Aliases &
Descriptions
for POM121C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| POM121 membrane glycoprotein C1 2 | | DKFZp586P22202 | | Nuclear pore membrane protein 121-22 3 | | DKFZp779K17132 | | Pore membrane protein of 121 kDa C2 3 | | nuclear envelope pore membrane protein POM 121C2 | | POM121-22 3 | | MGC1634592 | | MGC1634612 | | FLJ438772 | | POM121 membrane glycoprotein-like2 | | FLJ450822 |
Export aliases for POM121C gene to outside databasesPrevious GC identifers: GC07M074884 GC07M075046 |
Summaries
for POM121C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: P121C_HUMAN, A8CG34Function: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved inanchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation ofcytoplasmic annulate lamellae (AL)
|
Genomic Views
for POM121C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for POM121C
Other transcription factors
Search SABiosciences Chromatin IP Primers for POM121C
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for POM121C  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.2 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23POM121C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M071202: view genomic region
(about GC identifiers)
Start:
|
71,202,006 bp from pter |
End:
|
71,202,491 bp from pter |
Size:
|
486 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7- 75,046,065-75,115,548 |
RefSeq DNA sequence:- NC_000007.13 NT_007933.15 NT_079595.2
|
Proteins
for POM121C gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: P121C_HUMAN, A8CG34 (See
protein sequence)Recommended Name: Nuclear envelope pore membrane protein POM 121C Size: 1229 amino acids; 125059 Da
Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane; Single-pass membrane protein. Endoplasmicreticulum membrane; Single-pass membrane protein (By similarity). Note=Stably associated with the NPC throughoutinterphase and the endoplasmic reticulum during metaphase (By similarity)
Secondary accessions: O75115 Q9Y2N3 Q9Y4S7Explore the universe of human proteins at neXtProt for POM121C: NX_A8CG34
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001092885.1
ENSEMBL proteins: ENSP00000414208 ENSP00000410033 ENSP00000404714 ENSP00000381415 ENSP00000257665
Human Recombinant Proteins
5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7): About this table
POM121C for ontologies About GeneDecksing
Antibodies for POM121C:
Assays for POM121C: |
Protein
Domains/
Families
for POM121C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: A8CG34 UniProtKB/Swiss-Prot: P121C_HUMAN, A8CG34Domain: Contains F-X-F-G repeatsSimilarity: Belongs to the POM121 family |
Gene Function
for POM121C gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: P121C_HUMAN, A8CG34Function: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved inanchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation ofcytoplasmic annulate lamellae (AL)
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): About this table
POM121C for ontologies About GeneDecksing
|
Pathways & Interactions
for POM121C gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
POM121C for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for POM121C):
SABiosciences Custom Pathway-Focused PCR Arrays for POM121C
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POM121C
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
POM121C for ontologies About GeneDecksing
|
Drugs & Compounds
for POM121C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for POM121C
|
Transcripts
for POM121C gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for POM121C gene: NM_001099415.1 Additional cDNA sequence: AB354586.1 AK127026.1 AK293305.1 AK293781.1 AK311407.1 AL050158.1 BC013954.2 BC082993.1 BC130587.1 BC130589.1 BX649044.1 24/40 DOTS entries (see all 40): DT.100878800 DT.40108690 DT.121116955 DT.40223154 DT.97862722 DT.121116908 DT.75157102 DT.95312575 DT.121117133 DT.121116723 DT.121116879 DT.101979533 DT.121117114 DT.121116675 DT.40132467 DT.92469787 DT.100059442 DT.121090498 DT.121116880 DT.452605 DT.75102100 DT.92469877 DT.95128557 DT.95145207 Unigene Cluster for POM121C: POM121 membrane glycoprotein C Hs.712563 [show with all ESTs]Unigene Representative Sequence: NM_001099415
GeneLoc Exon Structure
9 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000476072 ENST00000453279(uc003udk.3) ENST00000473609 ENST00000473168
ENST00000439629 ENST00000479864 ENST00000416332 ENST00000398379(uc003udl.1)
ENST00000257665(uc010lde.1)
|
Expression
for POM121C gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| POM121C expression in normal and diseased human tissues
1 / 2 5 probe-sets matching POM121C gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 40160_at2
|
U95-A |
2 |
0.81 |
0.67 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
| 213360_s_at2
|
U133-A |
2 |
1.00 |
0.64 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 212178_s_at2
|
U133-A |
3 |
1.00 |
0.47 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 213360_s_at2
|
U133Plus2 |
2 |
1.00 |
0.64 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 212178_s_at2
|
U133Plus2 |
3 |
1.00 |
0.47 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
POM121C for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.712563
SABiosciences Custom PCR Arrays for POM121C
|
Orthologs
for POM121C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for POM121C gene from 5/7 species (see all 7)
About this table Species with no ortholog for POM121C
ENSEMBL Gene Tree for POM121C (if available) |
Paralogs
for POM121C gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for POM121C gene
- POM1211 2 NUP2142 POM121L22
POM121C for paralogs About GeneDecksing
|
Genomic Variants
for POM121C gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for POM121C (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for POM121C
5 CNVs: 3686 22956 4545 69960 94616
2 Indels: 33847 12936 | | QIAGEN SeqTarget long-range PCR primers for resequencing POM121C |
|
Disorders & Mutations
for POM121C gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for POM121C gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for POM121C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for POM121C gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with POM121C)- Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes. (PubMed id 17900573)1, 2, 3 Funakoshi T....Imamoto N. (2007)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. (PubMed id 17577209)1 Miele A....Stein J.L. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. (PubMed id 11779826)1 DeSilva U....Green E.D. (2002)
- Identification of additional transcripts in the Williams-Beuren syndrome critical region. (PubMed id 12073013)1 Merla G....Reymond A. (2002)
|
External Searches for POM121C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing POM121C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing POM121C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing POM121C gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for POM121C gene:
Search GeneIP for patents involving POM121C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for POM121C gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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