Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS
Search by expression pattern Search by expression pattern


POU2AF1 Gene

protein-coding   GIFtS: 55

GC11M107147
POU class 2 associating factor 1
(Previous names: POU domain class 2, associating factor 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for POU2AF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
POU class 2 associating factor 11 2     POU domain class 2, associating factor 11
OBF11 2 3 5     OBF-12
BOB-12 3     BOB12
OCT-binding factor 12 3     OCAB2
OCA-B2 3     POU domain, class 2, associating factor 12
B-cell-specific coactivator OBF-12 3     POU domain class 2-associating factor 12

External Ids:    HGNC: 92111   Entrez Gene: 54502   Ensembl: ENSG000001107777   UniProtKB: Q166333   

Export aliases for POU2AF1 gene to outside databases

Previous GC identifers: GC11M113575 GC11M112735 GC11M111256 GC11M110760 GC11M110728 GC11M111222


Summaries
for POU2AF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
Function: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1
mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It
recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for
the formation of germinal centers

Gene Wiki entry for POU2AF1

Genomic Views
for POU2AF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU2AF1 gene promoter:
         TBP   TFIID   SREBP-1a   SREBP-1c   SREBP-1b   IRF-1   ATF6   Tal-1beta   ITF-2   Sox9   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for POU2AF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

POU2AF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU2AF1 gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M107147:  view genomic region     (about GC identifiers)

Start:
 107,147,948 bp from pter
End:
 107,174,870 bp from pter
Size:
 26,923 bases
Orientation:
 minus strand

1 alternative location:
Chr11- 111,222,980-111,250,157     
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  

Proteins
for POU2AF1 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633 (See protein sequence)
Recommended Name: POU domain class 2-associating factor 1  
Size: 256 amino acids; 27436 Da
Subcellular location: Nucleus
PDB structures from and Proteopedia :
1CQT (3D)    
Secondary accessions: B2R8Z9 Q14983

Explore the universe of human proteins at neXtProt for POU2AF1: NX_Q16633 

Post-translational modifications:

  • Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (Probable)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_006226.2  

    ENSEMBL proteins: 
    ENSP00000228217 ENSP00000376786 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: POU2AF1
    GenScript Custom Purified and Recombinant Proteins Services for POU2AF1 
    Novus Biologicals Proteins for POU2AF1
    Novus Biologicals Lysate for POU2AF1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    POU2AF1 for ontologies           About GeneDecksing



    Antibodies for POU2AF1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibody Arrays and Antibodies for POU2AF1
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 3): POU2AF1
    GenScript Custom Superior Antibodies Services for POU2AF1 
    Novus Biologicals Antibodies for POU2AF1
    Epitomics antibodies for POU2AF1

    Assays for POU2AF1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POU2AF1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for POU2AF1 

    Protein Domains/
    Families
    for POU2AF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POU2AF1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR015389 PD-C2-AF1

    Graphical View of Domain Structure for InterPro Entry Q16633

    ProtoNet protein and cluster: Q16633

    UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
    Similarity: Belongs to the POU2AF1 family


    Gene Function
    for POU2AF1 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
    Function: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1
    mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It
    recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for
    the formation of germinal centers

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for POU2AF1
    Sigma-Aldrich shRNA for POU2AF1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): POU2AF1
    OriGene shRNA RFP (see all 2): POU2AF1
    OriGene basic RS shRNA (see all 2): POU2AF1
    OriGene siRNA (see all 2): POU2AF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POU2AF1 
    miRNA:Sigma-Aldrich microRNA Mimics for POU2AF1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POU2AF1 
    3 SABiosciences Assays for microRNAs that regulate POU2AF1:
    hsa-miR-1321 hsa-miR-1252 hsa-miR-766

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: POU2AF1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: POU2AF1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): POU2AF1
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for POU2AF1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for POU2AF1 

    Genatlas biochemistry entry for POU2AF1:
    POU domain class 2,associating factor 1,B-cell specific coactivator,specifically associating with OCT1 (OTF1) and
    OCT2,fused with LAZ3/BCL6 in a B-cell leukemia cell line (Karpas 231)

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0003712 transcription cofactor activity TAS7859290
    GO:0003713 transcription coactivator activity TAS7859290
    GO:0005515 protein binding IPI16713566
    About this table

    POU2AF1 for ontologies           About GeneDecksing

    Animal Models: 5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Pou2af1):

    growth/sizehematopoietic systemimmune systemlife span-post-weaning/agingrenal/urinary system

    POU2AF1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for POU2AF1 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Arrays including POU2AF1: PAHS-066A PAHS-075A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU2AF1

    3 Interacting proteins for POU2AF1 (ENSP000002282173 Q166331) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POU2F1ENSP000003568363STRING: ENSP00000356836
    --ENSP000003530903STRING: ENSP00000353090
    About this table

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366 transcription from RNA polymerase II promoter TAS7859290
    GO:0006959 humoral immune response TAS7859290
    GO:0045449 regulation of transcription IEA--
    About this table

    POU2AF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for POU2AF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    POU2AF1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POU2AF1
    1 Novoseek chemical compound relationship for POU2AF1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 2 10604987 (2)
    About this table



    Transcripts
    for POU2AF1 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for POU2AF1
    Sigma-Aldrich shRNA for POU2AF1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): POU2AF1
    OriGene shRNA RFP (see all 2): POU2AF1
    OriGene basic RS shRNA (see all 2): POU2AF1
    OriGene siRNA (see all 2): POU2AF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POU2AF1 
    miRNA: Sigma-Aldrich microRNA Mimics for POU2AF1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POU2AF1 
    3 SABiosciences Assays for microRNAs that regulate POU2AF1:
    hsa-miR-1321 hsa-miR-1252 hsa-miR-766
    Clones: Sigma-Aldrich FLAG tag genes for POU2AF1
    OriGene GFP tagged cDNA clones in CMV expression vector: POU2AF1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: POU2AF1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): POU2AF1
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for POU2AF1 
    Primers: OriGene genome-wide validated SYBR primer pairs: POU2AF1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for POU2AF1: PPH02067A

    REFSEQ mRNAs for POU2AF1 gene: 

    NM_006235.2  

    Additional cDNA sequence: 

    AK313573.1 BC022056.1 BC032549.1 CR599556.1 X83504.1 Z47550.1 Z49194.1 

    7 DOTS entries:

    DT.97858926  DT.208246  DT.101977522  DT.302944  DT.120710296  DT.92427082  DT.99962992 

    24/64 AceView cDNA sequences (see all 64):

    AA928017 BF510638 AA362508 AI888552 BX462387 BX443224 AL560547 BQ423501 
    Z47550 X83504 BM795830 CR599556 BG756199 NM_006235 BX445716 BI908827 
    CF121528 BG757562 BM464990 AW207472 AW405850 AW663547 BX283630 BM464708 

    highest scoring ESTs for POU2AF1:

    AW499772 AW501101 BF797462 BG341016 BI908827 BI912349 X83504 Z47550 Z49194 AA362508 

    Unigene Cluster for POU2AF1:

    POU class 2 associating factor 1
    Hs.654525  [show with all ESTs]
    Unigene Representative Sequence: Z49194


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228217(uc001plg.3) ENST00000393067

    Expression
    for POU2AF1 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    POU2AF1 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching POU2AF1 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36239_at2, 3 U95-A 1 0.94 1.00 1.00 1.00 Z49194 0.80 1.00 0.91 1
    205267_at2, 3 U133-A 1 0.91 1.00 -- -- NM_006235 0.60 1.00 0.82 1
    205267_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    POU2AF1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    POU2AF1 gene expression
    POU2AF1 gene electronic northern expression
    POU2AF1 gene sage expression
    About these images

    CGAP SAGE TAG: GACTTTTCTG

    SOURCE GeneReport for Unigene cluster: Hs.654525

    Expression variation in blood from EXPOLDB for POU2AF1

    UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
    Tissue specificity: B-cell specific

    Primers: OriGene genome-wide validated SYBR primer pairs: POU2AF1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for POU2AF1: PPH02067A
        SABiosciences Expression via Pathway-Focused PCR Arrays including POU2AF1: PAHS-066A PAHS-075A 


    Orthologs
    for POU2AF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for POU2AF1 gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 POU2AF11   -- POU class 2 associating factor 1 89.45(n)
    92.97(a)    		 489413  XM_546531.2  XP_546531.2 
    chimpanzee
    (Pan troglodytes)    		 POU2AF11   -- POU class 2 associating factor 1 98.56(n)
    97.65(a)    		 451537  XM_508747.2  XP_508747.1 
    cow
    (Bos taurus)    		 POU2AF11   -- POU class 2 associating factor 1 86.98(n)
    91.41(a)    		 528475  NM_001075915.1  NP_001069383.1 
    rat
    (Rattus norvegicus)    		 Pou2af11   -- POU class 2 associating factor 1 85.29(n)
    87.89(a)    		 690528  XM_001074701.1  XP_001074701.1 
    mouse
    (Mus musculus)    		 Pou2af11 , 5 9 (27.95 cM)5
    		 POU domain, class 2, associating factor 11, 5 86.07(n)1
    88.67(a)1    		 189851  NM_011136.21  NP_035266.11 
     AF2412575  AK0885875  (see all 10)
    About this table        Species with no ortholog for POU2AF1

    ENSEMBL Gene Tree for POU2AF1 (if available)

    Paralogs
    for POU2AF1 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    		  --

    Genomic Variants
    for POU2AF1 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/361 NCBI SNPs in POU2AF1 are shown (see all 361)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs10427501,2
    		--111228205(-) TGTTGA/GCCTAT 2 T A ref1 mis10--------
    rs10427511,2
    		--111225176(-) GTACCA/GGCCTC 2 Q R ref1 mis1 ese31Minor allele frequency- G:0.00MN 184
    rs10427521,2
    		C,F,O,A,H,111223111(-) GTCACT/CATTAA 1 -- ut31 ese322Minor allele frequency- C:0.31MN NA NS EA WA 1370
    rs11268841,2
    		--111223433(-) tccgcC/Gcgcct 1 -- ut310--------
    rs11268861,2
    		--111223004(-) TGCCCA/CCTTTA 1 -- ut310--------
    rs18064341,2
    		H111233332(-) ctggaG/Cgacgt 1 -- int14Minor allele frequency- C:0.00NS EA 420
    rs18159451,2
    		C,F,A,H,111235756(+) AAACAT/GAACTT 1 -- int115Minor allele frequency- G:0.43NS EA NA WA 678
    rs18159461,2
    		C,F,A,111236988(+) GAGGAC/TCCTGC 1 -- int112Minor allele frequency- T:0.42NS EA NA WA 510
    rs18159471,2
    		C,F,H,111241826(+) TCAGCA/GTTTCC 1 -- int112Minor allele frequency- G:0.03NS EA NA WA 480
    rs18159481,2
    		C,F,A,111232348(-) AATATC/GCCCCC 1 -- int110Minor allele frequency- G:0.05NS EA NA WA 898
    About this table

    HapMap Linkage Disequilibrium images for POU2AF1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for POU2AF1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing POU2AF1 

    Disorders & Mutations
    for POU2AF1 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POU2AF1 for disorders           About GeneDecksing

    OMIM: 601206

    UniProtKB/Swiss-Prot: OBF1_HUMAN, Q16633
  • Note=A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia.
    • Translocation t(3;11)(q27;q23) with BCL6

    2 Novoseek disease relationships for POU2AF1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 36 3 17562619 (1), 11280769 (1), 15796964 (1)
    lymphoma 21.6 3 16186795 (1), 19224997 (1)
    About this table

    1 PharmGKB disease relationship for POU2AF1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872 12730115
    About this table

    Human Genome Epidemiology (HuGE) Navigator: POU2AF1 (5 documents)

    Export disorders and mutations for POU2AF1 gene to outside databases

    Medical News
    for POU2AF1 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for POU2AF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/80 PubMed articles for POU2AF1 gene, integrated from 7 sources (see all 80):
    (articles sorted by number of sources associating them with POU2AF1)
    1. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. (PubMed id 7623806)1, 2, 7 Luo Y. and Roeder R.G. (1995)
    2. Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization. (PubMed id 8617501)1, 3, 7 Junker S....Tommerup N. (1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1. (PubMed id 11483517)1, 2 Tiedt R.... Matthias P. (2001)
    5. Regulation of BOB.1/OBF.1 stability by SIAH. (PubMed id 11483518)1, 2 Boehm J.... Wirth T. (2001)
    6. A B-cell coactivator of octamer-binding transcription factors. (PubMed id 7779176)1, 2 Gstaiger M.... Hovens C.M. (1995)
    7. Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation. (PubMed id 8574789)1, 2 Galiegue-Zouitina S.... Kerckaert J.-P. (1995)
    8. OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer- binding proteins. (PubMed id 7859290)1, 2 Strubin M.... Matthias P. (1995)
    9. Bob1 (OCA-B/OBF-1) differential transactivation of the B cell-specific B29 (Ig beta) and mb-1 (Ig alpha) promoters. (PubMed id 11907094)1, 7 Malone C.S. and Wall R. (2002)
    10. Coactivator OBF-1 makes selective contacts with both the POU-specific domain and the POU homeodomain and acts as a molecular clamp on DNA. (PubMed id 9819426)1, 7 Sauter P. and Matthias P. (1998)

    External Searches for POU2AF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POU2AF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5450 HGNC: 9211 AceView: POU2AF1 Ensembl:ENSG00000110777 euGenes: HUgn5450
    ECgene: POU2AF1 H-InvDB: POU2AF1

    Other Databases showing POU2AF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POU2AF1 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for POU2AF1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for POU2AF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for POU2AF1 gene:
    Search GeneIP for patents involving POU2AF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for POU2AF1 gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for POU2AF1 Antibodies for POU2AF1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for POU2AF1 microRNA Mimics for POU2AF1
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     FLAG tag genes for POU2AF1 Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POU2AF1
     SeqTarget long-range PCR primers for resequencing POU2AF1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POU2AF1
     GenScript Custom Purified and Recombinant Proteins Services for POU2AF1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for POU2AF1
     GenScript Custom Assay Services for POU2AF1 GenScript Custom Superior Antibodies Services for POU2AF1
     GenScript Custom overexpressing Cell Line Services for POU2AF1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in POU2AF1 promoter
     Search Chromatin IP Primers for POU2AF1
     RT2 qPCR Primer Assay for POU2AF1
     GNC Network for POU2AF1
     Assays for microRNAs that regulate POU2AF1
     SABiosciences PCR Arrays including POU2AF1
     Search Tocris compounds for POU2AF1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for POU2AF1
     Proteins for POU2AF1
     Lysates for POU2AF1
     Antibodies for POU2AF1
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for POU2AF1
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    POU2AF1 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4