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PIWIL1 Gene

protein-coding   GIFtS: 58

GC12P127807
piwi-like 1 (Drosophila)
(Previous name: piwi (Drosophila)-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
piwi-like 1 (Drosophila)1 2     piwi homolog2
HIWI1 2 3     piwi-like protein 12
PIWI1 2     MIWI2
piwi (Drosophila)-like 11     

External Ids:    HGNC: 90071   Entrez Gene: 92712   Ensembl: ENSG000001252077   UniProtKB: Q96J943   

Export aliases for PIWIL1 gene to outside databases

Previous GC identifers: GC12P129251 GC12P130586 GC12P129175 GC12P129347 GC12P130822


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIWIL1:
This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing
both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational
regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal
capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: PIWL1_HUMAN, Q96J94
Function: Plays a central role during spermatogenesis by repressing transposable elements and prevent their
mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the
repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and
govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide
RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated
sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other
processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA
cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some
miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator

Gene Wiki entry for PIWIL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIWIL1 gene promoter:
         Elk-1   ER-alpha   AP-2rep   FOXJ2 (long isoform)   CP1A   CP1C   NF-Y   NF-YA   Arnt   ATF-2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PIWIL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PIWIL1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

PIWIL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIWIL1 gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P127807:  view genomic region     (about GC identifiers)

Start:
127,807,883 bp from pter
End:
127,841,997 bp from pter
Size:
34,115 bases
Orientation:
plus strand

1 alternative location:
Chr12+ 130,822,614-130,856,872     
RefSeq DNA sequence:
NC_000012.11  NT_009755.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PIWL1_HUMAN, Q96J94 (See protein sequence)
Recommended Name: Piwi-like protein 1  
Size: 861 amino acids; 98603 Da
Subunit: Interacts (via Piwi domain) with DICER1, suggesting that it forms ribonucleoprotein RISC complexes. This
interaction is regulated by HSP90AB1 activity. Interacts with MAEL, KIF17, PABPC1, PRMT5 and WDR77. Interacts (when
methylated on arginine residues) with TDRD1, TDRKH/TDRD2, RNF17/TDRD4, TDRD6, TDRD7 and TDRD9 (By similarity)
Subcellular location: Cytoplasm (By similarity). Note=Component of the meiotic nuage, also named P granule, a
germ-cell-specific organelle required to repress transposon during meiosis. Also present in chromatoid body (By
similarity)
Secondary accessions: A4F266 O95404 Q8NA60 Q8TBY5 Q96JD5
Alternative splicing: 3 isoforms:  Q96J94-1   Q96J94-2   Q96J94-3   

Explore the universe of human proteins at neXtProt for PIWIL1: NX_Q96J94 

Post-translational modifications:

  • Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein (TDRD1, TDRKH/TDRD2,
  • RNF17/TDRD4, TDRD6, TDRD7 and TDRD9) and subsequent localization to the meiotic nuage, also named P granule (By
    similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001177900.1  NP_004755.2  


    ENSEMBL proteins: 
    ENSP00000245255 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for PIWIL1 
    Novus Biologicals Protein for PIWIL1
    Novus Biologicals Lysate for PIWIL1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm ISS--
    GO:0005844 polysome IEA--
    GO:0005845 mRNA cap binding complex IEA--
    GO:0033391 chromatoid body ISS--
    GO:0043186 P granule ISS--
    About this table

    PIWIL1 for ontologies           About GeneDecksing



    Antibodies for PIWIL1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for PIWIL1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Superior Antibodies for PIWIL1 
    Novus Biologicals Antibodies for PIWIL1
    Browse antibodies at Epitomics

    Assays for PIWIL1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PIWIL1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PIWIL1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PIWIL1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003165 Piwi
     IPR003100 PAZ
     IPR008625 GAGE
     IPR012337 RNaseH-like

    Graphical View of Domain Structure for InterPro Entry Q96J94

    ProtoNet protein and cluster: Q96J94

    2 Blocks protein families:
    IPB003100 Argonaute and Dicer protein
    IPB003165 Stem cell self-renewal protein Piwi


    UniProtKB/Swiss-Prot: PIWL1_HUMAN, Q96J94
    Similarity: Belongs to the argonaute family. Piwi subfamily
    Similarity: Contains 1 PAZ domain
    Similarity: Contains 1 Piwi domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PIWL1_HUMAN, Q96J94
    Function: Plays a central role during spermatogenesis by repressing transposable elements and prevent their
    mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the
    repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and
    govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide
    RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated
    sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other
    processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA
    cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some
    miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator
    Induction: Isoform 3 is down-regulated in CD34(+) hematopoietic cells during differentiation

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for PIWIL1
    Sigma-Aldrich shRNA for PIWIL1
    OriGene 29mer shRNA kits in GFP-retroviral vector: PIWIL1
    OriGene shRNA RFP: PIWIL1
    OriGene basic RS shRNA: PIWIL1
    OriGene siRNA: PIWIL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PIWIL1 
    miRNA:Sigma-Aldrich microRNA Mimics for PIWIL1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PIWIL1 
    2 SABiosciences Assays for microRNAs that regulate PIWIL1:
    hsa-miR-577 hsa-miR-548c-3p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PIWIL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PIWIL1
    OriGene untagged cDNA clones in CMV expression vector: PIWIL1
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PIWIL1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PIWIL1 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding ----
    GO:0003727 single-stranded RNA binding IEA--
    GO:0003729 mRNA binding ISS--
    GO:0005515 protein binding IPI14749716
    GO:0034584 piRNA binding ISS--
    About this table

    PIWIL1 for ontologies           About GeneDecksing

    Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Piwil1):

    endocrine/exocrine glandreproductive system

    PIWIL1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    PIWIL1 for pathways           About GeneDecksing

    1 Kegg Pathway  (Kegg details for PIWIL1):
        hsa04320 Dorso-ventral axis formation

        SABiosciences Custom Pathway-Focused PCR Arrays for PIWIL1 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PIWIL1

    4 Interacting proteins for PIWIL1 (Q96J941 ENSP000002452553) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DICER1Q9UPY31EBI-527417,EBI-395506
    HSD3B7ENSP000003706623STRING: ENSP00000370662
    PIWIL3ENSP000003300313STRING: ENSP00000330031
    PIWIL4ENSP000002990013STRING: ENSP00000299001
    About this table

    5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417 regulation of translation IEA--
    GO:0007126 meiosis IEA--
    GO:0007275 multicellular organismal development IEA--
    GO:0007283 spermatogenesis IEA--
    GO:0007286 spermatid development ISS--
    About this table

    PIWIL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIWIL1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for PIWIL1
    Sigma-Aldrich shRNA for PIWIL1
    OriGene 29mer shRNA kits in GFP-retroviral vector: PIWIL1
    OriGene shRNA RFP: PIWIL1
    OriGene basic RS shRNA: PIWIL1
    OriGene siRNA: PIWIL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PIWIL1 
    miRNA: Sigma-Aldrich microRNA Mimics for PIWIL1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PIWIL1 
    2 SABiosciences Assays for microRNAs that regulate PIWIL1:
    hsa-miR-577 hsa-miR-548c-3p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PIWIL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PIWIL1
    OriGene untagged cDNA clones in CMV expression vector: PIWIL1
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PIWIL1 
    Primers: OriGene genome-wide validated SYBR primer pairs: PIWIL1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PIWIL1: PPH19177A

    REFSEQ mRNAs for PIWIL1 gene (2 alternative transcripts): 

    NM_001190971.1  NM_004764.4  

    Additional cDNA sequence: 

    AB274731.1 AF104260.2 AF264004.1 AF387507.1 AK093133.1 BC028581.2 

    6 DOTS entries:

    DT.405949  DT.100001500  DT.97790109  DT.303336  DT.121169040  DT.97825156 

    24/56 AceView cDNA sequences (see all 56):

    AA639672 BF092403 AA969660 NM_004764 AK093133 BX281582 AI208149 AX747944 
    AA774856 AL041473 BC028581 AL705072 BM728018 BU732873 AA757218 AF104260 
    BM680592 BI459464 BI463897 BG718168 BG721550 AI125224 BF092519 AL704986 

    highest scoring ESTs for PIWIL1:

    AF104260 AA639672 AA904973 AA969660 AF264004 AF387507 AI125224 AI538315 AI698821 AL044133 

    Unigene Cluster for PIWIL1:

    Piwi-like 1 (Drosophila)
    Hs.405659  [show with all ESTs]
    Unigene Representative Sequence: NM_004764


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PIWIL1 (see all 9)

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
    SP1:                          -     -     -     -     -     -                                                                                                   
    SP2:                          -     -     -     -     -     -                                                                                                   
    SP3:        -     -     -     -     -     -     -     -     -                                                                                                   
    SP4:                                -     -     -     -     -                                                                                                   
    SP5:                                      -     -     -     -                                                                                                   

    ExUns: 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25
    SP1:                                            -                 -         
    SP2:                                            -                           
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        

    About this scheme

    ECgene alternative splicing isoforms for PIWIL1
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000245255(uc001uij.1 uc001uik.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PIWIL1 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching PIWIL1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35901_at2, 3 U95-A 1 0.75 1.00 0.05 0.34 AF104260 1.00 1.00 1.00 1
    76330_r_at2, 3 U95-D 1 0.38 1.00 0.91 1.23 AA889526 0.60 1.00 0.82 1
    76328_i_at2, 3 U95-D 1 0.31 1.00 0.72 0.78 AA889526 0.60 1.00 0.82 1
    214868_at2, 3 U133-A 1 0.73 1.00 -- -- AW189518 0.80 1.00 0.91 1
    214868_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    PIWIL1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PIWIL1 gene expression
    PIWIL1 gene electronic northern expression
    PIWIL1 gene sage expression
    About these images

    CGAP SAGE TAG: ATTCTATTTG

    SOURCE GeneReport for Unigene cluster: Hs.405659

    Expression variation in blood from EXPOLDB for PIWIL1

    UniProtKB/Swiss-Prot: PIWL1_HUMAN, Q96J94
    Tissue specificity: Detected in most fetal and adult tissues. Expressed in testes, specifically in germline cells;
    detected in spermatocytes and spermatids during spermatogenesis. Increased expression in testicular tumors originating
    from embryonic germ cells with retention of germ cells phenotype. No expression in testicular tumors of somatic
    origin, such as Sertoli cell and Leydig cell tumors. Overexpressed in gastric cancer cells. Isoform 3 is ubiquitously
    expressed, and specifically in CD34+ hematopoietic progenitor cells but not in more differentiated cells

    Primers: OriGene genome-wide validated SYBR primer pairs: PIWIL1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PIWIL1: PPH19177A
        SABiosciences Custom PCR Arrays for PIWIL1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PIWIL1 gene from 5/10 species (see all 10)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PIWIL11   -- piwi-like 1 (Drosophila) 89.59(n)
    95.93(a)
    477440  XM_534638.2  XP_534638.2 
    chimpanzee
    (Pan troglodytes)
    PIWIL11   -- piwi-like 1 (Drosophila) 99.38(n)
    99.19(a)
    452369  XM_001137815.1  XP_001137815.1 
    cow
    (Bos taurus)
    PIWIL11   -- piwi-like 1 (Drosophila) 91.06(n)
    96.17(a)
    537833  XM_618020.2  XP_618020.2 
    rat
    (Rattus norvegicus)
    Piwil11   -- piwi-like 1 (Drosophila) 81.8(n)
    95.01(a)
    363912  XM_344105.3  XP_344106.3 
    mouse
    (Mus musculus)
    Piwil11 , 5 5 (67.86 cM)5
    piwi-like homolog 1 (Drosophila)1, 5 82.11(n)1
    95.01(a)1
    577491  NM_021311.31  NP_067286.11 
     AB0326045  AF4384055  (see all 10)
    About this table        Species with no ortholog for PIWIL1

    ENSEMBL Gene Tree for PIWIL1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PIWIL1 gene
    PIWIL42  PIWIL22  EIF2C22  EIF2C42  PIWIL32  EIF2C12  EIF2C32  

    PIWIL1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/21 NCBI SNPs in PIWIL1 are shown (see all 21)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs11060411,2
    C,F,130841561(+) TATACG/ACGAAG 2 /T syn1 ref1 ese312Minor allele frequency- A:0.02NS EA MN NA WA 1106
    rs11060421,2
    C,F,130841638(+) AATGAG/AAAAAG 2 /K /R mis1 ref114Minor allele frequency- A:0.12NA NS EA WA 2640
    rs14968561,2
    C130831029(-) GGAGTC/TTTCTG 2 K R mis1 ref1 ese35Minor allele frequency- T:0.00MN NS EA 596
    rs107737711,2
    C,F,A,H,130856316(+) TTATAC/TGTAAA 1 -- ut31 ese314Minor allele frequency- T:0.48NS EA NA WA 1044
    rs108480871,2
    C,F,A,H,130839165(+) ACACTG/ACCAGG 2 /L syn1 ref1 ese311Minor allele frequency- A:0.18NS EA NA WA 604
    rs178525681,2
    --130845783(+) ATACCC/TGTGTA 2 P L mis1 ref1 ese30--------
    rs178568121,2
    --130841531(+) GTTAAG/TCCACT 2 K N ref1 mis1 ese30--------
    rs342758381,2
    --130842047(+) AGAACT/CGAAGC 2 /T syn1 ref11Minor allele frequency- C:0.01NA 72
    rs353777261,2
    --130846069(+) GGCATC/TGATTG 2 I ref1 syn11Minor allele frequency- T:0.01NA 68
    rs355400711,2
    --130839516(+) GGCAGC/TGTGAA 2 R C ref1 mis11Minor allele frequency- T:0.01NA 78
    About this table

    HapMap Linkage Disequilibrium images for PIWIL1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for PIWIL1
         5 CNVs: 71624 8740 3000 3901 35062

    QIAGEN SeqTarget long-range PCR primers for resequencing PIWIL1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PIWIL1 for disorders           About GeneDecksing

    OMIM: 605571

    Human Genome Epidemiology (HuGE) Navigator: PIWIL1 (4 documents)

    Export disorders and mutations for PIWIL1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/23 PubMed articles for PIWIL1 gene, integrated from 7 sources (see all 23):
    (articles sorted by number of sources associating them with PIWIL1)
    1. Identification of eight members of the Argonaute family in the human genome. (PubMed id 12906857)1, 2, 3 Sasaki T.... Shimizu N. (2003)
    2. Human CD34+ stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi. (PubMed id 11154219)1, 2, 7 Sharma A.K.... Hoffman R. (2001)
    3. Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. (PubMed id 16287078)1, 2, 7 Liu X.... Shou C. (2006)
    4. The induction of H3K9 methylation by PIWIL4 at the p16(Ink4a) locus. (PubMed id 17544373)1, 2 Sugimoto K.... Takai D. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. (PubMed id 14749716)1, 2 Tahbaz N....Hobman T.C. (2004)
    8. Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. (PubMed id 12037681)1, 2 Qiao D.... Lin H. (2002)
    9. A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. (PubMed id 9851978)1, 3 Cox D.N....Lin H. (1998)
    10. Expression of PSCA, PIWIL1, and TBX2 in endometrial a denocarcinoma. (PubMed id 20502058)1, 7 Liu W.K....Zhang Z.X. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9271 HGNC: 9007 AceView: PIWIL1 Ensembl:ENSG00000125207 euGenes: HUgn9271
    ECgene: PIWIL1 Kegg: 9271 H-InvDB: PIWIL1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for PIWIL1 gene:
    Search GeneIP for patents involving PIWIL1

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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