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PPP1R1B Gene

protein-coding   GIFtS: 59

GC17P033576
protein phosphatase 1, regulatory (inhibitor) subunit 1B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
protein phosphatase 1, regulatory (inhibitor) subunit 1B1 2     dopamine and cAMP-regulated neuronal phosphoprotein 322
DARPP-321 2 3     protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP
regulated phosphoprotein, DARPP-32)2
FLJ209401 2     OTTHUMP000001642762
Dopamine- and cAMP-regulated neuronal phosphoprotein2 3     dopamine and cAMP regulated phosphoprotein2
DARPP322 3     protein phosphatase 1 regulatory subunit 1B2
OTTHUMP000001642752     

External Ids:    HGNC: 92871   Entrez Gene: 841522   Ensembl: ENSG000001317717   UniProtKB: Q9UD713   

Export aliases for PPP1R1B gene to outside databases

Previous GC identifers: GC17P037283 GC17P039780 GC17P037693 GC17P038158 GC17P035036 GC17P037783


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP1R1B:
Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through
dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied
target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen,
DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990 (PubMed 2191086)) that also express
dopamine D1 receptors (Walaas and Greengard, 1984 (PubMed 6319627)). The function of DARPP32 seems to be regulated by
receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32
phosphorylation, but in opposite directions (Halpain et al., 1990 (PubMed 2153935)). Dopamine D1 receptor stimulation
enhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984 (PubMed 6319627));
phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984 (PubMed
6087160)). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and
dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain et
al., 1990 (PubMed 2153935)).(supplied by OMIM)

UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71
Function: Inhibitor of protein-phosphatase 1

Gene Wiki entry for PPP1R1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1R1B gene promoter:
         CREB   deltaCREB   Sp1   POU2F2   Oct-B1   POU2F1   oct-B3   POU2F2 (Oct-2.1)   POU2F2B   POU2F2C   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PPP1R1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PPP1R1B 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC chromosome: 17

PPP1R1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R1B gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P033576:  view genomic region     (about GC identifiers)

Start:
33,576,902 bp from pter
End:
33,586,601 bp from pter
Size:
9,700 bases
Orientation:
plus strand

1 alternative location:
Chr17+ 37,783,179-37,792,879     
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 1B  
Size: 204 amino acids; 22963 Da
Subcellular location: Cytoplasm
Secondary accessions: Q547V9 Q547W0 Q9H7G1
Alternative splicing: 2 isoforms:  Q9UD71-1   Q9UD71-2   

Explore the universe of human proteins at neXtProt for PPP1R1B: NX_Q9UD71 

Post-translational modifications:

  • Dopamine- and cyclic AMP-regulated neuronal phosphoprotein1
  • Phosphorylation of Thr-34 is required for activity (By similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_115568.2  NP_852606.1  


    ENSEMBL proteins: 
    ENSP00000254079 ENSP00000377813 ENSP00000377810 ENSP00000377808 ENSP00000349688 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant PPP1R1B Protein
    Sigma-Aldrich Proteins for PPP1R1B
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): PPP1R1B
    OriGene Protein Over-expression Lysate (see all 2): PPP1R1B
    GenScript Custom Purified and Recombinant Proteins Services for PPP1R1B 
    Novus Biologicals Protein for PPP1R1B
    Novus Biologicals Lysates for PPP1R1B
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus ----
    GO:0005737 cytoplasm NAS--
    GO:0005829 cytosol TAS--
    About this table

    PPP1R1B for ontologies           About GeneDecksing



    Antibodies for PPP1R1B: 
    Millipore Mono- and Polyclonal Antibodies for the study of PPP1R1B
    Sigma-Aldrich Antibodies for PPP1R1B
    R&D Systems Antibodies for PPP1R1B (DARPP-32)
    Cell Signaling Technology (CST) Antibodies for PPP1R1B  (DARPP)
    OriGene Antibodies (see all 2): PPP1R1B
    GenScript Superior Antibodies for PPP1R1B 
    Novus Biologicals Antibodies for PPP1R1B
    Epitomics antibodies for PPP1R1B

    Assays for PPP1R1B: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPP1R1B 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PPP1R1B 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PPP1R1B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015670 Dopamine/cAMP_neuron_P-prot
     IPR008466 PPI_1DARPP-32

    Graphical View of Domain Structure for InterPro Entry Q9UD71

    ProtoNet protein and cluster: Q9UD71

    1 Blocks protein family: IPB008466 Protein phosphatase inhibitor

    UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71
    Similarity: Belongs to the protein phosphatase inhibitor 1 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PPR1B_HUMAN, Q9UD71
    Function: Inhibitor of protein-phosphatase 1

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PPP1R1B
    Sigma-Aldrich shRNA for PPP1R1B
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PPP1R1B
    OriGene shRNA RFP (see all 2): PPP1R1B
    OriGene basic RS shRNA (see all 2): PPP1R1B
    OriGene siRNA (see all 2): PPP1R1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PPP1R1B 
    miRNA:Sigma-Aldrich microRNA Mimics for PPP1R1B
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PPP1R1B 
    4 SABiosciences Assays for microRNAs that regulate PPP1R1B:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-330-3p hsa-miR-1207-5p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PPP1R1B
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PPP1R1B
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PPP1R1B
    OriGene 3'-UTR clone (see all 2): PPP1R1B 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PPP1R1B 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PPP1R1B 

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860 protein kinase inhibitor activity TAS10604473
    GO:0004864 phosphoprotein phosphatase inhibitor activity TAS10604473
    GO:0005102 receptor binding ----
    About this table

    PPP1R1B for ontologies           About GeneDecksing

    Animal Models: 3 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ppp1r1b):

    behavior/neurologicalhomeostasis/metabolismnervous system

    PPP1R1B for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    PPP1R1B for pathways           About GeneDecksing

    2 Millipore Pathways for PPP1R1B
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Signal transduction PKA signaling

    3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  PPP1R1B
        Dopamine Receptor Signaling
    Protein Kinase A Signaling
    CDK5 Signaling

        SABiosciences Custom Pathway-Focused PCR Arrays for PPP1R1B 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PPP1R1B
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1R1B

    5/20 Interacting proteins for PPP1R1B (ENSP000002540793 Q9UD712) via UniProtKB, MINT, and/or STRING (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ROBO2Q9HCK42MINT-65696
    CALM3ENSP000002912953STRING: ENSP00000291295
    CDK5R1ENSP000003184863STRING: ENSP00000318486
    CSNK1DENSP000003244643STRING: ENSP00000324464
    PPP3CAENSP000003205803STRING: ENSP00000320580
    About this table

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription ----
    GO:0007165 signal transduction TAS10604473
    GO:0007621 negative regulation of female receptivity ----
    About this table

    PPP1R1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PPP1R1B for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP1R1B
    10/15 Novoseek chemical compound relationships for PPP1R1B gene (see all 15)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dopamine 78.3 91 1663529 (3), 17194217 (3), 16965177 (3), 17948899 (2) (see all 55)
    okadaic acid 38.1 1 9606178 (1)
    glutamate 34.4 12 17194217 (3), 12538871 (2), 9483560 (2), 8248241 (1) (see all 6)
    threonine 32 3 15464122 (1), 9108011 (1), 16353915 (1)
    cyclic amp 19.7 2 1975775 (1), 8298087 (1)
    tyrosine 17.2 9 1971224 (2), 9483560 (2), 1975775 (1), 19254752 (1) (see all 6)
    serine 16.8 3 15464122 (1), 14744247 (1), 16353915 (1)
    nicotine 16.1 9 16040813 (4), 17171661 (2)
    forskolin 9.36 3 9606178 (2), 12538871 (1)
    nmda 6.68 1 16764827 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PPP1R1B
    Sigma-Aldrich shRNA for PPP1R1B
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PPP1R1B
    OriGene shRNA RFP (see all 2): PPP1R1B
    OriGene basic RS shRNA (see all 2): PPP1R1B
    OriGene siRNA (see all 2): PPP1R1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PPP1R1B 
    miRNA: Sigma-Aldrich microRNA Mimics for PPP1R1B
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PPP1R1B 
    4 SABiosciences Assays for microRNAs that regulate PPP1R1B:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-330-3p hsa-miR-1207-5p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PPP1R1B
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PPP1R1B
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PPP1R1B
    OriGene 3'-UTR Clone (see all 2): PPP1R1B 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PPP1R1B 
    Primers: OriGene genome-wide validated SYBR primer pairs: PPP1R1B
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PPP1R1B: PPH05948A

    REFSEQ mRNAs for PPP1R1B gene (2 alternative transcripts): 

    NM_032192.2  NM_181505.2  

    Additional cDNA sequence: 

    AF233349.1 AF435972.1 AF435973.1 AF435974.1 AF464196.1 AK024593.1 AK123112.1 AK123950.1 
    AK124417.1 AK127542.1 AK129537.1 AK225058.1 AY070271.1 BC001519.2 BC118070.1 BC122554.1 
    BT007076.1 BX648641.1 CR606470.1 CR621995.1 

    12 DOTS entries:

    DT.415849  DT.97864082  DT.101984124  DT.91684332  DT.100795528  DT.101984126  DT.120893113  DT.91759174 
    DT.70100705  DT.95087649  DT.100795525  DT.95291236 

    24/984 AceView cDNA sequences (see all 984):

    AI275233 BM694929 AU142072 BM839764 AW850113 BQ891748 BQ928310 CA946509 
    AI335884 BM745919 AI673239 BM795312 AI865332 CB141589 AI912491 NM_032192 
    AW882123 AA485238 AA122353 CA389360 BM046300 BU541964 BX506001 AA662372 

    highest scoring ESTs for PPP1R1B:

    AA526079 AA292365 AA293626 AA336805 AA336843 AA337307 AA394121 AA480480 AA480481 AA506059 

    Unigene Cluster for PPP1R1B:

    Protein phosphatase 1, regulatory (inhibitor) subunit 1B
    Hs.286192  [show with all ESTs]
    Unigene Representative Sequence: AK123950


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R1B (see all 6)

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
    SP1:        -     -                 -                                                         
    SP2:                                -                                                         
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                -           -     -                                       

    About this scheme

    ECgene alternative splicing isoforms for PPP1R1B
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254079 ENST00000394271 ENST00000466381 ENST00000394267(uc002hsb.2)
    ENST00000394265(uc002hsc.2) ENST00000492037 ENST00000357165(uc002hrz.2 uc002hsa.2 uc010cvx.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PPP1R1B expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching PPP1R1B gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    65792_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 AA526079 1.00 0.90 0.95 1
    225165_at2, 3 U133-B 1 1.00 1.00 -- -- AK024593 0.80 0.88 0.84 1
    225165_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    PPP1R1B for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PPP1R1B gene expression
    PPP1R1B gene electronic northern expression
    PPP1R1B gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.286192
    Primers: OriGene genome-wide validated SYBR primer pairs: PPP1R1B
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PPP1R1B: PPH05948A
        SABiosciences Custom PCR Arrays for PPP1R1B 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PPP1R1B gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PPP1R1B1   -- protein phosphatase 1, regulatory (inhibitor) subunit more 89.87(n)
    91.18(a)
    608394  XM_845423.1  XP_850516.1 
    chimpanzee
    (Pan troglodytes)
    PPP1R1B1   -- protein phosphatase 1, regulatory (inhibitor) subunit more 99.17(n)
    100(a)
    744755  XM_001149814.1  XP_001149814.1 
    cow
    (Bos taurus)
    PPP1R1B1   -- protein phosphatase 1, regulatory (inhibitor) subunit more 90.43(n)
    92.08(a)
    282459  NM_174647.2  NP_777072.1 
    rat
    (Rattus norvegicus)
    Ppp1r1b1   -- protein phosphatase 1, regulatory (inhibitor) subunit more 86.6(n)
    84.8(a)
    360616  NM_138521.1  NP_612530.1 
    mouse
    (Mus musculus)
    Ppp1r1b1 , 5 11 (61.75 cM)5
    protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 87.33(n)1
    88.54(a)1
    190491  NM_144828.11  NP_659077.11 
     AB2215445  AF2816625  (see all 16)
    About this table        Species with no ortholog for PPP1R1B

    ENSEMBL Gene Tree for PPP1R1B (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PPP1R1B gene
    PPP1R1A2  PPP1R1C2  

    PPP1R1B for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/68 NCBI SNPs in PPP1R1B are shown (see all 68)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs1933591,2
    --37782931(+) TCCCCG/ACTGCC 1 -- ng511Minor allele frequency- A:0.00MN 184
    rs3805031,2
    H37786145(+) GGTCGC/GCATGG 1 -- int18Minor allele frequency- G:0.00EA NA NS 568
    rs3927411,2
    H37788808(-) CTCTAG/AGGCCC 1 -- int17Minor allele frequency- A:0.00EA NA NS 480
    rs4518491,2
    --37786143(+) TGGGTC/GGGCAT 1 -- int10--------
    rs9070941,2
    C,F,A,37790371(-) CACAGT/CTAATC 1 -- int120Minor allele frequency- C:0.39EA NA NS WA 3170
    rs14950991,2
    C,F,37784464(+) TGCAGG/CTGGCT 1 -- ng5113Minor allele frequency- C:0.46MN EA NA WA 894
    rs22713091,2
    C,F,A,H,37784990(-) CCCCAT/CGGGCC 1 -- int117Minor allele frequency- C:0.47EA NS NA WA 2390
    rs37519031,2
    C,37783787(-) GGGAGC/GGCGAA 1 -- ng516Minor allele frequency- G:0.25NA EA 970
    rs37643521,2
    C,F,A,37790939(-) TAGGGA/GTGGTT 1 -- int115Minor allele frequency- G:0.45EA NS NA WA 2116
    rs37643531,2
    C,F,37790781(-) TGGAGG/AGGGCA 1 -- int110Minor allele frequency- A:0.39NA EA WA 226
    About this table

    HapMap Linkage Disequilibrium images for PPP1R1B (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PPP1R1B
         2 CNVs: 77591 49853

    QIAGEN SeqTarget long-range PCR primers for resequencing PPP1R1B 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PPP1R1B for disorders           About GeneDecksing

    OMIM: 604399

    4 Novoseek disease relationships for PPP1R1B gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcyon 82.4 1 16199832 (1)
    schizophrenia 49.3 25 16750903 (5), 18573638 (3), 17618027 (3), 19059449 (1) (see all 7)
    adenocarcinoma 0 7 15707466 (5), 16061638 (1), 14508844 (1)
    tumors 0 3 16061638 (1), 14508844 (1), 19301121 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: PPP1R1B (19 documents)

    Export disorders and mutations for PPP1R1B gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/120 PubMed articles for PPP1R1B gene, integrated from 7 sources (see all 120):
    (articles sorted by number of sources associating them with PPP1R1B)
    1. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PubMed id 8120638)1, 2, 3, 7 Brene S.... Persson H. (1994)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP. (PubMed id 12124342)1, 2 El-Rifai W....Powell S.M. (2002)
    5. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. (PubMed id 10604473)1, 2 Bibb J.A.... Greengard P. (1999)
    6. Mutation analysis of DARPP-32 as a candidate gene for schizophrenia. (PubMed id 16750903)1, 7 Li C.H....Chen C.H. (2006)
    7. Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas. (PubMed id 14508844)1, 7 Beckler A....El-Rifai W. (2003)
    8. Reversal of multidrug resistance of adriamycin-resistant gastric adenocarcinoma cells through the up-regulation of DARPP-32. (PubMed id 17492506)1, 7 Hong L....Fan D. (2008)
    9. Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. (PubMed id 17171661)1, 7 Beuten J....Li M.D. (2007)
    10. Wnt-5a-induced phosphorylation of DARPP-32 inhibits b reast cancer cell migration in a CREB-dependent manner. (PubMed id 19651774)1, 7 Hansen C....Andersson T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84152 HGNC: 9287 AceView: LASP1andPPP1R1B Ensembl:ENSG00000131771 euGenes: HUgn84152
    ECgene: PPP1R1B H-InvDB: PPP1R1B

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for PPP1R1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for PPP1R1B gene:
    Search GeneIP for patents involving PPP1R1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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