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PRDM1 Gene

protein-coding   GIFtS: 60

GC06P103981
PR domain containing 1, with ZNF domain
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: BLIMP1)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
PR domain containing 1, with ZNF domain1 2     PR-domain zinc finger protein 12
PRDI-BF11 2 3     beta-interferon gene positive-regulatory domain I binding factor2
BLIMP12 3 5     MGC1189222
Positive regulatory domain I-binding factor 12 3     PRDI-binding factor-12
Beta-interferon gene positive regulatory domain I-binding factor2 3     OTTHUMP000002021732
BLIMP-12 3     B-lymphocyte-induced maturation protein 12
PR domain-containing protein 12 3     MGC1189252
PRDI-binding factor 12 3     MGC1189242
PR domain zinc finger protein 12     MGC1189232

External Ids:    HGNC: 93461   Entrez Gene: 6392   Ensembl: ENSG000000576577   UniProtKB: O756263   

Export aliases for PRDM1 gene to outside databases

Previous GC identifers: GC06P106371 GC06P106557 GC06P106579 GC06P106640


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRDM1:
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically
to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases
upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
(provided by RefSeq)

UniProtKB/Swiss-Prot: PRDM1_HUMAN, O75626
Function: Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon
gene. Drives the maturation of B-lymphocytes into Ig secreting cells

Gene Wiki entry for PRDM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRDM1 gene promoter:
         NF-kappaB1   NF-kappaB   IRF-1   STAT3   p53   Cdc5   PPAR-gamma1   PPAR-gamma2   c-Rel   RSRFC4   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PRDM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

PRDM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDM1 gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P103981:  view genomic region     (about GC identifiers)

Start:
103,981,166 bp from pter
End:
104,004,788 bp from pter
Size:
23,623 bases
Orientation:
plus strand

1 alternative location:
Chr6+ 106,534,195-106,557,814     
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PRDM1_HUMAN, O75626 (See protein sequence)
Recommended Name: PR domain zinc finger protein 1  
Size: 825 amino acids; 91771 Da
Subunit: Interacts with PRMT5 (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAO45623.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
PDB structures from and Proteopedia :
3DAL (3D)    
Secondary accessions: B2REA6
Alternative splicing: 2 isoforms:  O75626-1   O75626-2   

Explore the universe of human proteins at neXtProt for PRDM1: NX_O75626 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001189.2  NP_878911.1  


    ENSEMBL proteins: 
    ENSP00000358087 ENSP00000358092 ENSP00000395566 ENSP00000399772 ENSP00000358085 ENSP00000071246 
    ENSP00000401403 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): PRDM1
    GenScript Custom Purified and Recombinant Proteins Services for PRDM1 
    Novus Biologicals Protein for PRDM1
    Novus Biologicals Lysates for PRDM1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm ----
    About this table

    PRDM1 for ontologies           About GeneDecksing



    Antibodies for PRDM1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for PRDM1
    R&D Systems Antibodies for PRDM1 (BLIMP1/PRDM1)
    Cell Signaling Technology (CST) Antibodies for PRDM1 (PRD1, PRD)
    OriGene Antibodies (see all 2): PRDM1
    GenScript Custom Superior Antibodies Services for PRDM1 
    Novus Biologicals Antibodies for PRDM1
    Browse antibodies at Epitomics

    Assays for PRDM1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRDM1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PRDM1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PRDM1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001214 SET_dom
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR016608 Znf_PRDM1

    Graphical View of Domain Structure for InterPro Entry O75626

    ProtoNet protein and cluster: O75626

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: PRDM1_HUMAN, O75626
    Similarity: Contains 4 C2H2-type zinc fingers
    Similarity: Contains 1 SET domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PRDM1_HUMAN, O75626
    Function: Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon
    gene. Drives the maturation of B-lymphocytes into Ig secreting cells

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for PRDM1
    Sigma-Aldrich shRNA for PRDM1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PRDM1
    OriGene shRNA RFP (see all 2): PRDM1
    OriGene basic RS shRNA (see all 2): PRDM1
    OriGene siRNA (see all 2): PRDM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PRDM1 
    miRNA:Sigma-Aldrich microRNA Mimics for PRDM1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PRDM1 
    8/22 SABiosciences Assays for microRNAs that regulate PRDM1 (see all 22):
    hsa-miR-30c hsa-miR-125a-5p hsa-miR-137 hsa-miR-520d-5p hsa-miR-429 hsa-miR-557 hsa-miR-30d hsa-miR-944

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PRDM1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): PRDM1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PRDM1
    OriGene 3'-UTR clone (see all 2): PRDM1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PRDM1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PRDM1 

    Genatlas biochemistry entry for PRDM1:
    PR domain containing 1,B-lymphocyte maturation promoting transcription factor,repressing the expression of IFNB
    promoter,and the transcription by recruiting a complex of Groucho family proteins to DNA,deleted in several B-cell non
    Hodgkin lymphoma and other cancers

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding ----
    GO:0003677 DNA binding IEA--
    GO:0003700 sequence-specific DNA binding transcription factor activity TAS1851123
    GO:0004812 aminoacyl-tRNA ligase activity ----
    GO:0005524 ATP binding ----
    About this table

    PRDM1 for ontologies           About GeneDecksing

    Animal Models: 14 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Prdm1):

    cardiovascular systemcraniofacialembryogenesisendocrine/exocrine glandgrowth/size
    hematopoietic systemimmune systemlethality-postnatallethality-prenatal/perinatallimbs/digits/tail
    muscleno phenotypic analysisnormalreproductive system

    PRDM1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for PRDM1 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRDM1

    1 Interacting protein for PRDM1 (O756262) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532MINT-2857170
    About this table

    5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS1851123
    GO:0001892 embryonic placenta development IEA--
    GO:0001893 maternal placenta development IEA--
    GO:0006412 translation ----
    GO:0006418 tRNA aminoacylation for protein translation ----
    About this table

    PRDM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PRDM1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRDM1
    3 Novoseek chemical compound relationships for PRDM1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-methoxyestradiol 74.2 5 17877160 (3), 18192112 (2)
    cytidine 68.3 4 17339456 (1), 16895557 (1), 16339522 (1)
    zinc 36.1 18 14656887 (1), 11342629 (1), 19433448 (1), 16506071 (1) (see all 9)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for PRDM1
    Sigma-Aldrich shRNA for PRDM1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PRDM1
    OriGene shRNA RFP (see all 2): PRDM1
    OriGene basic RS shRNA (see all 2): PRDM1
    OriGene siRNA (see all 2): PRDM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PRDM1 
    miRNA: Sigma-Aldrich microRNA Mimics for PRDM1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PRDM1 
    8/22 SABiosciences Assays for microRNAs that regulate PRDM1 (see all 22):
    hsa-miR-30c hsa-miR-125a-5p hsa-miR-137 hsa-miR-520d-5p hsa-miR-429 hsa-miR-557 hsa-miR-30d hsa-miR-944
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PRDM1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): PRDM1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PRDM1
    OriGene 3'-UTR Clone (see all 2): PRDM1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PRDM1 
    Primers: OriGene genome-wide validated SYBR primer pairs: PRDM1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PRDM1: PPH18652A

    REFSEQ mRNAs for PRDM1 gene (2 alternative transcripts): 

    NM_001198.3  NM_182907.1  

    Additional cDNA sequence: 

    AF084199.1 AK129768.1 AK289556.1 AK301341.1 AL832963.1 AY198414.1 AY198415.1 BC103832.1 
    BC103833.1 BC103834.1 BC103835.1 EF151143.1 

    6 DOTS entries:

    DT.100751567  DT.436483  DT.100736390  DT.100751566  DT.91842415  DT.86843045 

    24/76 AceView cDNA sequences (see all 76):

    BM710624 Z42260 AY198415 AA743541 NM_001198 AI269812 Z38498 AA921725 
    NM_182907 BE219817 AW188348 BQ018743 AW408568 BX284091 BM667340 AW594160 
    BF516514 BU680075 AY198414 AA664123 AI671598 AA858171 AA857721 AA372865 

    highest scoring ESTs for PRDM1:

    AF084199 AA664123 AA730123 AA743541 AA766820 AA768582 AA827238 AA857721 AA858171 AA921725 

    Unigene Cluster for PRDM1:

    PR domain containing 1, with ZNF domain
    Hs.436023  [show with all ESTs]
    Unigene Representative Sequence: AY198414


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PRDM1 (see all 10)

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:        -     -     -                 -           -     -     -     -                                                         
    SP2:              -     -                 -           -     -     -     -                                                         
    SP3:                                                                    -                                                         
    SP4:                                                              -     -                                                         
    SP5:                                      -           -     -     -     -                                                         

    About this scheme

    ECgene alternative splicing isoforms for PRDM1
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369091 ENST00000369096 ENST00000424894 ENST00000489365 ENST00000450060
    ENST00000481163 ENST00000369089(uc003pre.2) ENST00000071246(uc003prd.2)
    ENST00000456278

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PRDM1 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching PRDM1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    31779_s_at2, 3 U95-A 1 1.00 1.00 0.94 0.60 AF084199 1.00 1.00 1.00 1
    87673_at2, 3 U95-E 1 0.62 1.00 0.95 1.43 AI982610 0.80 1.00 0.91 1
    217192_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --
    228964_at2, 3 U133-B 1 0.91 1.00 -- -- AI692659 0.80 1.00 0.91 1
    217192_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    228964_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    PRDM1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PRDM1 gene expression
    PRDM1 gene electronic northern expression
    PRDM1 gene sage expression
    About these images

    CGAP SAGE TAG: TTTGCATAGC

    SOURCE GeneReport for Unigene cluster: Hs.436023

    Expression variation in blood from EXPOLDB for PRDM1

    Primers: OriGene genome-wide validated SYBR primer pairs: PRDM1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PRDM1: PPH18652A
        SABiosciences Custom PCR Arrays for PRDM1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PRDM1 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PRDM11   -- PR domain containing 1, with ZNF domain 85.79(n)
    86.3(a)
    481947  XM_539068.2  XP_539068.2 
    chimpanzee
    (Pan troglodytes)
    PRDM11   -- PR domain containing 1, with ZNF domain 99.62(n)
    99.24(a)
    462904  XM_518658.2  XP_518658.2 
    cow
    (Bos taurus)
    PRDM11   -- PR domain containing 1, with ZNF domain 86.21(n)
    88.32(a)
    538384  XM_618588.3  XP_618588.3 
    rat
    (Rattus norvegicus)
    Prdm11   -- PR domain containing 1, with ZNF domain 86.97(n)
    88.96(a)
    309871  XM_228320.4  XP_228320.4 
    mouse
    (Mus musculus)
    Prdm11 , 5 10 (23.24 cM)5
    PR domain containing 1, with ZNF domain1, 5 86.97(n)1
    89.85(a)1
    121421  NM_007548.21  NP_031574.11 
     AF3055345  AF3055355  (see all 15)
    About this table        Species with no ortholog for PRDM1

    ENSEMBL Gene Tree for PRDM1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PRDM1 gene
    ZNF6832  PRDM22  

    PRDM1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/198 NCBI SNPs in PRDM1 are shown (see all 198)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs4782951,2
    C,F,106556368(+) GTCTGG/AGTGGT 2 -- ut31 ese313Minor allele frequency- A:0.03EA NA MN NS 1172
    rs4865221,2
    C,F,106549398(+) AAATGG/ATGGTT 2 -- int17Minor allele frequency- A:0.11NS EA NA WA 544
    rs5302391,2
    C,F,A,H,106548131(+) CTCTTT/GGAGCA 2 -- int121Minor allele frequency- G:0.19EA MN NA NS WA 2204
    rs5357801,2
    C,F,A,H,106548730(+) GGCTCT/CCAGTT 2 -- int113Minor allele frequency- C:0.40MN EA NS NA WA 2280
    rs5470571,2
    C,F,O,A,H,106551403(+) GACTGT/CCCTCC 2 -- int115Minor allele frequency- C:0.39MN EA NS NA 2618
    rs5738691,2
    C,F,A,H,106552031(+) TTAACC/TTATGA 2 -- int115Minor allele frequency- T:0.14EA NS NA 2458
    rs8119251,2
    C,F,106547372(-) GCAAAG/CTCCCG 4 /D /E ref1 mis1 ese323Minor allele frequency- C:0.19EA NA MN NS WA 1856
    rs13400641,2
    C,F,O,A,H,106532658(+) TTCCAG/CCCCCA 1 -- ng5114Minor allele frequency- C:0.43EA NA NS WA 690
    rs13400651,2
    C,F,O,A,H,106535936(+) GGCTTT/CTTGGC 1 -- int116Minor allele frequency- C:0.16NS EA NA WA 992
    rs18832301,2
    C,F,O,A,H,106545118(+) AGTTCT/GTGGAG 2 -- int1 ng5120Minor allele frequency- G:0.09MN NA NS EA WA 1710
    About this table

    HapMap Linkage Disequilibrium images for PRDM1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PRDM1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing PRDM1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PRDM1 for disorders           About GeneDecksing

    OMIM: 603423

    9 Novoseek disease relationships for PRDM1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma b-cell 55.7 15 17213024 (4), 16585013 (3), 19380033 (2), 18596541 (1) (see all 6)
    plasmacytoma 51.2 3 18089822 (2)
    lymphoma 50.7 12 17682124 (1), 11067898 (1), 16778825 (1), 8168136 (1) (see all 11)
    myeloma 50.3 8 15195108 (2), 16982896 (1), 18192112 (1), 17877160 (1) (see all 6)
    lymphoma large cell diffuse 41.6 1 16492805 (1)
    virus infection 3.17 6 19664943 (3), 16708403 (1), 14985713 (1)
    hodgkin disease 0.852 1 16585013 (1)
    leukemia 0 3 11841448 (1), 8921366 (1)
    tumors 0 10 16585013 (2), 20047096 (2), 16492805 (2), 18596541 (1) (see all 5)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: PRDM1 (6 documents)

    Export disorders and mutations for PRDM1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/143 PubMed articles for PRDM1 gene, integrated from 7 sources (see all 143):
    (articles sorted by number of sources associating them with PRDM1)
    1. Identification and characterization of a novel repressor of beta- interferon gene expression. (PubMed id 1851123)1, 2, 3, 7 Keller A.D. and Maniatis T. (1991)
    2. Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. (PubMed id 12626569)1, 2, 7 Gyory I.... Wright K.L. (2003)
    3. Regulation and functions of Blimp-1 in T and B lymphocytes. (PubMed id 18370921)1, 7 Martins G. and Calame K. (2008)
    4. Induction of apoptosis in plasma cells by B lymphocyte-induced maturation protein-1 knockdown. (PubMed id 18089822)1, 7 Lin F.R....Lin K.I. (2007)
    5. Human BSAP and BLIMP1 conform an autoregulatory feedback loop. (PubMed id 17682124)1, 7 Mora-Lopez F....Campos-Caro A. (2007)
    6. Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. (PubMed id 10713181)1, 7 Yu J....Calame K. (2000)
    7. Blimp-1 is a tumor suppressor gene in lymphoid malign ancies. (PubMed id 20047096)1, 7 Hangaishi A. and Kurokawa M. (2010)
    8. Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. (PubMed id 16492805)1, 7 Pasqualucci L....Dalla-Favera R. (2006)
    9. Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo. (PubMed id 11067898)1, 7 Angelin-Duclos C....Calame K. (2000)
    10. Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. (PubMed id 19124609)1, 7 Su S.T....Lin K.I. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 639 HGNC: 9346 AceView: PRDM1 Ensembl:ENSG00000057657 euGenes: HUgn639
    ECgene: PRDM1 H-InvDB: PRDM1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for PRDM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for PRDM1 gene:
    Search GeneIP for patents involving PRDM1

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