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POLR2B Gene

protein-coding GIFtS: 63

GC04P053798

polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
(Previous name: polymerase (RNA) II (DNA directed) polypeptide B (140kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa¹ ²		hsRPB2²
RPB2¹ ²		hRPB140²
RNA polymerase II subunit 2² ³		DNA-directed RNA polymerase II subunit RPB2²
DNA-directed RNA polymerase II 140 kDa polypeptide² ³		OTTHUMP00000158973²
DNA-directed RNA polymerase II subunit B² ³		OTTHUMP00000218969²
RNA polymerase II subunit B2² ³		DNA directed RNA polymerase II 140 kDa polypeptide, RNA polymerase II subunit 2, RNA polymerase II second largest subunit²
POL2RB² ⁵		OTTHUMP00000201827²
polymerase (RNA) II (DNA directed) polypeptide B (140kD)¹		EC 2.7.7.6³

External Ids:	HGNC: 9188¹	Entrez Gene: 5431²	Ensembl: ENSG00000047315⁷	UniProtKB: P30876³

Export aliases for POLR2B gene to outside databases

Previous GC identifers: GC04P057648 GC04P057841 GC04P057760 GC04P057685 GC04P057538

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POLR2B:

This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing

messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a

structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and

the newly synthesized RNA. (provided by RefSeq)

UniProtKB/Swiss-Prot: RPB2_HUMAN, P30876

Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside

triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many

functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase

active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II

transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core

element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are

thought to grab the incoming DNA template (By similarity)

Gene Wiki entry for POLR2B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POLR2B gene promoter:
         RP58   POU3F2   Meis-1   HOXA9B   STAT5A   STAT2   STAT1beta   STAT1alpha   STAT1   STAT3
         Other transcription factors

Search SABiosciences Chromatin IP Primers for POLR2B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12 Ensembl cytogenetic band: 4q12 HGNC cytogenetic band: 4q12

POLR2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2B gene location

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P053798: view genomic region (about GC identifiers)

Start:	53,798,541 bp from pter
End:	53,850,908 bp from pter
Size:	52,368 bases
Orientation:	plus strand

1 alternative location:

Chr4+ 57,843,888-57,897,324

RefSeq DNA sequence:

NC_000004.11 NT_022853.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RPB2_HUMAN, P30876 (See protein sequence)

Recommended Name: DNA-directed RNA polymerase II subunit RPB2

Size: 1174 amino acids; 133897 Da

Subunit: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits

Subcellular location: Nucleus

Miscellaneous: The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably

involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion

coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity)

Secondary accessions: A8K1A8 Q8IZ61

Explore the universe of human proteins at neXtProt for POLR2B: NX_P30876

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000929.1

ENSEMBL proteins:

ENSP00000407728 ENSP00000379541 ENSP00000312735 ENSP00000391452 ENSP00000391096 ENSP00000408638

ENSP00000370625

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for POLR2B
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9852112
GO:0005654	nucleoplasm	TAS	--
GO:0005665	DNA-directed RNA polymerase II, core complex	IDA	9852112

About this table

POLR2B for ontologies About GeneDecksing

Antibodies for POLR2B:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for POLR2B
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for POLR2B
	Novus Biologicals Antibodies for POLR2B
	Epitomics antibodies for POLR2B

Assays for POLR2B:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for POLR2B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for POLR2B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

POLR2B for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR007120 DNA-dir_RNA_pol_su2_6

IPR007641 RNA_pol_Rpb2_7

IPR007644 RNA_pol_bsu_protrusion

IPR015712 DNA-dir_RNA_pol_su2

IPR007645 RNA_pol_Rpb2_3

Graphical View of Domain Structure for InterPro Entry P30876

ProtoNet protein and cluster: P30876

4 Blocks protein families:

IPB007120 RNA polymerase Rpb2

IPB007121 RNA polymerase

IPB007646 RNA polymerase Rpb2

IPB007647 RNA polymerase Rpb2

UniProtKB/Swiss-Prot: RPB2_HUMAN, P30876

Similarity: Belongs to the RNA polymerase beta chain family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: RPB2_HUMAN, P30876

Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside

triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many

functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase

active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II

transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core

element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are

thought to grab the incoming DNA template (By similarity)

Catalytic activity: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

Enzyme Number (IUBMB): EC 2.7.7.6

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for POLR2B Sigma-Aldrich shRNA for POLR2B
		OriGene 29mer shRNA kits in GFP-retroviral vector: POLR2B OriGene shRNA RFP: POLR2B OriGene basic RS shRNA: POLR2B OriGene siRNA: POLR2B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POLR2B

miRNA:		Sigma-Aldrich microRNA Mimics for POLR2B Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POLR2B
		1 SABiosciences Assays for microRNA that regulate POLR2B:
		hsa-miR-1283

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: POLR2B OriGene Myc/DDK tagged cDNA clones in CMV expression vector: POLR2B OriGene untagged cDNA clones in CMV expression vector: POLR2B OriGene 3'-UTR clone: POLR2B Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: POLR2B
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for POLR2B

Genatlas biochemistry entry for POLR2B:

polymerase II,RNA (DNA directed) large polypeptide B (140kDa)

5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003899	DNA-directed RNA polymerase activity	IEA	--
GO:0004672	contributes to protein kinase activity	IDA	9852112
GO:0005515	protein binding	IPI	17353931
GO:0016740	transferase activity	IEA	--

About this table

POLR2B for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

POLR2B for pathways About GeneDecksing

3 Millipore Pathways for POLR2B

	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	DNA damage Role of Brca1 and Brca2 in DNA repair
	ATP/ITP metabolism

5/9 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for POLR2B (see all 9)

	Pyrimidine Metabolism
	Huntington's Disease Signaling
	Hereditary Breast Cancer Signaling
	Estrogen Receptor Signaling
	CREB Signaling in Neurons

5 Kegg Pathways (Kegg details for POLR2B):

	hsa00230 Purine metabolism
	hsa00240 Pyrimidine metabolism
	hsa01100 Metabolic pathways
	hsa03020 RNA polymerase
	hsa05016 Huntington's disease

SABiosciences Custom Pathway-Focused PCR Arrays for POLR2B

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for POLR2B

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for POLR2B

5/254 Interacting proteins for POLR2B (ENSP00000370625³ P30876^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 254)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTDP1	Q9Y5B0²	STRING: ENSP00000299543 MINT-51646 MINT-51650
MAGI2	Q86UL8¹	EBI-394712,EBI-311035
WWOX	Q9NZC7²	MINT-72766
POLR2C	ENSP00000219252³	STRING: ENSP00000219252
POLR2D	ENSP00000272645³	STRING: ENSP00000272645

About this table

5/13 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 13):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	nuclear mRNA splicing, via spliceosome	TAS	--
GO:0006281	DNA repair	TAS	--
GO:0006283	transcription-coupled nucleotide-excision repair	TAS	--
GO:0006289	nucleotide-excision repair	TAS	--
GO:0006350	transcription	TAS	--

About this table

POLR2B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POLR2B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for POLR2B Sigma-Aldrich shRNA for POLR2B
		OriGene 29mer shRNA kits in GFP-retroviral vector: POLR2B OriGene shRNA RFP: POLR2B OriGene basic RS shRNA: POLR2B OriGene siRNA: POLR2B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POLR2B

miRNA:		Sigma-Aldrich microRNA Mimics for POLR2B Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POLR2B
		1 SABiosciences Assays for microRNA that regulate POLR2B:
		hsa-miR-1283

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: POLR2B OriGene Myc/DDK tagged cDNA clones in CMV expression vector: POLR2B OriGene untagged cDNA clones in CMV expression vector: POLR2B OriGene 3'-UTR Clone: POLR2B Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: POLR2B

Primers:		OriGene genome-wide validated SYBR primer pairs: POLR2B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for POLR2B: PPH12742A

REFSEQ mRNAs for POLR2B gene:

NM_000938.1

Additional cDNA sequence:

AF055028.1 AK098271.1 AK289823.1 AK294901.1 AK295132.1 AK299090.1 BC023503.2 BC046499.1

CR591583.1 CR592056.1 CR609388.1 X63563.1

24/31 DOTS entries (see all 31):

DT.100674865 DT.97760173 DT.65285131 DT.100674870 DT.100706253 DT.91806226 DT.121219395 DT.40205446

DT.92040454 DT.95170547 DT.95170564 DT.100045783 DT.95278266 DT.121219269 DT.121219296 DT.121219317

DT.100639411 DT.101978157 DT.121219282 DT.121219386 DT.91916126 DT.92461397 DT.92461407 DT.95278263

24/414 AceView cDNA sequences (see all 414):

BU628845 BU195049 BE550741 BM818298 AF055028 CA429196 BU615587 AI992183

AA001828 BM673648 BU183822 AI093559 CK431060 BQ771577 BM769676 BQ001027

BQ001562 AA376849 BQ020611 BE645837 AI801273 BQ215678 AL043215 CR592056

highest scoring ESTs for POLR2B:

X63563 AA001828 AA002032 AA076596 AA232818 AA255492 AA256916 AA258348 AA258505 AA455376

Unigene Cluster for POLR2B:

Polymerase (RNA) II (DNA directed) polypeptide B, 140kDa

Hs.602757 [show with all ESTs]

Unigene Representative Sequence: AK295132

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for POLR2B (see all 15)

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·
SP1:									-
SP2:
SP3:
SP4:
SP5:

ExUns:	12b	^	13	^	14	^	15	^	16a	·	16b	^	17a	·	17b	^	18a	·	18b	^	19	^	20	^	21a	·	21b	^	22a	·	22b	^	23a	·	23b	^	24a	·	24b	^	25	^	26
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for POLR2B
13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000484821 ENST00000433463 ENST00000396241 ENST00000314595 ENST00000441246(uc011cae.1)

ENST00000431623 ENST00000478188(uc003hcm.1) ENST00000495311 ENST00000510355

ENST00000464918 ENST00000497845 ENST00000450656 ENST00000381227(uc003hcl.1 uc011caf.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

POLR2B expression in normal and diseased human tissues

¹ / ² / ³

5 probe-sets matching POLR2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39746_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X63563	1.00	0.90	0.95	1
201803_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000938	0.60	1.00	0.82	1
1555837_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201803_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555836_at*²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--

About this table

POLR2B for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

POLR2B gene electronic northern expression

About these images

CGAP SAGE TAG: CTTTTCTTCT

SOURCE GeneReport for Unigene cluster: Hs.602757

Expression variation in blood from EXPOLDB for POLR2B

Primers:		OriGene genome-wide validated SYBR primer pairs: POLR2B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for POLR2B: PPH12742A

SABiosciences Custom PCR Arrays for POLR2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for POLR2B gene from 5/26 species (see all 26)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	POLR2B¹	--	polymerase (RNA) II (DNA directed) polypeptide B, 14 more	94.92(n) 99.91(a)	475152 XM_855837.1 XP_860930.1
chimpanzee (Pan troglodytes)	POLR2B¹	--	polymerase (RNA) II (DNA directed) polypeptide B, 14 more	99.66(n) 100(a)	461305 XM_517275.2 XP_517275.2
cow (Bos taurus)	POLR2B¹	--	polymerase (RNA) II (DNA directed) polypeptide B, 14 more	94.32(n) 99.91(a)	538184 XM_618380.3 XP_618380.3
rat (Rattus norvegicus)	Polr2b¹	--	polymerase (RNA) II (DNA directed) polypeptide B, 14 more	89.89(n) 100(a)	289561 XM_214021.4 XP_214021.3
mouse (Mus musculus)	Polr2b^{1 , 5}	5 (41.66 cM)⁵	polymerase (RNA) II (DNA directed) polypeptide B^{1, 5}	90.37(n)¹ 99.91(a)¹	231329¹ NM_153798.1¹ NP_722493.1¹ AA501042⁵ AK039766⁵ (see all 12)

About this table Species with no ortholog for POLR2B

ENSEMBL Gene Tree for POLR2B (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for POLR2B gene

POLR3B²

POLR2B for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1056364^1,2	C,F,A,H,	57889677(-)	`GTCTCA/GCTAGT`	2	S	syn¹ ref¹ ese³		22	MN EA NS NA	2918
rs1277279^1,2	C,H,	57865403(+)	`CTCTCA/TTCTAT`	1	--	int¹ trp³		6	NA WA	12
rs1277280^1,2	C,A,H,	57866872(+)	`TTTTTT/GGGGGG`	1	--	int¹		4	NA WA	80
rs1277281^1,2	C,F,O,H,	57856092(-)	`AAAAGT/CAGACA`	1	--	int¹		19	MN NS EA NA WA	862
rs1277282^1,2	C,F,O,H,	57855819(-)	`GAGACT/CTTCTT`	1	--	int¹		27	MN NS EA NA WA	1820
rs1277283^1,2	C,F,O,H,	57855641(-)	`ACCAAT/AATTAG`	1	--	int¹		21	MN NS EA NA WA	1344
rs1277284^1,2	C,F,O,A,H,	57855361(-)	`ACTTTA/CCCCAA`	1	--	int¹		26	MN EA NA NS WA	3220
rs1277285^1,2	C,H,	57854486(-)	`CCTTCG/TATTTT`	1	--	int¹		10	NA EA WA	228
rs1277286^1,2	C,F,O,H,	57854298(-)	`TCACCC/ATCAAC`	1	--	int¹		11	NA WA	274
rs1277287^1,2	C,F,A,H,	57853147(-)	`acatgC/Gcatga`	1	--	int¹		10	NS EA NA WA	636

About this table

HapMap Linkage Disequilibrium images for POLR2B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for POLR2B: --

QIAGEN SeqTarget long-range PCR primers for resequencing POLR2B

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

POLR2B for disorders About GeneDecksing

OMIM: 180661

Human Genome Epidemiology (HuGE) Navigator: POLR2B (3 documents)

Export disorders and mutations for POLR2B gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/144 PubMed articles for POLR2B gene, integrated from 7 sources (see all 144):
(articles sorted by number of sources associating them with POLR2B)

Primary structure of the second largest subunit of human RNA polymerase II (or B). (PubMed id 1518060)^{1, 2, 3} Acker J.... Kedinger C. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PubMed id 9852112)^{1, 2} Kershnar E.... Chiang C.-M. (1998)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)^{1, 2} Yu W.... Gibbs R.A. (1997)
Chromosomal localization of human RNA polymerase II subunit genes. (PubMed id 8034326)^{1, 3} Acker J....Kedinger C. (1994)
Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation. (PubMed id 15670829)^{1, 7} Amente S....Majello B. (2005)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010 Mar 5)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Aire's partners in the molecular control of immunolog ical tolerance. (PubMed id 20085707)¹ Abramson J....Mathis D. (2010)
MRE11 complex links RECQ5 helicase to sites of DNA damage. (PubMed id 19270065)¹ Zheng L....Janscak P. (2009)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5431	HGNC: 9188	AceView: POLR2B	Ensembl:ENSG00000047315	euGenes: HUgn5431
ECgene: POLR2B	Kegg: 5431	H-InvDB: POLR2B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for POLR2B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for POLR2B gene:
Search GeneIP for patents involving POLR2B

GeneCards and IP:
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