Aliases &
Descriptions
for PSG4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| pregnancy specific beta-1-glycoprotein 41 2 | | PS-beta-G-42 3 | | Pregnancy-specific glycoprotein 42 3 | | PSBG-92 3 | | Pregnancy-specific beta-1-glycoprotein 92 3 | | PS-beta-G-92 3 | | Pregnancy-specific glycoprotein 92 3 | | Pregnancy-specific beta-1-glycoprotein-42 | | PSG92 3 | | pregnancy-specific beta-1-glycoprotein 42 | | PSBG-42 3 | | CGM43 |
Export aliases for PSG4 gene to outside databasesPrevious GC identifers: GC19M044343 GC19M044088 GC19M048372 GC19M048388 GC19M048124 GC19M047918 GC19M043696 |
Summaries
for PSG4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PSG4:
The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts byplacental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis ofseveral PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, whichbelongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, withstructural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulinconstant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as anadhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 (PubMed7851896)). For additional general information about the PSG gene family, see PSG1 (MIM 176390).(supplied by OMIM)
Gene Wiki entry for PSG4 |
Genomic Views
for PSG4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PSG4 gene promoter:
NF-kappaB1 NF-kappaB POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 p300 POU3F1 RelA AP-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for PSG4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.2PSG4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M040126: view genomic region
(about GC identifiers)
Start:
|
40,126,540 bp from pter |
End:
|
40,139,477 bp from pter |
Size:
|
12,938 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr19- 43,696,854-43,709,926 |
RefSeq DNA sequence:- NC_000019.9 NT_011109.16
|
Proteins
for PSG4 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: PSG4_HUMAN, Q00888 (See
protein sequence)Recommended Name: Pregnancy-specific beta-1-glycoprotein 4 precursor Size: 419 amino acids; 47113 Da
Subcellular location: Secreted (Potential)
Developmental stage: PSBG are produced in high quantity during pregnancy
Sequence caution: Sequence=AAA60208.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknownorigin in the N-terminal part; Sequence=M32625; Type=Erroneous gene model prediction;
Secondary accessions: Q13047 Q13048 Q15234 Q15240 Q9UQ76Alternative splicing: 2 isoforms: Q00888-1 Q00888-2 Explore the universe of human proteins at neXtProt for PSG4: NX_Q00888
REFSEQ proteins (2 alternative transcripts):
NP_002771.2 NP_998798.1
ENSEMBL proteins: ENSP00000384770 ENSP00000244295 ENSP00000388134
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
NAS | -- |
About this table
PSG4 for ontologies About GeneDecksing
Antibodies for PSG4:
Assays for PSG4: |
Protein
Domains/
Families
for PSG4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PSG4 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q00888ProtoNet protein and cluster: Q00888 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: PSG4_HUMAN, Q00888Similarity: Belongs to the immunoglobulin superfamily. CEA familySimilarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Gene Function
for PSG4 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
Genatlas biochemistry entry for PSG4:pregnancy specific beta-1-glycoprotein 4,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonicantigen (CEA family),immunoglobulin superfamily |
Pathways & Interactions
for PSG4 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for PSG4
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PSG4
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
PSG4 for ontologies About GeneDecksing
|
Drugs & Compounds
for PSG4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
PSG4 for compounds About GeneDecksing
 Browse Tocris compounds for PSG4
2  Novoseek chemical compound relationships for PSG4 gene
About this table
|
Transcripts
for PSG4 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PSG4 gene (2 alternative transcripts): NM_002780.3 NM_213633.1 Additional cDNA sequence: AF289606.1 AK002132.1 AK075149.1 BC008405.1 BC013431.1 BC022316.1 BC063127.1 BT007413.1 CR590580.1 CR592018.1 CR592059.1 CR593222.1 CR596357.1 CR597735.1 CR598758.1 CR599583.1 CR600983.1 CR604601.1 CR604687.1 CR605064.1 CR605078.1 CR605538.1 CR609817.1 CR610366.1 CR611858.1 CR613614.1 CR615378.1 CR616976.1 CR621099.1 CR622324.1 CR623361.1 CR625588.1 CR625690.1 CR625940.1 CR626512.1 M20882.1 M33665.1 M37398.1 M94891.1 U18468.1 U18469.1 X17097.1 24/150 DOTS entries (see all 150): DT.91781710 DT.91781740 DT.121424184 DT.402914 DT.100884399 DT.87005084 DT.95226495 DT.91695586 DT.121424255 DT.121424448 DT.40218659 DT.121424674 DT.121424827 DT.100784595 DT.100772800 DT.100772793 DT.121424032 DT.100803011 DT.91777619 DT.100772802 DT.91777627 DT.92055056 DT.95375831 DT.100764243 1 AceView cDNA sequence: BG620818
 highest scoring ESTs for PSG4:BC035419 AA368645 AA368671 AI263104 AL544787 AL546610 AL549854 AL570919 AL571248 AL571430 Unigene Cluster for PSG4: Pregnancy specific beta-1-glycoprotein 4 Hs.709200 [show with all ESTs]Unigene Representative Sequence: BC063127
GeneLoc Exon Structure
5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000405312(uc002owa.2 uc002owb.2 uc002ovy.2 uc002ovz.2)
ENST00000244295 ENST00000490769 ENST00000495316 ENST00000451895
|
Expression
for PSG4 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PSG4 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching PSG4 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 35956_s_at2, 3
|
U95-A |
7 |
1.00 |
0.43 |
1.00 |
1.00 |
U18467 |
0.20 |
0.08 |
0.15 |
3 |
| 208191_x_at2, 3
|
U133-A |
5 |
1.00 |
0.77 |
-- |
-- |
NM_002780 |
0.20 |
0.50 |
0.38 |
1 |
| 208191_x_at2
|
U133Plus2 |
5 |
1.00 |
0.77 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1568999_at*2
|
U133Plus2 |
NULL |
0.00 |
0.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PSG4 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TACCACATTT
SOURCE GeneReport for Unigene cluster: Hs.709200
SABiosciences Custom PCR Arrays for PSG4
|
Orthologs
for PSG4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for PSG4 (if available) |
Paralogs
for PSG4 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PSG4 gene
- PSG92 PSG82 CEACAM52 CEACAM42 PSG112 CEACAM72 PSG32 CEACAM212
- PSG12 PSG52 PSG62 CEACAM12 CEACAM82 CEACAM62 PSG22 CEACAM182
- CEACAM162 CEACAM32
PSG4 for paralogs About GeneDecksing
|
Genomic Variants
for PSG4 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PSG4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 27 variations for PSG4
15/27 CNVs (see all 27): 9309 8873 34532 8872 63063 10561 35649 34649 50174 78206 1301 89254 23236 9307 38084 | | QIAGEN SeqTarget long-range PCR primers for resequencing PSG4 |
|
Disorders & Mutations
for PSG4 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PSG4 for disorders About GeneDecksing
OMIM: 176393
Export disorders and mutations for PSG4 gene to outside databases
|
Medical News
for PSG4 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PSG4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/16 PubMed articles for PSG4 gene, integrated from 7 sources (see all 16):
(articles sorted by number of sources associating them with PSG4)- cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver. (PubMed id 2783133)1, 2, 3 Zimmermann W.A.... Thompson J.A. (1989)
- Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (PubMed id 7794280)1, 2, 7 Teglund S.... Hammarstroem S. (1995)
- Characterization of new members of the pregnancy-specific beta 1- glycoprotein family. (PubMed id 1922019)1, 2 Chan W.Y.... Tease L.A. (1991)
- The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (PubMed id 1690992)1, 2 Thompson J.... Hardman N. (1990)
- Characterization of two new members of the pregnancy-specific beta 1- glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit. (PubMed id 2271648)1, 2 Barnett T.R.... Elting J.J. (1990)
- The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (PubMed id 2346490)1, 2 (1990)
- Characterization of cDNA encoding human pregnancy-specific beta 1- glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen. (PubMed id 3180995)1, 2 Chan W.-Y.... Shupert W.L. (1988)
- A single human cell expresses all messenger ribonucleic acids: the arrow of time in a cell. (PubMed id 9645429)1, 7 Kimoto Y. (1998)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for PSG4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing PSG4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PSG4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PSG4 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PSG4 gene:
Search GeneIP for patents involving PSG4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PSG4 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for PSG4 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for PSG4 |
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