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POLR3B Gene

protein-coding   GIFtS: 49

GC12P103811
polymerase (RNA) III (DNA directed) polypeptide B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for POLR3B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
polymerase (RNA) III (DNA directed) polypeptide B1 2     RNA polymerase III subunit C22 3
RPC21 2     DNA-directed RNA polymerase III 127.6 kDa polypeptide2 3
FLJ103881 2     DNA-directed RNA polymerase III subunit RPC22
DNA-directed RNA polymerase III subunit B2 3     DKFZp686B101172
C1282 3     EC 2.7.7.63

External Ids:    HGNC: 303481   Entrez Gene: 557032   Ensembl: ENSG000000135037   UniProtKB: Q9NW083   

Export aliases for POLR3B gene to outside databases

Previous GC identifers: GC12P105254 GC12P105255 GC12P106751


Summaries
for POLR3B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RPC2_HUMAN, Q9NW08
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as
5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center
together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with
the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a
key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic
DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into
dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I
interferon and NF- Kappa-B through the RIG-I pathway


Genomic Views
for POLR3B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POLR3B gene promoter:
         RFX1   YY1   POU2F1   GCNF-2   GCNF-1   NF-AT4   NF-AT3   NF-AT2   NF-AT1   LCR-F1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for POLR3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for POLR3B 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q24

POLR3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR3B gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P103811:  view genomic region     (about GC identifiers)

Start:
 103,811,761 bp from pter
End:
 103,964,299 bp from pter
Size:
 152,539 bases
Orientation:
 plus strand

1 alternative location:
Chr12+ 106,751,489-106,903,974     
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  

Proteins
for POLR3B gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: RPC2_HUMAN, Q9NW08 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase III subunit RPC2  
Size: 1133 amino acids; 127785 Da
Subunit: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA91527.1; Type=Erroneous initiation; Sequence=BAA91581.1; Type=Erroneous initiation;
Secondary accessions: A8K6H0 Q9NW59

Explore the universe of human proteins at neXtProt for POLR3B: NX_Q9NW08 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001154180.1  NP_060552.4  


    ENSEMBL proteins: 
    ENSP00000228347 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for POLR3B 
    Novus Biologicals Protein for POLR3B
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005654 nucleoplasm TAS--
    About this table

    POLR3B for ontologies           About GeneDecksing



    Antibodies for POLR3B: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for POLR3B
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for POLR3B 
    Novus Biologicals Antibodies for POLR3B
    Browse antibodies at Epitomics

    Assays for POLR3B: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POLR3B 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for POLR3B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POLR3B for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR007120 DNA-dir_RNA_pol_su2_6
     IPR007641 RNA_pol_Rpb2_7
     IPR007644 RNA_pol_bsu_protrusion
     IPR015712 DNA-dir_RNA_pol_su2
     IPR007645 RNA_pol_Rpb2_3

    Graphical View of Domain Structure for InterPro Entry Q9NW08

    ProtoNet protein and cluster: Q9NW08

    2 Blocks protein families:
    IPB007646 RNA polymerase Rpb2
    IPB007647 RNA polymerase Rpb2


    UniProtKB/Swiss-Prot: RPC2_HUMAN, Q9NW08
    Similarity: Belongs to the RNA polymerase beta chain family


    Gene Function
    for POLR3B gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: RPC2_HUMAN, Q9NW08
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as
    5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center
    together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with
    the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a
    key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic
    DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into
    dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I
    interferon and NF- Kappa-B through the RIG-I pathway
    Catalytic activity: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
    Enzyme Number (IUBMB): EC 2.7.7.6 

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for POLR3B
    Sigma-Aldrich shRNA for POLR3B
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): POLR3B
    OriGene shRNA RFP (see all 3): POLR3B
    OriGene basic RS shRNA (see all 3): POLR3B
    OriGene siRNA (see all 2): POLR3B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POLR3B 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POLR3B 
    Search SABiosciences for Assays for microRNAs that regulate POLR3B

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): POLR3B
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): POLR3B
    OriGene untagged cDNA clones in CMV expression vector: POLR3B
    OriGene 3'-UTR clone (see all 2): POLR3B 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for POLR3B 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for POLR3B 

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0003899 DNA-directed RNA polymerase activity IEA--
    GO:0016740 transferase activity IEA--
    GO:0016779 nucleotidyltransferase activity IEA--
    GO:0032549 ribonucleoside binding IEA--
    About this table

    POLR3B for ontologies           About GeneDecksing


    Pathways & Interactions
    for POLR3B gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    POLR3B for pathways           About GeneDecksing

    1 Millipore Pathway for POLR3B
        ATP/ITP metabolism

    2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  POLR3B
        Pyrimidine Metabolism
    Purine Metabolism

    5 Kegg Pathways  (Kegg details for POLR3B):
        hsa00230 Purine metabolism
    hsa00240 Pyrimidine metabolism
    hsa01100 Metabolic pathways
    hsa03020 RNA polymerase
    hsa04623 Cytosolic DNA-sensing pathway

        SABiosciences Custom Pathway-Focused PCR Arrays for POLR3B 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for POLR3B
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POLR3B

    5/78 Interacting proteins for POLR3B (ENSP000002283473) via UniProtKB, MINT, and/or STRING (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRF1ENSP000003290293STRING: ENSP00000329029
    BRF2ENSP000002206593STRING: ENSP00000220659
    CTPSENSP000003616993STRING: ENSP00000361699
    GTF3AENSP000003705323STRING: ENSP00000370532
    GTF3C1ENSP000003485103STRING: ENSP00000348510
    About this table

    5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription TAS--
    GO:0006383 transcription from RNA polymerase III promoter TAS--
    GO:0006385 RNA elongation from RNA polymerase III promoter TAS--
    GO:0006386 termination of RNA polymerase III transcription TAS--
    GO:0009615 response to virus IEA--
    About this table

    POLR3B for ontologies           About GeneDecksing



    Drugs & Compounds
    for POLR3B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POLR3B


    Transcripts
    for POLR3B gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for POLR3B
    Sigma-Aldrich shRNA for POLR3B
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): POLR3B
    OriGene shRNA RFP (see all 3): POLR3B
    OriGene basic RS shRNA (see all 3): POLR3B
    OriGene siRNA (see all 2): POLR3B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POLR3B 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POLR3B 
    Search SABiosciences for Assays for microRNAs that regulate POLR3B
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): POLR3B
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): POLR3B
    OriGene untagged cDNA clones in CMV expression vector: POLR3B
    OriGene 3'-UTR Clone (see all 2): POLR3B 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for POLR3B 
    Primers: OriGene genome-wide validated SYBR primer pairs: POLR3B
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for POLR3B: PPH10883A

    REFSEQ mRNAs for POLR3B gene (2 alternative transcripts): 

    NM_001160708.1  NM_018082.5  

    Additional cDNA sequence: BC033542.1 

    8 DOTS entries:

    DT.406080  DT.100778661  DT.101973149  DT.99944362  DT.121150665  DT.97762598  DT.92407267  DT.121150675 

    24/104 AceView cDNA sequences (see all 104):

    BX648712 BC046238 AK092031 AY092084 AI755102 AX747324 BM788368 BE263182 
    AW196487 BU155606 CR595354 BX537447 AX746551 NM_018082 AK122713 BC017501 
    AU123324 AK090636 AK001250 BI871505 BI089699 BE541441 BU752357 N75936 

    highest scoring ESTs for POLR3B:

    AI653046 AA121153 AI339183 AI651396 AI653259 AI755102 AI917104 AL536755 AV749110 AV749337 

    Unigene Clusters for POLR3B:

    Polymerase (RNA) III (DNA directed) polypeptide B
    Hs.62696  [show with all ESTs], Hs.610795  [show with all ESTs]
    Unigene Representative Sequences: NM_018082, BC033542


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000228347(uc001tlp.2 uc001tlq.2)

    Expression
    for POLR3B gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    POLR3B expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching POLR3B gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    62810_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 AI653046 1.00 1.00 1.00 1
    219459_at2, 3 U133-A 1 1.00 1.00 -- -- NM_018082 0.60 1.00 0.82 1
    219459_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1556804_s_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    1556803_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    POLR3B for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    POLR3B gene expression
    POLR3B gene electronic northern expression
    POLR3B gene sage expression
    About these images

    CGAP SAGE TAG: GAGAAATTTA TGGACTGCAA

    SOURCE GeneReport for Unigene clusters: Hs.62696 Hs.610795
    Primers: OriGene genome-wide validated SYBR primer pairs: POLR3B
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for POLR3B: PPH10883A
        SABiosciences Custom PCR Arrays for POLR3B 


    Orthologs
    for POLR3B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for POLR3B gene from 5/24 species (see all 24)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 POLR3B1   -- polymerase (RNA) III (DNA directed) polypeptide B 92.38(n)
    99.74(a)    		 474531  XM_531760.2  XP_531760.2 
    chimpanzee
    (Pan troglodytes)    		 POLR3B1   -- polymerase (RNA) III (DNA directed) polypeptide B 99.76(n)
    99.91(a)    		 452201  XM_001161567.1  XP_001161567.1 
    cow
    (Bos taurus)    		 POLR3B1   -- polymerase (RNA) III (DNA directed) polypeptide B 92.97(n)
    99.65(a)    		 540839  XM_613382.3  XP_613382.3 
    rat
    (Rattus norvegicus)    		 Polr3b1   -- polymerase (RNA) III (DNA directed) polypeptide B 89.06(n)
    99.29(a)    		 362858  XM_343188.3  XP_343189.3 
    mouse
    (Mus musculus)    		 Polr3b1 , 5 10 (41.58 cM)5
    		 polymerase (RNA) III (DNA directed) polypeptide B1, 5 89.44(n)1
    99.29(a)1    		 704281  NM_027423.11  NP_081699.11 
     AK0125325  AK0392445  (see all 12)
    About this table        Species with no ortholog for POLR3B

    ENSEMBL Gene Tree for POLR3B (if available)

    Paralogs
    for POLR3B gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for POLR3B gene
    POLR2B2  

    POLR3B for paralogs           About GeneDecksing



    Genomic Variants
    for POLR3B gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1190 NCBI SNPs in POLR3B are shown (see all 1190)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs135611,2
    		C,F,O,A,106903321(-) CATTCA/GTTGTA 6 N syn1 ref1 ese328Minor allele frequency- G:0.47MN EA NA NS WA 3716
    rs7214381,2
    		C,F,A,106890059(-) AAGGGA/GCAGAA 2 -- int121Minor allele frequency- G:0.34EA NS NA WA 2734
    rs10046011,2
    		C,F,A,106898357(+) GAATCA/GCAGTG 2 -- int114Minor allele frequency- G:0.34EA NS NA WA 752
    rs12301461,2
    		C,H,106895756(-) TTAACA/CCACAG 2 -- int18Minor allele frequency- C:0.00NA WA 28
    rs15789651,2
    		H106836973(-) tagtaG/Agaaaa 2 -- int1 trp34Minor allele frequency- A:0.00NS EA 392
    rs18824131,2
    		C,F,O,A,106755078(+) GTAGAA/CTTTTT 2 -- int112Minor allele frequency- C:0.34NS EA NA 724
    rs21417741,2
    		C,F,A,106825352(+) AAATAA/GTTTTA 2 -- int18Minor allele frequency- G:0.29NS EA NA WA 628
    rs21417751,2
    		C,F,A,H,106825440(+) ATGTAA/GCCATA 2 -- int111Minor allele frequency- G:0.32NS EA NA WA 636
    rs22435061,2
    		C,F,A,H,106767976(-) AAATTT/GGGTAC 2 -- int114Minor allele frequency- G:0.35NS EA NA 1014
    rs22435311,2
    		C,F,A,106749804(+) CCCCCA/CCCAAA 1 -- ng513Minor allele frequency- C:0.35NA WA 54
    About this table

    HapMap Linkage Disequilibrium images for POLR3B (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for POLR3B: --

    QIAGEN SeqTarget long-range PCR primers for resequencing POLR3B 

    Disorders & Mutations
    for POLR3B gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POLR3B for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: POLR3B (1 document)

    Export disorders and mutations for POLR3B gene to outside databases

    Medical News
    for POLR3B gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for POLR3B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/16 PubMed articles for POLR3B gene, integrated from 7 sources (see all 16):
    (articles sorted by number of sources associating them with POLR3B)
    1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PubMed id 12391170)1, 2, 3 Hu P....Hernandez N. (2002)
    2. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. (PubMed id 19609254)1, 2 Ablasser A....Hornung V. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Identification and characterization of INMAP, a novel interphase nucleus and mitotic apparatus protein that is involved in spindle formation and cell cycle progression. (PubMed id 19331820)1 Shen E....Liang Q. (2009)
    7. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (PubMed id 19631370)2 Chiu Y.-H.... Chen Z.J. (2009)
    8. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    9. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
    10. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)1 Seshadri S....Wolf P.A. (2007)

    External Searches for POLR3B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing POLR3B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55703 HGNC: 30348 AceView: POLR3B Ensembl:ENSG00000013503 euGenes: HUgn55703
    ECgene: POLR3B Kegg: 55703 H-InvDB: POLR3B

    Other Databases showing POLR3B gene

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    Specialized Databases showing POLR3B gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    Intellectual Property
    for POLR3B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    		Patent Information for POLR3B gene:
    Search GeneIP for patents involving POLR3B

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