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PPP1R14A Gene

protein-coding   GIFtS: 55

GC19M035189
protein phosphatase 1, regulatory (inhibitor) subunit 14A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PPP1INL)
Products    

Aliases &
Descriptions
for PPP1R14A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
protein phosphatase 1, regulatory (inhibitor) subunit 14A1 2     PPP1INL2 3
CPI-171 2 3     protein phosphatase 1 regulatory subunit 14A2
CPI172 3 5     17-KDa protein2
Protein kinase C-potentiated inhibitor protein of 17 kDa2 3     PKC-potentiated inhibitory protein of PP12
17 kDa PKC-potentiated inhibitory protein of PP12 3     17-kDa PKC-potentiated inhibitory protein of PP12

External Ids:    HGNC: 148711   Entrez Gene: 942742   Ensembl: ENSG000001676417   UniProtKB: Q96A003   

Export aliases for PPP1R14A gene to outside databases

Previous GC identifers: GC19M039356 GC19M039133 GC19M043417 GC19M043433 GC19M038741


Summaries
for PPP1R14A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPP1R14A:
PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase (see MIM 603768). Inhibition
leads to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased
intracellular Ca(2+) concentration.(supplied by OMIM)

UniProtKB/Swiss-Prot: PP14A_HUMAN, Q96A00
Function: Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular
switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction

Gene Wiki entry for PPP1R14A

Genomic Views
for PPP1R14A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1R14A gene promoter:
         NF-kappaB1   AP-1   CREB   deltaCREB   Elk-1   NF-kappaB   GATA-1   AhR   c-Fos   c-Jun   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PPP1R14A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PPP1R14A 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

PPP1R14A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R14A gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M035189:  view genomic region     (about GC identifiers)

Start:
 35,189,903 bp from pter
End:
 35,195,195 bp from pter
Size:
 5,293 bases
Orientation:
 minus strand

1 alternative location:
Chr19- 38,741,877-38,747,231     
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  

Proteins
for PPP1R14A gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: PP14A_HUMAN, Q96A00 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 14A  
Size: 147 amino acids; 16693 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q7Z4X7 Q96S54
Alternative splicing: 2 isoforms:  Q96A00-1   Q96A00-2   

Explore the universe of human proteins at neXtProt for PPP1R14A: NX_Q96A00 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_150281.1  

    ENSEMBL proteins: 
    ENSP00000301243 ENSP00000301242 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant PPP1R14A Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PPP1R14A
    OriGene Protein Over-expression Lysate: PPP1R14A
    GenScript Custom Purified and Recombinant Proteins Services for PPP1R14A 
    Novus Biologicals Proteins for PPP1R14A
    Novus Biologicals Lysates for PPP1R14A
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PPP1R14A

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    About this table

    PPP1R14A for ontologies           About GeneDecksing



    Antibodies for PPP1R14A: 
    Millipore Mono- and Polyclonal Antibodies for the study of PPP1R14A
    Sigma-Aldrich Antibodies for PPP1R14A
    Browse R&D Systems for Antibodies
    OriGene Antibodies: PPP1R14A
    GenScript Custom Superior Antibodies Services for PPP1R14A 
    Novus Biologicals Antibodies for PPP1R14A
    Epitomics antibodies for PPP1R14A

    Assays for PPP1R14A: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPP1R14A 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PPP1R14A 

    Protein Domains/
    Families
    for PPP1R14A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPP1R14A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008025 PP1_inhibitor

    Graphical View of Domain Structure for InterPro Entry Q96A00

    ProtoNet protein and cluster: Q96A00

    UniProtKB/Swiss-Prot: PP14A_HUMAN, Q96A00
    Similarity: Belongs to the PP1 inhibitor family


    Gene Function
    for PPP1R14A gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PP14A_HUMAN, Q96A00
    Function: Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular
    switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PPP1R14A
    Sigma-Aldrich shRNA Panels and shRNA for PPP1R14A
    OriGene 29mer shRNA kits in GFP-retroviral vector: PPP1R14A
    OriGene shRNA RFP: PPP1R14A
    OriGene basic RS shRNA: PPP1R14A
    OriGene siRNA: PPP1R14A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PPP1R14A 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PPP1R14A 
    Search SABiosciences for Assays for microRNAs that regulate PPP1R14A

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PPP1R14A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PPP1R14A
    OriGene untagged cDNA clones in CMV expression vector: PPP1R14A
    OriGene 3'-UTR clone: PPP1R14A 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PPP1R14A 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for PPP1R14A 

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004864 phosphoprotein phosphatase inhibitor activity IEA--
    GO:0005515 protein binding IPI18482256
    About this table

    PPP1R14A for ontologies           About GeneDecksing


    Pathways & Interactions
    for PPP1R14A gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    PPP1R14A for pathways           About GeneDecksing

    1 Millipore Pathway for PPP1R14A
        Signal transduction Activation of PKC via G-Protein coupled receptor

    5/10 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  PPP1R14A (see all 10)
        Cardiac β-adrenergic Signaling
    Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
    Dopamine Receptor Signaling
    Protein Kinase A Signaling
    Synaptic Long Term Potentiation

    1 Cell Signaling Technology (CST) Pathway for PPP1R14A
        Cytoskeletal Signaling

    1 Kegg Pathway  (Kegg details for PPP1R14A):
        hsa04270 Vascular smooth muscle contraction

        SABiosciences Custom Pathway-Focused PCR Arrays for PPP1R14A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PPP1R14A
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1R14A

    5/8 Interacting proteins for PPP1R14A (Q96A001, 2 ENSP000003012423) via UniProtKB, MINT, and/or STRING (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041561EBI-2602646,EBI-977302
    CSNK1A1P487292MINT-16604 MINT-15004
    INSRRENSP000003571783STRING: ENSP00000357178
    PKN1ENSP000003433253STRING: ENSP00000343325
    PPP1R12BENSP000003562403STRING: ENSP00000356240
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042325 regulation of phosphorylation IEA--
    About this table

    PPP1R14A for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPP1R14A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PPP1R14A for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP1R14A
    9 Novoseek chemical compound relationships for PPP1R14A gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phorbol 12,13-dibutyrate 70.7 9 16052505 (2), 18986333 (2), 15956760 (1), 14727519 (1)
    bisindolylmaleimide 69.9 3 18237278 (1), 15475516 (1), 12733988 (1)
    gf 109203x 67.1 3 14727519 (1), 10744661 (1)
    threonine 37.3 3 19012039 (1), 17200564 (1), 10924361 (1)
    phenylephrine 31.1 2 19298234 (1), 10744661 (1)
    calcium 24.5 6 17237191 (1), 17301291 (1)
    serine 15.7 3 19012039 (1), 17200564 (1), 10924361 (1)
    arachidonic acid 6.04 1 10924361 (1)
    histamine 5.27 12 10744661 (3), 15234908 (3)
    About this table



    Transcripts
    for PPP1R14A gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PPP1R14A
    Sigma-Aldrich shRNA Panels and shRNA for PPP1R14A
    OriGene 29mer shRNA kits in GFP-retroviral vector: PPP1R14A
    OriGene shRNA RFP: PPP1R14A
    OriGene basic RS shRNA: PPP1R14A
    OriGene siRNA: PPP1R14A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PPP1R14A 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PPP1R14A 
    Search SABiosciences for Assays for microRNAs that regulate PPP1R14A
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PPP1R14A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PPP1R14A
    OriGene untagged cDNA clones in CMV expression vector: PPP1R14A
    OriGene 3'-UTR Clone: PPP1R14A 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PPP1R14A 
    Primers: OriGene genome-wide validated SYBR primer pairs: PPP1R14A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PPP1R14A: PPH02212A

    REFSEQ mRNAs for PPP1R14A gene: 

    NM_033256.1  

    Additional cDNA sequence: 

    AB056508.1 AB056509.1 AF123763.1 AY050670.1 BC021089.1 CR623926.1 

    7 DOTS entries:

    DT.40110313  DT.101972124  DT.121483090  DT.91698167  DT.445191  DT.121483069  DT.95116417 

    24/118 AceView cDNA sequences (see all 118):

    BM541475 AY050670 BQ961682 BM857528 AW026171 AI601192 AI934636 AB056508 
    AI056504 BM708910 BC021089 AI128172 AI363017 CR623926 AW007357 BQ101171 
    BU186268 AI144361 CK824121 AI199586 NM_033256 CA445023 AB056509 AI694261 

    highest scoring ESTs for PPP1R14A:

    AA156998 AI380979 AA040191 AA156757 AA400046 AA609645 AA652994 AA677630 AA702503 AA868084 

    Unigene Cluster for PPP1R14A:

    Protein phosphatase 1, regulatory (inhibitor) subunit 14A
    Hs.631569  [show with all ESTs]
    Unigene Representative Sequence: BM811652


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347262 ENST00000301242(uc002ohq.2 uc010efv.2)

    Expression
    for PPP1R14A gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PPP1R14A expression in normal and diseased human tissues

    1  / 2  / 3

    4 probe-sets matching PPP1R14A gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    63893_f_at2, 3 U95-C 1 1.00 1.00 1.00 0.99 AA156998 1.00 1.00 1.00 1
    58774_at2, 3 U95-C 1 1.00 1.00 1.00 1.01 AI380979 1.00 1.00 1.00 1
    227006_at2, 3 U133-B 1 0.91 1.00 -- -- AA156998 1.00 1.00 1.00 1
    227006_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    PPP1R14A for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PPP1R14A gene expression
    PPP1R14A gene electronic northern expression
    PPP1R14A gene sage expression
    About these images

    CGAP SAGE TAG: TGGGAAACCT

    SOURCE GeneReport for Unigene cluster: Hs.631569

    UniProtKB/Swiss-Prot: PP14A_HUMAN, Q96A00
    Tissue specificity: Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta

    Primers: OriGene genome-wide validated SYBR primer pairs: PPP1R14A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PPP1R14A: PPH02212A
        SABiosciences Custom PCR Arrays for PPP1R14A 


    Orthologs
    for PPP1R14A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for PPP1R14A gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 PPP1R14A1   -- protein phosphatase 1, regulatory (inhibitor) subunit more 84.96(n)
    78.05(a)    		 612579  XM_850314.1  XP_855407.1 
    chimpanzee
    (Pan troglodytes)    		 PPP1R14A1   -- protein phosphatase 1, regulatory (inhibitor) subunit more 99.02(n)
    100(a)    		 747250  XM_001166316.1  XP_001166316.1 
    cow
    (Bos taurus)    		 PPP1R14A1   -- protein phosphatase 1, regulatory (inhibitor) subunit more 90.93(n)
    91.84(a)    		 615348  XM_867134.2  XP_872227.1 
    rat
    (Rattus norvegicus)    		 Ppp1r14a1   -- protein phosphatase 1, regulatory (inhibitor) subunit more 83.67(n)
    85.03(a)    		 114004  NM_130403.1  NP_569087.1 
    mouse
    (Mus musculus)    		 Ppp1r14a1 , 5 7 (16.94 cM)5
    		 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 84.81(n)1
    85.03(a)1    		 684581  NM_026731.31  NP_081007.21 
     AF3525735  AI8536185  (see all 8)
    About this table        Species with no ortholog for PPP1R14A

    ENSEMBL Gene Tree for PPP1R14A (if available)

    Paralogs
    for PPP1R14A gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PPP1R14A gene
    PPP1R14C2  PPP1R14D2  PPP1R14B2  

    PPP1R14A for paralogs           About GeneDecksing



    Genomic Variants
    for PPP1R14A gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/62 NCBI SNPs in PPP1R14A are shown (see all 62)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs109931,2
    		C,F,38743591(+) ATGTTG/TATCTC 2 I syn1 ref110Minor allele frequency- T:0.34NS EA NA 936
    rs48039341,2
    		C,F,A,38746567(+) CAAGTG/CTTTGT 1 -- int111Minor allele frequency- C:0.49NS EA NA WA 634
    rs72463861,2
    		--38747094(+) GGGAGG/TTCTGC 1 -- ut51 ese30--------
    rs72472411,2
    		C,H,38747272(+) GGGCCC/TGGGAC 1 -- ng514Minor allele frequency- T:0.12NA 8
    rs81003951,2
    		C,38747117(+) GCCTCG/AGGCCT 1 -- ut51 ese33Minor allele frequency- A:0.17NA 6
    rs106527971,2
    		--38747457(+) ttttt-/TTttttt 1 -- ng51 trp30--------
    rs116680701,2
    		C,F,A,H,38748913(+) ttgcaA/Gtcatg 1 -- ng519Minor allele frequency- G:0.42NS EA NA 508
    rs118803011,2
    		C,F,H,38746119(+) GTCAGT/CTTTTT 1 -- int1 trp38Minor allele frequency- C:0.09NS EA NA WA 634
    rs118803261,2
    		C,F,A,H,38746209(+) GCCCAT/CGCCGC 1 -- int12Minor allele frequency- C:0.05EA NA 92
    rs126102671,2
    		C,F,A,H,38744733(+) TCACCG/ATGGGA 1 -- int17Minor allele frequency- A:0.49NA EA WA 220
    About this table

    HapMap Linkage Disequilibrium images for PPP1R14A (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PPP1R14A: --

    QIAGEN SeqTarget long-range PCR primers for resequencing PPP1R14A 

    Disorders & Mutations
    for PPP1R14A gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPP1R14A for disorders           About GeneDecksing

    OMIM: 608153


    Export disorders and mutations for PPP1R14A gene to outside databases

    Medical News
    for PPP1R14A gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for PPP1R14A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/63 PubMed articles for PPP1R14A gene, integrated from 7 sources (see all 63):
    (articles sorted by number of sources associating them with PPP1R14A)
    1. Identification of human CPI-17, an inhibitory phosphoprotein for myosin phosphatase. (PubMed id 11467857)1, 2, 3, 7 Yamawaki K.... Nakano T. (2001)
    2. GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA. (PubMed id 12974676)1, 2 Liu Q.-R....Uhl G.R. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of human, mouse and rat PPP1R14A, protein phosphatase-1 inhibitor subunit 14A, & mapping human PPP1R14A to chromosome 19q13.13-q13.2. (PubMed id 11931393)1, 7 Li Z....Zhao S. (2001)
    5. Role of CPI-17 in the regulation of endothelial cytoskeleton. (PubMed id 15234908)1, 7 Kolosova I.A....Verin A.D. (2004)
    6. Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N. (PubMed id 10924361)1, 7 Hamaguchi T....Nakano T. (2000)
    7. Association of CPI-17 with protein kinase C and casein kinase I. (PubMed id 15003508)1, 7 Zemlickova E....Dubois T. (2004)
    8. CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi. (PubMed id 18757304)1, 7 Morin C....Rousseau E. (2008)
    9. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. (PubMed id 10869555)1, 7 Koyama M....Nakano T. (2000)
    10. Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor. (PubMed id 17301291)1, 7 Lartey J....Lopez Bernal A. (2007)

    External Searches for PPP1R14A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PPP1R14A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 94274 HGNC: 14871 AceView: PPP1R14A Ensembl:ENSG00000167641 euGenes: HUgn94274
    ECgene: PPP1R14A Kegg: 94274 H-InvDB: PPP1R14A

    Other Databases showing PPP1R14A gene

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    Specialized Databases showing PPP1R14A gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    Intellectual Property
    for PPP1R14A gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
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    		Patent Information for PPP1R14A gene:
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