Aliases &
Descriptions
for PSRC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| proline/serine-rich coiled-coil 11 2 | | OTTHUMP000002058342 | | DDA31 2 3 5 | | FP32142 | | proline/serine-rich coiled-coil protein 12 | | differential display and activated by p532 | | MGC17802 | | OTTHUMP000000137902 | | OTTHUMP000000137892 | | p53-regulated DDA32 |
Export aliases for PSRC1 gene to outside databasesPrevious GC identifers: GC01M109535 GC01M109624 GC01M109625 GC01M109822 |
Summaries
for PSRC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PSRC1:
This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene isregulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as amicrotubule destabilizing protein that controls spindle dynamics and mitotic progression by recruiting and regulatingmicrotubule depolymerases. At least one genetic variation in this gene has been associated with decreased serum levelsof low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding different isoforms havebeen described. (provided by RefSeq)
UniProtKB/Swiss-Prot: PSRC1_HUMAN, Q6PGN9Function: Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphaseplate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitoticspindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to thegeneration of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. Mayparticipate in p53/TP53-regulated growth suppression
Gene Wiki entry for PSRC1 |
Genomic Views
for PSRC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PSRC1 gene promoter:
p53 STAT5A MEF-2A RSRFC4 GATA-1 LUN-1 NF-1 Tal-1beta ITF-2 AP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PSRC1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PSRC1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3PSRC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M107715: view genomic region
(about GC identifiers)
Start:
|
107,715,423 bp from pter |
End:
|
107,719,037 bp from pter |
Size:
|
3,615 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr1- 109,822,176-109,825,808 |
RefSeq DNA sequence:- NC_000001.10 NT_032977.9
|
Proteins
for PSRC1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PSRC1_HUMAN, Q6PGN9 (See
protein sequence)Recommended Name: Proline/serine-rich coiled-coil protein 1 Size: 363 amino acids; 38796 Da
Subunit: Interacts with APC2 (By similarity). Interacts with KIF2A
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detectedat the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase
Secondary accessions: Q5T2Z3 Q6ZTI8 Q71MG3 Q9BV77Alternative splicing: 4 isoforms: Q6PGN9-1 Q6PGN9-2 Q6PGN9-3 Q6PGN9-4 Explore the universe of human proteins at neXtProt for PSRC1: NX_Q6PGN9
Post-translational modifications:
Phosphorylated during mitosis1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (3 alternative transcripts):
NP_001005290.1 NP_001027462.1 NP_116025.1
ENSEMBL proteins: ENSP00000358920 ENSP00000358923 ENSP00000387791 ENSP00000358925 ENSP00000386323 ENSP00000413591 ENSP00000413186 ENSP00000358919
Human Recombinant Proteins
5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7): About this table
PSRC1 for ontologies About GeneDecksing
Antibodies for PSRC1:
Assays for PSRC1: |
Protein
Domains/
Families
for PSRC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6PGN9 UniProtKB/Swiss-Prot: PSRC1_HUMAN, Q6PGN9Similarity: Belongs to the PSRC1 family |
Gene Function
for PSRC1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PSRC1_HUMAN, Q6PGN9Function: Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphaseplate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitoticspindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to thegeneration of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. Mayparticipate in p53/TP53-regulated growth suppression
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
PSRC1 for ontologies About GeneDecksing
|
Pathways & Interactions
for PSRC1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for PSRC1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSRC1
5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10): About this table
PSRC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PSRC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PSRC1
|
Transcripts
for PSRC1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PSRC1 gene (3 alternative transcripts): NM_001005290.3 NM_001032291.2 NM_032636.7 Additional cDNA sequence: AF223000.1 AK126567.1 AK289593.1 BX649139.1 CR590786.1 CR590881.1 CR596962.1 CR598811.1 CR616373.1 CR617198.1 CR623580.1 CR624502.1 CR625810.1 15 DOTS entries: DT.441131 DT.95200431 DT.100039478 DT.101983669 DT.100039476 DT.91753608 DT.92009820 DT.100039477 DT.95073194 DT.100039475 DT.100837762 DT.100882017 DT.102819554 DT.91753611 DT.97860601 24/297 AceView cDNA sequences (see all 297): AA768820 AA765540 CR590881 BM916533 AA740609 CR624502 CA455390 AA047880 BM553038 BE336859 BM716318 BU688344 AF447874 BE856345 AI214290 BE336603 BX410344 AI827975 BP366111 BE465952 AI990235 BQ686423 BG248089 BG822488
 highest scoring ESTs for PSRC1:H04928 AA031488 AF223000 AK126567 AL521829 AW002984 AW956919 BC056909 BE264060 BE265161 Unigene Cluster for PSRC1: Proline/serine-rich coiled-coil 1 Hs.405925 [show with all ESTs]Unigene Representative Sequence: CR623580
GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for PSRC1 (see all 15)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PSRC1
13 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369904 ENST00000409138(uc001dxh.2 uc001dxi.2 uc001dxj.2)
ENST00000369907 ENST00000471740 ENST00000474126 ENST00000429031 ENST00000369909(uc001dxd.2 uc001dxf.2)
ENST00000409267(uc001dxc.2) ENST00000438534(uc001dxe.2 uc001dxg.2)
ENST00000418914 ENST00000369903 ENST00000492431(uc001dxb.2) ENST00000459765
|
Expression
for PSRC1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PSRC1 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching PSRC1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 72452_at2, 3
|
U95-E |
1 |
1.00 |
1.00 |
0.93 |
0.76 |
H04928 |
1.00 |
1.00 |
1.00 |
1 |
| 49156_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.99 |
1.14 |
AA031488 |
0.80 |
1.00 |
0.91 |
1 |
| 43026_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.97 |
1.11 |
AW002984 |
0.80 |
1.00 |
0.91 |
1 |
| 201896_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
BC001425 |
0.40 |
0.75 |
0.60 |
1 |
| 201896_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PSRC1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGAAATGGGG
SOURCE GeneReport for Unigene cluster: Hs.405925
UniProtKB/Swiss-Prot: PSRC1_HUMAN, Q6PGN9Tissue specificity: Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetalthymus. Not detected in adult skeletal muscle
SABiosciences Custom PCR Arrays for PSRC1
|
Orthologs
for PSRC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PSRC1 gene from 4 species
About this table Species with no ortholog for PSRC1
ENSEMBL Gene Tree for PSRC1 (if available) |
Paralogs
for PSRC1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for PSRC1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 1 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PSRC1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PSRC1
1 CNV: 48080 | | QIAGEN SeqTarget long-range PCR primers for resequencing PSRC1 |
|
Disorders & Mutations
for PSRC1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PSRC1 for disorders About GeneDecksing
OMIM: 613126
Human Genome Epidemiology (HuGE) Navigator: PSRC1 (23 documents)
Export disorders and mutations for PSRC1 gene to outside databases
|
Medical News
for PSRC1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PSRC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/48 PubMed articles for PSRC1 gene, integrated from 7 sources (see all 48):
(articles sorted by number of sources associating them with PSRC1)- Cloning and characterization of human and mouse DDA3 genes. (PubMed id 12427559)1, 2, 3 Lo P.-K. and Wang F.-F. (2002)
- The N-terminal domain of DDA3 regulates the spindle-a ssociation of the microtubule depolymerase Kif2a and controls the mitotic funct ion of DDA3. (PubMed id 19738423)1, 2 Jang C.Y. and Fang G. (2009)
- DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. (PubMed id 18411309)1, 2 Jang C.Y....Fang G. (2008)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of a novel mouse p53 target gene DDA3. (PubMed id 10618717)1, 3 Lo P.K....Wang F.F. (1999)
- Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk. (PubMed id 20167577)1 Reynolds C.A....Prince J.A. (2010)
|
External Searches for PSRC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PSRC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PSRC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PSRC1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PSRC1 gene:
Search GeneIP for patents involving PSRC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PSRC1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
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 |  |  |  | |
| |  | Search Tocris compounds for PSRC1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for PSRC1 |
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