Aliases &
Descriptions
for PLGLB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| plasminogen-like B11 2 | | OTTHUMP000002035112 | | PRGB2 3 5 | | OTTHUMP000002035092 | | PLGL2 3 5 | | plasminogen-related protein B2 | | PRP-B1 2 | | OTTHUMP000002035122 | | PLGP12 3 | | type B plasminogen related2 | | plasminogen-like1 | | |
Export aliases for PLGLB1 gene to outside databasesPrevious GC identifers: GC00U921621 GC02U900794 GC02M087083 |
Summaries
for PLGLB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PLGB_HUMAN, Q02325Function: May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This mayinterfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization ofactivity at sites necessary for extracellular matrix destruction
|
Genomic Views
for PLGLB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PLGLB1 gene promoter:
GATA-1 HNF-1A POU2F1 CUTL1 Pax-6 FOXI1 FOXO3b FOXO3a Cdc5 FOXO4
Other transcription factors
Search SABiosciences Chromatin IP Primers for PLGLB1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2PLGLB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M087229: view genomic region
(about GC identifiers)
Start:
|
87,229,682 bp from pter |
End:
|
87,248,975 bp from pter |
Size:
|
19,294 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.11 NT_022184.15
|
Proteins
for PLGLB1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PLGB_HUMAN, Q02325 (See
protein sequence)Recommended Name: Plasminogen-related protein B precursor Size: 96 amino acids; 10971 Da
Subcellular location: Secreted
Secondary accessions: Q580R1Explore the universe of human proteins at neXtProt for PLGLB1: NX_Q02325
REFSEQ proteins: NP_001027564.1
ENSEMBL proteins: ENSP00000387083 ENSP00000347933 ENSP00000386975 ENSP00000386505
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
About this table
PLGLB1 for ontologies About GeneDecksing
Antibodies for PLGLB1:
Assays for PLGLB1: |
Protein
Domains/
Families
for PLGLB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PLGLB1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q02325ProtoNet protein and cluster: Q02325 UniProtKB/Swiss-Prot: PLGB_HUMAN, Q02325Similarity: Contains 1 PAN domain |
Gene Function
for PLGLB1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PLGB_HUMAN, Q02325Function: May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This mayinterfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization ofactivity at sites necessary for extracellular matrix destruction
|
Pathways & Interactions
for PLGLB1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for PLGLB1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLGLB1
|
Drugs & Compounds
for PLGLB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PLGLB1
|
Transcripts
for PLGLB1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PLGLB1 gene: NM_001032392.2 12 DOTS entries: DT.91938200 DT.86855200 DT.91748454 DT.92414250 DT.121025805 DT.121025681 DT.120933569 DT.121324519 DT.40119955 DT.91671965 DT.92044277 DT.95361932
 highest scoring ESTs for PLGLB1:CV027415 T69545 BF905498 BG545138 BG568415 BX507634 CR745278 DA329742 H52933 H67257 Unigene Cluster for PLGLB1: Plasminogen-like B1 Hs.652174 [show with all ESTs]Unigene Representative Sequence: NM_001032392
GeneLoc Exon Structure
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000467745 ENST00000409795 ENST00000355705(uc002ssd.2) ENST00000409801
ENST00000494194 ENST00000478636 ENST00000409310
|
Expression
for PLGLB1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PLGLB1 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching PLGLB1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 49814_at2, 3
|
U95-C |
2 |
0.44 |
0.55 |
1.00 |
1.00 |
AI088455 |
0.20 |
0.07 |
0.15 |
3 |
| 205871_at2, 3
|
U133-A |
5 |
1.00 |
0.39 |
-- |
-- |
BC005379 |
0.20 |
0.12 |
0.17 |
2 |
| 230120_s_at2, 3
|
U133-B |
2 |
0.27 |
0.50 |
-- |
-- |
AI088455 |
0.20 |
0.07 |
0.15 |
3 |
| 205871_at2
|
U133Plus2 |
5 |
1.00 |
0.39 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1558603_at2
|
U133Plus2 |
2 |
0.27 |
0.50 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 230120_s_at2
|
U133Plus2 |
2 |
0.27 |
0.50 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PLGLB1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TACAAATATA
SOURCE GeneReport for Unigene cluster: Hs.652174
SABiosciences Custom PCR Arrays for PLGLB1
|
Orthologs
for PLGLB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for PLGLB1 (if available) |
Paralogs
for PLGLB1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PLGLB1 gene
- PLGLB21 2 ENSG000001696592
PLGLB1 for paralogs About GeneDecksing
|
Genomic Variants
for PLGLB1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PLGLB1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for PLGLB1
6 CNVs: 7283 4294 89760 2399 50583 3374 |
Disorders & Mutations
for PLGLB1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PLGLB1 for disorders About GeneDecksing
OMIM: 173340
1  Novoseek disease relationship for PLGLB1 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
11 |
12631627 (2), 12799192 (1) |
About this table
Human Genome Epidemiology (HuGE) Navigator: PLGLB1 (2 documents)
Export disorders and mutations for PLGLB1 gene to outside databases
|
Medical News
for PLGLB1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PLGLB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/14 PubMed articles for PLGLB1 gene, integrated from 7 sources (see all 14):
(articles sorted by number of sources associating them with PLGLB1)- Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. (PubMed id 1554698)1, 2, 3 Ichinose A. (1992)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A plasminogen-related gene is expressed in cancer cells. (PubMed id 1379800)1, 2 Weissbach L. and Treadwell B.V. (1992)
- A gene homologous to plasminogen located on human chr omosome 2q11-p11. (PubMed id 2714803)1, 3 Frank S.L....Lusis A.J. (1989)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis. (PubMed id 1986355)1 Ichinose A.... Davie E.W. (1991)
- Interaction of plasminogen-related protein B with end othelial and smooth muscle cells in vitro. (PubMed id 12799192)7 Morioka H....Weissbach L. (2003)
|
External Searches for PLGLB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PLGLB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PLGLB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PLGLB1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PLGLB1 gene:
Search GeneIP for patents involving PLGLB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PLGLB1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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