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PSMB3 Gene

protein-coding   GIFtS: 60

GC17P032705
proteasome (prosome, macropain) subunit, beta type, 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for PSMB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
proteasome (prosome, macropain) subunit, beta type, 31 2     Proteasome component C10-II2 3
HC10-II1 2     Proteasome theta chain2 3
MGC41471 2     proteasome subunit beta type-32
Proteasome chain 132 3     EC 3.4.25.13

External Ids:    HGNC: 95401   Entrez Gene: 56912   Ensembl: ENSG000001082947   UniProtKB: P497203   

Export aliases for PSMB3 gene to outside databases

Previous GC identifers: GC17P036394 GC17P038902 GC17P036819 GC17P037284 GC17P037285 GC17P034162 GC17P036909


Summaries
for PSMB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PSMB3:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core
structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings
are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and
cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified
proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the
proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Pseudogenes have been
identified on chromosomes 2 and 12. (provided by RefSeq)

UniProtKB/Swiss-Prot: PSB3_HUMAN, P49720
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
proteasome has an ATP-dependent proteolytic activity

Gene Wiki entry for PSMB3

Genomic Views
for PSMB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMB3 gene promoter:
         NF-kappaB1   NF-kappaB   GCNF-2   GCNF-1   FOXJ2 (long isoform)   Nkx3-1   Nkx3-1 v1   Nkx3-1 v3   Nkx3-1 v4   Nkx3-1 v2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PSMB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PSMB3 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

PSMB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMB3 gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032705:  view genomic region     (about GC identifiers)

Start:
 32,705,092 bp from pter
End:
 32,716,582 bp from pter
Size:
 11,491 bases
Orientation:
 plus strand

1 alternative location:
Chr17+ 36,909,003-36,920,483     
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  

Proteins
for PSMB3 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: PSB3_HUMAN, P49720 (See protein sequence)
Recommended Name: Proteasome subunit beta type-3  
Size: 205 amino acids; 22949 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core
is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two
end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
The catalytic chamber with the active sites is on the inside of the barrel. Interacts with HIV-1 TAT protein
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: P31147 Q0P6J7 Q96E27

Explore the universe of human proteins at neXtProt for PSMB3: NX_P49720 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_002786.2  

    ENSEMBL proteins: 
    ENSP00000225426 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PSMB3
    GenScript Custom Purified and Recombinant Proteins Services for PSMB3 
    Novus Biologicals Proteins for PSMB3
    Novus Biologicals Lysates for PSMB3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502 proteasome complex TAS8811196
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005839 proteasome core complex IEA--
    About this table

    PSMB3 for ontologies           About GeneDecksing



    Antibodies for PSMB3: 
    Millipore Mono- and Polyclonal Antibodies for the study of PSMB3
    Sigma-Aldrich Antibodies for PSMB3
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PSMB3 
    Novus Biologicals Antibodies for PSMB3
    Browse antibodies at Epitomics

    Assays for PSMB3: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PSMB3 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for PSMB3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PSMB3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001353 Proteasome_sua/b
     IPR016050 Proteasome_bsu_CS

    Graphical View of Domain Structure for InterPro Entry P49720

    ProtoNet protein and cluster: P49720

    1 Blocks protein family: IPB000243 Proteasome B-type subunit

    UniProtKB/Swiss-Prot: PSB3_HUMAN, P49720
    Similarity: Belongs to the peptidase T1B family


    Gene Function
    for PSMB3 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PSB3_HUMAN, P49720
    Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
    peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
    proteasome has an ATP-dependent proteolytic activity
    Catalytic activity: Cleavage of peptide bonds with very broad specificity
    Induction: Up-regulated in asthenozoospermic sperm
    Enzyme Number (IUBMB): EC 3.4.25.1 

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PSMB3
    Sigma-Aldrich shRNA Panels and shRNA for PSMB3
    OriGene 29mer shRNA kits in GFP-retroviral vector: PSMB3
    OriGene shRNA RFP: PSMB3
    OriGene basic RS shRNA: PSMB3
    OriGene siRNA: PSMB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PSMB3 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PSMB3 
    Search SABiosciences for Assays for microRNAs that regulate PSMB3

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PSMB3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PSMB3
    OriGene untagged cDNA clones in CMV expression vector (see all 3): PSMB3
    OriGene 3'-UTR clone: PSMB3 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PSMB3 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for PSMB3 

    Genatlas biochemistry entry for PSMB3:
    multicatalytic proteinase complex (20s),proteasome component beta 3 (HSC10-I1),22.9kDa

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004298 threonine-type endopeptidase activity IEA--
    GO:0005515 protein binding IPI17353931
    GO:0008233 peptidase activity IEA--
    About this table

    PSMB3 for ontologies           About GeneDecksing


    Pathways & Interactions
    for PSMB3 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    PSMB3 for pathways           About GeneDecksing

    2 Millipore Pathways for PSMB3
        Immune response Antigen presentation by MHC class I
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  PSMB3
        Protein Ubiquitination Pathway

    1 Kegg Pathway  (Kegg details for PSMB3):
        hsa03050 Proteasome

        SABiosciences Pathway-Focused PCR Array including PSMB3: PAHS-032A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PSMB3
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PSMB3

    5/107 Interacting proteins for PSMB3 (P497201, 2 ENSP000002254263) via UniProtKB, MINT, and/or STRING (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMB2P497212, ENSP000003623373MINT-4050722 MINT-6176676 MINT-6176193 MINT-6176204 MINT-6176080 STRING: ENSP00000362337
    PSMA7O148182, ENSP000003599103MINT-4050722 MINT-6176676 MINT-6176471 MINT-6176080 STRING: ENSP00000359910
    PSMA1P257862, ENSP000003153093MINT-4050722 MINT-6176676 MINT-6176080 STRING: ENSP00000315309
    PSMB1P206182, ENSP000002621933MINT-4050722 MINT-6176080 MINT-6176141 STRING: ENSP00000262193
    PSMB5P280742, ENSP000003553253MINT-4050722 MINT-6176151 MINT-6176080 STRING: ENSP00000355325
    About this table

    5/16 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 16):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075 cell cycle checkpoint TAS--
    GO:0000082 G1/S transition of mitotic cell cycle TAS--
    GO:0000084 S phase of mitotic cell cycle TAS--
    GO:0000216 M/G1 transition of mitotic cell cycle TAS--
    GO:0000278 mitotic cell cycle TAS--
    About this table

    PSMB3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PSMB3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMB3


    Transcripts
    for PSMB3 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PSMB3
    Sigma-Aldrich shRNA Panels and shRNA for PSMB3
    OriGene 29mer shRNA kits in GFP-retroviral vector: PSMB3
    OriGene shRNA RFP: PSMB3
    OriGene basic RS shRNA: PSMB3
    OriGene siRNA: PSMB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PSMB3 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PSMB3 
    Search SABiosciences for Assays for microRNAs that regulate PSMB3
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PSMB3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PSMB3
    OriGene untagged cDNA clones in CMV expression vector (see all 3): PSMB3
    OriGene 3'-UTR Clone: PSMB3 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PSMB3 
    Primers: OriGene genome-wide validated SYBR primer pairs: PSMB3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PSMB3: PPH01260A

    REFSEQ mRNAs for PSMB3 gene: 

    NM_002795.2  

    Additional cDNA sequence: 

    BC013008.2 CR590404.1 CR607993.1 D26598.1 

    23 DOTS entries:

    DT.455659  DT.120989587  DT.97862020  DT.100814129  DT.97762226  DT.100814130  DT.121198981  DT.92450261 
    DT.95149280  DT.95197381  DT.100046124  DT.100656593  DT.100814126  DT.120989581  DT.75187131  DT.91783902 
    DT.95175299  DT.95332054  DT.100647401  DT.100850152  DT.453586  DT.91783978  DT.91804685 

    24/433 AceView cDNA sequences (see all 433):

    BE909573 BQ338647 N64527 BM998334 BQ647798 AA425646 CA420673 BU731352 
    BM668811 AI356190 BM771881 D11620 AA308300 AW951445 BE899255 N45460 
    AI150689 BX364244 BU625810 BU681681 BU623941 BE540572 BX364245 CF129556 

    highest scoring ESTs for PSMB3:

    D26598 AA091878 AA100510 AA156007 AA353052 AA372403 AA425646 AA428511 AA454781 AA482993 

    Unigene Cluster for PSMB3:

    Proteasome (prosome, macropain) subunit, beta type, 3
    Hs.82793  [show with all ESTs]
    Unigene Representative Sequence: BI333607


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PSMB3

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
    SP1:                                                      
    SP2:                                -                     
    SP3:                                -     -               

    About this scheme

    ECgene alternative splicing isoforms for PSMB3
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000225426(uc002hqr.2)

    Expression
    for PSMB3 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PSMB3 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching PSMB3 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1309_at2, 3 U95-A 2 0.88 0.96 1.00 1.00 D26598 1.00 1.00 1.00 1
    201400_at2, 3 U133-A 1 0.82 1.00 -- -- NM_002795 0.60 1.00 0.82 1
    201400_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    PSMB3 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PSMB3 gene expression
    PSMB3 gene electronic northern expression
    PSMB3 gene sage expression
    About these images

    CGAP SAGE TAG: GGAGTCATTG

    SOURCE GeneReport for Unigene cluster: Hs.82793

    Expression variation in blood from EXPOLDB for PSMB3

    Primers: OriGene genome-wide validated SYBR primer pairs: PSMB3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PSMB3: PPH01260A
        SABiosciences Expression via Pathway-Focused PCR Array including PSMB3: PAHS-032A 


    Orthologs
    for PSMB3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for PSMB3 gene from 5/23 species (see all 23)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 PSMB31   -- proteasome (prosome, macropain) subunit, beta type, 3 less 94.31(n)
    99.02(a)    		 480537  XM_537658.2  XP_537658.1 
    cow
    (Bos taurus)    		 PSMB31   -- proteasome (prosome, macropain) subunit, beta type, 3 less 93.98(n)
    99.02(a)    		 533874  NM_001034596.1  NP_001029768.1 
    rat
    (Rattus norvegicus)    		 Psmb31   -- proteasome (prosome, macropain) subunit, beta type 3 less 91.22(n)
    98.54(a)    		 29676  NM_017285.1  NP_058981.1 
    mouse
    (Mus musculus)    		 Psmb31 , 5 11 (61.07 cM)5
    		 proteasome (prosome, macropain) subunit, beta type 3 less1, 5 91.06(n)1
    98.54(a)1    		 264461  NM_011971.31  NP_036101.11 
     AF0600925  AK0023315  (see all 17)
    chicken
    (Gallus gallus)    		 PSMB31   -- proteasome (prosome, macropain) subunit, beta type, 3 less 81.95(n)
    91.71(a)    		 419997  XM_418119.2  XP_418119.2 
    About this table        Species with no ortholog for PSMB3

    ENSEMBL Gene Tree for PSMB3 (if available)

    Paralogs
    for PSMB3 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Pseudogenes
    1 related pseudogene



    Genomic Variants
    for PSMB3 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/159 NCBI SNPs in PSMB3 are shown (see all 159)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs49071,2
    		C,F,36909499(+) CCCAGA/TTGGTG 2 M L ref1 mis1 ese310Minor allele frequency- T:0.31MN NS EA NA 1050
    rs659261,2
    		C,F,A,H,36916433(+) AGGAGG/CACAAG 1 -- int115Minor allele frequency- C:0.31MN EA NS NA WA 2324
    rs2282731,2
    		C,F,A,H,36908123(+) ACCGGC/TGTAGT 1 -- ng5115Minor allele frequency- T:0.41NS EA NA WA 950
    rs2282741,2
    		C,F,O,H,36909061(+) GAGGGG/ATCCTA 1 -- ut51 ese317Minor allele frequency- A:0.21MN NS EA NA WA 1124
    rs2282751,2
    		C,F,O,A,H,36910825(+) GCCTGC/TCCTTT 1 -- int1 trp310Minor allele frequency- T:0.45MN NS EA NA WA 816
    rs2282761,2
    		C,A,H36911699(+) cgagaT/Ccatcc 1 -- int15Minor allele frequency- C:0.00NA WA 12
    rs2282771,2
    		C,A36915238(+) agcttC/Gcagtg 1 -- int14Minor allele frequency- G:0.12NA WA 8
    rs2282781,2
    		C,F,A,H,36915630(+) ccacaT/Aattgc 1 -- int117Minor allele frequency- A:0.15NS EA NA WA 834
    rs2282791,2
    		C,F,A,H,36918350(+) CTAAAT/CAGGGA 1 -- int18Minor allele frequency- C:0.28NA EA WA 352
    rs2282801,2
    		C,F,A,H,36918551(+) TTCAGG/TCATGT 1 -- int111Minor allele frequency- T:0.39EA MN NA WA 1980
    About this table

    HapMap Linkage Disequilibrium images for PSMB3 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PSMB3: --

    QIAGEN SeqTarget long-range PCR primers for resequencing PSMB3 

    Disorders & Mutations
    for PSMB3 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PSMB3 for disorders           About GeneDecksing

    OMIM: 602176


    Export disorders and mutations for PSMB3 gene to outside databases

    Medical News
    for PSMB3 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for PSMB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/42 PubMed articles for PSMB3 gene, integrated from 7 sources (see all 42):
    (articles sorted by number of sources associating them with PSMB3)
    1. Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues. (PubMed id 7918633)1, 2, 3 Nothwang H.G.... Ichihara A. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. (PubMed id 14550573)1, 2 Apcher G.S.... Krueger E. (2003)
    4. Human proteasome subunits from 2-dimensional gels identified by partial sequencing. (PubMed id 7811265)1, 2 Kristensen P.... Hendil K.B. (1994)
    5. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
    6. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PubMed id 19596235)1 Svendsen J.M.... Harper J.W. (2009)
    7. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    8. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    9. Identification of proteomic differences in asthenozoospermic sperm samples. (PubMed id 18281682)2 Martinez-Heredia J....Oliva R. (2008)
    10. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)

    External Searches for PSMB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PSMB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5691 HGNC: 9540 AceView: PSMB3 Ensembl:ENSG00000108294 euGenes: HUgn5691
    ECgene: PSMB3 Kegg: 5691 H-InvDB: PSMB3

    Other Databases showing PSMB3 gene

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    Specialized Databases showing PSMB3 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    Intellectual Property
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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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