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PPP1R15B Gene

protein-coding GIFtS: 44

GC01M175537

protein phosphatase 1, regulatory (inhibitor) subunit 15B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
protein phosphatase 1, regulatory (inhibitor) subunit 15B¹ ²
FLJ14744¹ ²
CREP² ⁵
protein phosphatase 1 regulatory subunit 15B²

External Ids:	HGNC: 14951¹	Entrez Gene: 84919²	Ensembl: ENSG00000158615⁷	UniProtKB: Q5SWA1³

Export aliases for PPP1R15B gene to outside databases

Previous GC identifers: GC01M202101 GC01M199833 GC01M200736 GC01M201552 GC01M201549 GC01M201104 GC01M202639 GC01M204372

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP1R15B:

PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1; MIM 603907) through

recruitment of protein phosphatase-1 (PP1) catalytic subunits (see MIM 176875) (Harding et al., 2009 (PubMed

19181853)).(supplied by OMIM)

UniProtKB/Swiss-Prot: PR15B_HUMAN, Q5SWA1

Function: Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1

(By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPP1R15B gene promoter:
         oct-B2   Oct-B1   POU2F2C   POU2F2B   oct-B3   POU2F2 (Oct-2.1)   POU2F2   POU2F1   CP1A   NF-Y
         Other transcription factors

Search SABiosciences Chromatin IP Primers for PPP1R15B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PPP1R15B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1

PPP1R15B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R15B gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M175537: view genomic region (about GC identifiers)

Start:	175,537,638 bp from pter
End:	175,546,091 bp from pter
Size:	8,454 bases
Orientation:	minus strand

1 alternative location:

Chr1- 204,372,515-204,380,919

RefSeq DNA sequence:

NC_000001.10 NT_004487.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PR15B_HUMAN, Q5SWA1 (See protein sequence)

Recommended Name: Protein phosphatase 1 regulatory subunit 15B

Size: 713 amino acids; 79152 Da

Subunit: Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PP1

Miscellaneous: The phosphatase activity of the PPP1R15B-PP1 complex toward EIF2S1 is specifically inhibited by

Salubrinal, a drug that protects cells from endoplasmic reticulum stress

Secondary accessions: Q53GQ4 Q658M2 Q6P156 Q96SN1

Explore the universe of human proteins at neXtProt for PPP1R15B: NX_Q5SWA1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_116222.3

ENSEMBL proteins:

ENSP00000356156

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000164	protein phosphatase type 1 complex	IEA	--

About this table

PPP1R15B for ontologies About GeneDecksing

Antibodies for PPP1R15B:

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	Novus Biologicals Antibody for PPP1R15B
	Browse antibodies at Epitomics

Assays for PPP1R15B:

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	GenScript Custom Assay Services for PPP1R15B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PPP1R15B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPP1R15B for domains About GeneDecksing

2 InterPro domains/families:

IPR019512 Prot_Pase1_reg-su15B_N

IPR019523 Prot_Pase1_reg-su15A/B_C

Graphical View of Domain Structure for InterPro Entry Q5SWA1

ProtoNet protein and cluster: Q5SWA1

UniProtKB/Swiss-Prot: PR15B_HUMAN, Q5SWA1

Similarity: Belongs to the PPP1R15 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: PR15B_HUMAN, Q5SWA1

Function: Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1

(By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PPP1R15B Sigma-Aldrich shRNA Panels and shRNA for PPP1R15B
		OriGene 29mer shRNA kits in GFP-retroviral vector: PPP1R15B OriGene shRNA RFP: PPP1R15B OriGene basic RS shRNA: PPP1R15B OriGene siRNA: PPP1R15B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PPP1R15B

miRNA:		Sigma-Aldrich microRNA Mimics for PPP1R15B Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PPP1R15B
		8/41 SABiosciences Assays for microRNAs that regulate PPP1R15B (see all 41):
		hsa-let-7d hsa-miR-106a hsa-miR-29a hsa-miR-301a hsa-let-7g hsa-let-7a hsa-miR-93 hsa-miR-556-3p

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PPP1R15B OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PPP1R15B OriGene untagged cDNA clones in CMV expression vector: PPP1R15B OriGene 3'-UTR clone: PPP1R15B Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PPP1R15B
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for PPP1R15B

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004722	protein serine/threonine phosphatase activity	IEA	--

About this table

PPP1R15B for ontologies About GeneDecksing

Animal Models: 8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ppp1r15b):

behavior/neurological	growth/size	hematopoietic system	homeostasis/metabolism	lethality-prenatal/perinatal
life span-post-weaning/aging	liver/biliary system	skin/coat/nails

PPP1R15B for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Pathway-Focused PCR Array including PPP1R15B: PAHS-3401A

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PPP1R15B

1 Interacting protein for PPP1R15B (Q5SWA1²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP1CA	P62136²	MINT-62191

About this table

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006417	regulation of translation	IEA	--
GO:0006950	response to stress	--	--
GO:0006979	response to oxidative stress	IEA	--
GO:0006983	ER overload response	IEA	--
GO:0042542	response to hydrogen peroxide	IEA	--

About this table

PPP1R15B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PPP1R15B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PPP1R15B Sigma-Aldrich shRNA Panels and shRNA for PPP1R15B
		OriGene 29mer shRNA kits in GFP-retroviral vector: PPP1R15B OriGene shRNA RFP: PPP1R15B OriGene basic RS shRNA: PPP1R15B OriGene siRNA: PPP1R15B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PPP1R15B

miRNA:		Sigma-Aldrich microRNA Mimics for PPP1R15B Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PPP1R15B
		8/41 SABiosciences Assays for microRNAs that regulate PPP1R15B (see all 41):
		hsa-let-7d hsa-miR-106a hsa-miR-29a hsa-miR-301a hsa-let-7g hsa-let-7a hsa-miR-93 hsa-miR-556-3p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PPP1R15B OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PPP1R15B OriGene untagged cDNA clones in CMV expression vector: PPP1R15B OriGene 3'-UTR Clone: PPP1R15B Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PPP1R15B

Primers:		OriGene genome-wide validated SYBR primer pairs: PPP1R15B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PPP1R15B: PPH06077A

REFSEQ mRNAs for PPP1R15B gene:

NM_032833.3

Additional cDNA sequence:

AK023680.1 AK027650.1 AK222877.1 AK303535.1 AK316092.1 AL833746.1 AY007107.1 BC065280.1

CR595060.1

15 DOTS entries:

DT.99947727 DT.116650 DT.91756981 DT.100808754 DT.91756977 DT.99999932 DT.100808750 DT.91756973

DT.91756979 DT.95237744 DT.91756982 DT.95237730 DT.100686076 DT.100808752 DT.95237725

24/290 AceView cDNA sequences (see all 290):

BG056420 BQ221596 CA442888 AA878183 CA308480 AI219802 BP364190 BF592980

CA397898 BU617635 CB155963 BC065280 AK023680 BG567959 AW070743 BP359001

CK903904 AL705093 AA813825 AW088834 AA459426 AA369245 AA190705 BI962677

highest scoring ESTs for PPP1R15B:

R59635 AA158646 AA158659 AA188594 AA190705 AA337480 AA382831 AA459426 AI078825 AI082300

Unigene Cluster for PPP1R15B:

Protein phosphatase 1, regulatory (inhibitor) subunit 15B

Hs.304376 [show with all ESTs]

Unigene Representative Sequence: NM_032833

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000367188(uc001hav.3)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

PPP1R15B expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching PPP1R15B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
78776_at²^{, 3}	U95-D	1	1.00	1.00	0.24	1.25	AA188594	0.80	1.00	0.91	1
87401_at²^{, 3}	U95-E	1	1.00	1.00	0.75	0.98	R59635	1.00	1.00	1.00	1
54819_r_at²^{, 3}	U95-B	1	0.69	1.00	0.51	0.57	AI720898	0.80	1.00	0.91	1
60485_at²^{, 3}	U95-C	1	0.56	1.00	0.85	1.22	AI659699	0.60	1.00	0.82	1
224692_at²^{, 3}	U133-B	1	0.64	1.00	--	--	BF796046	0.40	1.00	0.76	1
224692_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

About this table

PPP1R15B for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

PPP1R15B gene electronic northern expression

About these images

CGAP SAGE TAG: TAAAAGGCTT

SOURCE GeneReport for Unigene cluster: Hs.304376

Primers:		OriGene genome-wide validated SYBR primer pairs: PPP1R15B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PPP1R15B: PPH06077A

SABiosciences Expression via Pathway-Focused PCR Array including PPP1R15B: PAHS-3401A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PPP1R15B gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PPP1R15B¹	--	protein phosphatase 1, regulatory (inhibitor) subunit more	78.17(n) 68.7(a)	488563 XM_545680.2 XP_545680.2
chimpanzee (Pan troglodytes)	PPP1R15B¹	--	protein phosphatase 1, regulatory (inhibitor) subunit more	99.39(n) 98.6(a)	742092 XM_001159260.1 XP_001159260.1
cow (Bos taurus)	PPP1R15B¹	--	protein phosphatase 1, regulatory (inhibitor) subunit more	83(n) 75.5(a)	538754 XM_611147.3 XP_611147.2
rat (Rattus norvegicus)	Ppp1r15b¹	--	protein phosphatase 1, regulatory (inhibitor) subunit more	78.04(n) 70.29(a)	304799 XM_222633.4 XP_222633.2
mouse (Mus musculus)	Ppp1r15b^{1 , 5}	1 (57.80 cM)⁵	protein phosphatase 1, regulatory (inhibitor) subunit more^{1, 5}	78.14(n)¹ 70.28(a)¹	108954¹ NM_133819.2¹ NP_598580.1¹ AA869927⁵ AI606441⁵ (see all 18)

About this table Species with no ortholog for PPP1R15B

ENSEMBL Gene Tree for PPP1R15B (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs14575^1,2	--	204372685(+)	`AAAAAA/TAAAAT`	1	--	ut3¹		0	--	--	--	--
rs3014624^1,2	C,A,H	204375669(+)	`ggtcaC/Ggagtt`	1	--	int¹		7		NA WA	14
rs3014625^1,2	C,F,A,	204378019(+)	`TACCAT/CTTCCT`	1	--	int¹		11		NS EA NA WA	480
rs6686717^1,2	--	204382114(+)	`ggcgtA/Gagcca`	1	--	ng5¹		0	--	--	--	--
rs11240739^1,2	--	204374797(+)	`TTTGGA/GAAAGA`	1	--	ut3¹ trp³		0	--	--	--	--
rs11240740^1,2	H	204376540(+)	`CTACTC/TATTAC`	1	--	int¹		4		NS EA	418
rs11800807^1,2	C,F,H,	204382506(+)	`CAGCCA/GAAAAG`	1	--	ng5¹ trp³		7		NS EA NA	512
rs12062484^1,2	C	204372533(+)	`AATATA/GTTTAT`	1	--	ut3¹		0	--	--	--	--
rs12091367^1,2	--	204373609(+)	`ctctgC/Tctcaa`	1	--	ut3¹		0	--	--	--	--
rs12095238^1,2	H	204378334(+)	`TGAAGC/ATTGTA`	1	--	int¹		4		NS EA	406

About this table

HapMap Linkage Disequilibrium images for PPP1R15B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPP1R15B: --

Search QIAGEN SeqTarget long-range PCR primers for resequencing for PPP1R15B

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PPP1R15B for disorders About GeneDecksing

OMIM: 613257

Export disorders and mutations for PPP1R15B gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/11 PubMed articles for PPP1R15B gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with PPP1R15B)

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PubMed id 11948623)^{1, 3} Ceulemans H....Bollen M. (2002)
Ppp1r15 gene knockout reveals an essential role for t ranslation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. (PubMed id 19181853)¹ Harding H.P....Ron D. (2009)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. (PubMed id 15705855)² Boyce M....Yuan J. (2005)
Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)¹ Colland F....Gauthier J.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)¹ Suzuki Y.... Sugano S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84919	HGNC: 14951	AceView: PPP1R15B	Ensembl:ENSG00000158615	euGenes: HUgn84919
ECgene: PPP1R15B	H-InvDB: PPP1R15B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for PPP1R15B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for PPP1R15B gene:
Search GeneIP for patents involving PPP1R15B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
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	Predesigned and custom siRNAs for PPP1R15B		Antibodies for PPP1R15B
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	Lentivirus-delivered shRNAs for PPP1R15B		microRNA Mimics for PPP1R15B
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PPP1R15B
	Search QIAGEN SeqTarget long-range PCR primers for resequencing for PPP1R15B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PPP1R15B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PPP1R15B

	GenScript Custom Purified and Recombinant Proteins Services for PPP1R15B		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for PPP1R15B
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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ELISAs and CLIAs for PPP1R15B

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

PPP1R15B gene at Home site.

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PPP1R15B Gene

protein-coding GIFtS: 44

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for PPP1R15B gene

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PPP1R15B Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor PPP1R15B gene

Summariesfor PPP1R15B gene

Genomic Viewsfor PPP1R15B gene

Proteinsfor PPP1R15B gene

Protein Domains/Familiesfor PPP1R15B gene

Gene Functionfor PPP1R15B gene

Pathways & Interactionsfor PPP1R15B gene

Drugs & Compoundsfor PPP1R15B gene

Transcriptsfor PPP1R15B gene

Expression for PPP1R15B gene

Orthologsfor PPP1R15B gene

Paralogsfor PPP1R15B gene

Genomic Variantsfor PPP1R15B gene

Disorders & Mutationsfor PPP1R15B gene

Medical Newsfor PPP1R15B gene

Publicationsfor PPP1R15B gene

External Searches for PPP1R15B gene

Genome Databases showing PPP1R15B gene

Other Databases showing PPP1R15B gene

Specialized Databases showing PPP1R15B gene

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Productsfor PPP1R15B gene

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Aliases &
Descriptions
for PPP1R15B gene

Summaries
for PPP1R15B gene

Genomic Views
for PPP1R15B gene

Proteins
for PPP1R15B gene

Protein Domains/
Families
for PPP1R15B gene

Gene Function
for PPP1R15B gene

Pathways & Interactions
for PPP1R15B gene

Drugs & Compounds
for PPP1R15B gene

Transcripts
for PPP1R15B gene

Expression
for PPP1R15B gene

Orthologs
for PPP1R15B gene

Paralogs
for PPP1R15B gene

Genomic Variants
for PPP1R15B gene

Disorders & Mutations
for PPP1R15B gene

Medical News
for PPP1R15B gene

Publications
for PPP1R15B gene

Intellectual Property
for PPP1R15B gene

Products
for PPP1R15B gene