Aliases &
Descriptions
for PSMD14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| proteasome (prosome, macropain) 26S subunit, non-ATPase, 141 2 | | pad11 | | POH11 2 3 5 | | Rpn111 | | 26S proteasome regulatory subunit RPN112 3 | | RPN112 | | 26S proteasome-associated PAD1 homolog 12 3 | | 26S proteasome non-ATPase regulatory subunit 142 | | PAD12 5 | | EC 3.4.19.-3 |
Export aliases for PSMD14 gene to outside databasesPrevious GC identifers: GC02P160692 GC02P162128 GC02P162367 GC02P161990 GC02P161872 GC02P162164 |
Summaries
for PSMD14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PSMD14:
PSMD14 is a component of the 26S proteasome, a multiprotein complex that degrades proteins targeted for destruction bythe ubiquitin pathway (Spataro et al., 1997 (PubMed 9374539)).(supplied by OMIM)
UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487Function: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitinchains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the'Lys-63'-specific deubiquitination of the proteasome is unclear
Gene Wiki entry for PSMD14 |
Genomic Views
for PSMD14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PSMD14 gene promoter:
AP-1 c-Jun c-Fos Pax-2 Fra-1 JunB JunD ATF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PSMD14
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PSMD14  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q24.2 Ensembl cytogenetic band: 2q24.2 HGNC cytogenetic band: 2q14.3PSMD14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P154049: view genomic region
(about GC identifiers)
Start:
|
154,049,213 bp from pter |
End:
|
154,152,682 bp from pter |
Size:
|
103,470 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr2+ 162,164,549-162,268,228 |
RefSeq DNA sequence:- NC_000002.11 NT_005403.17
|
Proteins
for PSMD14 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487 (See
protein sequence)Recommended Name: 26S proteasome non-ATPase regulatory subunit 14 Size: 310 amino acids; 34577 Da
Subunit: Component of the 19S regulatory cap of the 26S proteasome
Secondary accessions: B3KNW2 O00176Explore the universe of human proteins at neXtProt for PSMD14: NX_O00487
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005796.1
ENSEMBL proteins: ENSP00000263639 ENSP00000399311 ENSP00000386541
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): About this table
PSMD14 for ontologies About GeneDecksing
Antibodies for PSMD14:
Assays for PSMD14: |
Protein
Domains/
Families
for PSMD14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PSMD14 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O00487ProtoNet protein and cluster: O00487 1 Blocks protein family: IPB000555 Mov34 family
UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487Similarity: Belongs to the peptidase M67A family. PSMD14 subfamilySimilarity: Contains 1 MPN (JAB/Mov34) domain |
Gene Function
for PSMD14 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487Function: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitinchains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the'Lys-63'-specific deubiquitination of the proteasome is unclearEnzyme Number (IUBMB): EC 3.4.19.-
5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): About this table
PSMD14 for ontologies About GeneDecksing
|
Pathways & Interactions
for PSMD14 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
PSMD14 for pathways About GeneDecksing
3  Millipore Pathways for PSMD14
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for PSMD14
1  Kegg Pathway (Kegg details for PSMD14):
SABiosciences Custom Pathway-Focused PCR Arrays for PSMD14
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PSMD14
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMD14
5/109 Interacting proteins for PSMD14 (ENSP000002636393 O004871, 2) via UniProtKB, MINT, and/or STRING (see all 109)About this table
5/17 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 17): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000075 | cell cycle checkpoint |
TAS | -- | | GO:0000082 | G1/S transition of mitotic cell cycle |
TAS | -- | | GO:0000084 | S phase of mitotic cell cycle |
TAS | -- | | GO:0000216 | M/G1 transition of mitotic cell cycle |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- |
About this table
PSMD14 for ontologies About GeneDecksing
|
Drugs & Compounds
for PSMD14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PSMD14
|
Transcripts
for PSMD14 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PSMD14 gene: NM_005805.4 Additional cDNA sequence: AB209220.1 AK055128.1 AK091095.1 BC009524.1 BC066336.1 CR595585.1 CR606475.1 CR615752.1 CR617325.1 U86782.1 14 DOTS entries: DT.454530 DT.95307891 DT.422466 DT.40238609 DT.99939165 DT.100815487 DT.120956024 DT.100815485 DT.101985697 DT.120955969 DT.91761278 DT.91761290 DT.95149152 DT.91761281 24/330 AceView cDNA sequences (see all 330): BQ691109 U86782 BU729969 BQ011444 BM977394 BU621390 CB145914 CD513062 BM474108 BM550388 CK822271 CA431624 BU159846 CB115181 BX506781 AA306073 BC009524 AU138633 BQ772201 BM978668 CR606475 CR615752 BU615342 BM712859
 highest scoring ESTs for PSMD14:AI984100 U86782 AA320379 AA482701 AA513177 AA621752 AA715379 AI150787 AI168699 AI291370 Unigene Cluster for PSMD14: Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Hs.567410 [show with all ESTs]Unigene Representative Sequence: AB209220
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for PSMD14
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PSMD14
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263639 ENST00000492908 ENST00000478123 ENST00000437630 ENST00000477232
ENST00000409682(uc002ubu.2)
|
Expression
for PSMD14 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PSMD14 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching PSMD14 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 33247_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.59 |
1.15 |
U86782 |
1.00 |
1.00 |
1.00 |
1 |
| 43809_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.42 |
1.34 |
AI984100 |
1.00 |
1.00 |
1.00 |
1 |
| 87461_at2, 3
|
U95-D |
1 |
0.56 |
1.00 |
0.72 |
0.53 |
AI539365 |
0.60 |
1.00 |
0.82 |
1 |
| 212296_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_005805 |
0.60 |
1.00 |
0.82 |
1 |
| 212296_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PSMD14 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AATACATCAA
SOURCE GeneReport for Unigene cluster: Hs.567410
Expression variation in blood from EXPOLDB for PSMD14 UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487Tissue specificity: Widely expressed. Highest levels in heart and skeletal muscle
SABiosciences Custom PCR Arrays for PSMD14
|
Orthologs
for PSMD14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PSMD14 gene from 5/28 species (see all 28)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
PSMD141 |
-- |
proteasome (prosome, macropain) 26S subunit, non-ATPase, more |
96.94(n)
98.64(a) |
478765 XM_535931.2 XP_535931.2 |
chimpanzee
(Pan troglodytes) |
PSMD141 |
-- |
proteasome (prosome, macropain) 26S subunit, non-ATPase, more |
99.89(n)
100(a) |
459686 XM_515855.2 XP_515855.2 |
cow
(Bos taurus) |
PSMD141 |
-- |
proteasome (prosome, macropain) 26S subunit, non-ATPase, more |
97.1(n)
100(a) |
535683 NM_001076067.1 NP_001069535.1 |
rat
(Rattus norvegicus) |
Psmd141 |
-- |
proteasome (prosome, macropain) 26S subunit, non-ATPase, more |
93.42(n)
100(a) |
311078 XM_001059730.1 XP_001059730.1 |
mouse
(Mus musculus) |
Psmd141 , 5 |
2 (35.56 cM)5
|
proteasome (prosome, macropain) 26S subunit, non-ATPase, more1, 5 |
94.5(n)1
99.35(a)1 |
590291 NM_021526.11 NP_067501.11
AA9867325 AI4488785 (see all 18) |
About this table Species with no ortholog for PSMD14
ENSEMBL Gene Tree for PSMD14 (if available) |
Paralogs
for PSMD14 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PSMD14 gene
- EIF3H2
PSMD14 for paralogs About GeneDecksing
Pseudogenes
- 1 related pseudogene
|
Genomic Variants
for PSMD14 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PSMD14 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PSMD14
2 CNVs: 9968 1358 | | QIAGEN SeqTarget long-range PCR primers for resequencing PSMD14 |
|
Disorders & Mutations
for PSMD14 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PSMD14 for disorders About GeneDecksing
OMIM: 607173
Export disorders and mutations for PSMD14 gene to outside databases
|
Medical News
for PSMD14 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PSMD14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/26 PubMed articles for PSMD14 gene, integrated from 7 sources (see all 26):
(articles sorted by number of sources associating them with PSMD14)- Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit. (PubMed id 9374539)1, 2, 3, 7 Spataro V....Norbury C. (1997)
- K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1. (PubMed id 19214193)1, 2 Cooper E.M....Cohen R.E. (2009)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The 19 S proteasomal subunit POH1 contributes to the regulation of c-Jun ubiquitination, stability, and subcellular localization. (PubMed id 16569633)1, 7 Nabhan J.F. and Ribeiro P. (2006)
- Relationship between expression of Pad1 homologue and multidrug resistance of idiopathic nephrotic syndrome. (PubMed id 19419512)1, 7 Ma Z....Li C. (2009)
- Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence. (PubMed id 19732767)1 Byrne A....Jiang Y. (2010)
- Chaperone-mediated pathway of proteasome regulatory p article assembly. (PubMed id 19412159)1 Roelofs J....Finley D. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
|
External Searches for PSMD14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PSMD14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PSMD14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PSMD14 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PSMD14 gene:
Search GeneIP for patents involving PSMD14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PSMD14 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for PSMD14 |
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