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PSMA3 Gene

protein-coding   GIFtS: 62

GC14P038877
proteasome (prosome, macropain) subunit, alpha type, 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for PSMA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
proteasome (prosome, macropain) subunit, alpha type, 31 2     proteasome subunit C82
HC81 2 3     proteasome subunit alpha type-32
Macropain subunit C82 3     PSC32
Multicatalytic endopeptidase complex subunit C82 3     MGC123062
Proteasome component C82 3     PSC83
MGC326312     EC 3.4.25.13

External Ids:    HGNC: 95321   Entrez Gene: 56842   Ensembl: ENSG000001005677   UniProtKB: P257883   

Export aliases for PSMA3 gene to outside databases

Previous GC identifers: GC14P056035 GC14P052507 GC14P056701 GC14P057781 GC14P058711


Summaries
for PSMA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PSMA3:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core
structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings
are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and
cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified
proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the
peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have
been identified. (provided by RefSeq)

UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its
degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R)
isoform 2

Gene Wiki entry for PSMA3

Genomic Views
for PSMA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMA3 gene promoter:
         AP-1   IRF-7A   NF-E2 p45   NF-E2   MEF-2A   LCR-F1   NF-AT1   NF-AT2   NF-AT3   NF-AT4   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PSMA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PSMA3 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q23

PSMA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMA3 gene location

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P038877:  view genomic region     (about GC identifiers)

Start:
 38,877,128 bp from pter
End:
 38,904,215 bp from pter
Size:
 27,088 bases
Orientation:
 plus strand

1 alternative location:
Chr14+ 58,711,549-58,738,725     
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  

Proteins
for PSMA3 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788 (See protein sequence)
Recommended Name: Proteasome subunit alpha type-3  
Size: 255 amino acids; 28433 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core
is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two
end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
The catalytic chamber with the active sites is on the inside of the barrel. Interacts with AURKB. Interacts with
CDKN1A. Interacts with HIV-1 TAT protein. Interacts with hepatitis C virus (HCV) F protein. Interacts with
Epstein-Barr virus EBNA3 proteins. Interacts with MDM2 and RB1. Interacts with the C-terminus of TBXA2R isoform 2
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: B2RCK6 Q86U83 Q8N1D8 Q9BS70
Alternative splicing: 2 isoforms:  P25788-1   P25788-2   

Explore the universe of human proteins at neXtProt for PSMA3: NX_P25788 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_002779.1  NP_687033.1  


    ENSEMBL proteins: 
    ENSP00000216455 ENSP00000390491 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PSMA3
    GenScript Custom Purified and Recombinant Proteins Services for PSMA3 
    Novus Biologicals Proteins for PSMA3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502 proteasome complex TAS8811196
    GO:0005634 nucleus TAS16130169
    GO:0005737 cytoplasm TAS16130169
    GO:0005839 proteasome core complex IDA19208651
    GO:0015630 microtubule cytoskeleton ----
    About this table

    PSMA3 for ontologies           About GeneDecksing



    Antibodies for PSMA3: 
    Millipore Mono- and Polyclonal Antibodies for the study of PSMA3
    Sigma-Aldrich Antibodies for PSMA3
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PSMA3 
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PSMA3 
    Novus Biologicals Antibodies for PSMA3
    Epitomics antibodies for PSMA3

    Assays for PSMA3: 
    Millipore Kits and Assays for the Analysis of PSMA3
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PSMA3 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for PSMA3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PSMA3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001353 Proteasome_sua/b
     IPR000426 Proteasome_asu_CS

    Graphical View of Domain Structure for InterPro Entry P25788

    ProtoNet protein and cluster: P25788

    1 Blocks protein family: IPB000426 Proteasome subunit

    UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788
    Similarity: Belongs to the peptidase T1A family


    Gene Function
    for PSMA3 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788
    Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
    peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
    proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its
    degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R)
    isoform 2
    Catalytic activity: Cleavage of peptide bonds with very broad specificity
    Induction: Down-regulated by antioxidants BO-653 and probucol. Up-regulated by bacterial lipopolysaccharides (LPS) and
    TNF
    Enzyme Number (IUBMB): EC 3.4.25.1 

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PSMA3
    Sigma-Aldrich shRNA Panels and shRNA for PSMA3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): PSMA3
    OriGene shRNA RFP (see all 3): PSMA3
    OriGene basic RS shRNA (see all 3): PSMA3
    OriGene siRNA (see all 3): PSMA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PSMA3 
    miRNA:Sigma-Aldrich microRNA Mimics for PSMA3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PSMA3 
    Search SABiosciences for Assays for microRNAs that regulate PSMA3

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PSMA3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PSMA3
    OriGene untagged cDNA clones in CMV expression vector (see all 4): PSMA3
    OriGene 3'-UTR clone (see all 2): PSMA3 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): PSMA3 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for PSMA3 

    Genatlas biochemistry entry for PSMA3:
    multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 3,subunit HC8

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175 endopeptidase activity ----
    GO:0004298 threonine-type endopeptidase activity IEA--
    GO:0005515 protein binding IPI14667819
    GO:0008233 peptidase activity IEA--
    About this table

    PSMA3 for ontologies           About GeneDecksing


    Pathways & Interactions
    for PSMA3 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    PSMA3 for pathways           About GeneDecksing

    2 Millipore Pathways for PSMA3
        Immune response Antigen presentation by MHC class I
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  PSMA3
        Protein Ubiquitination Pathway

    1 Kegg Pathway  (Kegg details for PSMA3):
        hsa03050 Proteasome

        SABiosciences Custom Pathway-Focused PCR Arrays for PSMA3 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PSMA3
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMA3

    5/128 Interacting proteins for PSMA3 (P257881, 2 ENSP000002164553) via UniProtKB, MINT, and/or STRING (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMA7O148181, 2, ENSP000003599103EBI-348380,EBI-603272 MINT-6176676 MINT-51345 MINT-4050722 MINT-51354 MINT-6176052 MINT-51368 MINT-51335 MINT-6176080 STRING: ENSP00000359910
    PSMA4P257891, 2, ENSP000000444623EBI-348380,EBI-359310 MINT-4050722 MINT-51344 MINT-51348 MINT-51361 MINT-6176676 MINT-6176052 MINT-6176080 STRING: ENSP00000044462
    PSMA6P609001, 2, ENSP000002614793EBI-348380,EBI-357793 MINT-4050722 MINT-6176676 MINT-6176052 MINT-63926 MINT-6176080 STRING: ENSP00000261479
    PSMA1P257862, ENSP000003153093MINT-4050722 MINT-6176676 MINT-6176052 MINT-6176080 STRING: ENSP00000315309
    PSMA2P257872, ENSP000002233213MINT-4050722 MINT-6176676 MINT-6176052 MINT-6176080 STRING: ENSP00000223321
    About this table

    5/17 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 17):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075 cell cycle checkpoint TAS--
    GO:0000082 G1/S transition of mitotic cell cycle TAS--
    GO:0000084 S phase of mitotic cell cycle TAS--
    GO:0000216 M/G1 transition of mitotic cell cycle TAS--
    GO:0000278 mitotic cell cycle TAS--
    About this table

    PSMA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PSMA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMA3


    Transcripts
    for PSMA3 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PSMA3
    Sigma-Aldrich shRNA Panels and shRNA for PSMA3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): PSMA3
    OriGene shRNA RFP (see all 3): PSMA3
    OriGene basic RS shRNA (see all 3): PSMA3
    OriGene siRNA (see all 3): PSMA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PSMA3 
    miRNA: Sigma-Aldrich microRNA Mimics for PSMA3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PSMA3 
    Search SABiosciences for Assays for microRNAs that regulate PSMA3
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PSMA3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PSMA3
    OriGene untagged cDNA clones in CMV expression vector (see all 4): PSMA3
    OriGene 3'-UTR Clone (see all 2): PSMA3 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): PSMA3 
    Primers: OriGene genome-wide validated SYBR primer pairs: PSMA3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PSMA3: PPH14930A

    REFSEQ mRNAs for PSMA3 gene (2 alternative transcripts): 

    NM_002788.2  NM_152132.1  

    Additional cDNA sequence: 

    AK315158.1 BC005265.1 BC029402.1 BC038990.1 BT006711.1 BT019715.1 CR456933.1 CR607027.1 
    CR608468.1 CR615289.1 CR619196.1 CR621171.1 CR626135.1 CR626517.1 D00762.1 

    24/27 DOTS entries (see all 27):

    DT.418208  DT.100880879  DT.100703585  DT.100044492  DT.100880895  DT.427712  DT.65285051  DT.95191317 
    DT.120766595  DT.120766741  DT.121487706  DT.95214729  DT.208775  DT.40126212  DT.91690599  DT.92449580 
    DT.100035486  DT.120766726  DT.40230676  DT.91823022  DT.95134620  DT.95147801  DT.95147805  DT.208776 

    24/494 AceView cDNA sequences (see all 494):

    AI288939 BU934786 CD369562 BQ084419 BG028576 CA943594 AI699756 BM714328 
    AI378423 CF594039 AI553756 BU186847 BE379904 BM763800 T27426 BX363762 
    BM689530 AA309688 BI492387 BQ955290 BM699263 CB122389 BM772482 CB157476 

    highest scoring ESTs for PSMA3:

    D00762 AA032283 AA035579 AA129977 AA232282 AA417992 AA421766 AA448162 AA456114 AA465237 

    Unigene Cluster for PSMA3:

    Proteasome (prosome, macropain) subunit, alpha type, 3
    Hs.558799  [show with all ESTs]
    Unigene Representative Sequence: BM918616


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PSMA3 (see all 6)

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:                                                                          -                                             
    SP2:                          -                                               -                                             
    SP3:                          -                                               -                                             
    SP4:                          -                                                                                             
    SP5:                                                                                                                        

    About this scheme

    ECgene alternative splicing isoforms for PSMA3
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216455(uc001xdj.1 uc001xdk.1) ENST00000412908

    Expression
    for PSMA3 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PSMA3 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching PSMA3 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1448_at2, 3 U95-A 1 0.88 1.00 0.93 0.98 D00762 1.00 1.00 1.00 1
    85203_at2, 3 U95-E 1 0.31 1.00 0.94 1.02 AI417084 0.60 1.00 0.82 1
    201532_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002788 0.60 1.00 0.82 1
    232648_at*2 U133-B NULL 0.00 0.00 -- -- -- -- -- -- --
    201532_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    232648_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    About this table

    PSMA3 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PSMA3 gene expression
    PSMA3 gene electronic northern expression
    PSMA3 gene sage expression
    About these images

    CGAP SAGE TAG: AAATTGTTCC

    SOURCE GeneReport for Unigene cluster: Hs.558799

    Expression variation in blood from EXPOLDB for PSMA3

    Primers: OriGene genome-wide validated SYBR primer pairs: PSMA3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PSMA3: PPH14930A
        SABiosciences Custom PCR Arrays for PSMA3 


    Orthologs
    for PSMA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for PSMA3 gene from 5/26 species (see all 26)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 PSMA31   -- proteasome (prosome, macropain) subunit, alpha type, more 94.64(n)
    99.22(a)    		 480338  XM_537460.2  XP_537460.2 
    chimpanzee
    (Pan troglodytes)    		 PSMA31   -- proteasome (prosome, macropain) subunit, alpha type, more 99.74(n)
    100(a)    		 467469  XM_001164848.1  XP_001164848.1 
    cow
    (Bos taurus)    		 PSMA31   -- proteasome (prosome, macropain) subunit, alpha type, more 93.86(n)
    98.82(a)    		 505176  NM_001034235.1  NP_001029407.1 
    rat
    (Rattus norvegicus)    		 Psma3l1   -- proteasome subunit alpha type 3-like 93.33(n)
    98.82(a)    		 408248  NM_001004094.1  NP_001004094.1 
    mouse
    (Mus musculus)    		 Psma31 , 5 12 (29.39 cM)5
    		 proteasome (prosome, macropain) subunit, alpha type more1, 5 91.63(n)1
    98.43(a)1    		 191671  NM_011184.31  NP_035314.21 
     AF0559835  AF0600895  (see all 18)
    About this table        Species with no ortholog for PSMA3

    ENSEMBL Gene Tree for PSMA3 (if available)

    Paralogs
    for PSMA3 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Pseudogenes
    2 related pseudogenes



    Genomic Variants
    for PSMA3 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/258 NCBI SNPs in PSMA3 are shown (see all 258)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs11359361,2
    		--58736676(+) aattcC/Tcctgc 1 -- int10--------
    rs11372261,2
    		--58725051(+) tacttA/Gggagc 1 -- int10--------
    rs18851331,2
    		C,F,O,58737402(+) AGATAT/CTATGC 1 -- int111Minor allele frequency- C:0.42NS EA NA WA 636
    rs18851341,2
    		C,F,O,A,58737530(+) ACTCAA/TAGTAC 1 -- int112Minor allele frequency- T:0.44NS EA NA WA 638
    rs20043121,2
    		C,A58729762(-) gaccgT/Cgccac 1 -- int13Minor allele frequency- C:0.33NA WA 6
    rs21455991,2
    		C,A58729316(+) tgctcT/Agttgc 1 -- int14Minor allele frequency- A:0.12NA 8
    rs23480711,2
    		C,F,A,H,58730626(+) acactG/Aatgat 1 -- int112Minor allele frequency- A:0.42NS EA NA WA 506
    rs32088671,2
    		--58737172(+) AAAGCA/TTTTGA 2 A syn1 ref10--------
    rs32088681,2
    		--58737711(+) AATATC/GCTAAG 2 P A mis1 ref10--------
    rs32088691,2
    		--58737712(+) ATATGC/TTAAGG 2 A V ref1 mis10--------
    About this table

    HapMap Linkage Disequilibrium images for PSMA3 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PSMA3: --

    QIAGEN SeqTarget long-range PCR primers for resequencing PSMA3 

    Disorders & Mutations
    for PSMA3 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PSMA3 for disorders           About GeneDecksing

    OMIM: 176843


    Export disorders and mutations for PSMA3 gene to outside databases

    Medical News
    for PSMA3 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for PSMA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/80 PubMed articles for PSMA3 gene, integrated from 7 sources (see all 80):
    (articles sorted by number of sources associating them with PSMA3)
    1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PubMed id 2025653)1, 2, 3 Tamura T.... Ichihara A. (1991)
    2. Ubiquitin-independent degradation of hepatitis C virus F protein. (PubMed id 18971267)1, 2 Yuksek K.... Ou J.-H. (2009)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. Epstein-Barr virus EBNA3 proteins bind to the C8/alpha7 subunit of the 20S proteasome and are degraded by 20S proteasomes in vitro, but are very stable in latently infected B cells. (PubMed id 15831937)1, 2 Touitou R.... Allday M.J. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner. (PubMed id 14674694)1, 2 Shu F....Yu L. (2003)

    External Searches for PSMA3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PSMA3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5684 HGNC: 9532 AceView: PSMA3 Ensembl:ENSG00000100567 euGenes: HUgn5684
    ECgene: PSMA3 Kegg: 5684 H-InvDB: PSMA3

    Other Databases showing PSMA3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PSMA3 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for PSMA3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for PSMA3 gene:
    Search GeneIP for patents involving PSMA3

    GeneCards and IP:
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    Products
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    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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