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PRKCG Gene

protein-coding   GIFtS: 74

GC19P050704
protein kinase C, gamma
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: PKCG, SCA14)
Products    

Aliases &
Descriptions
for PRKCG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
protein kinase C, gamma1 2     PKC-gamma2 3
PKCC1 2 5     SCA142 5
PKCG2 3 5     protein kinase C gamma type2
MGC575641 2     EC 2.7.11.133

External Ids:    HGNC: 94021   Entrez Gene: 55822   Ensembl: ENSG000001265837   UniProtKB: P051293   

Export aliases for PRKCG gene to outside databases

Previous GC identifers: GC19P055031 GC19P054810 GC19P059061 GC19P059077 GC19P054382


Summaries
for PRKCG gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRKCG:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium
and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known
to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class
of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct
roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed
solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that
several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically
require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain
development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14
(SCA14). (provided by RefSeq)

UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129
Function: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme
Function: PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves
as the receptor for phorbol esters, a class of tumor promoters

summary for PRKCG:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCG

Genomic Views
for PRKCG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKCG gene promoter:
         TFIID   TBP   CREB   deltaCREB   GR-alpha   SRF   p53   PPAR-gamma1   PPAR-gamma2   GR-beta   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PRKCG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

PRKCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCG gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050704:  view genomic region     (about GC identifiers)

Start:
 50,704,660 bp from pter
End:
 50,730,288 bp from pter
Size:
 25,629 bases
Orientation:
 plus strand

1 alternative location:
Chr19+ 54,382,444-54,410,906     
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  

Proteins
for PRKCG gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129 (See protein sequence)
Recommended Name: Protein kinase C gamma type  
Size: 697 amino acids; 78448 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity)
Subunit: Interacts with CDCP1
PDB structure from and Proteopedia :
2E73 (3D)    2UZP (3D)    

Explore the universe of human proteins at neXtProt for PRKCG: NX_P05129 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_002730.1  

    ENSEMBL proteins: 
    ENSP00000263431 ENSP00000387919 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant PRKCG Protein
    Sigma-Aldrich Proteins for PRKCG
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PRKCG
    OriGene Protein Over-expression Lysate: PRKCG
    GenScript Custom Purified and Recombinant Proteins Services for PRKCG 
    Novus Biologicals Protein for PRKCG
    Novus Biologicals Lysate for PRKCG
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PRKCG

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005829 cytosol EXP9814702
    GO:0019717 synaptosome IEA--
    GO:0030425 dendrite IEA--
    About this table

    PRKCG for ontologies           About GeneDecksing



    Antibodies for PRKCG: 
    Millipore Mono- and Polyclonal Antibodies for the study of PRKCG
    Sigma-Aldrich Antibodies for PRKCG
    R&D Systems Antibodies for PRKCG (PKC gamma)
    Cell Signaling Technology (CST) Antibodies for PRKCG  (PKCgamma)
    OriGene Antibodies (see all 2): PRKCG
    GenScript Custom Superior Antibodies Services for PRKCG 
    Novus Biologicals Antibodies for PRKCG
    Epitomics antibodies for PRKCG

    Assays for PRKCG: 
    Millipore Kits and Assays for the Analysis of PRKCG
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKCG 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for PRKCG gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRKCG for domains           About GeneDecksing

    5/16 InterPro domains/families (see all 16):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry P05129

    ProtoNet protein and cluster: P05129

    3 Blocks protein families:
    IPB000008 C2 domain
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    Gene Function
    for PRKCG gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129
    Function: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme
    Function: PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves
    as the receptor for phorbol esters, a class of tumor promoters
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme Number (IUBMB): EC 2.7.11.13 

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for PRKCG
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PRKCG
    Sigma-Aldrich shRNA Panels and shRNA for PRKCG
    OriGene 29mer shRNA kits in GFP-retroviral vector: PRKCG
    OriGene shRNA RFP: PRKCG
    OriGene basic RS shRNA: PRKCG
    OriGene siRNA: PRKCG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PRKCG 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PRKCG 
    2 SABiosciences Assays for microRNAs that regulate PRKCG:
    hsa-miR-608 hsa-miR-766

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PRKCG
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PRKCG
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PRKCG
    OriGene 3'-UTR clone: PRKCG 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PRKCG 
    Sino Biological Human cDNA Clone for PRKCG

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for PRKCG 

    Genatlas biochemistry entry for PRKCG:
    protein kinase C,gamma polypeptide

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity IDA15808853
    GO:0004674 protein serine/threonine kinase activity ----
    GO:0004697 protein kinase C activity IEA--
    GO:0005524 ATP binding IEA--
    About this table

    PRKCG for ontologies           About GeneDecksing

    Animal Models: 6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Prkcc):

    behavior/neurologicalimmune systemnervous systemnormaltaste/olfaction
    touch/vibrissae

    PRKCG for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PRKCG gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    PRKCG for pathways           About GeneDecksing

    5/14 Millipore Pathways for PRKCG (see all 14)
        Transcription Transcription factor Tubby signaling pathways
    Development VEGF signaling and activation
    Development Angiotensin signaling via beta-Arrestin
    Signal transduction Calcium signaling
    Signal transduction IP3 signaling

    5/62 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  PRKCG (see all 62)
        Thrombopoietin Signaling
    NRF2-mediated Oxidative Stress Response
    Growth Hormone Signaling
    IL-12 Signaling and Production in Macrophages
    IL-8 Signaling

    5/25 Kegg Pathways  (Kegg details for PRKCG) (see all 25):
        hsa04010 MAPK signaling pathway
    hsa04012 ErbB signaling pathway
    hsa04020 Calcium signaling pathway
    hsa04070 Phosphatidylinositol signaling system
    hsa04270 Vascular smooth muscle contraction

        SABiosciences Pathway-Focused PCR Arrays including PRKCG (see all 5): PAHS-030A PAHS-057A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PRKCG
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKCG

    5/100 Interacting proteins for PRKCG (ENSP000002634313 P051292) via UniProtKB, MINT, and/or STRING (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PICK1Q9NRD52MINT-2866769 MINT-2866750
    PTPN1P180312MINT-6795361 MINT-6794972
    CCHCR1Q8TD312MINT-2873755
    ENSG00000206355Q8TD312
    ENSG00000234114Q8TD312
    About this table

    5/14 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 14):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein phosphorylation IEA--
    GO:0007202 activation of phospholipase C activity TAS--
    GO:0007268 synaptic transmission TAS--
    GO:0007596 blood coagulation TAS--
    GO:0007611 learning or memory IEA--
    About this table

    PRKCG for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRKCG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PRKCG for compounds           About GeneDecksing

    Sigma-Aldrich Small Molecules for PRKCG:
    Small Molecule - Inhibitor Small Molecule - Agonist
    Enzo Life Sciences drugs & compounds for PRKCG

    Compounds for PRKCG available from Tocris Bioscience
    CompoundAction CAS number
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    About this table


    10/19 Novoseek chemical compound relationships for PRKCG gene (see all 19)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 83.6 7 12954613 (2), 17784814 (1)
    aristolochic acid 50.5 1 15917990 (1)
    gf 109203x 44.9 1 15917990 (1)
    phorbol 12,13-dibutyrate 44.8 8 8051084 (4)
    phosphatidylserine 42.5 5 8051084 (2), 17878267 (1)
    threonine 42.1 5 12438709 (1), 16189624 (1), 12644968 (1)
    phorbol 39.7 1 10428394 (1)
    12-o-tetradecanoylphorbol 13-acetate 36.5 3 11313866 (2), 1388136 (1)
    serine 31 7 12438709 (1), 16189624 (1), 18652891 (1), 12644968 (1) (see all 5)
    calcium 24 25 16571747 (3), 17878267 (3), 8051084 (3), 15917990 (2) (see all 12)
    About this table



    Transcripts
    for PRKCG gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for PRKCG
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PRKCG
    Sigma-Aldrich shRNA Panels and shRNA for PRKCG
    OriGene 29mer shRNA kits in GFP-retroviral vector: PRKCG
    OriGene shRNA RFP: PRKCG
    OriGene basic RS shRNA: PRKCG
    OriGene siRNA: PRKCG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PRKCG 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PRKCG 
    2 SABiosciences Assays for microRNAs that regulate PRKCG:
    hsa-miR-608 hsa-miR-766
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PRKCG
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PRKCG
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PRKCG
    OriGene 3'-UTR Clone: PRKCG 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PRKCG 
    Primers: OriGene genome-wide validated SYBR primer pairs: PRKCG
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PRKCG: PPH02186A

    REFSEQ mRNAs for PRKCG gene: 

    NM_002739.3  

    Additional cDNA sequence: 

    AB209671.1 AF345987.1 AK296412.1 AK296434.1 AK302958.1 AK303741.1 AK312302.1 BC047876.1 
    M13977.1 Z15114.1 

    2 DOTS entries:

    DT.411273  DT.95351170 

    24/41 AceView cDNA sequences (see all 41):

    F06530 F09673 Z15114 T28078 AL133962 AA338339 F12027 BX101823 
    T16339 H14047 BC047876 NM_002739 M13977 T65563 T65631 CB155791 
    BI757265 AF345987 F07006 F02800 BI490011 Z40116 BM926293 H50904 

    highest scoring ESTs for PRKCG:

    Z15114 AA989401 AF345987 BC047876 F06530 AA338339 AL133962 AL137986 AW027690 AW868123 

    Unigene Cluster for PRKCG:

    Protein kinase C, gamma
    Hs.631564  [show with all ESTs]
    Unigene Representative Sequence: NM_002739


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479081 ENST00000474397 ENST00000263431(uc010eqz.1 uc010yef.1 uc010yeg.1 uc002qcq.1 uc010yeh.1)
    ENST00000419486

    Expression
    for PRKCG gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PRKCG expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching PRKCG gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    363_at2, 3 U95-A 1 1.00 1.00 0.94 0.71 Z15114 1.00 1.00 1.00 1
    48335_at2, 3 U95-B 1 0.62 1.00 0.85 1.30 AA989401 0.80 1.00 0.91 1
    206270_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002739 0.60 1.00 0.82 1
    236195_x_at2, 3 U133-B 1 0.82 1.00 -- -- AW027690 0.60 1.00 0.82 1
    206270_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    236195_x_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    PRKCG for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PRKCG gene expression
    PRKCG gene electronic northern expression
    PRKCG gene sage expression
    About these images

    CGAP SAGE TAG: GCTCCTGTCT

    SOURCE GeneReport for Unigene cluster: Hs.631564

    Expression variation in blood from EXPOLDB for PRKCG

    Primers: OriGene genome-wide validated SYBR primer pairs: PRKCG
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PRKCG: PPH02186A
        SABiosciences Expression via Pathway-Focused PCR Arrays including PRKCG (see all 5): PAHS-030A PAHS-057A  


    Orthologs
    for PRKCG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for PRKCG gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 PRKCG1   -- protein kinase C, gamma 88.99(n)
    94.49(a)    		 484316  XM_541432.2  XP_541432.2 
    cow
    (Bos taurus)    		 PRKCG1   -- protein kinase C, gamma 91.77(n)
    98.13(a)    		 282002  XM_602125.3  XP_602125.3 
    rat
    (Rattus norvegicus)    		 Prkcg1   -- protein kinase C, gamma 89.96(n)
    99(a)    		 24681  NM_012628.1  NP_036760.1 
    mouse
    (Mus musculus)    		 Prkcc1 , 5 7 (1.93 cM)5
    		 protein kinase C, gamma1, 5 89.48(n)1
    99(a)1    		 187521  NM_011102.31  NP_035232.11 
     AC0795575  AK1444195  (see all 10)
    zebrafish
    (Danio rerio)    		 LOC1000035141   -- similar to Protein kinase C gamma type (PKC-gamma) 67.49(n)
    71.12(a)    		 100003514  XM_001921680.1  XP_001921715.1 
    About this table        Species with no ortholog for PRKCG

    ENSEMBL Gene Tree for PRKCG (if available)

    Paralogs
    for PRKCG gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PRKCG gene
    PRKCB2  PRKCA2  PRKCZ2  PRKCI2  

    PRKCG for paralogs           About GeneDecksing



    Genomic Variants
    for PRKCG gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/371 NCBI SNPs in PRKCG are shown (see all 371)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs3079411,2
    		C,F,H,54385104(+) GAACCC/TTAGCG 1 -- ng5112Minor allele frequency- T:0.08MN NS EA NA WA 692
    rs3079421,2
    		C,H,54385437(+) CCCCCC/AACCCG 1 -- ng515Minor allele frequency- A:0.13MN NA 194
    rs3079431,2
    		C,F,A,54404476(+) AAGTGG/TACTGG 1 -- int112Minor allele frequency- T:0.17NS EA NA WA 508
    rs3079441,2
    		C,F,A,H,54394301(-) ATTgcC/Tgggca 1 -- int19Minor allele frequency- T:0.09NS EA NA 498
    rs3079451,2
    		C,F,A,H,54392826(+) ATAAAA/CGGGCC 1 -- int17Minor allele frequency- C:0.08NS EA NA WA 540
    rs3079461,2
    		C,F,A,H,54392748(+) gtgctC/Gaatga 1 -- int16Minor allele frequency- G:0.10NS EA WA NA 460
    rs3079471,2
    		C,F,A,H,54392581(-) GGGTGC/TTCTGG 1 -- int19Minor allele frequency- T:0.12NS EA NA 634
    rs3079481,2
    		--54392459(-) aggccC/Gaggtg 1 -- int10--------
    rs3079491,2
    		--54392316(+) attctC/Tatgcc 1 -- int10--------
    rs3079501,2
    		C,F,A,H54392259(+) tggagC/Tgcagt 1 -- int12Minor allele frequency- T:0.50NA WA 6
    About this table

    HapMap Linkage Disequilibrium images for PRKCG (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PRKCG
         1 CNV: 5115

    QIAGEN SeqTarget long-range PCR primers for resequencing PRKCG 

    Disorders & Mutations
    for PRKCG gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRKCG for disorders           About GeneDecksing

    OMIM: 176980   disorders: 605361  

    UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129

  • Defects in PRKCG are the cause of spinocerebellar ataxia type 14 (SCA14) [MIM:605361]. Spinocerebellar ataxia
    • is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination
    of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with
    variable involvement of the brainstem and spinal cord. SCA14 is an autosomal dominant cerebellar ataxia (ADCA)

    4 Novoseek disease relationships for PRKCG gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sca14 96.9 59 18577575 (5), 15618281 (4), 16763984 (3), 14676051 (3) (see all 16)
    spinocerebellar ataxias 85.2 25 18577575 (2), 16763984 (2), 15313841 (2), 17562946 (1) (see all 13)
    neurodegenerative diseases 41.5 8 18577575 (1), 16763984 (1), 17822669 (1)
    tumors 3.21 1 9113106 (1)
    About this table

    GeneTests: PRKCG
    Spinocerebellar Ataxia Type14

    Locus Specific Mutation Databases (LSDB): PRKCG
    Human Gene Mutation Database (HGMD): PRKCG
    Genetic Association Database (GAD): PRKCG
    Human Genome Epidemiology (HuGE) Navigator: PRKCG (7 documents)

    Export disorders and mutations for PRKCG gene to outside databases

    Medical News
    for PRKCG gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for PRKCG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/230 PubMed articles for PRKCG gene, integrated from 7 sources (see all 230):
    (articles sorted by number of sources associating them with PRKCG)
    1. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. (PubMed id 3755548)1, 2, 3 Coussens L....Ullrich A. (1986)
    2. Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia. (PubMed id 12644968)1, 2, 7 Chen D.-H.... Raskind W.H. (2003)
    3. New mutations in protein kinase Cgamma associated with spinocerebellar ataxia type 14. (PubMed id 16193476)1, 4, 7 Klebe S....Stevanin G. (2005)
    4. The C2 domain of PKCdelta is a phosphotyrosine binding domain. (PubMed id 15851033)1, 2 Benes C.H.... Soltoff S.P. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. No mutations in the coding region of the PRKCG gene in three families with retinitis pigmentosa linked to the RP11 locus on chromosome 19q. (PubMed id 10441600)1, 2 Dryja T.P.... Berson E.L. (1999)
    7. Segregation of a PRKCG mutation in two RP11 families. (PubMed id 9545390)1, 2 Al-Maghtheh M....Bhattacharya S.S. (1998)
    8. Fluorescence in situ hybridization mapping of human c hromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA mark ers. (PubMed id 8432525)1, 3 Trask B....Carrano A. (1993)
    9. Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes. (PubMed id 8375396)1, 2 Kochs G.... Sarre T.F. (1993)
    10. PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling. (PubMed id 18577575)1, 7 Verbeek D.S....Reits E.A. (2008)

    External Searches for PRKCG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRKCG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5582 HGNC: 9402 AceView: PRKCG Ensembl:ENSG00000126583 euGenes: HUgn5582
    ECgene: PRKCG Kegg: 5582 H-InvDB: PRKCG

    Other Databases showing PRKCG gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRKCG gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for PRKCG Genetics and Cytogenetics in Oncology and Haematology
    Mutations of the PRKCG genehttp://www.retina-international.com/sci-news/prkcgmut.htm
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PRKCG

    Intellectual Property
    for PRKCG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for PRKCG gene:
    Search GeneIP for patents involving PRKCG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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