Aliases &
Descriptions
for POU2F3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| POU class 2 homeobox 31 2 | | POU domain class 2, transcription factor 31 | | OCT111 2 5 | | MGC1266982 | | Skn-1a1 2 | | oct-112 | | PLA-11 2 | | POU transcription factor2 | | Epoc-11 2 | | POU domain, class 2, transcription factor 32 | | Transcription factor PLA-12 3 | | FLJ400632 | | Transcription factor Skn-12 3 | | Oct-113 | | Octamer-binding protein 112 3 | | PLA13 | | Octamer-binding transcription factor 112 3 | | OTF113 | | OTF-112 3 | | |
Export aliases for POU2F3 gene to outside databasesPrevious GC identifers: GC11P122110 GC11P121622 GC11P120144 GC11P119648 GC11P119616 |
Summaries
for POU2F3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a numberof genes such as SPRR2A or placental lactogen
Gene Wiki entry for POU2F3 |
Genomic Views
for POU2F3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POU2F3 gene promoter:
IRF-7A POU2F2B Oct-B1 oct-B3 POU2F1 POU2F2 oct-B2 POU2F2 (Oct-2.1) POU2F2C RREB-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for POU2F3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for POU2F3  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3POU2F3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P116050: view genomic region
(about GC identifiers)
Start:
|
116,050,523 bp from pter |
End:
|
116,130,682 bp from pter |
Size:
|
80,160 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr11+ 120,110,951-120,190,653 |
RefSeq DNA sequence:- NC_000011.9 NT_033899.8
|
Proteins
for POU2F3 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9 (See
protein sequence)Recommended Name: POU domain, class 2, transcription factor 3 Size: 436 amino acids; 47432 Da
Subcellular location: Nucleus
Secondary accessions: A8K7H8 Q3MIY3 Q9UKR7 Q9Y504Explore the universe of human proteins at neXtProt for POU2F3: NX_Q9UKI9
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055167.2
ENSEMBL proteins: ENSP00000260264
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
POU2F3 for ontologies About GeneDecksing
Antibodies for POU2F3:
Assays for POU2F3: |
Protein
Domains/
Families
for POU2F3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
POU2F3 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9UKI9ProtoNet protein and cluster: Q9UKI9 3 Blocks protein families: IPB000327 POU domain IPB000972 Octamer-binding transcription factor signature IPB013847 POU
UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9Similarity: Belongs to the POU transcription factor family. Class-2 subfamilySimilarity: Contains 1 homeobox DNA-binding domainSimilarity: Contains 1 POU-specific domain |
Gene Function
for POU2F3 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a numberof genes such as SPRR2A or placental lactogen
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
POU2F3 for ontologies About GeneDecksing
Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Pou2f3):
POU2F3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for POU2F3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for POU2F3
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU2F3
5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
TAS | 10473598 | | GO:0008544 | epidermis development |
IEA | -- | | GO:0030216 | keratinocyte differentiation |
IEA | -- | | GO:0042060 | wound healing |
IEA | -- |
About this table
POU2F3 for ontologies About GeneDecksing
|
Drugs & Compounds
for POU2F3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
POU2F3 for compounds About GeneDecksing
 Browse Tocris compounds for POU2F3
4  Novoseek chemical compound relationships for POU2F3 gene
About this table
|
Transcripts
for POU2F3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for POU2F3 gene: NM_014352.2 Additional cDNA sequence: AF133895.1 AF162278.1 AF162715.2 AJ012214.1 AK097382.1 AK291993.1 AK302212.1 BC101649.1 BC143593.1 BC143594.1 BC143595.1 CR593728.1 5 DOTS entries: DT.422614 DT.100008374 DT.40190810 DT.100767682 DT.91731669 24/84 AceView cDNA sequences (see all 84): AL531164 BQ573722 CA778080 BM971471 CR593728 BC015232 AI822098 AA422067 CR602717 AW361691 BQ690587 AW297273 BX281405 NM_174926 BU151499 AJ012214 AF162278 AA341047 BG707889 AI686582 AI457756 AF162715 AW614120 AI338546
 highest scoring ESTs for POU2F3:AJ012214 AF133895 AF162278 AI804543 AW139181 BE707487 R23834 R39704 AK097382 AW273398 Unigene Cluster for POU2F3: POU class 2 homeobox 3 Hs.227115 [show with all ESTs]Unigene Representative Sequence: AF162715
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000260264(uc001pxc.2 uc010rzk.1 uc010rzl.1 uc001pxe.1 uc001pxf.1)
|
Expression
for POU2F3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| POU2F3 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching POU2F3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 32928_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AJ012214 |
1.00 |
1.00 |
1.00 |
1 |
| 207109_at2, 3
|
U133-A |
1 |
0.64 |
1.00 |
-- |
-- |
NM_014352 |
0.60 |
1.00 |
0.82 |
1 |
| 215355_at*2, 3
|
U133-A |
1 |
0.27 |
1.00 |
-- |
-- |
AI686582 |
0.40 |
1.00 |
0.76 |
1 |
| 207109_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 215355_at*2
|
U133Plus2 |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
POU2F3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TCTAGGAAAC
SOURCE GeneReport for Unigene cluster: Hs.227115
Expression variation in blood from EXPOLDB for POU2F3 UniProtKB/Swiss-Prot: PO2F3_HUMAN, Q9UKI9Tissue specificity: Specifically expressed in epidermis and cultured keratinocytes
SABiosciences Custom PCR Arrays for POU2F3
|
Orthologs
for POU2F3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for POU2F3 gene from 5/7 species (see all 7)
About this table Species with no ortholog for POU2F3
ENSEMBL Gene Tree for POU2F3 (if available) |
Paralogs
for POU2F3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for POU2F3 gene
- POU2F12 POU3F12 POU3F42 POU3F32 POU3F22 POU2F22
POU2F3 for paralogs About GeneDecksing
|
Genomic Variants
for POU2F3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 11 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for POU2F3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for POU2F3
2 CNVs: 101355 101354 | | QIAGEN SeqTarget long-range PCR primers for resequencing POU2F3 |
|
Disorders & Mutations
for POU2F3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
POU2F3 for disorders About GeneDecksing
OMIM: 607394
4 Novoseek disease relationships for POU2F3 gene
About this table
Human Genome Epidemiology (HuGE) Navigator: POU2F3 (1 document)
Export disorders and mutations for POU2F3 gene to outside databases
|
Medical News
for POU2F3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for POU2F3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/86 PubMed articles for POU2F3 gene, integrated from 7 sources (see all 86):
(articles sorted by number of sources associating them with POU2F3)- Characterization of the regulatory domains of the human skn-1a/Epoc- 1/Oct-11 POU transcription factor. (PubMed id 10473598)1, 2, 3 Hildesheim J.... Vogel J.C. (1999)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer. (PubMed id 16607278)1, 7 Zhang Z....Rader J.S. (2006)
- Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PubMed id 17195013)1, 7 Beck I.M....Sedlacek R. (2007)
- The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression. (PubMed id 16005513)1, 7 Jimenez-Mateo O....Castrillo J.L. (2006)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Skn-1a/Oct-11 and I9Np63I+ exert antagonizing effects o n human keratin expression. (PubMed id 20888799)1 Lena A.M....Candi E. (2010 Oct 29)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Transcription factor human Skn-1a enhances replication of human papillomavirus DNA through the direct binding to two sites near the viral replication origin. (PubMed id 18479461)1 Kukimoto I....Kanda T. (2008)
- Identification of Skn-1n, a splice variant induced by high calcium concentration and specifically expressed in normal human keratinocytes. (PubMed id 17989732)1 Nakajima K....Sawamura D. (2008)
|
External Searches for POU2F3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing POU2F3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing POU2F3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing POU2F3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for POU2F3 gene:
Search GeneIP for patents involving POU2F3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for POU2F3 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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