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PPP1R9B Gene

protein-coding   GIFtS: 52

GC17M043579
protein phosphatase 1, regulatory (inhibitor) subunit 9B
(Previous names: protein phosphatase 1, regulatory subunit 9B, spinophilin )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: PPP1R6, PPP1R9)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
protein phosphatase 1, regulatory (inhibitor) subunit 9B1 2     neurabin-22
protein phosphatase 1, regulatory subunit 9B, spinophilin1 2     PPP1R92
Spn1 2     neurabin II2
SPINO1 2     neurabin-II2
Protein phosphatase 1 regulatory subunit 9B2 3     spinophilin2
PPP1R62 3     Spinophilin3
FLJ303452     Neurabin-II3

External Ids:    HGNC: 92981   Entrez Gene: 846872   Ensembl: ENSG000001088197   UniProtKB: Q96SB33   

Export aliases for PPP1R9B gene to outside databases

Previous GC identifers: GC17U990076 GC17M050692 GC17M048553 GC17M048687 GC17M048685 GC17M045567 GC17M048211


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP1R9B:
Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly
enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input
in the central nervous system (Allen et al., 1997 (PubMed 9275233)).(supplied by OMIM)

UniProtKB/Swiss-Prot: NEB2_HUMAN, Q96SB3
Function: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission
and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the
sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the
synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and
regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate
receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and
alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors
by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates
regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector
proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity)

Gene Wiki entry for PPP1R9B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1R9B gene promoter:
         CREB   deltaCREB   NRSF form 2   NRSF form 1   JunB   Fra-1   c-Jun   JunD   AP-1   c-Fos   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PPP1R9B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PPP1R9B 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

PPP1R9B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R9B gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M043579:  view genomic region     (about GC identifiers)

Start:
43,578,978 bp from pter
End:
43,595,756 bp from pter
Size:
16,779 bases
Orientation:
minus strand

1 alternative location:
Chr17- 48,211,104-48,227,991     
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NEB2_HUMAN, Q96SB3 (See protein sequence)
Recommended Name: Neurabin-2  
Size: 815 amino acids; 89192 Da
Subunit: Possibly exists as an homodimer, homotrimer or an homotetramer. Interacts with F-actin, PPP1CA, neurabin-1,
TGN38 and D(2) dopamine receptor. Interacts with RGS1, RGS2, RGS4, RGS19 and ADRA1B, ADRA2A, ADRA2B, ADRA2C, CDKN2A,
PPP1R2, RASGFR1 and TIAM1
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Cell projection, dendritic
spine (By similarity). Cell junction, synapse. Note=Enriched at synapse and cadherin-based cell-cell adhesion sites.
In neurons, both cytosolic and membrane-associated, and highly enriched in the post-synaptic density apposed to
exitatory synapses. Colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells and in dendritic
spines (By similarity)
Secondary accessions: Q8TCR9

Explore the universe of human proteins at neXtProt for PPP1R9B: NX_Q96SB3 

Post-translational modifications:

  • Stimulation of D1 (but not D2) dopamine receptors induces Ser-94 phosphorylation. Dephosphorylation of Ser-94 is
  • mediated mainly by PP1 and to a lesser extent by PP2A. Phosphorylation of spinophilin disrupts its association with
    F-actin, but does not affect its binding to PP1 (By similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_115984.3  
    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for PPP1R9B 
    Novus Biologicals Protein for PPP1R9B
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000164 protein phosphatase type 1 complex TAS11278317
    GO:0005634 nucleus IEA--
    GO:0005654 nucleoplasm IMP11278317
    GO:0005737 cytoplasm IDA11278317
    GO:0005856 cytoskeleton IEA--
    About this table

    PPP1R9B for ontologies           About GeneDecksing



    Antibodies for PPP1R9B: 
    Millipore Mono- and Polyclonal Antibodies for the study of PPP1R9B
    Sigma-Aldrich Antibody Arrays and Antibodies for PPP1R9B
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PPP1R9B 
    Novus Biologicals Antibody for PPP1R9B
    Browse antibodies at Epitomics

    Assays for PPP1R9B: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPP1R9B 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PPP1R9B for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001478 PDZ/DHR/GLGF

    Graphical View of Domain Structure for InterPro Entry Q96SB3

    ProtoNet protein and cluster: Q96SB3

    2 Blocks protein families:
    IPB000515 Binding-protein-dependent transport systems inner membrane component
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: NEB2_HUMAN, Q96SB3
    Similarity: Contains 1 PDZ (DHR) domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: NEB2_HUMAN, Q96SB3
    Function: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission
    and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the
    sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the
    synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and
    regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate
    receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and
    alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors
    by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates
    regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector
    proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PPP1R9B
    Sigma-Aldrich shRNA Panels and shRNA for PPP1R9B
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PPP1R9B
    OriGene shRNA RFP (see all 2): PPP1R9B
    OriGene basic RS shRNA (see all 2): PPP1R9B
    OriGene siRNA: PPP1R9B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PPP1R9B 
    miRNA:Sigma-Aldrich microRNA Mimics for PPP1R9B
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PPP1R9B 
    8 SABiosciences Assays for microRNAs that regulate PPP1R9B:
    hsa-miR-198 hsa-miR-346 hsa-miR-1224-5p hsa-miR-1205 hsa-miR-656 hsa-miR-637 hsa-miR-608 hsa-miR-1207-5p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PPP1R9B
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PPP1R9B
    OriGene untagged cDNA clones in CMV expression vector (see all 3): PPP1R9B
    OriGene 3'-UTR clone: PPP1R9B 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PPP1R9B 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PPP1R9B 

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779 actin binding IEA--
    GO:0004864 phosphoprotein phosphatase inhibitor activity NAS11278317
    GO:0005515 protein binding IPI11278317
    GO:0008157 protein phosphatase 1 binding NAS11278317
    About this table

    PPP1R9B for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppp1r9b):

    behavior/neurologicalgrowth/sizehomeostasis/metabolismnervous system

    PPP1R9B for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for PPP1R9B 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1R9B

    5/7 Interacting proteins for PPP1R9B (Q96SB32) via UniProtKB, MINT, and/or STRING (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRA1BP353682MINT-4953469
    CCKARP322382MINT-4953493
    CCKBRP322392MINT-4953514
    CHRM3P203092MINT-4953558
    DRD2P144162MINT-4953534
    About this table

    5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001560 regulation of cell growth by extracellular stimulus TAS11278317
    GO:0007050 cell cycle arrest TAS11278317
    GO:0007096 regulation of exit from mitosis NAS11278317
    GO:0007275 multicellular organismal development IEA--
    GO:0007399 nervous system development IEA--
    About this table

    PPP1R9B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PPP1R9B for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP1R9B
    4 Novoseek chemical compound relationships for PPP1R9B gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    letrozole 63.8 6 15229239 (2), 16502389 (2), 16344155 (1), 20097718 (1)
    dopamine 37.5 4 16462601 (1), 10194355 (1), 16199832 (1), 17157277 (1)
    glutamate 33.3 7 17279777 (2), 15217898 (1), 15728359 (1), 12230305 (1) (see all 6)
    estradiol 28.7 2 12351732 (1), 15229239 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PPP1R9B
    Sigma-Aldrich shRNA Panels and shRNA for PPP1R9B
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PPP1R9B
    OriGene shRNA RFP (see all 2): PPP1R9B
    OriGene basic RS shRNA (see all 2): PPP1R9B
    OriGene siRNA: PPP1R9B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PPP1R9B 
    miRNA: Sigma-Aldrich microRNA Mimics for PPP1R9B
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PPP1R9B 
    8 SABiosciences Assays for microRNAs that regulate PPP1R9B:
    hsa-miR-198 hsa-miR-346 hsa-miR-1224-5p hsa-miR-1205 hsa-miR-656 hsa-miR-637 hsa-miR-608 hsa-miR-1207-5p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PPP1R9B
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PPP1R9B
    OriGene untagged cDNA clones in CMV expression vector (see all 3): PPP1R9B
    OriGene 3'-UTR Clone: PPP1R9B 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PPP1R9B 
    Primers: OriGene genome-wide validated SYBR primer pairs: PPP1R9B
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PPP1R9B: PPH11139A

    REFSEQ mRNAs for PPP1R9B gene: 

    NM_032595.3  

    Additional cDNA sequence: 

    AJ401189.1 AK054907.1 AL157449.1 AL713642.1 BC008564.1 BC011232.1 BC016162.1 CR605734.1 

    5 DOTS entries:

    DT.312456  DT.95243515  DT.97868666  DT.100044479  DT.95072296 

    24/135 AceView cDNA sequences (see all 135):

    AI475690 BF726761 BM695932 AI056581 BM991997 BC008564 AW451413 BC011232 
    AI242565 BU620207 AL157449 CO246370 BE646343 AI251854 AI766708 BM460087 
    CA944794 BE895415 BM548779 BI912507 BM718161 BG393753 NM_032595 AI621262 

    highest scoring ESTs for PPP1R9B:

    AI523759 AI797774 AI808223 AI969706 AJ401189 AL713642 AW028349 AW302139 BF109903 BF448737 

    Unigene Cluster for PPP1R9B:

    Protein phosphatase 1, regulatory (inhibitor) subunit 9B
    Hs.514323  [show with all ESTs]
    Unigene Representative Sequence: NM_032595


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R9B

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                -                                                   
    SP2:                                -                                                   
    SP3:                                -                                                   
    SP4:                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for PPP1R9B
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316878(uc002iqh.3) ENST00000501501 ENST00000513579

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PPP1R9B expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching PPP1R9B gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    52900_at2, 3 U95-B 1 0.94 1.00 0.77 1.36 AI797774 0.80 1.00 0.91 1
    70964_at2, 3 U95-E 1 0.62 1.00 0.76 0.64 AI523759 1.00 1.00 1.00 1
    225124_at2, 3 U133-B 1 0.91 1.00 -- -- BF508705 0.60 1.00 0.82 1
    230455_at2, 3 U133-B 1 0.73 1.00 -- -- AI523759 1.00 1.00 1.00 1
    225124_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    230455_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    PPP1R9B for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PPP1R9B gene expression
    PPP1R9B gene electronic northern expression
    PPP1R9B gene sage expression
    About these images

    CGAP SAGE TAG: CCCTCTGTCA

    SOURCE GeneReport for Unigene cluster: Hs.514323
    Primers: OriGene genome-wide validated SYBR primer pairs: PPP1R9B
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PPP1R9B: PPH11139A
        SABiosciences Custom PCR Arrays for PPP1R9B 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PPP1R9B gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PPP1R9B1   -- protein phosphatase 1, regulatory (inhibitor) subunit more 92.9(n)
    96.21(a)
    491076  XM_548196.2  XP_548196.2 
    rat
    (Rattus norvegicus)
    Ppp1r9b1   -- protein phosphatase 1, regulatory subunit 9B 90.11(n)
    95.83(a)
    84686  NM_053474.1  NP_445926.1 
    mouse
    (Mus musculus)
    Ppp1r9b1 , 5 11 (59.01 cM)5
    protein phosphatase 1, regulatory subunit 9B1, 5 90.89(n)1
    96.57(a)1
    2171241  NM_172261.21  NP_758465.21 
     AI8416105  AI8416865  (see all 14)
    zebrafish
    (Danio rerio)
    Dr.140452   -- Transcribed sequence with weak similarity to protein more 81.4(n)  BI840817.1 
    About this table        Species with no ortholog for PPP1R9B

    ENSEMBL Gene Tree for PPP1R9B (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/160 NCBI SNPs in PPP1R9B are shown (see all 160)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs113651,2
    C,F,48211533(+) GGAGGG/TGGTCT 1 -- ut3110Minor allele frequency- T:0.44MN NS EA WA NA 842
    rs121111,2
    --48211479(+) CAGGGG/ACATGA 1 -- ut311Minor allele frequency- A:0.00MN 184
    rs8476801,2
    C,F,A,H,48224075(-) GTGCAA/GTGGAC 1 -- int113Minor allele frequency- G:0.18NA MN NS EA 1000
    rs8476871,2
    C,F,48229441(+) GTTCAG/TTCCAC 1 -- ng5118Minor allele frequency- T:0.47NS EA NA WA 2476
    rs8476881,2
    C,F,A,48228981(-) GCTGGG/ACCAAG 1 -- ng516Minor allele frequency- A:0.47NA EA WA 216
    rs10075581,2
    C,F,A,H,48214134(+) CTGCCC/ATGGGG 1 -- int14Minor allele frequency- A:0.24NA WA 128
    rs15691161,2
    C,F,48216944(+) TCTCCC/TGTCTG 2 T syn1 ref114Minor allele frequency- T:0.31NA NS EA WA 1088
    rs37445351,2
    C,A,48212910(-) GGGCCC/TGGGGC 1 -- int13Minor allele frequency- T:0.37WA NA 54
    rs37445361,2
    C,F,48212876(-) AGGGAG/ACAGCA 1 -- int17Minor allele frequency- A:0.01EA NS NA 2080
    rs38097641,2
    C,48229753(+) ATGGGG/ATGTGG 1 -- ng51 tfbs35Minor allele frequency- A:0.12NA EA WA 214
    About this table

    HapMap Linkage Disequilibrium images for PPP1R9B (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PPP1R9B
         2 CNVs: 88525 77656

    QIAGEN SeqTarget long-range PCR primers for resequencing PPP1R9B 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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    PPP1R9B for disorders           About GeneDecksing

    OMIM: 603325

    5 Novoseek disease relationships for PPP1R9B gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcyon 88.3 6 16199832 (3), 12622665 (2), 16786528 (1)
    schizophrenia 37 10 15465982 (3), 16199832 (2), 15184234 (2), 16786528 (1) (see all 6)
    bipolar disorder 11.5 1 15465982 (1)
    major depression 3.74 1 15465982 (1)
    tumors 0 2 11278317 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: PPP1R9B (1 document)

    Export disorders and mutations for PPP1R9B gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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    10/81 PubMed articles for PPP1R9B gene, integrated from 7 sources (see all 81):
    (articles sorted by number of sources associating them with PPP1R9B)
    1. The human tumor suppressor ARF interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein. (PubMed id 11278317)1, 2, 7 Vivo M.... La Mantia G. (2001)
    2. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. (PubMed id 9275233)1, 3, 7 Allen P.B....Greengard P. (1997)
    3. Phosphorylation of spinophilin modulates its interaction with actin filaments. (PubMed id 12417592)1, 7 Hsieh-Wilson L.C....Greengard P. (2003)
    4. Scaffold proteins IRSp53 and spinophilin regulate loc alized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1) . (PubMed id 20360004)1, 7 Rajagopal S....Buchsbaum R.J. (2010)
    5. Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5). (PubMed id 15728359)1, 7 Futter M....Nairn A.C. (2005)
    6. Identification of neurabin II as a novel doublecortin interacting protein. (PubMed id 14550532)1, 7 Tsukada M....Eichele G. (2003)
    7. The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines. (PubMed id 12230305)1, 7 Grossman S.D....Greengard P. (2002)
    8. Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1. (PubMed id 10194355)1, 7 Hsieh-Wilson L.C....Greengard P. (1999)
    9. PPP1R9B (Neurabin 2): involvement and dynamics in the NK immunological synapse. (PubMed id 19130477)1, 7 Meng X....Wilkins J.A. (2009)
    10. Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin. (PubMed id 12531897)1, 7 Buchsbaum R.J....Feig L.A. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84687 HGNC: 9298 AceView: PPP1R9B Ensembl:ENSG00000108819 euGenes: HUgn84687
    ECgene: PPP1R9B H-InvDB: PPP1R9B

    (According to HUGE)
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      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for PPP1R9B gene:
    Search GeneIP for patents involving PPP1R9B

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