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PIP5KL1 Gene

protein-coding   GIFtS: 49

GC09M100300
phosphatidylinositol-4-phosphate 5-kinase-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
phosphatidylinositol-4-phosphate 5-kinase-like 11 2     PIPKH2 5
MGC464241 2     phosphatidylinositol-4-phosphate 5-kinase-like protein 12
bA203J24.51 2     phosphatidylinositol phosphate kinase homolog2
PtdIns(4)P-5-kinase-like protein 12 3     EC 2.7.1.683
PI(4)P 5-kinase-like protein 12 3     

External Ids:    HGNC: 287111   Entrez Gene: 1384292   Ensembl: ENSG000001671037   UniProtKB: Q5T9C93   

Export aliases for PIP5KL1 gene to outside databases

Previous GC identifers: GC09M126060 GC09M127763 GC09M129723 GC09M130683


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIP5KL1:
PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I
PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 (PubMed
14701839)).(supplied by OMIM)

UniProtKB/Swiss-Prot: PI5L1_HUMAN, Q5T9C9
Function: May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the
cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to
PI(3,4,5)P3 (By similarity)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIP5KL1 gene promoter:
         MEF-2A   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PIP5KL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PIP5KL1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.13

PIP5KL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIP5KL1 gene location

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M100300:  view genomic region     (about GC identifiers)

Start:
100,300,746 bp from pter
End:
100,310,021 bp from pter
Size:
9,276 bases
Orientation:
minus strand

1 alternative location:
Chr9- 130,683,158-130,693,076     
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PI5L1_HUMAN, Q5T9C9 (See protein sequence)
Recommended Name: Phosphatidylinositol-4-phosphate 5-kinase-like protein 1  
Size: 394 amino acids; 44572 Da
Subunit: Heterodimerizes with other type I phosphatidylinositol-4-phosphate 5-kinase (By similarity)
Subcellular location: Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures (By similarity)
Caution: It is unsure if the enzyme has intrinsic kinase activity
Secondary accessions: Q8IVS3
Alternative splicing: 2 isoforms:  Q5T9C9-1   Q5T9C9-2   

Explore the universe of human proteins at neXtProt for PIP5KL1: NX_Q5T9C9 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001128691.1  NP_775763.1  


    ENSEMBL proteins: 
    ENSP00000373398 ENSP00000373399 ENSP00000300432 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PIP5KL1
    GenScript Custom Purified and Recombinant Proteins Services for PIP5KL1 
    Novus Biologicals Protein for PIP5KL1
    Novus Biologicals Lysate for PIP5KL1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0016020 membrane IEA--
    GO:0042995 cell projection IEA--
    About this table

    PIP5KL1 for ontologies           About GeneDecksing



    Antibodies for PIP5KL1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for PIP5KL1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PIP5KL1 
    Browse antibodies at Epitomics

    Assays for PIP5KL1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PIP5KL1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PIP5KL1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PIP5KL1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002498 PInositol-4-P-5-kinase_core

    Graphical View of Domain Structure for InterPro Entry Q5T9C9

    ProtoNet protein and cluster: Q5T9C9

    1 Blocks protein family: IPB002498 Phosphatidylinositol-4-phosphate 5-kinase

    UniProtKB/Swiss-Prot: PI5L1_HUMAN, Q5T9C9
    Similarity: Contains 1 PIPK domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PI5L1_HUMAN, Q5T9C9
    Function: May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the
    cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to
    PI(3,4,5)P3 (By similarity)
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    4,5-bisphosphate
    Enzyme Number (IUBMB): EC 2.7.1.68 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for PIP5KL1
    Sigma-Aldrich shRNA Panels and shRNA for PIP5KL1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PIP5KL1
    OriGene shRNA RFP (see all 2): PIP5KL1
    OriGene basic RS shRNA (see all 2): PIP5KL1
    OriGene siRNA (see all 2): PIP5KL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PIP5KL1 
    miRNA:Sigma-Aldrich microRNA Mimics for PIP5KL1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PIP5KL1 
    2 SABiosciences Assays for microRNAs that regulate PIP5KL1:
    hsa-miR-137 hsa-miR-338-3p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PIP5KL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PIP5KL1
    OriGene untagged cDNA clones in CMV expression vector: PIP5KL1
    OriGene 3'-UTR clone (see all 2): PIP5KL1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PIP5KL1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PIP5KL1 

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005515 protein binding IEA--
    GO:0005524 ATP binding IEA--
    GO:0016301 kinase activity IEA--
    GO:0016307 phosphatidylinositol phosphate kinase activity ----
    About this table

    PIP5KL1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    PIP5KL1 for pathways           About GeneDecksing

    5 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  PIP5KL1
        Rac Signaling
    Aldosterone Signaling in Epithelial Cells
    Inositol Phosphate Metabolism
    RhoA Signaling
    Regulation of Actin-based Motility by Rho

    3 Kegg Pathways  (Kegg details for PIP5KL1):
        hsa00562 Inositol phosphate metabolism
    hsa01100 Metabolic pathways
    hsa04144 Endocytosis

        SABiosciences Custom Pathway-Focused PCR Arrays for PIP5KL1 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PIP5KL1
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PIP5KL1

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046488 phosphatidylinositol metabolic process IEA--
    About this table

    PIP5KL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PIP5KL1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIP5KL1
    8 Novoseek chemical compound relationships for PIP5KL1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol phosphate 98.9 46 15728183 (2), 14691141 (2), 16616931 (2), 15623515 (2) (see all 35)
    pip2 74 2 16616931 (1)
    phosphatidylinositol 69.3 7 8395284 (1), 9879681 (1), 1655800 (1), 7928021 (1) (see all 6)
    phosphoinositide 66.1 4 11134066 (1), 19638643 (1)
    phosphotyrosine 37 1 16616931 (1)
    choline 21.4 1 9879681 (1)
    tyrosine 18.4 3 14691141 (1), 14701839 (1), 12422220 (1)
    phospholipid 8.89 1 11134066 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for PIP5KL1
    Sigma-Aldrich shRNA Panels and shRNA for PIP5KL1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PIP5KL1
    OriGene shRNA RFP (see all 2): PIP5KL1
    OriGene basic RS shRNA (see all 2): PIP5KL1
    OriGene siRNA (see all 2): PIP5KL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PIP5KL1 
    miRNA: Sigma-Aldrich microRNA Mimics for PIP5KL1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PIP5KL1 
    2 SABiosciences Assays for microRNAs that regulate PIP5KL1:
    hsa-miR-137 hsa-miR-338-3p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PIP5KL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PIP5KL1
    OriGene untagged cDNA clones in CMV expression vector: PIP5KL1
    OriGene 3'-UTR Clone (see all 2): PIP5KL1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PIP5KL1 
    Primers: OriGene genome-wide validated SYBR primer pairs: PIP5KL1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PIP5KL1: PPH21296A

    REFSEQ mRNAs for PIP5KL1 gene (2 alternative transcripts): 

    NM_001135219.1  NM_173492.1  

    Additional cDNA sequence: BC042184.1 

    6 DOTS entries:

    DT.100022493  DT.91899619  DT.91812678  DT.91837732  DT.97777253  DT.95362824 

    24/33 AceView cDNA sequences (see all 33):

    NM_173492 Z38321 BM980218 BU739350 BC042184 BM726577 CA425729 BI520079 
    BQ014508 BM714700 BE019642 BM786675 BF817093 BX112998 BQ774376 AI923090 
    BI085535 BG697332 BU621382 BG676659 BQ574658 BE787282 BE881330 BM476476 

    highest scoring ESTs for PIP5KL1:

    BC042184 BI520079 BE787282 BE881330 BF761749 BF971892 BI085535 BI462029 BI830688 BM476476 

    Unigene Cluster for PIP5KL1:

    Phosphatidylinositol-4-phosphate 5-kinase-like 1
    Hs.445486  [show with all ESTs]
    Unigene Representative Sequence: NM_001135219


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PIP5KL1 (see all 6)

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b
    SP1:                                      -     -     -                 -     -                                       
    SP2:              -                       -     -     -                                                               
    SP3:                                                                          -                                       
    SP4:                                                              -           -                                       
    SP5:                                                                    -     -                                       

    About this scheme

    ECgene alternative splicing isoforms for PIP5KL1
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495448 ENST00000464759 ENST00000477191 ENST00000490773 ENST00000388746
    ENST00000497234 ENST00000498783 ENST00000485562 ENST00000476624 ENST00000388747(uc011mao.1)
    ENST00000300432(uc004bsu.2) ENST00000464108 ENST00000492296

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PIP5KL1 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching PIP5KL1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    57855_at2, 3 U95-C 1 0.31 1.00 1.00 1.00 AI923090 0.40 1.00 0.76 1
    243116_at2, 3 U133-B 1 0.36 1.00 -- -- AI923090 0.40 1.00 0.76 1
    208162_s_at*2 U133-A 7 0.46 0.14 -- -- -- -- -- -- --
    243116_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    208162_s_at*2 U133Plus2 7 0.46 0.14 -- -- -- -- -- -- --
    About this table

    PIP5KL1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PIP5KL1 gene expression
    PIP5KL1 gene electronic northern expression
    PIP5KL1 gene sage expression
    About these images

    CGAP SAGE TAG: AAATGGAGGC

    SOURCE GeneReport for Unigene cluster: Hs.445486
    Primers: OriGene genome-wide validated SYBR primer pairs: PIP5KL1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PIP5KL1: PPH21296A
        SABiosciences Custom PCR Arrays for PIP5KL1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PIP5KL1 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PIP5KL11   -- phosphatidylinositol-4-phosphate 5-kinase-like 1 91.62(n)
    93.19(a)
    609122  XM_846326.1  XP_851419.1 
    chimpanzee
    (Pan troglodytes)
    PIP5KL11   -- phosphatidylinositol-4-phosphate 5-kinase-like 1 99.3(n)
    100(a)
    464758  XM_520281.2  XP_520281.2 
    cow
    (Bos taurus)
    PIP5KL11   -- phosphatidylinositol-4-phosphate 5-kinase-like 1 90.48(n)
    91.43(a)
    523736  NM_001075847.1  NP_001069315.1 
    mouse
    (Mus musculus)
    Pip5kl11 , 5 2 (22.09 cM)5
    phosphatidylinositol-4-phosphate 5-kinase-like 11, 5 78.25(n)1
    73.16(a)1
    2277331  NM_198191.11  NP_937834.11 
     AK1332445  AK1649985  (see all 13)
    zebrafish
    (Danio rerio)
    LOC1001498431   -- similar to Phosphatidylinositol-4-phosphate 5-kinase-like more 63.87(n)
    64.4(a)
    100149843  XM_001923957.1  XP_001923992.1 
    About this table        Species with no ortholog for PIP5KL1

    ENSEMBL Gene Tree for PIP5KL1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PIP5KL1 gene
    PIP5K1B2  PIP4K2A2  PIP5K1C2  PIP4K2B2  PIP4K2C2  PIP5K1A2  

    PIP5KL1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/96 NCBI SNPs in PIP5KL1 are shown (see all 96)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs48365921,2
    C,A,130694244(+) ggcccG/Acgctg 1 -- ng516Minor allele frequency- A:0.17NA WA 12
    rs48372061,2
    C,A,H130684751(+) gcgggC/Tggatc 1 -- int16Minor allele frequency- T:0.00NA WA 12
    rs48372071,2
    C,A130684961(+) agagcT/Gagact 1 -- int14Minor allele frequency- G:0.00NA WA 8
    rs48372081,2
    C,F,A,H,130691489(+) ACACAG/TGCACA 1 -- int18Minor allele frequency- T:0.19NA WA 138
    rs48372091,2
    C,A130694726(+) agagcC/Gggggt 1 -- ng513Minor allele frequency- G:0.00NA 6
    rs59007781,2
    --130686276(+) AGACA-/GGAAGA 1 -- int10--------
    rs59007791,2
    --130688505(+) ttccc-/Tttttt 1 -- int1 trp30--------
    rs101565801,2
    C,A,H130686549(+) GGATCG/ACTTGA 1 -- int17Minor allele frequency- A:0.12NA WA 16
    rs107605141,2
    C,A,H,130689030(+) TGGGGA/GCAGCC 1 -- int16Minor allele frequency- G:0.08NA WA 12
    rs107605151,2
    C,F,A,H,130690412(+) CCCAGC/GGCAGC 2 A ref1 syn110Minor allele frequency- G:0.23NS EA NA WA 500
    About this table

    HapMap Linkage Disequilibrium images for PIP5KL1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PIP5KL1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing PIP5KL1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PIP5KL1 for disorders           About GeneDecksing

    OMIM: 612865

    1 Novoseek disease relationship for PIP5KL1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 8.86 1 8395284 (1)
    About this table


    Export disorders and mutations for PIP5KL1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/41 PubMed articles for PIP5KL1 gene, integrated from 7 sources (see all 41):
    (articles sorted by number of sources associating them with PIP5KL1)
    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Identification and characterization of a phosphoinositide phosphate kinase homolog. (PubMed id 14701839)1, 7 Chang J.D....Cantley L.C. (2004)
    3. Overexpression of PIP5KL1 suppresses cell proliferati on and migration in human gastric cancer cells. (PubMed id 19680787)1 Shi L....Huang C.Z. (2010)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Overexpression of PIP5KL1 suppresses the growth of hu man cervical cancer cells in vitro and in vivo. (PubMed id 19947914)7 Shi L....Huang C. (2010)
    8. Structural basis for the phosphorylation-regulated focal adhesion targeting of type Igamma phosphatidylinositol phosphate kinase (PIPKIgamma) by talin. (PubMed id 16616931)7 Kong X....Qin J. (2006)
    9. Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. (PubMed id 15623515)7 de Pereda J.M....Liddington R.C. (2005)
    10. Phosphatidylinositol phosphate kinases put PI4,5P(2) in its place. (PubMed id 14502432)7 Doughman R.L....Anderson R.A. (2003)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 138429 HGNC: 28711 AceView: PIP5KL1 Ensembl:ENSG00000167103 euGenes: HUgn138429
    ECgene: PIP5KL1 Kegg: 138429 H-InvDB: PIP5KL1

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    (Patent information from GeneIP,
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    Patent Information for PIP5KL1 gene:
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