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PRDX2 Gene

protein-coding   GIFtS: 70

GC19M012479
peroxiredoxin 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TDPX1)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
peroxiredoxin 21 2     Thioredoxin-dependent peroxide reductase 12 3
PRP1 2 3     TDPX12 3
TSA1 2 3     NKEF-B2 3
NKEFB1 2 3     natural killer-enhancing factor B2
MGC41041 2     torin2
PRX21 2     peroxiredoxin-22
PRXII1 2     thiol-specific antioxidant 12
Thioredoxin peroxidase 12 3     TPX12
Natural killer cell-enhancing factor B2 3     EC 1.11.1.153
Thiol-specific antioxidant protein2 3     

External Ids:    HGNC: 93531   Entrez Gene: 70012   Ensembl: ENSG000001678157   UniProtKB: P321193   

Export aliases for PRDX2 gene to outside databases

Previous GC identifers: GC19M013039 GC19M013130 GC19M012752 GC19M012768 GC19M012907


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRDX2:
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl
hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the
antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer
development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript
variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: PRDX2_HUMAN, P32119
Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the
thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating
peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor
necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)

Gene Wiki entry for PRDX2 (Peroxiredoxin 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRDX2 gene promoter:
         Egr-1   STAT1alpha   STAT1   STAT1beta   C/EBPbeta   IRF-1   AhR   NF-kappaB   AP-1   c-Fos   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PRDX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PRDX2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

PRDX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDX2 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012479:  view genomic region     (about GC identifiers)

Start:
12,479,370 bp from pter
End:
12,484,430 bp from pter
Size:
5,061 bases
Orientation:
minus strand

1 alternative location:
Chr19- 12,907,634-12,912,694     
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PRDX2_HUMAN, P32119 (See protein sequence)
Recommended Name: Peroxiredoxin-2  
Size: 198 amino acids; 21892 Da
Subunit: Homodimer; disulfide-linked, upon oxidation. May be found as a toroid-shaped decamer composed of 5 dimers,
depending on pH and calcium concentration. Interacts with TIPIN
Subcellular location: Cytoplasm
Miscellaneous: The active site is the redox-active Cys-51 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-172-SH
of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be
subsequently regenerated by reduction of the disulfide by thioredoxin
Miscellaneous: Inactivated upon oxidative stress by overoxidation of Cys-51 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is
retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized
PDB structures from and Proteopedia :
1QMV (3D)    
Secondary accessions: P31945 P32118 P35701 Q6FHG4 Q92763 Q9UC23

Explore the universe of human proteins at neXtProt for PRDX2: NX_P32119 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_005800.3  NP_859428.1  


    ENSEMBL proteins: 
    ENSP00000334063 ENSP00000408139 ENSP00000301522 ENSP00000408905 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins and AQUA Peptides for PRDX2
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PRDX2
    OriGene Protein Over-expression Lysate: PRDX2
    GenScript Custom Purified and Recombinant Proteins Services for PRDX2 
    Novus Biologicals Proteins for PRDX2
    Novus Biologicals Lysates for PRDX2
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PRDX2

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm TAS16130169
    GO:0005739 mitochondrion IEA--
    About this table

    PRDX2 for ontologies           About GeneDecksing



    Antibodies for PRDX2: 
    Millipore Mono- and Polyclonal Antibodies for the study of PRDX2
    Sigma-Aldrich Antibodies for PRDX2
    R&D Systems Antibodies for PRDX2 (Peroxiredoxin 2)
    OriGene Antibodies (see all 2): PRDX2
    GenScript Custom Superior Antibodies Services for PRDX2 
    Novus Biologicals Antibodies for PRDX2
    Epitomics antibodies for PRDX2

    Assays for PRDX2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRDX2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PRDX2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PRDX2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR019479 Peroxiredoxin_C
     IPR012336 Thioredoxin-like_fold
     IPR012335 Thioredoxin_fold
     IPR000866 AhpC/TSA
     IPR017936 Thioredoxin-like

    Graphical View of Domain Structure for InterPro Entry P32119

    ProtoNet protein and cluster: P32119

    1 Blocks protein family: IPB000866 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

    UniProtKB/Swiss-Prot: PRDX2_HUMAN, P32119
    Similarity: Belongs to the ahpC/TSA family
    Similarity: Contains 1 thioredoxin domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PRDX2_HUMAN, P32119
    Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the
    thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating
    peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor
    necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)
    Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH
    Enzyme Number (IUBMB): EC 1.11.1.15 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for PRDX2
    Sigma-Aldrich shRNA for PRDX2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): PRDX2
    OriGene shRNA RFP (see all 5): PRDX2
    OriGene basic RS shRNA (see all 5): PRDX2
    OriGene siRNA (see all 3): PRDX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PRDX2 
    miRNA:Sigma-Aldrich microRNA Mimics for PRDX2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PRDX2 
    Search SABiosciences for Assays for microRNAs that regulate PRDX2

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PRDX2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PRDX2
    OriGene untagged cDNA clones in CMV expression vector (see all 3): PRDX2
    OriGene 3'-UTR clone (see all 2): PRDX2 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): PRDX2 
    Sino Biological Human cDNA Clone for PRDX2

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PRDX2 

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IEA--
    GO:0008379 thioredoxin peroxidase activity TAS18606987
    GO:0016209 antioxidant activity NAS12943237
    GO:0016491 oxidoreductase activity IEA--
    About this table

    PRDX2 for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prdx2):

    cellularhematopoietic systemhomeostasis/metabolismimmune system

    PRDX2 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    PRDX2 for pathways           About GeneDecksing

    1 Millipore Pathway for PRDX2
        Prostaglandin 2 biosynthesis and metabolism FM

    3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  PRDX2
        Stilbene, Coumarine and Lignin Biosynthesis
    Methane Metabolism
    Phenylalanine Metabolism

        SABiosciences Pathway-Focused PCR Arrays including PRDX2 (see all 5): PAHS-003A PAHS-062A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PRDX2
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRDX2

    1 Interacting protein for PRDX2 (P321192) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TXNP105992MINT-5115275
    About this table

    5/18 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 18):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187 activation of MAPK activity IEA--
    GO:0002536 respiratory burst involved in inflammatory response IEA--
    GO:0006916 anti-apoptosis TAS16130169
    GO:0006979 response to oxidative stress NAS11904290
    GO:0010310 regulation of hydrogen peroxide metabolic process IEA--
    About this table

    PRDX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PRDX2 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRDX2
    10/21 Novoseek chemical compound relationships for PRDX2 gene (see all 21)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ammonium molybdate 61.6 2 11410278 (1), 16839769 (1)
    glyceraldehyde 3-phosphate 61.4 6 18156650 (1), 18647502 (1), 17522728 (1), 16540677 (1) (see all 6)
    isocitrate 56 4 18647502 (1), 15292099 (1), 15936593 (1), 16009011 (1)
    h2o2 51.3 16 8663080 (4), 16045763 (3), 17329258 (2), 9356316 (2) (see all 9)
    oxygen 26.7 9 16288023 (2), 11152390 (1), 15259009 (1), 7607688 (1) (see all 7)
    superoxide 25.8 8 12401949 (1), 15158439 (1), 16372267 (1), 11762590 (1) (see all 8)
    trehalose 23.4 2 17522728 (1), 11410278 (1)
    nicotinamide 23.3 1 12555668 (1)
    dithiothreitol 11.9 7 8663080 (2), 8123012 (1)
    nad+ 11.3 1 15947248 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for PRDX2
    Sigma-Aldrich shRNA for PRDX2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): PRDX2
    OriGene shRNA RFP (see all 5): PRDX2
    OriGene basic RS shRNA (see all 5): PRDX2
    OriGene siRNA (see all 3): PRDX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PRDX2 
    miRNA: Sigma-Aldrich microRNA Mimics for PRDX2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PRDX2 
    Search SABiosciences for Assays for microRNAs that regulate PRDX2
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PRDX2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PRDX2
    OriGene untagged cDNA clones in CMV expression vector (see all 3): PRDX2
    OriGene 3'-UTR Clone (see all 2): PRDX2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): PRDX2 
    Primers: OriGene genome-wide validated SYBR primer pairs: PRDX2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PRDX2: PPH00069A

    REFSEQ mRNAs for PRDX2 gene (2 alternative transcripts): 

    NM_005809.4  NM_181738.1  

    Additional cDNA sequence: 

    AK289485.1 AK293957.1 BC000452.2 BC003022.1 BC039428.1 CR450356.1 CR541789.1 CR594988.1 
    CR598714.1 CR599094.1 CR599252.1 CR600194.1 CR601986.1 CR602223.1 CR602550.1 CR605244.1 
    CR606963.1 CR611026.1 CR615046.1 CR616344.1 CR620967.1 CR622487.1 CR622535.1 CR623841.1 
    CR624097.1 CR625757.1 X82321.1 Z22548.1 

    22 DOTS entries:

    DT.40205724  DT.91770119  DT.92324962  DT.100883045  DT.100883050  DT.121434504  DT.95276743  DT.100883043 
    DT.100060112  DT.100883038  DT.92047475  DT.100883036  DT.100883051  DT.100883052  DT.120789846  DT.121434506 
    DT.121434510  DT.91770120  DT.99944330  DT.100737839  DT.91770137  DT.95276744 

    24/1272 AceView cDNA sequences (see all 1272):

    F03585 F35275 CR602550 NM_181738 BI771061 AA338776 BI752960 BQ348560 
    BU660953 BM982600 BU661303 AJ346466 AU107633 BG504395 BG741335 BF929977 
    BQ901129 CB306097 F36857 AI299982 BE264790 AV710261 BG110851 BI117869 

    highest scoring ESTs for PRDX2:

    AA190913 AA292014 AA295761 AA305860 AA306058 AA308026 AA311864 AA316059 AA325627 AA328252 

    Unigene Cluster for PRDX2:

    Peroxiredoxin 2
    Hs.432121  [show with all ESTs]
    Unigene Representative Sequence: BM805899


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PRDX2 (see all 6)

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                    -                       -                           
    SP2:                    -                       -     -                     
    SP3:                    -                                                   
    SP4:                    -                                                   
    SP5:                    -           -           -                           

    About this scheme

    ECgene alternative splicing isoforms for PRDX2
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466174(uc002mve.1) ENST00000477555 ENST00000334482 ENST00000478908
    ENST00000428341 ENST00000301522(uc002mvd.2) ENST00000435703 ENST00000498785


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PRDX2 expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching PRDX2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39729_at2, 3 U133-A 1 0.94 1.00 1.00 1.00 L19185 0.80 1.00 0.91 1
    39729_at2, 3 U133-A 1 0.94 1.00 -- -- L19185 0.80 1.00 0.91 1
    201006_at2, 3 U133-A 1 0.64 1.00 -- -- NM_005809 0.60 1.00 0.82 1
    211658_at2, 3 U133-A 1 0.46 1.00 -- -- L19185 0.80 1.00 0.91 1
    215067_x_at2, 3 U133-A 1 0.27 1.00 -- -- AU147942 0.20 1.00 0.72 1
    39729_at2 U133Plus2 1 0.94 1.00 -- -- -- -- -- -- --
    201006_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    211658_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    215067_x_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    About this table

    PRDX2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PRDX2 gene expression
    PRDX2 gene electronic northern expression
    PRDX2 gene sage expression
    About these images

    CGAP SAGE TAG: CCTCCACCTA

    SOURCE GeneReport for Unigene cluster: Hs.432121

    Expression variation in blood from EXPOLDB for PRDX2

    Primers: OriGene genome-wide validated SYBR primer pairs: PRDX2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PRDX2: PPH00069A
        SABiosciences Expression via Pathway-Focused PCR Arrays including PRDX2 (see all 5): PAHS-003A PAHS-062A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PRDX2 gene from 5/14 species (see all 14)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PRDX21   -- peroxiredoxin 2 88.22(n)
    93.43(a)
    484926  XM_862333.1  XP_867426.1 
    chimpanzee
    (Pan troglodytes)
    PRDX21   -- peroxiredoxin 2 99.83(n)
    100(a)
    468740  XM_524127.2  XP_524127.2 
    cow
    (Bos taurus)
    PRDX21   -- peroxiredoxin 2 87.39(n)
    91.19(a)
    286793  NM_174763.2  NP_777188.1 
    rat
    (Rattus norvegicus)
    Prdx21   -- peroxiredoxin 2 87.04(n)
    93.43(a)
    29338  NM_017169.1  NP_058865.1 
    mouse
    (Mus musculus)
    Prdx21 , 5 8 (41.40 cM)5
    peroxiredoxin 21, 5 86.87(n)1
    91.41(a)1
    216721  NM_011563.31  NP_035693.21 
     AF0327165  AF0327175  (see all 26)
    About this table        Species with no ortholog for PRDX2

    ENSEMBL Gene Tree for PRDX2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PRDX2 gene
    PRDX32  PRDX12  PRDX42  

    PRDX2 for paralogs           About GeneDecksing


    Pseudogenes
    2 related pseudogenes



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/69 NCBI SNPs in PRDX2 are shown (see all 69)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs10566481,2
    --12911076(-) GCCCCC/TTGAAC 3 L ng31 ref1 syn1 ese30--------
    rs10573821,2
    --12907751(-) GAGGGC/GTAGGC 1 -- ut311Minor allele frequency- G:0.00MN 184
    rs10574431,2
    --12907736(-) GCCTTC/TTCATG 1 -- ut311Minor allele frequency- T:0.00MN 184
    rs10641441,2
    --12912588(-) CGCGTG/TTGATC 2 -- ut51 ese31Minor allele frequency- T:0.00MN 184
    rs11350051,2
    H12910996(-) ATTGCT/CTACAG 3 /A ref1 syn1 ng31 ese34Minor allele frequency- C:0.00NS EA 406
    rs12051711,2
    C,F,A,H,12911340(+) CATGTG/ACTTGT 2 -- ng31 int123Minor allele frequency- A:0.40NS EA NA WA 2635
    rs18040131,2
    --12907816(-) GGTGCC/TCTATG 1 -- ut310--------
    rs18040141,2
    --12912027(-) TCAAGG/TCCACA 4 A S ref1 mis10--------
    rs31980341,2
    C12907725(-) CCTCCA/CCCTAG 1 -- ut311Minor allele frequency- C:0.00MN 184
    rs72511401,2
    --12913658(+) gcggtA/Ggctca 2 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for PRDX2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PRDX2
         1 CNV: 4400

    QIAGEN SeqTarget long-range PCR primers for resequencing PRDX2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PRDX2 for disorders           About GeneDecksing

    OMIM: 600538

    8 Novoseek disease relationships for PRDX2 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 35.8 13 16038965 (2), 20363977 (2), 20477814 (1), 17124717 (1) (see all 10)
    tumors 13.1 6 15936593 (2), 18424265 (1), 19444892 (1), 18037904 (1)
    cancer 13 11 17679169 (3), 17600477 (3), 15986332 (1), 19016754 (1) (see all 7)
    breast cancer 6.45 3 7607688 (1), 11469800 (1), 16288023 (1)
    necrosis 2.26 1 18037904 (1)
    carcinoma squamous cell 0 1 15986332 (1)
    metastasis 0 2 16192647 (1), 15936593 (1)
    carcinoma 0 1 17443844 (1)
    About this table

    1 PharmGKB disease relationship for PRDX2 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table

    Human Genome Epidemiology (HuGE) Navigator: PRDX2 (5 documents)

    Export disorders and mutations for PRDX2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/164 PubMed articles for PRDX2 gene, integrated from 7 sources (see all 164):
    (articles sorted by number of sources associating them with PRDX2)
    1. Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12. (PubMed id 7607688)1, 3, 7 Pahl P....Patterson D. (1995)
    2. The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions. (PubMed id 8144038)1, 2, 7 Lim Y.-S.... Kim I.-H. (1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress. (PubMed id 12853451)1, 2 Chevallet M....Rabilloud T. (2003)
    5. Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site. (PubMed id 11904290)1, 2 Rabilloud T.... Lunardi J. (2002)
    6. Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution. (PubMed id 10873855)1, 2 Schroeder E.... Isupov M.N. (2000)
    7. A two-dimensional gel database of human colon carcinoma proteins. (PubMed id 9150948)1, 2 Ji H.... Simpson R.J. (1997)
    8. Cloning and sequence analysis of candidate human natural killer- enhancing factor genes. (PubMed id 8026862)1, 2 Shau H.... Kim A. (1994)
    9. Plasma and red blood cell protein maps: update 1993. (PubMed id 8313871)1, 2 Golaz O.... Hochstrasser D.F. (1993)
    10. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7001 HGNC: 9353 AceView: PRDX2 Ensembl:ENSG00000167815 euGenes: HUgn7001
    ECgene: PRDX2 H-InvDB: PRDX2

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for PRDX2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/prdx2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for PRDX2 gene:
    Search GeneIP for patents involving PRDX2

    GeneCards and IP:
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