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PPFIBP2 Gene

protein-coding GIFtS: 52

GC11P007193

PTPRF interacting protein, binding protein 2 (liprin beta 2)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
PTPRF interacting protein, binding protein 2 (liprin beta 2)¹ ²		DKFZp781K06126²
Cclp1¹ ²		liprin-beta-2²
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2² ³		MGC42541²
PTPRF-interacting protein-binding protein 2² ³

External Ids:	HGNC: 9250¹	Entrez Gene: 8495²	Ensembl: ENSG00000166387⁷	UniProtKB: Q8ND30³

Export aliases for PPFIBP2 gene to outside databases

Previous GC identifers: GC11P008370 GC11P007995 GC11P007494 GC11P007499 GC11P007491

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPFIBP2:

PPFIBP2, or liprin-beta-2, belongs to the liprin-beta family. See liprin-beta-1 (MIM 603141) for background on

liprins.(supplied by OMIM)

UniProtKB/Swiss-Prot: LIPB2_HUMAN, Q8ND30

Function: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPFIBP2 gene promoter:
         Chx10   Max1   c-Myc   MEF-2A   FOXC1   USF1   NF-E2 p45   NF-E2   E47   E2F-1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for PPFIBP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PPFIBP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4

PPFIBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPFIBP2 gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P007193: view genomic region (about GC identifiers)

Start:	7,193,533 bp from pter
End:	7,333,709 bp from pter
Size:	140,177 bases
Orientation:	plus strand

1 alternative location:

Chr11+ 7,535,001-7,674,989

RefSeq DNA sequence:

NC_000011.9 NT_009237.18

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: LIPB2_HUMAN, Q8ND30 (See protein sequence)

Recommended Name: Liprin-beta-2

Size: 876 amino acids; 98544 Da

Subunit: Forms homodimers and heterodimers (By similarity)

Secondary accessions: O75337 Q8WW26

Explore the universe of human proteins at neXtProt for PPFIBP2: NX_Q8ND30

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003612.2

ENSEMBL proteins:

ENSP00000299492

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PPFIBP2
	GenScript Custom Purified and Recombinant Proteins Services for PPFIBP2
	Novus Biologicals Proteins for PPFIBP2
	Novus Biologicals Lysates for PPFIBP2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	TAS	9624153

About this table

PPFIBP2 for ontologies About GeneDecksing

Antibodies for PPFIBP2:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PPFIBP2
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	GenScript Custom Superior Antibodies Services for PPFIBP2
	Novus Biologicals Antibodies for PPFIBP2
	Epitomics antibodies for PPFIBP2

Assays for PPFIBP2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PPFIBP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PPFIBP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPFIBP2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR010993 Sterile_alpha_motif_homology

IPR021129 SAM_type1

IPR004191 Integrase_Tn916-type_DNA-bd_N

IPR013761 SAM_type

IPR001660 SAM

Graphical View of Domain Structure for InterPro Entry Q8ND30

ProtoNet protein and cluster: Q8ND30

3 Blocks protein families:

IPB001660 Sterile alpha motif SAM

IPB004191 Tn916 integrase

IPB011510 Sterile alpha motif homology 2

UniProtKB/Swiss-Prot: LIPB2_HUMAN, Q8ND30

Domain: The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type

beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha (By similarity)

Similarity: Belongs to the liprin family. Liprin-beta subfamily

Similarity: Contains 3 SAM (sterile alpha motif) domains

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: LIPB2_HUMAN, Q8ND30

Function: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PPFIBP2 Sigma-Aldrich shRNA for PPFIBP2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): PPFIBP2 OriGene shRNA RFP (see all 3): PPFIBP2 OriGene basic RS shRNA (see all 3): PPFIBP2 OriGene siRNA (see all 2): PPFIBP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PPFIBP2

miRNA:		Sigma-Aldrich microRNA Mimics for PPFIBP2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PPFIBP2
		3 SABiosciences Assays for microRNAs that regulate PPFIBP2:
		hsa-miR-182 hsa-miR-124 hsa-miR-506

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PPFIBP2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PPFIBP2 OriGene untagged cDNA clones in CMV expression vector (see all 2): PPFIBP2 OriGene 3'-UTR clone: PPFIBP2 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PPFIBP2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for PPFIBP2

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	18482256
GO:0008907	integrase activity	IEA	--

About this table

PPFIBP2 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for PPFIBP2

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PPFIBP2

4 Interacting proteins for PPFIBP2 (Q8ND30^{1, 2}) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRNP	P04156¹	EBI-744056,EBI-977302
SFN	P31947²	MINT-3975178
TSG101	Q99816²	MINT-66433
--	Q96AW0²	MINT-68284

About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007154	cell communication	NAS	--
GO:0015074	DNA integration	IEA	--

About this table

PPFIBP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PPFIBP2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PPFIBP2 Sigma-Aldrich shRNA for PPFIBP2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): PPFIBP2 OriGene shRNA RFP (see all 3): PPFIBP2 OriGene basic RS shRNA (see all 3): PPFIBP2 OriGene siRNA (see all 2): PPFIBP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PPFIBP2

miRNA:		Sigma-Aldrich microRNA Mimics for PPFIBP2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PPFIBP2
		3 SABiosciences Assays for microRNAs that regulate PPFIBP2:
		hsa-miR-182 hsa-miR-124 hsa-miR-506

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PPFIBP2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PPFIBP2 OriGene untagged cDNA clones in CMV expression vector (see all 2): PPFIBP2 OriGene 3'-UTR Clone: PPFIBP2 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PPFIBP2

Primers:		OriGene genome-wide validated SYBR primer pairs: PPFIBP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PPFIBP2: PPH07898A

REFSEQ mRNAs for PPFIBP2 gene:

NM_003621.2

Additional cDNA sequence:

AF034803.1 AK001131.1 AK025337.1 AK097449.1 AK293669.1 AK294554.1 AK296718.1 AK301978.1

AK308398.1 AK311048.1 AL834426.1 BC021026.1 BC021714.1 CR749258.1

20 DOTS entries:

DT.452999 DT.100009989 DT.100787630 DT.91650802 DT.100787632 DT.95307781 DT.100787633 DT.100787637

DT.425417 DT.95145072 DT.120748187 DT.100809764 DT.120748153 DT.120748231 DT.40190437 DT.120748192

DT.75159030 DT.92027374 DT.120748173 DT.95195773

24/205 AceView cDNA sequences (see all 205):

CD109093 BX109147 AI868399 BF726125 BU624376 AA877353 AL834426 AA331841

AI057485 CB161350 AI692180 BF726124 CD171856 CB129260 CD364931 BM682279

AI149790 AI805241 AA583006 CA503137 AW576293 R72196 AU146640 AA815324

highest scoring ESTs for PPFIBP2:

AF034803 AA131100 AA502582 AA551750 AA583006 AA598564 AA760889 AA781767 AA804778 AA815324

Unigene Cluster for PPFIBP2:

PTPRF interacting protein, binding protein 2 (liprin beta 2)

Hs.655714 [show with all ESTs]

Unigene Representative Sequence: NM_003621

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PPFIBP2 (see all 12)

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18a	·	18b	^
SP1:																																																	-
SP2:							-		-		-												-						-		-
SP3:									-		-												-
SP4:
SP5:							-		-

ExUns:	19	^	20	^	21a	·	21b	^	22a	·	22b	^	23	^	24	^	25	^	26	^	27	^	28a	·	28b	^	29	^	30a	·	30b	^	31
SP1:											-												-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PPFIBP2
1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000299492(uc010rbd.1 uc010rbb.1 uc001mfk.1 uc001mfj.3 uc010rbc.1 uc010rbe.1 uc001mfl.3 uc009yfj.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

PPFIBP2 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching PPFIBP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41709_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF034803	1.00	1.00	1.00	1
212841_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI692180	0.80	1.00	0.91	1
212841_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

PPFIBP2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

PPFIBP2 gene electronic northern expression

About these images

CGAP SAGE TAG: GACACTCCCA

SOURCE GeneReport for Unigene cluster: Hs.655714

Expression variation in blood from EXPOLDB for PPFIBP2

UniProtKB/Swiss-Prot: LIPB2_HUMAN, Q8ND30

Tissue specificity: Widely expressed

Primers:		OriGene genome-wide validated SYBR primer pairs: PPFIBP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PPFIBP2: PPH07898A

SABiosciences Custom PCR Arrays for PPFIBP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PPFIBP2 gene from 5/10 species (see all 10)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PPFIBP2¹	--	PTPRF interacting protein, binding protein 2 (liprin more	90.59(n) 92.65(a)	485366 XM_542484.2 XP_542484.2
chimpanzee (Pan troglodytes)	PPFIBP2¹	--	PTPRF interacting protein, binding protein 2 (liprin more	99.39(n) 99.08(a)	749024 XM_001164875.1 XP_001164875.1
cow (Bos taurus)	PPFIBP2¹	--	PTPRF interacting protein, binding protein 2 (liprin more	87.45(n) 88.33(a)	614705 XM_866292.2 XP_871385.2
rat (Rattus norvegicus)	Ppfibp2¹	--	PTPRF interacting protein, binding protein 2 (liprin more	87.56(n) 90.04(a)	308918 XM_219201.4 XP_219201.4
mouse (Mus musculus)	Ppfibp2^{1 , 5}	7 (57.21 cM)⁵	PTPRF interacting protein, binding protein 2 (liprin more⁵ protein tyrosine phosphatase, receptor-type, F interacting more¹	87.51(n)¹ 89.89(a)¹	19024¹ NM_008905.1¹ NP_032931.1¹ AK012152⁵ AK035364⁵ (see all 21)

About this table Species with no ortholog for PPFIBP2

ENSEMBL Gene Tree for PPFIBP2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PPFIBP2 gene

PPFIBP1² PPFIA2² PPFIA4² KAZ² PPFIA3² PPFIA1²

PPFIBP2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs5864^1,2	C,F,A,	7673015(+)	`CAGGAA/GAAGCG`	2	E	syn¹ ref¹		18		NS EA NA MN WA	1386
rs13607^1,2	--	7674701(+)	`TTTTAC/AATGTC`	1	--	ut3¹ ese³		1		MN	184
rs1079025^1,2	C,	7596197(+)	`TTCTTC/GCCTCC`	1	--	int¹ trp³		0	--	--	--	--
rs1128012^1,2	F	7674401(+)	`CCCCTT/GGATGC`	2	/L	syn¹ ref¹		1		MN	184
rs1137622^1,2	--	7601092(+)	`AAACTC/TAAAGT`	1	--	int¹		0	--	--	--	--
rs3861066^1,2	C,F,A,	7663779(+)	`TCTTCC/TCCAGT`	1	--	int¹ trp³		11		NS EA NA WA	766
rs3889980^1,2	C,	7595965(+)	`GTGAGC/TGAGGA`	1	--	int¹		4		NS EA	404
rs3892335^1,2	C,F,	7627786(-)	`AATAAC/TAGAAC`	1	--	int¹		20		NS EA NA WA	1272
rs3892569^1,2	C,F,	7596387(+)	`CTTTAC/ACAGTC`	1	--	int¹		6		NA	394
rs3923491^1,2	C,F,A,H,	7672272(-)	`TTGTGT/CCTTGT`	1	--	int¹		21		NS EA NA WA	1266

About this table

HapMap Linkage Disequilibrium images for PPFIBP2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPFIBP2: --

QIAGEN SeqTarget long-range PCR primers for resequencing PPFIBP2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PPFIBP2 for disorders About GeneDecksing

OMIM: 603142

Human Genome Epidemiology (HuGE) Navigator: PPFIBP2 (2 documents)

Export disorders and mutations for PPFIBP2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/13 PubMed articles for PPFIBP2 gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with PPFIBP2)

Liprins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins. (PubMed id 9624153)^{1, 2, 3} Serra-Pages C.... Streuli M. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PubMed id 20095854)¹ Bhatti P....Sigurdson A.J. (2010)
Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)¹ Satoh J....Tabunoki H. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8495	HGNC: 9250	AceView: PPFIBP2	Ensembl:ENSG00000166387	euGenes: HUgn8495
ECgene: PPFIBP2	H-InvDB: PPFIBP2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for PPFIBP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for PPFIBP2 gene:
Search GeneIP for patents involving PPFIBP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PPFIBP2		Antibodies for PPFIBP2
	Super-pooled esiRNAs for PPFIBP2		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PPFIBP2		microRNA Mimics for PPFIBP2
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PPFIBP2
	SeqTarget long-range PCR primers for resequencing PPFIBP2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PPFIBP2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PPFIBP2

	GenScript Custom Purified and Recombinant Proteins Services for PPFIBP2		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for PPFIBP2
	GenScript Custom Assay Services for PPFIBP2		GenScript Custom Superior Antibodies Services for PPFIBP2
	GenScript Custom overexpressing Cell Line Services for PPFIBP2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search for Antibodies & Assays

	Regulatory tfbs in PPFIBP2 promoter
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ELISAs and CLIAs for PPFIBP2

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

PPFIBP2 gene at Home site.

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PPFIBP2 Gene

protein-coding GIFtS: 52

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PPFIBP2 Gene

protein-coding GIFtS: 52

Aliases & Descriptionsfor PPFIBP2 gene

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for PPFIBP2 gene

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for PPFIBP2 gene

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for PPFIBP2 gene

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for PPFIBP2 gene

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for PPFIBP2 gene

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for PPFIBP2 gene

Drugs & Compounds
for PPFIBP2 gene

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for PPFIBP2 gene

Expression
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Orthologs
for PPFIBP2 gene

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for PPFIBP2 gene

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