Aliases &
Descriptions
for PRAF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| PRA1 domain family, member 21 2 | | PRA1 domain family 21 2 | | JM41 | | Jena-Muenchen 42 | | PRA1 family protein 22 | | FLJ579162 |
Export aliases for PRAF2 gene to outside databasesPrevious GC identifers: GC0XM048685 GC0XM048815 GC0XM048928 |
Summaries
for PRAF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831Function: May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-inducedneuroblastoma apoptosis
|
Genomic Views
for PRAF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRAF2 gene promoter:
PPAR-gamma2 PPAR-gamma1 Bach1 NF-E2 NF-E2 p45 FOXD1 POU3F1 Pax-6 GCNF-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRAF2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PRAF2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23PRAF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM046585: view genomic region
(about GC identifiers)
Start:
|
46,585,451 bp from pter |
End:
|
46,588,295 bp from pter |
Size:
|
2,845 bases |
Orientation:
|
minus strand |
1 alternative location:
| ChrX- 48,928,820-48,931,733 |
RefSeq DNA sequence:- NC_000023.10 NT_079573.4
|
Proteins
for PRAF2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831 (See
protein sequence)Recommended Name: PRA1 family protein 2 Size: 178 amino acids; 19258 Da
Subunit: Interacts with CCR5 and GDE1
Subcellular location: Endosome membrane; Multi-pass membrane protein (Probable)
Secondary accessions: B2RD20Explore the universe of human proteins at neXtProt for PRAF2: NX_O60831
REFSEQ proteins: NP_009144.1
ENSEMBL proteins: ENSP00000365566 ENSP00000365570
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
PRAF2 for ontologies About GeneDecksing
Antibodies for PRAF2:
Assays for PRAF2: |
Protein
Domains/
Families
for PRAF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRAF2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O60831ProtoNet protein and cluster: O60831 UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831Similarity: Belongs to the PRA1 family |
Gene Function
for PRAF2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831Function: May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-inducedneuroblastoma apoptosis
|
Pathways & Interactions
for PRAF2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for PRAF2
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRAF2
5 Interacting proteins for PRAF2 (O608312) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- | | GO:0015813 | L-glutamate transport |
ISS | -- |
About this table
PRAF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PRAF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PRAF2
|
Transcripts
for PRAF2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PRAF2 gene: NM_007213.1 Additional cDNA sequence: AJ005896.1 AK023433.1 AK310550.1 AK315374.1 BC021213.2 CR457023.1 CR597667.1 CR605520.1 CR607931.1 CR614630.1 6 DOTS entries: DT.87016785 DT.100796043 DT.95126895 DT.40249386 DT.121290065 DT.40110915 24/247 AceView cDNA sequences (see all 247): BM699099 BF437713 BQ672022 BQ669351 BQ674893 CB141421 AI741751 BM684565 AW327921 BM801598 CB133307 CB155577 BI820498 BQ054846 BE302873 CR597667 BM552522 CB156338 AI560435 CB137088 CB136816 BU527209 BU156176 BU727938
 highest scoring ESTs for PRAF2:AJ005896 AA551276 AK023433 AL526580 AL555498 AL578513 AU100195 BC021213 BE254555 BE263463 Unigene Cluster for PRAF2: PRA1 domain family, member 2 Hs.29595 [show with all ESTs]Unigene Representative Sequence: BF982837
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376386 ENST00000376390(uc004dmh.2 uc004dmi.2) ENST00000491199
|
Expression
for PRAF2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PRAF2 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching PRAF2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 34318_at2, 3
|
U95-A |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
AJ005896 |
1.00 |
1.00 |
1.00 |
1 |
| 203456_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_007213 |
0.60 |
1.00 |
0.82 |
1 |
| 203456_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PRAF2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCCCTGTGTG
SOURCE GeneReport for Unigene cluster: Hs.29595
Expression variation in blood from EXPOLDB for PRAF2 UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831Tissue specificity: Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumortissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. Highexpression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecularand the granular layers in the cerebellum. Detected in neuronal cells, but not in non-neuronal cells in the cerebralcortex, hippocampus, and lateral ventricles
SABiosciences Custom PCR Arrays for PRAF2
|
Orthologs
for PRAF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PRAF2 gene from 5/6 species (see all 6)
About this table Species with no ortholog for PRAF2
ENSEMBL Gene Tree for PRAF2 (if available) |
Paralogs
for PRAF2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PRAF2 gene
- ARL6IP52
PRAF2 for paralogs About GeneDecksing
|
Genomic Variants
for PRAF2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr X pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PRAF2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PRAF2
1 CNV: 7789 | | QIAGEN SeqTarget long-range PCR primers for resequencing PRAF2 |
|
Disorders & Mutations
for PRAF2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for PRAF2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PRAF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10 PubMed articles for PRAF2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with PRAF2)- Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PubMed id 16481131)1, 2, 3, 7 Fo C.S.... Bachmann A.S. (2006)
- Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles. (PubMed id 18395978)1, 2, 7 Koomoa D.-L.... Bachmann A.S. (2008)
- Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation. (PubMed id 17975142)1, 2 Geerts D.... Bachmann A.S. (2007)
- JM4 is a four-transmembrane protein binding to the CCR5 receptor. (PubMed id 15757671)1, 2 Schweneker M.... Moelling K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration. (PubMed id 20412121)1 Borsics T....Bachmann A.S. (2010)
- Genomic organization, characterization, and molecular 3D model of GDE1, a novel mammalian glycerophosphoinositol phosphodiesterase. (PubMed id 16472945)2 Bachmann A.S.... Mocz G. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for PRAF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PRAF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRAF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRAF2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PRAF2 gene:
Search GeneIP for patents involving PRAF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRAF2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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