Aliases &
Descriptions
for PRTFDC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| phosphoribosyl transferase domain containing 11 2 | | HHGP1 2 3 | | phosphoribosyltransferase domain-containing protein 12 | | FLJ118882 | | OTTHUMP000000193322 |
Export aliases for PRTFDC1 gene to outside databasesPrevious GC identifers: GC10M025141 GC10M025177 |
Summaries
for PRTFDC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PRTFDC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRTFDC1 gene promoter:
HOXA9B Meis-1 FOXL1 AP-1 c-Fos c-Jun Pax-5 JunD Fra-1 JunB
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRTFDC1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p12.1 Ensembl cytogenetic band: 10p12.1 HGNC cytogenetic band: 10p12.31PRTFDC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M024799: view genomic region
(about GC identifiers)
Start:
|
24,799,013 bp from pter |
End:
|
24,902,637 bp from pter |
Size:
|
103,625 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr10- 25,137,554-25,241,533 |
RefSeq DNA sequence:- NC_000010.10 NT_008705.16
|
Proteins
for PRTFDC1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PRDC1_HUMAN, Q9NRG1 (See
protein sequence)Recommended Name: Phosphoribosyltransferase domain-containing protein 1 Size: 225 amino acids; 25674 Da
Sequence caution: Sequence=BAD93029.1; Type=Erroneous initiation;
PDB structures from  and Proteopedia  :2JBH (3D)
Secondary accessions: B7Z1Z3 Q53HA7 Q59EL9 Q5VV18 Q5VV20Alternative splicing: 3 isoforms: Q9NRG1-1 Q9NRG1-2 Q9NRG1-3 Explore the universe of human proteins at neXtProt for PRTFDC1: NX_Q9NRG1
REFSEQ proteins: NP_064585.1
ENSEMBL proteins: ENSP00000318602 ENSP00000365558 ENSP00000351096 ENSP00000365556
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
PRTFDC1 for ontologies About GeneDecksing
Antibodies for PRTFDC1:
Assays for PRTFDC1: |
Protein
Domains/
Families
for PRTFDC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRTFDC1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NRG1ProtoNet protein and cluster: Q9NRG1 UniProtKB/Swiss-Prot: PRDC1_HUMAN, Q9NRG1Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family |
Gene Function
for PRTFDC1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000287 | magnesium ion binding |
ISS | -- | | GO:0004422 | hypoxanthine phosphoribosyltransferase activity |
ISS | -- |
About this table
PRTFDC1 for ontologies About GeneDecksing
|
Pathways & Interactions
for PRTFDC1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
PRTFDC1 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for PRTFDC1
SABiosciences Custom Pathway-Focused PCR Arrays for PRTFDC1
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PRTFDC1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRTFDC1
5/7 Interacting proteins for PRTFDC1 (Q9NRG12) via UniProtKB, MINT, and/or STRING (see all 7)About this table
5/16 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 16): About this table
PRTFDC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PRTFDC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PRTFDC1
|
Transcripts
for PRTFDC1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PRTFDC1 gene: NM_020200.5 Additional cDNA sequence: AB209792.1 AF226056.1 AK021950.1 AK222674.1 AK294130.1 AK304055.1 AK309614.1 BC008662.2 CR596757.1 CR615591.1 CR617937.1 CR619546.1 8 DOTS entries: DT.409886 DT.75154558 DT.100774630 DT.91749750 DT.91749752 DT.121280446 DT.97807895 DT.121280444 24/108 AceView cDNA sequences (see all 108): AL535461 AK021950 AW026416 AL544876 AA557390 CR617937 BC008662 CK818776 CR596757 BI768153 AA358233 CR619546 AU120059 BM768969 BM831070 BM823597 NM_020200 BM821338 BP362073 BU151307 AV682666 BX440549 BM766205 AA007505
 highest scoring ESTs for PRTFDC1:AA317627 AA358233 AF226056 AI871620 AK021950 AU120059 BC008662 BE780488 BI767327 BI819670 Unigene Cluster for PRTFDC1: Phosphoribosyl transferase domain containing 1 Hs.405619 [show with all ESTs]Unigene Representative Sequence: NM_020200
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000320152(uc001ise.1 uc010qdd.1) ENST00000376378 ENST00000358336(uc001isf.1 uc009xkm.1)
ENST00000376376
|
Expression
for PRTFDC1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PRTFDC1 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching PRTFDC1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 86840_at2, 3
|
U95-E |
1 |
0.69 |
1.00 |
0.86 |
1.03 |
AI748877 |
0.60 |
1.00 |
0.82 |
1 |
| 49126_at2, 3
|
U95-B |
1 |
0.50 |
1.00 |
0.98 |
0.99 |
AI871620 |
0.80 |
1.00 |
0.91 |
1 |
| 222803_at2, 3
|
U133-B |
1 |
0.46 |
1.00 |
-- |
-- |
AI871620 |
0.80 |
1.00 |
0.91 |
1 |
| 222803_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PRTFDC1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.405619
SABiosciences Custom PCR Arrays for PRTFDC1
|
Orthologs
for PRTFDC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PRTFDC1 gene from 5/7 species (see all 7)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
PRTFDC11 |
-- |
phosphoribosyl transferase domain containing 1 |
88.39(n)
90.05(a) |
487103 XM_544231.2 XP_544231.2 |
chimpanzee
(Pan troglodytes) |
PRTFDC11 |
-- |
phosphoribosyl transferase domain containing 1 |
99.41(n)
100(a) |
450356 XM_507700.2 XP_507700.1 |
rat
(Rattus norvegicus) |
Prtfdc11 |
-- |
phosphoribosyl transferase domain containing 1 |
86(n)
91.32(a) |
291355 XM_214518.4 XP_214518.3 |
chicken
(Gallus gallus) |
PRTFDC11 |
-- |
phosphoribosyl transferase domain containing 1 |
78.35(n)
84.11(a) |
420499 XM_418601.2 XP_418601.2 |
zebrafish
(Danio rerio) |
hprt12 |
-- |
hypoxanthine guanine phosphoribosyltransferase-like |
75.72(n) |
30765 BC047173.1 |
About this table Species with no ortholog for PRTFDC1
ENSEMBL Gene Tree for PRTFDC1 (if available) |
Paralogs
for PRTFDC1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PRTFDC1 gene
- HPRT12
PRTFDC1 for paralogs About GeneDecksing
|
Genomic Variants
for PRTFDC1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 10 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PRTFDC1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PRTFDC1
1 Indel: 58434 | | QIAGEN SeqTarget long-range PCR primers for resequencing PRTFDC1 |
|
Disorders & Mutations
for PRTFDC1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRTFDC1 for disorders About GeneDecksing
OMIM: 610751
Export disorders and mutations for PRTFDC1 gene to outside databases
|
Medical News
for PRTFDC1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PRTFDC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/13 PubMed articles for PRTFDC1 gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with PRTFDC1)- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Gene duplication and inactivation in the HPRT gene family. (PubMed id 16928426)1 Keebaugh A.C....Thomas J.W. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. (PubMed id 17599052)1 Suzuki E....Inazawa J. (2007)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for PRTFDC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PRTFDC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRTFDC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRTFDC1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PRTFDC1 gene:
Search GeneIP for patents involving PRTFDC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRTFDC1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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