PPP1R3D Gene
protein-coding GIFtS : 49
GC20M055299
protein phosphatase 1, regulatory (inhibitor) subunit 3D (Previous names: protein phosphatase 1, regulatory subunit 3D )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: PPP1R6 )
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Aliases & Descriptionsfor PPP1R3D gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions protein phosphatase 1, regulatory (inhibitor) subunit 3D1 2 PP1 subunit R62 3 PPP1R62 3 5 protein phosphatase 1, regulatory subunit 6, spinophilin2 protein phosphatase 1, regulatory subunit 3D1 2 DKFZp781L24412 Protein phosphatase 1 regulatory subunit 62 3 protein phosphatase 1 regulatory subunit 3D2 Protein phosphatase 1-binding subunit R62 3
Export aliases for PPP1R3D gene to outside databases Previous GC identifers: GC20M058242 GC20M058201 GC20M059150 GC20M059199 GC20M059197 GC20M057945 GC20M058511
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Summariesfor PPP1R3D gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for PPP1R3D : Phosphorylation of serine and threonine residues in proteins is a crucial step in the regulation of many cellular functions ranging from hormonal regulation to cell division and even short-term memory. The level of phosphorylation is controlled by the opposing actions of protein kinases and protein phosphatases. Protein phosphatase 1 (PP1) is 1 of 4 major serine/threonine-specific protein phosphatases which have been identified in eukaryotic cells. PP1 associates with various regulatory subunits that dictate its subcellular localization and modulate its substrate specificity. Several subunits that target PP1 to glycogen have been identified. This gene encodes a glycogen-targeting subunit of PP1. (provided by RefSeq) UniProtKB/Swiss-Prot: PPR3D_HUMAN, O95685 Function : Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates inthe regulation of glycogen metabolism, muscle contractility and protein synthesis
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Genomic Viewsfor PPP1R3D gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PPP1R3D gene promoter: p300 CREB ATF-2 E4BP4 SRF CUTL1 Arnt RSRFC4 TGIF ATF Other transcription factors Search SABiosciences Chromatin IP Primers for PPP1R3D Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PPP1R3D
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20q13.3 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.3 PPP1R3D Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20M055299: view genomic region
(about GC identifiers )
Start:
55,299,100 bp from pter
End:
55,302,565 bp from pter
Size:
3,466 bases
Orientation:
minus strand
1 alternative location : Chr 20- 58,511,894-58,515,352
RefSeq DNA sequence: NC_000020.10 NT_011362.10
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Proteinsfor PPP1R3D gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: PPR3D_HUMAN, O95685 (See
protein sequence )Recommended Name: Protein phosphatase 1 regulatory subunit 3D Size : 299 amino acids; 32559 Da
Subunit : Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen
Secondary accessions : Q6DK02Explore the universe of human proteins at neXtProt for PPP1R3D: NX_O95685 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_006233.1 ENSEMBL proteins: ENSP00000360035 Human Recombinant Proteins Antibodies for PPP1R3D: Assays for PPP1R3D:
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Protein
Domains/ Familiesfor PPP1R3D gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
PPP1R3D for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O95685 ProtoNet protein and cluster: O95685
1 Blocks protein family : IPB005036 Putative phosphatase regulatory subunit UniProtKB/Swiss-Prot: PPR3D_HUMAN, O95685 Domain : The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of someregulatory subunit of phosphatase complexes Similarity : Contains 1 CBM21 (carbohydrate binding type-21) domain
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Gene Functionfor PPP1R3D gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: PPR3D_HUMAN, O95685 Function : Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates inthe regulation of glycogen metabolism, muscle contractility and protein synthesis
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
About this table
PPP1R3D for ontologies About GeneDecksing
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Pathways & Interactionsfor PPP1R3D gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
PPP1R3D for pathways About GeneDecksing 5/9 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for PPP1R3D (see all 9 )1 Kegg Pathway (Kegg details for PPP1R3D) : SABiosciences Custom Pathway-Focused PCR Arrays for PPP1R3D Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PPP1R3D Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP1R3D 2 Interacting proteins for PPP1R3D (O95685 1 , 2 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005975 carbohydrate metabolic process
IEA -- GO:0005977 glycogen metabolic process
IEA --
About this table
PPP1R3D for ontologies About GeneDecksing
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Drugs & Compoundsfor PPP1R3D gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for PPP1R3D
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Transcriptsfor PPP1R3D gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for PPP1R3D gene: NM_006242.3
Additional cDNA sequence: BC047502.1 BC074860.2 BC074861.2 BX647298.1 Y18206.1
1 DOTS entry : DT.443807
24/77 AceView cDNA sequences (see all 77 ):
AI338933 AI075344 AA227932 AA326551 AI458545 AA723361 AA227617 AI680750 BX119062 BC074861 AW873990 CK825369 BC074860 NM_006242 BF939036 AI015117 AI700308 BQ270649 AI590073 AI472595 AI702893 AI368076 CB215770 BQ894406
highest scoring ESTs for PPP1R3D :Y18206 AI018630 AI680750 AL532901 AW365038 BC047502 BE840620 R10183 AA227617 AA227932 Unigene Cluster for PPP1R3D:
Protein phosphatase 1, regulatory (inhibitor) subunit 3D Hs.42215 [show with all ESTs ] Unigene Representative Sequence: BC047502 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000370996 (uc002ybb.2 )
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Expression for PPP1R3D gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section PPP1R3D expression in normal and diseased human tissues 1 / 2 / 3
6 probe-sets matching PPP1R3D gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
38948_at2 , 3
U95-A
1
0.62
1.00
0.80
0.76
Y18206
1.00
1.00
1.00
1
45191_at2 , 3
U95-B
1
0.38
1.00
0.95
1.24
AI680750
0.80
1.00
0.91
1
204555_s_at2 , 3
U133-A
1
0.64
1.00
--
--
NM_006242
0.60
1.00
0.82
1
204554_at2
U133-A
1
0.36
1.00
--
--
--
--
--
--
--
204555_s_at2
U133Plus2
1
0.64
1.00
--
--
--
--
--
--
--
204554_at2
U133Plus2
1
0.36
1.00
--
--
--
--
--
--
--
About this table
PPP1R3D for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TAGAGAATCT SOURCE GeneReport for Unigene cluster: Hs.42215 Expression variation in blood from EXPOLDB for PPP1R3D
UniProtKB/Swiss-Prot: PPR3D_HUMAN, O95685 Tissue specificity : Expressed in all tissue tested. High expression in skeletal muscle and heart
SABiosciences Custom PCR Arrays for PPP1R3D
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Orthologsfor PPP1R3D gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for PPP1R3D gene from 5/8 species (see all 8 )
About this table Species with no ortholog for PPP1R3D ENSEMBL Gene Tree for PPP1R3D (if available)
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Paralogsfor PPP1R3D gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for PPP1R3D gene PPP1R3G 2 PPP1R3A 2 PPP1R3B 2 PPP1R3E 2 PPP1R3C 2
PPP1R3D for paralogs About GeneDecksing
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Genomic Variantsfor PPP1R3D gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section QIAGEN SeqTarget long-range PCR primers for resequencing PPP1R3D
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Disorders & Mutationsfor PPP1R3D gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
PPP1R3D for disorders About GeneDecksing
OMIM: 603326 Export disorders and mutations for PPP1R3D gene to outside databases
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Medical Newsfor PPP1R3D gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor PPP1R3D gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10 PubMed articles for PPP1R3D gene integrated from 7 sources : (articles sorted by number of sources associating them with PPP1R3D) PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1. (PubMed id 9414128) 1 , 2 , 3 Armstrong C.G.... Cohen P.T.W. (1997) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052) 1 , 2 Deloukas P....Rogers J. (2001) Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. (PubMed id 9275233) 1 , 3 Allen P.B....Greengard P. (1997) Phosphoproteome of resting human platelets. (PubMed id 18088087) 2 Zahedi R.P.... Sickmann A. (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147) 1 Wu C....Li S.S. (2007) Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. (PubMed id 15778465) 1 Benzinger A.... Hermeking H. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Genetic alterations and expression of the protein phosphatase 1 genes in human cancers. (PubMed id 11251179) 7 Takakura S....Yokota J. (2001)
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External Searches for PPP1R3D gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing PPP1R3D gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing PPP1R3D gene
(According to HUGE )
About This Section --
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Specialized Databases showing PPP1R3D gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for PPP1R3D gene: Search GeneIP for patents involving PPP1R3D GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor PPP1R3D gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for PPP1R3D
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