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

PIP5KL1 for pathways About GeneDecksing

5 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for PIP5KL1

	Rac Signaling
	Aldosterone Signaling in Epithelial Cells
	Inositol Phosphate Metabolism
	RhoA Signaling
	Regulation of Actin-based Motility by Rho

3 Kegg Pathways (Kegg details for PIP5KL1):

	hsa00562 Inositol phosphate metabolism
	hsa01100 Metabolic pathways
	hsa04144 Endocytosis

SABiosciences Custom Pathway-Focused PCR Arrays for PIP5KL1

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PIP5KL1

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PIP5KL1

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0046488	phosphatidylinositol metabolic process	IEA	--

About this table

PIP5KL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

PIP5KL1 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PIP5KL1
8 Novoseek chemical compound relationships for PIP5KL1 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol phosphate	98.9	46	15728183 (2), 14691141 (2), 16616931 (2), 15623515 (2) (see all 35)
pip2	74	2	16616931 (1)
phosphatidylinositol	69.3	7	8395284 (1), 9879681 (1), 1655800 (1), 7928021 (1) (see all 6)
phosphoinositide	66.1	4	11134066 (1), 19638643 (1)
phosphotyrosine	37	1	16616931 (1)
choline	21.4	1	9879681 (1)
tyrosine	18.4	3	14691141 (1), 14701839 (1), 12422220 (1)
phospholipid	8.89	1	11134066 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PIP5KL1 Sigma-Aldrich shRNA Panels and shRNA for PIP5KL1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PIP5KL1 OriGene shRNA RFP (see all 2): PIP5KL1 OriGene basic RS shRNA (see all 2): PIP5KL1 OriGene siRNA (see all 2): PIP5KL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PIP5KL1

miRNA:		Sigma-Aldrich microRNA Mimics for PIP5KL1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PIP5KL1
		2 SABiosciences Assays for microRNAs that regulate PIP5KL1:
		hsa-miR-137 hsa-miR-338-3p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PIP5KL1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PIP5KL1 OriGene untagged cDNA clones in CMV expression vector: PIP5KL1 OriGene 3'-UTR Clone (see all 2): PIP5KL1 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: PIP5KL1

Primers:		OriGene genome-wide validated SYBR primer pairs: PIP5KL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PIP5KL1: PPH21296A

REFSEQ mRNAs for PIP5KL1 gene (2 alternative transcripts):

NM_001135219.1 NM_173492.1

Additional cDNA sequence: BC042184.1

6 DOTS entries:

DT.100022493 DT.91899619 DT.91812678 DT.91837732 DT.97777253 DT.95362824

24/33 AceView cDNA sequences (see all 33):

NM_173492 Z38321 BM980218 BU739350 BC042184 BM726577 CA425729 BI520079

BQ014508 BM714700 BE019642 BM786675 BF817093 BX112998 BQ774376 AI923090

BI085535 BG697332 BU621382 BG676659 BQ574658 BE787282 BE881330 BM476476

highest scoring ESTs for PIP5KL1:

BC042184 BI520079 BE787282 BE881330 BF761749 BF971892 BI085535 BI462029 BI830688 BM476476

Unigene Cluster for PIP5KL1:

Phosphatidylinositol-4-phosphate 5-kinase-like 1

Hs.445486 [show with all ESTs]

Unigene Representative Sequence: NM_001135219

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PIP5KL1 (see all 6)

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9	^	10a	·	10b
SP1:													-		-		-						-		-
SP2:					-								-		-		-
SP3:																									-
SP4:																					-				-
SP5:																							-		-

About this scheme

ECgene alternative splicing isoforms for PIP5KL1
13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000495448 ENST00000464759 ENST00000477191 ENST00000490773 ENST00000388746

ENST00000497234 ENST00000498783 ENST00000485562 ENST00000476624 ENST00000388747(uc011mao.1)

ENST00000300432(uc004bsu.2) ENST00000464108 ENST00000492296

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

PIP5KL1 expression in normal and diseased human tissues

¹ / ² / ³

5 probe-sets matching PIP5KL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57855_at²^{, 3}	U95-C	1	0.31	1.00	1.00	1.00	AI923090	0.40	1.00	0.76	1
243116_at²^{, 3}	U133-B	1	0.36	1.00	--	--	AI923090	0.40	1.00	0.76	1
208162_s_at*²	U133-A	7	0.46	0.14	--	--	--	--	--	--	--
243116_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--
208162_s_at*²	U133Plus2	7	0.46	0.14	--	--	--	--	--	--	--

About this table

PIP5KL1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

PIP5KL1 gene electronic northern expression

About these images

CGAP SAGE TAG: AAATGGAGGC

SOURCE GeneReport for Unigene cluster: Hs.445486

Primers:		OriGene genome-wide validated SYBR primer pairs: PIP5KL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PIP5KL1: PPH21296A

SABiosciences Custom PCR Arrays for PIP5KL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PIP5KL1 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PIP5KL1¹	--	phosphatidylinositol-4-phosphate 5-kinase-like 1	91.62(n) 93.19(a)	609122 XM_846326.1 XP_851419.1
chimpanzee (Pan troglodytes)	PIP5KL1¹	--	phosphatidylinositol-4-phosphate 5-kinase-like 1	99.3(n) 100(a)	464758 XM_520281.2 XP_520281.2
cow (Bos taurus)	PIP5KL1¹	--	phosphatidylinositol-4-phosphate 5-kinase-like 1	90.48(n) 91.43(a)	523736 NM_001075847.1 NP_001069315.1
mouse (Mus musculus)	Pip5kl1^{1 , 5}	2 (22.09 cM)⁵	phosphatidylinositol-4-phosphate 5-kinase-like 1^{1, 5}	78.25(n)¹ 73.16(a)¹	227733¹ NM_198191.1¹ NP_937834.1¹ AK133244⁵ AK164998⁵ (see all 13)
zebrafish (Danio rerio)	LOC100149843¹	--	similar to Phosphatidylinositol-4-phosphate 5-kinase-like more	63.87(n) 64.4(a)	100149843 XM_001923957.1 XP_001923992.1

About this table Species with no ortholog for PIP5KL1

ENSEMBL Gene Tree for PIP5KL1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PIP5KL1 gene

PIP5K1B² PIP4K2A² PIP5K1C² PIP4K2B² PIP4K2C² PIP5K1A²

PIP5KL1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs4836592^1,2	C,A,	130694244(+)	`ggcccG/Acgctg`	1	--	ng5¹		6		NA WA	12
rs4837206^1,2	C,A,H	130684751(+)	`gcgggC/Tggatc`	1	--	int¹		6		NA WA	12
rs4837207^1,2	C,A	130684961(+)	`agagcT/Gagact`	1	--	int¹		4		NA WA	8
rs4837208^1,2	C,F,A,H,	130691489(+)	`ACACAG/TGCACA`	1	--	int¹		8		NA WA	138
rs4837209^1,2	C,A	130694726(+)	`agagcC/Gggggt`	1	--	ng5¹		3		NA	6
rs5900778^1,2	--	130686276(+)	`AGACA-/GGAAGA`	1	--	int¹		0	--	--	--	--
rs5900779^1,2	--	130688505(+)	`ttccc-/Tttttt`	1	--	int¹ trp³		0	--	--	--	--
rs10156580^1,2	C,A,H	130686549(+)	`GGATCG/ACTTGA`	1	--	int¹		7		NA WA	16
rs10760514^1,2	C,A,H,	130689030(+)	`TGGGGA/GCAGCC`	1	--	int¹		6		NA WA	12
rs10760515^1,2	C,F,A,H,	130690412(+)	`CCCAGC/GGCAGC`	2	A	ref¹ syn¹		10		NS EA NA WA	500

About this table

HapMap Linkage Disequilibrium images for PIP5KL1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PIP5KL1: --

QIAGEN SeqTarget long-range PCR primers for resequencing PIP5KL1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PIP5KL1 for disorders About GeneDecksing

OMIM: 612865

1 Novoseek disease relationship for PIP5KL1 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	8.86	1	8395284 (1)

About this table

Export disorders and mutations for PIP5KL1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/41 PubMed articles for PIP5KL1 gene, integrated from 7 sources (see all 41):
(articles sorted by number of sources associating them with PIP5KL1)

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Identification and characterization of a phosphoinositide phosphate kinase homolog. (PubMed id 14701839)^{1, 7} Chang J.D....Cantley L.C. (2004)
Overexpression of PIP5KL1 suppresses cell proliferati on and migration in human gastric cancer cells. (PubMed id 19680787)¹ Shi L....Huang C.Z. (2010)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Overexpression of PIP5KL1 suppresses the growth of hu man cervical cancer cells in vitro and in vivo. (PubMed id 19947914)⁷ Shi L....Huang C. (2010)
Structural basis for the phosphorylation-regulated focal adhesion targeting of type Igamma phosphatidylinositol phosphate kinase (PIPKIgamma) by talin. (PubMed id 16616931)⁷ Kong X....Qin J. (2006)
Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. (PubMed id 15623515)⁷ de Pereda J.M....Liddington R.C. (2005)
Phosphatidylinositol phosphate kinases put PI4,5P(2) in its place. (PubMed id 14502432)⁷ Doughman R.L....Anderson R.A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 138429	HGNC: 28711	AceView: PIP5KL1	Ensembl:ENSG00000167103	euGenes: HUgn138429
ECgene: PIP5KL1	Kegg: 138429	H-InvDB: PIP5KL1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for PIP5KL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for PIP5KL1 gene:
Search GeneIP for patents involving PIP5KL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PIP5KL1		Antibodies for PIP5KL1
	Super-pooled esiRNAs for PIP5KL1		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PIP5KL1		microRNA Mimics for PIP5KL1
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PIP5KL1
	SeqTarget long-range PCR primers for resequencing PIP5KL1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PIP5KL1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PIP5KL1

	GenScript Custom Purified and Recombinant Proteins Services for PIP5KL1		GenScript cDNA clones with any tag delivered in your preferred vector for PIP5KL1
	GenScript Custom Assay Services for PIP5KL1		GenScript Custom Superior Antibodies Services for PIP5KL1
	GenScript Custom overexpressing Cell Line Services for PIP5KL1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in PIP5KL1 promoter
	Search Chromatin IP Primers for PIP5KL1
	RT² qPCR Primer Assay for PIP5KL1
	Search GNC Networks for PIP5KL1
	Assays for microRNAs that regulate PIP5KL1
	SABiosciences Custom PCR Arrays for PIP5KL1

Search Tocris compounds for PIP5KL1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Proteins for PIP5KL1
	Lysates for PIP5KL1

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for PIP5KL1

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

PIP5KL1 gene at Home site.

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PIP5KL1 Gene

protein-coding GIFtS: 49

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PIP5KL1 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor PIP5KL1 gene

Summariesfor PIP5KL1 gene

Genomic Viewsfor PIP5KL1 gene

Proteinsfor PIP5KL1 gene

Protein Domains/Familiesfor PIP5KL1 gene

Gene Functionfor PIP5KL1 gene

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Genome Databases showing PIP5KL1 gene

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Specialized Databases showing PIP5KL1 gene

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Aliases &
Descriptions
for PIP5KL1 gene

Summaries
for PIP5KL1 gene

Genomic Views
for PIP5KL1 gene

Proteins
for PIP5KL1 gene

Protein Domains/
Families
for PIP5KL1 gene

Gene Function
for PIP5KL1 gene

Pathways & Interactions
for PIP5KL1 gene

Drugs & Compounds
for PIP5KL1 gene

Transcripts
for PIP5KL1 gene

Expression
for PIP5KL1 gene

Orthologs
for PIP5KL1 gene

Paralogs
for PIP5KL1 gene

Genomic Variants
for PIP5KL1 gene

Disorders & Mutations
for PIP5KL1 gene

Medical News
for PIP5KL1 gene

Publications
for PIP5KL1 gene

Intellectual Property
for PIP5KL1 gene

Products
for PIP5KL1 gene