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Aliases & Descriptionsfor POPDC2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions popeye domain containing 21 2 POP21 2 3 5 Popeye protein 22 3 popeye domain-containing protein 22 OTTHUMP000002153382 OTTHUMP000002155502
Export aliases for POPDC2 gene to outside databases Previous GC identifers: GC03M120643 GC03M120681 GC03M120843 GC03M119355
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Summariesfor POPDC2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for POPDC2 : This gene encodes a member of the POP family of proteins which contain three putative transmembrane domains. This membrane associated protein is predominantly expressed in skeletal and cardiac muscle, and may have an important function in these tissues. (provided by RefSeq) UniProtKB/Swiss-Prot: POPD2_HUMAN, Q9HBU9 Function : May play an important role in heart development
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Genomic Viewsfor POPDC2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the POPDC2 gene promoter: GATA-2 GATA-1 GATA-3 GR-alpha GR-beta c-Myb c-Rel Cdc5 CUTL1 POU2F1 Other transcription factors Search SABiosciences Chromatin IP Primers for POPDC2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3q13.33 Ensembl cytogenetic band: 3q13.33 HGNC cytogenetic band: 3q13.33 POPDC2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M116736: view genomic region
(about GC identifiers )
Start:
116,736,572 bp from pter
End:
116,755,066 bp from pter
Size:
18,495 bases
Orientation:
minus strand
1 alternative location : Chr 3- 119,355,304-119,384,171
RefSeq DNA sequence: NC_000003.11 NT_005612.16
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Proteinsfor POPDC2 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: POPD2_HUMAN, Q9HBU9 (See
protein sequence )Recommended Name: Popeye domain-containing protein 2 Size : 364 amino acids; 40448 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Sequence caution : Sequence=AAH26911.1; Type=Erroneous initiation;
Secondary accessions : Q86UE7Alternative splicing : 2 isoforms : Q9HBU9-1 Q9HBU9-2 Explore the universe of human proteins at neXtProt for POPDC2: NX_Q9HBU9 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_071418.2 ENSEMBL proteins: ENSP00000417250 ENSP00000264231 ENSP00000420715 ENSP00000340753 ENSP00000420795 Human Recombinant Proteins 2 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
POPDC2 for ontologies About GeneDecksing Antibodies for POPDC2: Assays for POPDC2:
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Protein
Domains/ Familiesfor POPDC2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
POPDC2 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9HBU9 ProtoNet protein and cluster: Q9HBU9
UniProtKB/Swiss-Prot: POPD2_HUMAN, Q9HBU9 Similarity : Belongs to the popeye family
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Gene Functionfor POPDC2 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: POPD2_HUMAN, Q9HBU9 Function : May play an important role in heart development
1 Gene Ontology (GO) molecular function term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
About this table
POPDC2 for ontologies About GeneDecksing Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Popdc2) :
POPDC2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor POPDC2 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for POPDC2 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POPDC2 1 Interacting protein for POPDC2 (Q9HBU9 2 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008150 biological_process
ND --
About this table
POPDC2 for ontologies About GeneDecksing
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Drugs & Compoundsfor POPDC2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for POPDC2
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Transcriptsfor POPDC2 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for POPDC2 gene: NM_022135.2
Additional cDNA sequence: AF204173.1 AK124602.1 AK226022.1 AK314819.1 BC026911.2 BC044929.1
9 DOTS entries : DT.95167023 DT.412864 DT.100709387 DT.86854326 DT.120909411 DT.100764985 DT.120909378 DT.95290768
DT.100764983 24/267 AceView cDNA sequences (see all 267 ):
F28207 BE644634 AA897414 AI093009 BQ267465 AW004609 F31554 F30220 BM720367 W05763 BU783975 L77701 AI453593 N75018 AI459181 BM510677 AW204888 BX094462 BX113663 AI741753 F26605 NM_022135 AI567443 BM828806
highest scoring ESTs for POPDC2 :BI711804 AF204173 BC026911 BC044929 BG292012 BI764980 T86404 W05763 W25440 BU789413 Unigene Cluster for POPDC2:
Popeye domain containing 2 Hs.656031 [show with all ESTs ] Unigene Representative Sequence: AK124602 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for POPDC2 (see all 7 ) ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c SP1 :     -             -     -         SP2 :     -             -   -   -         SP3 :     -                         SP4 :     -   -                       SP5 :                   -   -        
About this scheme ECgene alternative splicing isoforms for POPDC2 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000493094 ENST00000264231 ENST00000463323 ENST00000468801 ENST00000341124 (uc003ecx.1 uc010hqw.1 )ENST00000468916 ENST00000474523 (uc003ecy.1 ) ENST00000495362 ENST00000476092
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Expression for POPDC2 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section POPDC2 expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching POPDC2 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
64937_at2 , 3
U95-C
1
0.94
1.00
1.00
1.00
AA044732
0.40
0.50
0.45
1
219647_at2 , 3
U133-A
1
0.64
1.00
--
--
NM_022135
0.40
0.50
0.45
1
219647_at2
U133Plus2
1
0.64
1.00
--
--
--
--
--
--
--
About this table
POPDC2 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CCGTGGCACC SOURCE GeneReport for Unigene cluster: Hs.656031 UniProtKB/Swiss-Prot: POPD2_HUMAN, Q9HBU9 Tissue specificity : Expressed predominantly in the heart, and is also detected in the skeletal muscle
SABiosciences Custom PCR Arrays for POPDC2
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Orthologsfor POPDC2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for POPDC2 gene from 5/7 species (see all 7 )
About this table Species with no ortholog for POPDC2 ENSEMBL Gene Tree for POPDC2 (if available)
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Paralogsfor POPDC2 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for POPDC2 gene POPDC3 2 BVES 2
POPDC2 for paralogs About GeneDecksing
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Genomic Variantsfor POPDC2 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 3 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for POPDC2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for POPDC2: --
QIAGEN SeqTarget long-range PCR primers for resequencing POPDC2
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Disorders & Mutationsfor POPDC2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
POPDC2 for disorders About GeneDecksing
OMIM: 605823 Export disorders and mutations for POPDC2 gene to outside databases
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Medical Newsfor POPDC2 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor POPDC2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 8 PubMed articles for POPDC2 gene integrated from 7 sources : (articles sorted by number of sources associating them with POPDC2) Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. (PubMed id 10882522) 1 , 2 , 3, 7 Andree B.... Brand T. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149) 1 Suzuki Y.... Sugano S. (1997) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298) 1 Maruyama K. and Sugano S. (1994) Popeye domain containing gene 2 (Popdc2) is a myocyte-specific differentiation marker during chick heart development. (PubMed id 14991725) 7 Breher S.S....Brand T. (2004) Mutants of GABA transaminase (POP2) suppress the severe phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis. (PubMed id 18846220) 7 Ludewig F....Bouche N. (2008)
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External Searches for POPDC2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing POPDC2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing POPDC2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing POPDC2 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for POPDC2 gene: Search GeneIP for patents involving POPDC2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor POPDC2 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for POPDC2
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