Aliases &
Descriptions
for PPP1R1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| protein phosphatase 1, regulatory (inhibitor) subunit 1B1 2 | | dopamine and cAMP-regulated neuronal phosphoprotein 322 | | DARPP-321 2 3 | | protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMPregulated phosphoprotein, DARPP-32)2 | | FLJ209401 2 | | OTTHUMP000001642762 | | Dopamine- and cAMP-regulated neuronal phosphoprotein2 3 | | dopamine and cAMP regulated phosphoprotein2 | | DARPP322 3 | | protein phosphatase 1 regulatory subunit 1B2 | | OTTHUMP000001642752 | | |
Export aliases for PPP1R1B gene to outside databasesPrevious GC identifers: GC17P037283 GC17P039780 GC17P037693 GC17P038158 GC17P035036 GC17P037783 |
Summaries
for PPP1R1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PPP1R1B:
Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling throughdopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studiedtarget for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen,DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990 (PubMed 2191086)) that also expressdopamine D1 receptors (Walaas and Greengard, 1984 (PubMed 6319627)). The function of DARPP32 seems to be regulated byreceptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32phosphorylation, but in opposite directions (Halpain et al., 1990 (PubMed 2153935)). Dopamine D1 receptor stimulationenhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984 (PubMed 6319627));phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984 (PubMed6087160)). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin anddephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain etal., 1990 (PubMed 2153935)).(supplied by OMIM)
UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71Function: Inhibitor of protein-phosphatase 1
Gene Wiki entry for PPP1R1B |
Genomic Views
for PPP1R1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPP1R1B gene promoter:
CREB deltaCREB Sp1 POU2F2 Oct-B1 POU2F1 oct-B3 POU2F2 (Oct-2.1) POU2F2B POU2F2C
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPP1R1B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PPP1R1B  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC chromosome: 17PPP1R1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P033576: view genomic region
(about GC identifiers)
Start:
|
33,576,902 bp from pter |
End:
|
33,586,601 bp from pter |
Size:
|
9,700 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr17+ 37,783,179-37,792,879 |
RefSeq DNA sequence:- NC_000017.10 NT_010783.15
|
Proteins
for PPP1R1B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71 (See
protein sequence)Recommended Name: Protein phosphatase 1 regulatory subunit 1B Size: 204 amino acids; 22963 Da
Subcellular location: Cytoplasm
Secondary accessions: Q547V9 Q547W0 Q9H7G1Alternative splicing: 2 isoforms: Q9UD71-1 Q9UD71-2 Explore the universe of human proteins at neXtProt for PPP1R1B: NX_Q9UD71
Post-translational modifications:
Dopamine- and cyclic AMP-regulated neuronal phosphoprotein1
Phosphorylation of Thr-34 is required for activity (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_115568.2 NP_852606.1
ENSEMBL proteins: ENSP00000254079 ENSP00000377813 ENSP00000377810 ENSP00000377808 ENSP00000349688
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
PPP1R1B for ontologies About GeneDecksing
Antibodies for PPP1R1B:  | Millipore Mono- and Polyclonal Antibodies for the study of PPP1R1B |  | Sigma-Aldrich Antibodies for PPP1R1B |  | R&D Systems Antibodies for PPP1R1B (DARPP-32) |  | Cell Signaling Technology (CST) Antibodies for PPP1R1B (DARPP) |  | OriGene Antibodies (see all 2): PPP1R1B
|  | GenScript Superior Antibodies for PPP1R1B |  | Novus Biologicals Antibodies for PPP1R1B |  | Epitomics antibodies for PPP1R1B |
Assays for PPP1R1B: |
Protein
Domains/
Families
for PPP1R1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPP1R1B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UD71ProtoNet protein and cluster: Q9UD71 1 Blocks protein family: IPB008466 Protein phosphatase inhibitor
UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71Similarity: Belongs to the protein phosphatase inhibitor 1 family |
Gene Function
for PPP1R1B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71Function: Inhibitor of protein-phosphatase 1
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
PPP1R1B for ontologies About GeneDecksing
Animal Models: 3 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Ppp1r1b):
PPP1R1B for phenotypes About GeneDecksing
|
Pathways & Interactions
for PPP1R1B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
PPP1R1B for pathways About GeneDecksing
2 Millipore Pathways for PPP1R1B
3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for PPP1R1B
SABiosciences Custom Pathway-Focused PCR Arrays for PPP1R1B
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PPP1R1B
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1R1B
5/20 Interacting proteins for PPP1R1B (ENSP000002540793 Q9UD712) via UniProtKB, MINT, and/or STRING (see all 20)About this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
PPP1R1B for ontologies About GeneDecksing
|
Drugs & Compounds
for PPP1R1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
PPP1R1B for compounds About GeneDecksing
 Browse Tocris compounds for PPP1R1B
10/15  Novoseek chemical compound relationships for PPP1R1B gene (see all 15)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dopamine |
78.3 |
91 |
1663529 (3), 17194217 (3), 16965177 (3), 17948899 (2) (see all 55) |
| okadaic acid |
38.1 |
1 |
9606178 (1) |
| glutamate |
34.4 |
12 |
17194217 (3), 12538871 (2), 9483560 (2), 8248241 (1) (see all 6) |
| threonine |
32 |
3 |
15464122 (1), 9108011 (1), 16353915 (1) |
| cyclic amp |
19.7 |
2 |
1975775 (1), 8298087 (1) |
| tyrosine |
17.2 |
9 |
1971224 (2), 9483560 (2), 1975775 (1), 19254752 (1) (see all 6) |
| serine |
16.8 |
3 |
15464122 (1), 14744247 (1), 16353915 (1) |
| nicotine |
16.1 |
9 |
16040813 (4), 17171661 (2) |
| forskolin |
9.36 |
3 |
9606178 (2), 12538871 (1) |
| nmda |
6.68 |
1 |
16764827 (1) |
About this table
|
Transcripts
for PPP1R1B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PPP1R1B gene (2 alternative transcripts): NM_032192.2 NM_181505.2 Additional cDNA sequence: AF233349.1 AF435972.1 AF435973.1 AF435974.1 AF464196.1 AK024593.1 AK123112.1 AK123950.1 AK124417.1 AK127542.1 AK129537.1 AK225058.1 AY070271.1 BC001519.2 BC118070.1 BC122554.1 BT007076.1 BX648641.1 CR606470.1 CR621995.1 12 DOTS entries: DT.415849 DT.97864082 DT.101984124 DT.91684332 DT.100795528 DT.101984126 DT.120893113 DT.91759174 DT.70100705 DT.95087649 DT.100795525 DT.95291236 24/984 AceView cDNA sequences (see all 984): AI275233 BM694929 AU142072 BM839764 AW850113 BQ891748 BQ928310 CA946509 AI335884 BM745919 AI673239 BM795312 AI865332 CB141589 AI912491 NM_032192 AW882123 AA485238 AA122353 CA389360 BM046300 BU541964 BX506001 AA662372
 highest scoring ESTs for PPP1R1B:AA526079 AA292365 AA293626 AA336805 AA336843 AA337307 AA394121 AA480480 AA480481 AA506059 Unigene Cluster for PPP1R1B: Protein phosphatase 1, regulatory (inhibitor) subunit 1B Hs.286192 [show with all ESTs]Unigene Representative Sequence: AK123950
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R1B (see all 6)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PPP1R1B
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000254079 ENST00000394271 ENST00000466381 ENST00000394267(uc002hsb.2)
ENST00000394265(uc002hsc.2) ENST00000492037 ENST00000357165(uc002hrz.2 uc002hsa.2 uc010cvx.2)
|
Expression
for PPP1R1B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PPP1R1B expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching PPP1R1B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 65792_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AA526079 |
1.00 |
0.90 |
0.95 |
1 |
| 225165_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AK024593 |
0.80 |
0.88 |
0.84 |
1 |
| 225165_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PPP1R1B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.286192
SABiosciences Custom PCR Arrays for PPP1R1B
|
Orthologs
for PPP1R1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PPP1R1B gene from 5/7 species (see all 7)
About this table Species with no ortholog for PPP1R1B
ENSEMBL Gene Tree for PPP1R1B (if available) |
Paralogs
for PPP1R1B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PPP1R1B gene
- PPP1R1A2 PPP1R1C2
PPP1R1B for paralogs About GeneDecksing
|
Genomic Variants
for PPP1R1B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PPP1R1B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PPP1R1B
2 CNVs: 77591 49853 | | QIAGEN SeqTarget long-range PCR primers for resequencing PPP1R1B |
|
Disorders & Mutations
for PPP1R1B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPP1R1B for disorders About GeneDecksing
OMIM: 604399
4 Novoseek disease relationships for PPP1R1B gene
About this table
Human Genome Epidemiology (HuGE) Navigator: PPP1R1B (19 documents)
Export disorders and mutations for PPP1R1B gene to outside databases
|
Medical News
for PPP1R1B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PPP1R1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/120 PubMed articles for PPP1R1B gene, integrated from 7 sources (see all 120):
(articles sorted by number of sources associating them with PPP1R1B)- Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PubMed id 8120638)1, 2, 3, 7 Brene S.... Persson H. (1994)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP. (PubMed id 12124342)1, 2 El-Rifai W....Powell S.M. (2002)
- Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. (PubMed id 10604473)1, 2 Bibb J.A.... Greengard P. (1999)
- Mutation analysis of DARPP-32 as a candidate gene for schizophrenia. (PubMed id 16750903)1, 7 Li C.H....Chen C.H. (2006)
- Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas. (PubMed id 14508844)1, 7 Beckler A....El-Rifai W. (2003)
- Reversal of multidrug resistance of adriamycin-resistant gastric adenocarcinoma cells through the up-regulation of DARPP-32. (PubMed id 17492506)1, 7 Hong L....Fan D. (2008)
- Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. (PubMed id 17171661)1, 7 Beuten J....Li M.D. (2007)
- Wnt-5a-induced phosphorylation of DARPP-32 inhibits b reast cancer cell migration in a CREB-dependent manner. (PubMed id 19651774)1, 7 Hansen C....Andersson T. (2009)
|
External Searches for PPP1R1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PPP1R1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PPP1R1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PPP1R1B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PPP1R1B gene:
Search GeneIP for patents involving PPP1R1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PPP1R1B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 | Antibodies & Assays for PPP1R1B (DARPP) |
| | | | Search Tocris compounds for PPP1R1B |
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