Aliases &
Descriptions
for PLA2G4E gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| phospholipase A2, group IVE1 2 | | cytosolic phospholipase A2 epsilon2 | | FLJ456511 2 | | MGC1266332 | | cPLA2-epsilon2 3 | | Phospholipase A2 group IVE3 | | MGC1266612 | | EC 3.1.1.43 |
Export aliases for PLA2G4E gene to outside databasesPrevious GC identifers: GC15M040062 GC15M042273 |
Summaries
for PLA2G4E gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PA24E_HUMAN, Q3MJ16Function: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (Bysimilarity)
 summary
for PLA2G4E: Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which
cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates
lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+
concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including
roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.
|
Genomic Views
for PLA2G4E gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PLA2G4E gene promoter:
HNF-1A GCNF-1 GCNF-2 POU2F1 AhR p300 RFX1 AREB6 c-Rel Pbx1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for PLA2G4E
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.1 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q15.1PLA2G4E Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M019125: view genomic region
(about GC identifiers)
Start:
|
19,123,928 bp from pter |
End:
|
19,150,435 bp from pter |
Size:
|
26,508 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr15- 42,273,780-42,343,388 |
RefSeq DNA sequence:- NC_000015.9 NT_010194.17
|
Proteins
for PLA2G4E gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PA24E_HUMAN, Q3MJ16 (See
protein sequence)Recommended Name: Cytosolic phospholipase A2 epsilon Size: 838 amino acids; 95687 Da
Subcellular location: Cytoplasm, cytosol. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side (Bysimilarity). Note=Translocates to lysosomal membranes in a calcium-dependent fashion (By similarity)
Secondary accessions: Q6ZSC0Alternative splicing: 2 isoforms: Q3MJ16-1 Q3MJ16-2 Explore the universe of human proteins at neXtProt for PLA2G4E: NX_Q3MJ16
REFSEQ proteins: NP_001073959.1
ENSEMBL proteins: ENSP00000382434 ENSP00000413897 ENSP00000371857
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
PLA2G4E for ontologies About GeneDecksing
Antibodies for PLA2G4E:
Assays for PLA2G4E: |
Protein
Domains/
Families
for PLA2G4E gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PLA2G4E for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q3MJ16ProtoNet protein and cluster: Q3MJ16 2 Blocks protein families: IPB000008 C2 domain IPB002642 Lysophospholipase
UniProtKB/Swiss-Prot: PA24E_HUMAN, Q3MJ16Domain: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity bypresenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity)Similarity: Contains 1 C2 domainSimilarity: Contains 1 PLA2c domain |
Gene Function
for PLA2G4E gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PA24E_HUMAN, Q3MJ16Function: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (Bysimilarity)Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylateEnzyme regulation: Stimulated by cytosolic Ca(2+) (By similarity)Enzyme Number (IUBMB): EC 3.1.1.4
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
PLA2G4E for ontologies About GeneDecksing
|
Pathways & Interactions
for PLA2G4E gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
PLA2G4E for pathways About GeneDecksing
5/9  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for PLA2G4E (see all 9)
5/15  Kegg Pathways (Kegg details for PLA2G4E) (see all 15):
SABiosciences Custom Pathway-Focused PCR Arrays for PLA2G4E
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PLA2G4E
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLA2G4E
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008152 | metabolic process |
IEA | -- | | GO:0009395 | phospholipid catabolic process |
IEA | -- | | GO:0016042 | lipid catabolic process |
IEA | -- |
About this table
PLA2G4E for ontologies About GeneDecksing
|
Drugs & Compounds
for PLA2G4E gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for PLA2G4E available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| RHC 80267 | Diacylglycerol lipase inhibitor | [83654-05-1] | | AACOCF3 | Phospholipase A2 inhibitor | [149301-79-1] | | OBAA | Phospholipase A2 inhibitor | -- | | PACOCF3 | Phospholipase A2 inhibitor | [141022-99-3] |
About this table
|
Transcripts
for PLA2G4E gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PLA2G4E gene: NM_001080490.1 Additional cDNA sequence: AK127558.1 BC101584.1 BC101612.1 BC143436.1 BX648482.1 CR601075.1 3 DOTS entries: DT.65285500 DT.100806806 DT.100657634 14 AceView cDNA sequences: AW275838 BX102450 CR601075 AI379080 BG743628 BX648482 BG680954 AK127558 NM_198442 BX437373 BX437372 BF738363 AI224165 BF738119
 highest scoring ESTs for PLA2G4E:AI379080 AK127558 BX648482 AI224165 AW275838 BX102450 BC101584 BC101612 BF738363 BG680954 Unigene Cluster for PLA2G4E: Phospholipase A2, group IVE Hs.668060 [show with all ESTs]Unigene Representative Sequence: AK127558
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000399518(uc010udc.1 uc001zov.1) ENST00000413860(uc001zow.1)
ENST00000382420
|
Expression
for PLA2G4E gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PLA2G4E expression in normal and diseased human tissues
1 / 2 / 3 1 probe-set matching PLA2G4E gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 53400_at2, 3
|
U95-C |
1 |
0.81 |
1.00 |
1.00 |
1.00 |
AI379080 |
0.80 |
1.00 |
0.91 |
1 |
About this table
PLA2G4E for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGGGTGAAAA
SOURCE GeneReport for Unigene cluster: Hs.668060
SABiosciences Custom PCR Arrays for PLA2G4E
|
Orthologs
for PLA2G4E gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PLA2G4E gene from 5/6 species (see all 6)
About this table Species with no ortholog for PLA2G4E
ENSEMBL Gene Tree for PLA2G4E (if available) |
Paralogs
for PLA2G4E gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PLA2G4E gene
- PLA2G4D2 PLA2G4A2 PLA2G4B2 PLA2G4F2 JMJD7-PLA2G4B2 PLA2G4C2
PLA2G4E for paralogs About GeneDecksing
|
Genomic Variants
for PLA2G4E gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| | | QIAGEN SeqTarget long-range PCR primers for resequencing PLA2G4E |
|
Disorders & Mutations
for PLA2G4E gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PLA2G4E for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: PLA2G4E (2 documents)
Export disorders and mutations for PLA2G4E gene to outside databases
|
Medical News
for PLA2G4E gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PLA2G4E gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
8 PubMed articles for PLA2G4E gene integrated from 7 sources:
(articles sorted by number of sources associating them with PLA2G4E)- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)
- Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. (PubMed id 15866882)1, 3 Ohto T....Shimizu T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. (PubMed id 17693683)2 Tang L.Y....Zeng R. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for PLA2G4E gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PLA2G4E gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PLA2G4E gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PLA2G4E gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PLA2G4E gene:
Search GeneIP for patents involving PLA2G4E
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PLA2G4E gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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