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POP4 Gene

protein-coding GIFtS: 53

GC19P026609

processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)¹ ²
RPP29¹ ² ³ ⁵
hPOP4² ³
ribonuclease P protein subunit p29²
EC 3.1.26.5³

External Ids:	HGNC: 30081¹	Entrez Gene: 10775²	Ensembl: ENSG00000105171⁷	UniProtKB: O95707³

Export aliases for POP4 gene to outside databases

Previous GC identifers: GC19P030719 GC19P030546 GC19P034773 GC19P034789 GC19P030097

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POP4:

This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease

for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the

nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of

precursor RNAs. Alternative splicing results in multiple transcript variants. (provided by RefSeq)

UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707

Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May

function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P

Gene Wiki entry for POP4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POP4 gene promoter:
         TGIF   ISGF-3   GATA-1   c-Jun   c-Fos   AP-1   STAT6   STAT5A   STAT4   STAT3
         Other transcription factors

Search SABiosciences Chromatin IP Primers for POP4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for POP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12 Ensembl cytogenetic band: 19q12 HGNC cytogenetic band: 19q13.11

POP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POP4 gene location

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P026609: view genomic region (about GC identifiers)

Start:	26,609,015 bp from pter
End:	26,620,008 bp from pter
Size:	10,994 bases
Orientation:	plus strand

1 alternative location:

Chr19+ 30,097,201-30,106,706

RefSeq DNA sequence:

NC_000019.9 NT_011109.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707 (See protein sequence)

Recommended Name: Ribonuclease P protein subunit p29

Size: 220 amino acids; 25425 Da

Subunit: Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8

protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of a RNA

moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and

RPP21. Interacts with RPP25 and POP5

Subcellular location: Nucleus, nucleolus

Secondary accessions: Q5XKL7 Q6FHW9 Q9UQQ3

Explore the universe of human proteins at neXtProt for POP4: NX_O95707

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006618.1

ENSEMBL proteins:

ENSP00000376104 ENSP00000221770

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: POP4
	GenScript Custom Purified and Recombinant Proteins Services for POP4
	Novus Biologicals Proteins for POP4
	Novus Biologicals Lysate for POP4
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000172	ribonuclease MRP complex	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005655	nucleolar ribonuclease P complex	IEA	--
GO:0005730	nucleolus	IEA	--
GO:0030677	ribonuclease P complex	IEA	--

About this table

POP4 for ontologies About GeneDecksing

Antibodies for POP4:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for POP4
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for POP4
	Novus Biologicals Antibody for POP4
	Browse antibodies at Epitomics

Assays for POP4:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for POP4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for POP4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

POP4 for domains About GeneDecksing

2 InterPro domains/families:

IPR016848 RNase_P/MRP_p29-subunit_euk

IPR002730 RNase_P/MRP_p29_euk/arc

Graphical View of Domain Structure for InterPro Entry O95707

ProtoNet protein and cluster: O95707

1 Blocks protein family: IPB002730 Protein of unknown function UPF0086

UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707

Similarity: Belongs to the eukaryotic/archaeal RNase P protein component 1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: RPP29_HUMAN, O95707

Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May

function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P

Catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor

Enzyme Number (IUBMB): EC 3.1.26.5

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for POP4 Sigma-Aldrich shRNA for POP4
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): POP4 OriGene shRNA RFP (see all 3): POP4 OriGene basic RS shRNA (see all 3): POP4 OriGene siRNA (see all 3): POP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POP4

miRNA:		Sigma-Aldrich microRNA Mimics for POP4 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POP4
		Search SABiosciences for Assays for microRNAs that regulate POP4

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: POP4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: POP4 OriGene untagged cDNA clones in CMV expression vector: POP4 OriGene 3'-UTR clone: POP4 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for POP4
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for POP4

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0004526	ribonuclease P activity	IEA	--
GO:0004540	ribonuclease activity	IEA	--
GO:0005515	protein binding	IPI	15096576
GO:0016787	hydrolase activity	IEA	--

About this table

POP4 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

POP4 for pathways About GeneDecksing

1 Kegg Pathway (Kegg details for POP4):

hsa03013 RNA transport

SABiosciences Custom Pathway-Focused PCR Arrays for POP4

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for POP4

5/6 Interacting proteins for POP4 (O95707¹ ENSP00000221770³) via UniProtKB, MINT, and/or STRING (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POP5	Q969H6¹, ENSP00000350098³	EBI-366477,EBI-366525 STRING: ENSP00000350098
RPP38	P78345¹, ENSP00000367444³	EBI-366477,EBI-366493 STRING: ENSP00000367444
POP1	Q99575¹	EBI-366477,EBI-366741
POP4	O95707¹	EBI-366477,EBI-366477
RPP14	O95059¹	EBI-366477,EBI-366542

About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006364	rRNA processing	IEA	--
GO:0006379	mRNA cleavage	IEA	--
GO:0008033	tRNA processing	IEA	--

About this table

POP4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POP4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for POP4 Sigma-Aldrich shRNA for POP4
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): POP4 OriGene shRNA RFP (see all 3): POP4 OriGene basic RS shRNA (see all 3): POP4 OriGene siRNA (see all 3): POP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POP4

miRNA:		Sigma-Aldrich microRNA Mimics for POP4 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POP4
		Search SABiosciences for Assays for microRNAs that regulate POP4

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: POP4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: POP4 OriGene untagged cDNA clones in CMV expression vector: POP4 OriGene 3'-UTR Clone: POP4 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for POP4

Primers:		OriGene genome-wide validated SYBR primer pairs: POP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for POP4: PPH19611A

REFSEQ mRNAs for POP4 gene:

NM_006627.2

Additional cDNA sequence:

AF001176.2 AK090872.1 AK314790.1 BC004438.1 BC006098.1 BC013686.1 CR536569.1 CR620341.1

CR624820.1 CR936714.1 Y18863.1

12 DOTS entries:

DT.219248 DT.92021320 DT.311374 DT.75172550 DT.121489407 DT.99933112 DT.121489402 DT.95197196

DT.121489345 DT.92392293 DT.92435932 DT.95197195

24/277 AceView cDNA sequences (see all 277):

BQ428458 BE514692 BM750755 BM461646 BM726033 AI091498 CB163102 CR620341

BM766302 CB141662 BM985094 BE746054 AA934656 AA987278 CA314143 BE263449

BF434997 CA413556 BI116633 CD673378 BG697335 AA570404 BQ082298 CD370529

highest scoring ESTs for POP4:

Y18863 AA047381 AA074534 AA074975 AA082498 AA132960 AA132996 AA134866 AA150967 AA151076

Unigene Cluster for POP4:

Processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)

Hs.412870 [show with all ESTs]

Unigene Representative Sequence: NM_006627

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for POP4 (see all 12)

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	·	10d	·	10e	·	10f
SP1:					-				-		-		-		-		-						-						-		-
SP2:									-		-						-						-
SP3:					-				-		-		-		-		-				-		-		-				-		-
SP4:					-				-		-		-		-		-						-						-		-
SP5:																	-						-						-		-

About this scheme

ECgene alternative splicing isoforms for POP4
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392279 ENST00000221770(uc002nsf.2 uc002nsg.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

POP4 expression in normal and diseased human tissues

¹ / ² / ³

5 probe-sets matching POP4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38380_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	Y18863	1.00	1.00	1.00	1
202868_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006627	0.60	1.00	0.82	1
227583_at²^{, 3}	U133-B	1	0.36	1.00	--	--	BE742653	0.40	1.00	0.76	1
202868_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227583_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--

About this table

POP4 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

POP4 gene electronic northern expression

About these images

CGAP SAGE TAG: TTTTCTGAGT

SOURCE GeneReport for Unigene cluster: Hs.412870

Expression variation in blood from EXPOLDB for POP4

Primers:		OriGene genome-wide validated SYBR primer pairs: POP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for POP4: PPH19611A

SABiosciences Custom PCR Arrays for POP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for POP4 gene from 5/14 species (see all 14)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	POP4¹	--	processing of precursor 4, ribonuclease P/MRP subunit more	87.29(n) 87.91(a)	612732 XM_850448.1 XP_855541.1
chimpanzee (Pan troglodytes)	POP4¹	--	processing of precursor 4, ribonuclease P/MRP subunit more	99.55(n) 99.55(a)	456386 XM_512983.2 XP_512983.2
cow (Bos taurus)	POP4¹	--	processing of precursor 4, ribonuclease P/MRP subunit more	88.95(n) 92.27(a)	614870 NM_001034770.1 NP_001029942.1
rat (Rattus norvegicus)	Pop4¹	--	processing of precursor 4, ribonuclease P/MRP subunit more	84.55(n) 85(a)	292831 NM_001009642.1 NP_001009642.1
mouse (Mus musculus)	Pop4^{1 , 5}	7 (25.36 cM)⁵	processing of precursor 4, ribonuclease P/MRP family, more^{1, 5}	82.88(n)¹ 83.18(a)¹	66161¹ NM_025390.3¹ NP_079666.1¹ AI846493⁵ AK002855⁵ (see all 14)

About this table Species with no ortholog for POP4

ENSEMBL Gene Tree for POP4 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs7283^1,2	C,F,A,H,	30106659(-)	`ATGTAC/TTGTAT`	2	--	ut3¹		33	MN NA NS EA WA	2684
rs13767^1,2	C,F,	30106189(+)	`AAACCG/AATGGC`	4	/N /D	mis¹ ref¹		4	NS EA	420
rs891060^1,2	C,F,A,	30102283(+)	`ACAGGA/GTATCA`	1	--	int¹		14	NA EA MN NS	1188
rs891061^1,2	C,F,O,A,	30102477(+)	`AACCTC/TAAAAT`	1	--	int¹		20	NA EA NS WA	1300
rs978173^1,2	C,F,	30102386(+)	`ACCAGC/ACTGCT`	1	--	int¹		6	MN NS EA WA	654
rs1465585^1,2	C,	30099457(+)	`caggtG/Atgagc`	1	--	int¹		7	NA WA	14
rs2042968^1,2	C,F,	30106775(+)	`GAGGCT/ACGCCT`	1	--	ut3¹		6	EA NS NA	344
rs2042969^1,2	C,F,O,A,	30107422(+)	`GCGTTT/CCTGGT`	1	--	ut3¹		11	NS EA NA WA	518
rs2042970^1,2	C,F,O,A,	30107621(+)	`TCCTCC/TGCTCA`	1	--	ut3¹		14	MN EA NS NA WA	844
rs2115370^1,2	C,F,A,	30106891(+)	`AATCAT/CAGCTG`	1	--	ut3¹		15	NS EA NA WA	1054

About this table

HapMap Linkage Disequilibrium images for POP4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for POP4: --

QIAGEN SeqTarget long-range PCR primers for resequencing POP4

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

POP4 for disorders About GeneDecksing

OMIM: 606114

Export disorders and mutations for POP4 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/18 PubMed articles for POP4 gene, integrated from 7 sources (see all 18):
(articles sorted by number of sources associating them with POP4)

Rpp14 and Rpp29, two protein subunits of human ribonuclease P. (PubMed id 10024167)^{1, 2, 3, 7} Jarrous N.... Altman S. (1999)
hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes. (PubMed id 10352175)^{1, 2, 3, 7} van Eenennaam H.... van Venrooij W.J. (1999)
Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PubMed id 15096576)^{1, 2} Welting T.J.... Pruijn G.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Inhibition of the expression of the human RNase P protein subunits Rpp21, Rpp25, Rpp29 by external guide sequences (EGSs) and siRNA. (PubMed id 15351636)^{1, 7} Zhang H. and Altman S. (2004)
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)² Yu L.-R.... Veenstra T.D. (2007)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)² Matsuoka S.... Elledge S.J. (2007)
Differential association of protein subunits with the human RNase MRP and RNase P complexes. (PubMed id 16723659)¹ Welting T.J....Pruijn G.J. (2006)
Nucleolar proteome dynamics. (PubMed id 15635413)¹ Andersen J.S....Mann M. (2005)
RNase P: role of distinct protein cofactors in tRNA substrate recognition and RNA-based catalysis. (PubMed id 16155184)¹ Sharin E....Jarrous N. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10775	HGNC: 30081	AceView: POP4	Ensembl:ENSG00000105171	euGenes: HUgn10775
ECgene: POP4	Kegg: 10775	H-InvDB: POP4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for POP4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for POP4 gene:
Search GeneIP for patents involving POP4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for POP4		Antibodies for POP4
	Super-pooled esiRNAs for POP4		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for POP4		microRNA Mimics for POP4
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POP4
	SeqTarget long-range PCR primers for resequencing POP4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for POP4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POP4

	GenScript Custom Purified and Recombinant Proteins Services for POP4		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for POP4
	GenScript Custom Assay Services for POP4		GenScript Custom Superior Antibodies Services for POP4
	GenScript Custom overexpressing Cell Line Services for POP4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in POP4 promoter
	Search Chromatin IP Primers for POP4
	RT² qPCR Primer Assay for POP4
	GNC Network for POP4
	Search for Assays for microRNAs that regulate POP4
	SABiosciences Custom PCR Arrays for POP4

Search Tocris compounds for POP4

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for POP4
	Proteins for POP4
	Lysates for POP4

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for POP4

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

POP4 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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POP4 Gene

protein-coding GIFtS: 53

Aliases &
Descriptions
for POP4 gene

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for POP4 gene

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for POP4 gene

Proteins
for POP4 gene

Protein Domains/
Families
for POP4 gene

Gene Function
for POP4 gene

Pathways & Interactions
for POP4 gene

Drugs & Compounds
for POP4 gene

Transcripts
for POP4 gene

Expression
for POP4 gene

Orthologs
for POP4 gene

Paralogs
for POP4 gene

Genomic Variants
for POP4 gene

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for POP4 gene

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for POP4 gene

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Genome Databases showing POP4 gene

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Advanced Search

Export list of displayed genes

POP4 Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor POP4 gene

Summariesfor POP4 gene

Genomic Viewsfor POP4 gene

Proteinsfor POP4 gene

Protein Domains/Familiesfor POP4 gene

Gene Functionfor POP4 gene

Pathways & Interactionsfor POP4 gene

Drugs & Compoundsfor POP4 gene

Transcriptsfor POP4 gene

Expression for POP4 gene

Orthologsfor POP4 gene

Paralogsfor POP4 gene

Genomic Variantsfor POP4 gene

Disorders & Mutationsfor POP4 gene

Medical Newsfor POP4 gene

Publicationsfor POP4 gene

External Searches for POP4 gene

Genome Databases showing POP4 gene

Other Databases showing POP4 gene

Specialized Databases showing POP4 gene

Intellectual Propertyfor POP4 gene

Productsfor POP4 gene

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Aliases &
Descriptions
for POP4 gene

Summaries
for POP4 gene

Genomic Views
for POP4 gene

Proteins
for POP4 gene

Protein Domains/
Families
for POP4 gene

Gene Function
for POP4 gene

Pathways & Interactions
for POP4 gene

Drugs & Compounds
for POP4 gene

Transcripts
for POP4 gene

Expression
for POP4 gene

Orthologs
for POP4 gene

Paralogs
for POP4 gene

Genomic Variants
for POP4 gene

Disorders & Mutations
for POP4 gene

Medical News
for POP4 gene

Publications
for POP4 gene

Intellectual Property
for POP4 gene

Products
for POP4 gene