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PSMD14 Gene

protein-coding   GIFtS: 62

GC02P154049
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
proteasome (prosome, macropain) 26S subunit, non-ATPase, 141 2     pad11
POH11 2 3 5     Rpn111
26S proteasome regulatory subunit RPN112 3     RPN112
26S proteasome-associated PAD1 homolog 12 3     26S proteasome non-ATPase regulatory subunit 142
PAD12 5     EC 3.4.19.-3

External Ids:    HGNC: 168891   Entrez Gene: 102132   Ensembl: ENSG000001152337   UniProtKB: O004873   

Export aliases for PSMD14 gene to outside databases

Previous GC identifers: GC02P160692 GC02P162128 GC02P162367 GC02P161990 GC02P161872 GC02P162164


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSMD14:
PSMD14 is a component of the 26S proteasome, a multiprotein complex that degrades proteins targeted for destruction by
the ubiquitin pathway (Spataro et al., 1997 (PubMed 9374539)).(supplied by OMIM)

UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487
Function: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin
chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the
'Lys-63'-specific deubiquitination of the proteasome is unclear

Gene Wiki entry for PSMD14

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMD14 gene promoter:
         AP-1   c-Jun   c-Fos   Pax-2   Fra-1   JunB   JunD   ATF-2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PSMD14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PSMD14 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.2   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q14.3

PSMD14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMD14 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P154049:  view genomic region     (about GC identifiers)

Start:
154,049,213 bp from pter
End:
154,152,682 bp from pter
Size:
103,470 bases
Orientation:
plus strand

1 alternative location:
Chr2+ 162,164,549-162,268,228     
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487 (See protein sequence)
Recommended Name: 26S proteasome non-ATPase regulatory subunit 14  
Size: 310 amino acids; 34577 Da
Subunit: Component of the 19S regulatory cap of the 26S proteasome
Secondary accessions: B3KNW2 O00176

Explore the universe of human proteins at neXtProt for PSMD14: NX_O00487 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005796.1  

    ENSEMBL proteins: 
    ENSP00000263639 ENSP00000399311 ENSP00000386541 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PSMD14
    OriGene Protein Over-expression Lysate: PSMD14
    GenScript Custom Purified and Recombinant Proteins Services for PSMD14 
    Novus Biologicals Protein for PSMD14
    Novus Biologicals Lysates for PSMD14
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502 proteasome complex TAS19214193
    About this table

    PSMD14 for ontologies           About GeneDecksing



    Antibodies for PSMD14: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for PSMD14
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): PSMD14
    GenScript Custom Superior Antibodies Services for PSMD14 
    Novus Biologicals Antibodies for PSMD14
    Epitomics antibodies for PSMD14

    Assays for PSMD14: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PSMD14 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PSMD14 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PSMD14 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000555 Mov34_MPN_PAD1

    Graphical View of Domain Structure for InterPro Entry O00487

    ProtoNet protein and cluster: O00487

    1 Blocks protein family: IPB000555 Mov34 family

    UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487
    Similarity: Belongs to the peptidase M67A family. PSMD14 subfamily
    Similarity: Contains 1 MPN (JAB/Mov34) domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487
    Function: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin
    chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the
    'Lys-63'-specific deubiquitination of the proteasome is unclear
    Enzyme Number (IUBMB): EC 3.4.19.- 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PSMD14
    Sigma-Aldrich shRNA Panels and shRNA for PSMD14
    OriGene 29mer shRNA kits in GFP-retroviral vector: PSMD14
    OriGene shRNA RFP: PSMD14
    OriGene basic RS shRNA: PSMD14
    OriGene siRNA: PSMD14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PSMD14 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PSMD14 
    Search SABiosciences for Assays for microRNAs that regulate PSMD14

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PSMD14
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PSMD14
    OriGene untagged cDNA clones in CMV expression vector: PSMD14
    OriGene 3'-UTR clone: PSMD14 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PSMD14 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PSMD14 

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221 ubiquitin thiolesterase activity TAS19214193
    GO:0005515 protein binding IPI17353931
    GO:0008233 peptidase activity IEA--
    GO:0008237 metallopeptidase activity TAS19214193
    GO:0046872 metal ion binding IEA--
    About this table

    PSMD14 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    PSMD14 for pathways           About GeneDecksing

    3 Millipore Pathways for PSMD14
        Immune response Antigen presentation by MHC class I
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  PSMD14
        Protein Ubiquitination Pathway

    1 Kegg Pathway  (Kegg details for PSMD14):
        hsa03050 Proteasome

        SABiosciences Custom Pathway-Focused PCR Arrays for PSMD14 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PSMD14
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMD14

    5/109 Interacting proteins for PSMD14 (ENSP000002636393 O004871, 2) via UniProtKB, MINT, and/or STRING (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMD6Q150081, 2STRING: ENSP00000295901 EBI-722193,EBI-359701 MINT-7230300
    PAAF1Q9BRP41, 2EBI-722193,EBI-1056358 MINT-7230300
    PSMA7O148182STRING: ENSP00000359910 MINT-7230300
    PSMC1P621912STRING: ENSP00000261303 MINT-7230300
    PSMC2P359982STRING: ENSP00000292644 MINT-7230300
    About this table

    5/17 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 17):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075 cell cycle checkpoint TAS--
    GO:0000082 G1/S transition of mitotic cell cycle TAS--
    GO:0000084 S phase of mitotic cell cycle TAS--
    GO:0000216 M/G1 transition of mitotic cell cycle TAS--
    GO:0000278 mitotic cell cycle TAS--
    About this table

    PSMD14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMD14


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PSMD14
    Sigma-Aldrich shRNA Panels and shRNA for PSMD14
    OriGene 29mer shRNA kits in GFP-retroviral vector: PSMD14
    OriGene shRNA RFP: PSMD14
    OriGene basic RS shRNA: PSMD14
    OriGene siRNA: PSMD14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PSMD14 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PSMD14 
    Search SABiosciences for Assays for microRNAs that regulate PSMD14
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PSMD14
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PSMD14
    OriGene untagged cDNA clones in CMV expression vector: PSMD14
    OriGene 3'-UTR Clone: PSMD14 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PSMD14 
    Primers: OriGene genome-wide validated SYBR primer pairs: PSMD14
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PSMD14: PPH60098A

    REFSEQ mRNAs for PSMD14 gene: 

    NM_005805.4  

    Additional cDNA sequence: 

    AB209220.1 AK055128.1 AK091095.1 BC009524.1 BC066336.1 CR595585.1 CR606475.1 CR615752.1 
    CR617325.1 U86782.1 

    14 DOTS entries:

    DT.454530  DT.95307891  DT.422466  DT.40238609  DT.99939165  DT.100815487  DT.120956024  DT.100815485 
    DT.101985697  DT.120955969  DT.91761278  DT.91761290  DT.95149152  DT.91761281 

    24/330 AceView cDNA sequences (see all 330):

    BQ691109 U86782 BU729969 BQ011444 BM977394 BU621390 CB145914 CD513062 
    BM474108 BM550388 CK822271 CA431624 BU159846 CB115181 BX506781 AA306073 
    BC009524 AU138633 BQ772201 BM978668 CR606475 CR615752 BU615342 BM712859 

    highest scoring ESTs for PSMD14:

    AI984100 U86782 AA320379 AA482701 AA513177 AA621752 AA715379 AI150787 AI168699 AI291370 

    Unigene Cluster for PSMD14:

    Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
    Hs.567410  [show with all ESTs]
    Unigene Representative Sequence: AB209220


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PSMD14

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                    -                 -                             -                       -                     
    SP2:                                      -                                                                           
    SP3:                                                                                            -                     
    SP4:                    -                                                                                             
    SP5:                                                                                                                  

    About this scheme

    ECgene alternative splicing isoforms for PSMD14
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263639 ENST00000492908 ENST00000478123 ENST00000437630 ENST00000477232
    ENST00000409682(uc002ubu.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PSMD14 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching PSMD14 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33247_at2, 3 U95-A 1 1.00 1.00 0.59 1.15 U86782 1.00 1.00 1.00 1
    43809_at2, 3 U95-B 1 1.00 1.00 0.42 1.34 AI984100 1.00 1.00 1.00 1
    87461_at2, 3 U95-D 1 0.56 1.00 0.72 0.53 AI539365 0.60 1.00 0.82 1
    212296_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005805 0.60 1.00 0.82 1
    212296_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    PSMD14 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PSMD14 gene expression
    PSMD14 gene electronic northern expression
    PSMD14 gene sage expression
    About these images

    CGAP SAGE TAG: AATACATCAA

    SOURCE GeneReport for Unigene cluster: Hs.567410

    Expression variation in blood from EXPOLDB for PSMD14

    UniProtKB/Swiss-Prot: PSDE_HUMAN, O00487
    Tissue specificity: Widely expressed. Highest levels in heart and skeletal muscle

    Primers: OriGene genome-wide validated SYBR primer pairs: PSMD14
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PSMD14: PPH60098A
        SABiosciences Custom PCR Arrays for PSMD14 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PSMD14 gene from 5/28 species (see all 28)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PSMD141   -- proteasome (prosome, macropain) 26S subunit, non-ATPase, more 96.94(n)
    98.64(a)
    478765  XM_535931.2  XP_535931.2 
    chimpanzee
    (Pan troglodytes)
    PSMD141   -- proteasome (prosome, macropain) 26S subunit, non-ATPase, more 99.89(n)
    100(a)
    459686  XM_515855.2  XP_515855.2 
    cow
    (Bos taurus)
    PSMD141   -- proteasome (prosome, macropain) 26S subunit, non-ATPase, more 97.1(n)
    100(a)
    535683  NM_001076067.1  NP_001069535.1 
    rat
    (Rattus norvegicus)
    Psmd141   -- proteasome (prosome, macropain) 26S subunit, non-ATPase, more 93.42(n)
    100(a)
    311078  XM_001059730.1  XP_001059730.1 
    mouse
    (Mus musculus)
    Psmd141 , 5 2 (35.56 cM)5
    proteasome (prosome, macropain) 26S subunit, non-ATPase, more1, 5 94.5(n)1
    99.35(a)1
    590291  NM_021526.11  NP_067501.11 
     AA9867325  AI4488785  (see all 18)
    About this table        Species with no ortholog for PSMD14

    ENSEMBL Gene Tree for PSMD14 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PSMD14 gene
    EIF3H2  

    PSMD14 for paralogs           About GeneDecksing


    Pseudogenes
    1 related pseudogene



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/662 NCBI SNPs in PSMD14 are shown (see all 662)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs97131,2
    C,F,A,H,162165008(+) CAGACT/AGAGCC 1 -- ut51 ese312Minor allele frequency- A:0.31MN NS EA NA WA 784
    rs10645761,2
    C,F,162268108(+) CTAAAG/ATTATA 1 -- ut31 ese311Minor allele frequency- A:0.06NS MN EA NA 780
    rs11105871,2
    C,F,O,162264277(+) TCACCC/TCCTTT 1 -- int117Minor allele frequency- T:0.03EA NA NS WA 980
    rs11114161,2
    C,F,O,H,162212227(-) ATAAAC/TGAGTT 1 -- int113Minor allele frequency- T:0.05NA NS EA WA 640
    rs11114171,2
    C,F,O,A,H,162208985(-) TTATTT/CTAGTG 1 -- int120Minor allele frequency- C:0.06NS EA NA WA 910
    rs11161651,2
    C,162175290(-) CAAAAG/ATGTTT 1 -- int15Minor allele frequency- A:0.00NA WA 10
    rs11161731,2
    C,F,O,H,162226838(-) ACAGGC/TGGTGC 1 -- int122Minor allele frequency- T:0.23EA NA NS WA 2828
    rs11365481,2
    --162173001(+) ATTAGC/TAAGAG 1 -- ut510--------
    rs15594961,2
    C,F,O,A,162215094(+) GACCAG/CTCCTA 1 -- int120Minor allele frequency- C:0.40MN NS EA NA WA 1338
    rs18629531,2
    C,F,162206805(+) aatacT/Agcctg 1 -- int112Minor allele frequency- A:0.05NS EA NA WA 504
    About this table

    HapMap Linkage Disequilibrium images for PSMD14 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PSMD14
         2 CNVs: 9968 1358

    QIAGEN SeqTarget long-range PCR primers for resequencing PSMD14 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PSMD14 for disorders           About GeneDecksing

    OMIM: 607173


    Export disorders and mutations for PSMD14 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/26 PubMed articles for PSMD14 gene, integrated from 7 sources (see all 26):
    (articles sorted by number of sources associating them with PSMD14)
    1. Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit. (PubMed id 9374539)1, 2, 3, 7 Spataro V....Norbury C. (1997)
    2. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1. (PubMed id 19214193)1, 2 Cooper E.M....Cohen R.E. (2009)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The 19 S proteasomal subunit POH1 contributes to the regulation of c-Jun ubiquitination, stability, and subcellular localization. (PubMed id 16569633)1, 7 Nabhan J.F. and Ribeiro P. (2006)
    7. Relationship between expression of Pad1 homologue and multidrug resistance of idiopathic nephrotic syndrome. (PubMed id 19419512)1, 7 Ma Z....Li C. (2009)
    8. Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence. (PubMed id 19732767)1 Byrne A....Jiang Y. (2010)
    9. Chaperone-mediated pathway of proteasome regulatory p article assembly. (PubMed id 19412159)1 Roelofs J....Finley D. (2009)
    10. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10213 HGNC: 16889 AceView: PSMD14 Ensembl:ENSG00000115233 euGenes: HUgn10213
    ECgene: PSMD14 Kegg: 10213 H-InvDB: PSMD14

    (According to HUGE)
    About This Section
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for PSMD14 gene:
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