PPAPDC1A Gene
protein-coding GIFtS: 42
GC10P115845
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phosphatidic acid phosphatase type 2 domain containing 1A
(Previous name: phosphatidic acid phosphatase type 2 domain containing 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PPAPDC1)
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Aliases &
Descriptions
for PPAPDC1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| phosphatidic acid phosphatase type 2 domain containing 1A1 2 | | phosphatidate phosphatase PPAPDC1A2 | | Phosphatidic acid phosphatase type 2 domain-containing protein 1A2 3 | | MGC1202992 | | DPPL22 3 | | OTTHUMP000000206182 | | PPAPDC12 3 | | diacylglycerol pyrophosphate like 22 | | phosphatidic acid phosphatase type 2 domain containing 11 | | OTTHUMP000000206192 | | MGC1203002 | | EC 3.1.3.43 |
Export aliases for PPAPDC1A gene to outside databasesPrevious GC identifer: GC10P122207 |
Summaries
for PPAPDC1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PPC1A_HUMAN, Q5VZY2Function: Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion ofphosphatidic acid to diacylglycerol
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Genomic Views
for PPAPDC1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
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Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPAPDC1A gene promoter:
NRSF form 2 NRSF form 1 PPAR-gamma2 PPAR-gamma1 USF1 CUTL1 Arnt FOXL1 POU3F1 AREB6
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPAPDC1A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PPAPDC1A  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.12 Ensembl cytogenetic band: 10q26.12 HGNC cytogenetic band: 10q26.13PPAPDC1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P115845: view genomic region
(about GC identifiers)
Start:
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115,845,693 bp from pter |
End:
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115,978,671 bp from pter |
Size:
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132,979 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr10+ 122,216,466-122,349,367 |
RefSeq DNA sequence:- NC_000010.10 NT_030059.13
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Proteins
for PPAPDC1A gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
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UniProtKB/Swiss-Prot: PPC1A_HUMAN, Q5VZY2 (See
protein sequence)Recommended Name: Phosphatidate phosphatase PPAPDC1A Size: 271 amino acids; 30395 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=CAH70333.1; Type=Erroneous gene model prediction;
Secondary accessions: A2RU82 Q08EQ2 Q0IIP2 Q495B4 Q5VZY1Alternative splicing: 4 isoforms: Q5VZY2-1 Q5VZY2-2 Q5VZY2-3 Q5VZY2-4 Explore the universe of human proteins at neXtProt for PPAPDC1A: NX_Q5VZY2
REFSEQ proteins: NP_001025230.1
ENSEMBL proteins: ENSP00000407979 ENSP00000381300 ENSP00000358069 ENSP00000381302 ENSP00000403508
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
About this table
PPAPDC1A for ontologies About GeneDecksing
Antibodies for PPAPDC1A:
Assays for PPAPDC1A: |
Protein
Domains/
Families
for PPAPDC1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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PPAPDC1A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VZY2ProtoNet protein and cluster: Q5VZY2 1 Blocks protein family: IPB000326 PA-phosphatase related phosphoesterase
UniProtKB/Swiss-Prot: PPC1A_HUMAN, Q5VZY2Similarity: Belongs to the PA-phosphatase related phosphoesterase family |
Gene Function
for PPAPDC1A gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PPC1A_HUMAN, Q5VZY2Function: Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion ofphosphatidic acid to diacylglycerolCatalytic activity: A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphateEnzyme regulation: Inhibited by N-ethylmaleimideBiophysicochemical properties: Kinetic parameters: KM=104 uM for diacylglycerol pyrophosphate; KM=506 uM forphosphatidate; KM=580 uM for lysophosphatidate;Enzyme Number (IUBMB): EC 3.1.3.4
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003824 | catalytic activity |
-- | -- | | GO:0008195 | phosphatidate phosphatase activity |
IEA | -- | | GO:0016787 | hydrolase activity |
IEA | -- |
About this table
PPAPDC1A for ontologies About GeneDecksing
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Pathways & Interactions
for PPAPDC1A gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
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SABiosciences Custom Pathway-Focused PCR Arrays for PPAPDC1A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPAPDC1A
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Drugs & Compounds
for PPAPDC1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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 Browse Tocris compounds for PPAPDC1A
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Transcripts
for PPAPDC1A gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
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REFSEQ mRNAs for PPAPDC1A gene: NM_001030059.1 Additional cDNA sequence: AK098668.1 AK296273.1 AK310178.1 BC101267.2 BC101268.2 BC101269.1 BC122535.1 BC132787.1 3 DOTS entries: DT.309587 DT.121252446 DT.75112404 23 AceView cDNA sequences: BM930630 AK098668 AI418830 CD557662 CA433964 BI550027 AA418447 AW026561 AA424650 CA434138 CF264786 BU743282 AI126772 BG191521 AA631750 N25267 N22732 H83701 BG217560 BG216388 H83353 BG209093 CB994970
 highest scoring ESTs for PPAPDC1A:AK098668 BM930630 BU743282 CA433964 CA434138 N25267 AA424650 AA631750 AI126772 AI418830 Unigene Cluster for PPAPDC1A: Phosphatidic acid phosphatase type 2 domain containing 1A Hs.40479 [show with all ESTs]Unigene Representative Sequence: NM_001030059
GeneLoc Exon Structure
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000427079 ENST00000398248(uc001lex.1) ENST00000496437 ENST00000369073(uc001ley.1)
ENST00000398250(uc010qtd.1 uc001lev.1) ENST00000439221(uc009xzl.1 uc001lew.1)
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Expression
for PPAPDC1A gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PPAPDC1A expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching PPAPDC1A gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 46372_at2, 3
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U95-B |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
N25267 |
0.80 |
1.00 |
0.91 |
1 |
| 236044_at2, 3
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U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
BF130943 |
0.40 |
1.00 |
0.76 |
1 |
| 236044_at2
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U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PPAPDC1A for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTTGTAAAAC
SOURCE GeneReport for Unigene cluster: Hs.40479
UniProtKB/Swiss-Prot: PPC1A_HUMAN, Q5VZY2Tissue specificity: Expressed mainly to the brain, kidney and testis, and to a lesser extent the bone marrow, thymus,prostate, liver and uterus
SABiosciences Custom PCR Arrays for PPAPDC1A
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Orthologs
for PPAPDC1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for PPAPDC1A gene from 5/12 species (see all 12)
About this table Species with no ortholog for PPAPDC1A
ENSEMBL Gene Tree for PPAPDC1A (if available) |
Paralogs
for PPAPDC1A gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PPAPDC1A gene
- PPAPDC1B2
PPAPDC1A for paralogs About GeneDecksing
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Genomic Variants
for PPAPDC1A gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 10 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PPAPDC1A (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for PPAPDC1A
6 CNVs: 85495 101059 65797 22727 75397 85496
2 Indels: 75398 85497 | | QIAGEN SeqTarget long-range PCR primers for resequencing PPAPDC1A |
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Disorders & Mutations
for PPAPDC1A gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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PPAPDC1A for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: PPAPDC1A (1 document)
Export disorders and mutations for PPAPDC1A gene to outside databases
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Medical News
for PPAPDC1A gene(Possibly Related Articles in
Doctor's Guide)
About This Section
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Publications
for PPAPDC1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
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5 PubMed articles for PPAPDC1A gene integrated from 7 sources:
(articles sorted by number of sources associating them with PPAPDC1A)- Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. (PubMed id 17590538)1, 2 Takeuchi M....Kamatani N. (2007)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for PPAPDC1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PPAPDC1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing PPAPDC1A gene
(According to HUGE)
About This Section
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Specialized Databases showing PPAPDC1A gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for PPAPDC1A gene:
Search GeneIP for patents involving PPAPDC1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PPAPDC1A gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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