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PTCH2 Gene

protein-coding GIFtS: 56

GC01M043398

patched 2
(Previous names: patched (Drosophila) homolog 2, patched homolog 2 (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
patched 2¹ ²
PTC2² ³
patched (Drosophila) homolog 2¹
patched homolog 2 (Drosophila)¹
protein patched homolog 2²
patched homolog 2²

External Ids:	HGNC: 9586¹	Entrez Gene: 8643²	Ensembl: ENSG00000117425⁷	UniProtKB: Q9Y6C5³

Export aliases for PTCH2 gene to outside databases

Previous GC identifers: GC01M045015 GC01M044288 GC01M044716 GC01M044702 GC01M044703 GC01M044957 GC01M045060 GC01M045286

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTCH2:

This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor

suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell

carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively

spliced transcript variants have been described.

UniProtKB/Swiss-Prot: PTC2_HUMAN, Q9Y6C5

Function: May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTCH2 gene promoter:
         MIF-1   GATA-1   NF-kappaB1   PPAR-gamma2   PPAR-gamma1   Pbx1a   Chx10   RFX1   AP-4   Lmo2
         Other transcription factors

Search SABiosciences Chromatin IP Primers for PTCH2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PTCH2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p34.1

PTCH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTCH2 gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M043398: view genomic region (about GC identifiers)

Start:	43,398,182 bp from pter
End:	43,420,910 bp from pter
Size:	22,729 bases
Orientation:	minus strand

1 alternative location:

Chr1- 45,285,516-45,308,735

RefSeq DNA sequence:

NC_000001.10 NT_032977.9

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PTC2_HUMAN, Q9Y6C5 (See protein sequence)

Recommended Name: Protein patched homolog 2

Size: 1203 amino acids; 130544 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: O95341 O95856 Q53Z57 Q5QP87 Q6UX14

Alternative splicing: 2 isoforms: Q9Y6C5-1 Q9Y6C5-2

Explore the universe of human proteins at neXtProt for PTCH2: NX_Q9Y6C5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001159764.1 NP_003729.3

ENSEMBL proteins:

ENSP00000413169 ENSP00000361266 ENSP00000389703

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for PTCH2
	Novus Biologicals Protein for PTCH2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	9811851
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	--	--

About this table

PTCH2 for ontologies About GeneDecksing

Antibodies for PTCH2:

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	Novus Biologicals Antibodies for PTCH2
	Browse antibodies at Epitomics

Assays for PTCH2:

	Browse Kits and Assays available from Millipore
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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PTCH2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PTCH2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTCH2 for domains About GeneDecksing

3 InterPro domains/families:

IPR003392 Patched

IPR000731 SSD

IPR004766 TM_rcpt_patched

Graphical View of Domain Structure for InterPro Entry Q9Y6C5

ProtoNet protein and cluster: Q9Y6C5

1 Blocks protein family: IPB003392 Patched family

UniProtKB/Swiss-Prot: PTC2_HUMAN, Q9Y6C5

Similarity: Belongs to the patched family

Similarity: Contains 1 SSD (sterol-sensing) domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: PTC2_HUMAN, Q9Y6C5

Function: May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and siRNA for PTCH2 Sigma-Aldrich shRNA for PTCH2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PTCH2 OriGene shRNA RFP (see all 2): PTCH2 OriGene basic RS shRNA (see all 2): PTCH2 OriGene siRNA (see all 2): PTCH2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTCH2

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTCH2
		Search SABiosciences for Assays for microRNAs that regulate PTCH2

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PTCH2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PTCH2 OriGene untagged cDNA clones in CMV expression vector: PTCH2 Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PTCH2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for PTCH2

Genatlas biochemistry entry for PTCH2:

Drosophila segment polarity gene patched (PTC) homolog 2,expressed at high levels in the skin and spermatocytes,binding

to all hedgehog family members,forming complex with SMOH and likely with Desert hedgehog receptor,putative tumor

suppressor gene in basal cell carcinoma and medulloblastoma

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	TAS	9811851
GO:0008158	hedgehog receptor activity	IEA	--

About this table

PTCH2 for ontologies About GeneDecksing

Animal Models: 10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ptch2):

cardiovascular system	digestive/alimentary	hematopoietic system	immune system	muscle
nervous system	normal	reproductive system	skin/coat/nails	tumorigenesis

PTCH2 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

PTCH2 for pathways About GeneDecksing

5/6 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for PTCH2 (see all 6)

	Basal Cell Carcinoma Signaling
	Molecular Mechanisms of Cancer
	Protein Kinase A Signaling
	Corticotropin Releasing Hormone Signaling
	Axonal Guidance Signaling

3 Kegg Pathways (Kegg details for PTCH2):

	hsa04340 Hedgehog signaling pathway
	hsa05200 Pathways in cancer
	hsa05217 Basal cell carcinoma

SABiosciences Pathway-Focused PCR Array including PTCH2: PAHS-078A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PTCH2

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTCH2

5 Interacting proteins for PTCH2 (ENSP00000361266³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTCH1	ENSP00000332353³	STRING: ENSP00000332353
SMO	ENSP00000249373³	STRING: ENSP00000249373
DHH	ENSP00000266991³	STRING: ENSP00000266991
IHH	ENSP00000295731³	STRING: ENSP00000295731
SHH	ENSP00000297261³	STRING: ENSP00000297261

About this table

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	TAS	9811851
GO:0007283	spermatogenesis	TAS	9811851
GO:0008544	epidermis development	TAS	9811851
GO:0042633	hair cycle	IEA	--
GO:0043588	skin development	IEA	--

About this table

PTCH2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PTCH2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and siRNA for PTCH2 Sigma-Aldrich shRNA for PTCH2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PTCH2 OriGene shRNA RFP (see all 2): PTCH2 OriGene basic RS shRNA (see all 2): PTCH2 OriGene siRNA (see all 2): PTCH2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTCH2

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTCH2
		Search SABiosciences for Assays for microRNAs that regulate PTCH2

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PTCH2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PTCH2 OriGene untagged cDNA clones in CMV expression vector: PTCH2 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PTCH2

Primers:		OriGene genome-wide validated SYBR primer pairs: PTCH2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PTCH2: PPH00985A

REFSEQ mRNAs for PTCH2 gene (2 alternative transcripts):

NM_001166292.1 NM_003738.4

Additional cDNA sequence:

AF087651.1 AF091501.1 AF119569.1 AK307168.1 AY358555.1 AY359016.1 BC143712.1

5 DOTS entries:

DT.91722763 DT.101969902 DT.435500 DT.302735 DT.65284363

23 AceView cDNA sequences:

BX089003 NM_003738 AF119569 AY358555 D60589 AF091501 AY359016 AA781365

AA781148 BI913889 D60319 D61144 AI798853 AF087651 D60853 AV744412

D80874 D60408 AV739728 D61174 BE843857 BF376868 BF376870

highest scoring ESTs for PTCH2:

AF087651 AF091501 AF119569 AY358555 AY359016 BE843857 BF376868 BF376870 BI913889 D60319

Unigene Cluster for PTCH2:

Patched 2

Hs.591497 [show with all ESTs]

Unigene Representative Sequence: NM_001166292

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000438067 ENST00000372192(uc010olf.1 uc010olg.1) ENST00000447098

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

PTCH2 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching PTCH2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
73688_at²^{, 3}	U95-E	1	0.50	1.00	1.00	1.00	AI798853	0.20	0.50	0.38	1
221292_at²^{, 3}	U133-A	1	0.82	1.00	--	--	NM_003738	0.60	1.00	0.82	1
221292_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

About this table

PTCH2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

PTCH2 gene electronic northern expression

About these images

CGAP SAGE TAG: ACCGTGGCCA

SOURCE GeneReport for Unigene cluster: Hs.591497

Primers:		OriGene genome-wide validated SYBR primer pairs: PTCH2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PTCH2: PPH00985A

SABiosciences Expression via Pathway-Focused PCR Array including PTCH2: PAHS-078A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PTCH2 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PTCH2¹	--	patched homolog 2 (Drosophila)	90.16(n) 91.99(a)	482519 XM_539636.2 XP_539636.2
cow (Bos taurus)	PTCH2¹	--	patched homolog 2 (Drosophila)	91.27(n) 93.85(a)	507948 XM_584648.3 XP_584648.3
mouse (Mus musculus)	Ptch2^{1 , 5}	4 (53.41 cM)⁵	patched homolog 2^{1, 5}	88.23(n)¹ 91.02(a)¹	19207¹ NM_008958.2¹ NP_032984.1¹ AB000847⁵ AB010833⁵ (see all 13)
zebrafish (Danio rerio)	ptc1²	--	patched1	75.35(n)	30181 NM_130988.1
fruit fly (Drosophila melanogaster)	ptc³	44D5--E1	eye-antennal disc metamorphosis patched receptor	37(a)	--

About this table Species with no ortholog for PTCH2

ENSEMBL Gene Tree for PTCH2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PTCH2 gene

PTCH1² NPC1² NPC1L1² C6orf138² PTCHD3² PTCHD1²

PTCH2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs2273940^1,2	C,F,A,	45294156(+)	`TGAGCC/TGCCCC`	2	--	int¹		9		EA NS NA WA	1842
rs2295996^1,2	C,F,O,H,	45292866(+)	`TGGGCG/ATCTCC`	4	/D	ref¹ syn¹ ese³		20		EA NS NA	2718
rs2295997^1,2	C,F,A,	45293752(+)	`CTGGCT/CTCACA`	4	/E	ref¹ syn¹		21		EA NS NA WA	3050
rs2295998^1,2	C,F,A,H,	45296752(+)	`AGGGAC/TGAAAA`	2	--	int¹		20		EA NS NA WA	2152
rs2295999^1,2	C,F,	45297753(+)	`GAAGAA/C/GGGGGA`	2	--	int¹ trp³		11		EA NS NA WA	2204
rs3117845^1,2	--	45307059(+)	`CCCAGA/CCTTCT`	2	--	int¹		0	--	--	--	--
rs3795719^1,2	C,F,	45288527(+)	`TGGATC/GCTAAA`	2	--	int¹		11		NS EA NA WA	806
rs3795720^1,2	C,F,A,	45307506(+)	`CCAGTG/ATCCAC`	2	--	int¹		22		EA NS NA WA	3234
rs5773854^1,2	C,F	45295911(+)	`GGAAGTA/-GGCTT`	2	--	int¹		2		NS NA	104
rs6429549^1,2	C,F,A,H,	45300857(+)	`TCAAGT/CAGCTG`	2	--	int¹		7		NS NA WA	250

About this table

HapMap Linkage Disequilibrium images for PTCH2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PTCH2: --

QIAGEN SeqTarget long-range PCR primers for resequencing PTCH2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PTCH2 for disorders About GeneDecksing

OMIM: 603673 disorders: 155255 605462

UniProtKB/Swiss-Prot: PTC2_HUMAN, Q9Y6C5

Defects in PTCH2 are a cause of medulloblastoma (MDB) [MIM:155255]. MDB is a malignant, invasive embryonal

tumor of the cerebellum with a preferential manifestation in children. Although the majority of medulloblastomas occur

sporadically, some manifest within familial cancer syndromes such as Turcot syndrome and basal cell nevus syndrome

(Gorlin syndrome)

Defects in PTCH2 are a cause of sporadic basal cell carcinoma (BCC) [MIM:605462]

Human Gene Mutation Database (HGMD): PTCH2
Human Genome Epidemiology (HuGE) Navigator: PTCH2 (3 documents)

Export disorders and mutations for PTCH2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/13 PubMed articles for PTCH2 gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with PTCH2)

Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32. (PubMed id 9931336)^{1, 2, 3} Smyth I.... Wainwright B.J. (1999)
Characterization of two patched receptors for the vertebrate hedgehog protein family. (PubMed id 9811851)^{1, 2, 3} Carpenter D.... de Sauvage F.J. (1998)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas. (PubMed id 10029063)^{1, 2} Zaphiropoulos P.G....Toftgard R. (1999)
Distinct roles of PTCH2 splice variants in Hedgehog signalling. (PubMed id 14613484)^{1, 7} Rahnama F....Zaphiropoulos P.G. (2004)
Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)¹ Jugessur A....Murray J.C. (2010)
Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)¹ Michiels S....Benhamou S. (2009)
A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation. (PubMed id 19208383)¹ Fan Z....Wang S. (2009)
[Studies on keratocystic odontogenic tumors] (PubMed id 19221557)¹ Li T.J....Xu L.L. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8643	HGNC: 9586	AceView: PTCH2	Ensembl:ENSG00000117425	euGenes: HUgn8643
ECgene: PTCH2	Kegg: 8643	H-InvDB: PTCH2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PTCH2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ptch2/

Intellectual Property for PTCH2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for PTCH2 gene:
Search GeneIP for patents involving PTCH2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PTCH2		Antibodies for PTCH2
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	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies for PTCH2 (Patched 2/PTCH2)		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTCH2
	SeqTarget long-range PCR primers for resequencing PTCH2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PTCH2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTCH2

	GenScript Custom Purified and Recombinant Proteins Services for PTCH2		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for PTCH2
	GenScript Custom Assay Services for PTCH2		GenScript Custom Superior Antibodies Services for PTCH2
	GenScript Custom overexpressing Cell Line Services for PTCH2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for PTCH2

	Regulatory tfbs in PTCH2 promoter
	Search Chromatin IP Primers for PTCH2
	RT² qPCR Primer Assay for PTCH2
	GNC Network for PTCH2
	Search for Assays for microRNAs that regulate PTCH2
	SABiosciences PCR Arrays including PTCH2

Search Tocris compounds for PTCH2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for PTCH2
	Proteins for PTCH2

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for PTCH2

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

PTCH2 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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PTCH2 Gene

protein-coding GIFtS: 56

Aliases &
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for PTCH2 gene

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for PTCH2 gene

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for PTCH2 gene

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for PTCH2 gene

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for PTCH2 gene

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for PTCH2 gene

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Export list of displayed genes

PTCH2 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor PTCH2 gene

Summariesfor PTCH2 gene

Genomic Viewsfor PTCH2 gene

Proteinsfor PTCH2 gene

Protein Domains/Familiesfor PTCH2 gene

Gene Functionfor PTCH2 gene

Pathways & Interactionsfor PTCH2 gene

Drugs & Compoundsfor PTCH2 gene

Transcriptsfor PTCH2 gene

Expression for PTCH2 gene

Orthologsfor PTCH2 gene

Paralogsfor PTCH2 gene

Genomic Variantsfor PTCH2 gene

Disorders & Mutationsfor PTCH2 gene

Medical Newsfor PTCH2 gene

Publicationsfor PTCH2 gene

External Searches for PTCH2 gene

Genome Databases showing PTCH2 gene

Other Databases showing PTCH2 gene

Specialized Databases showing PTCH2 gene

Intellectual Propertyfor PTCH2 gene

Productsfor PTCH2 gene

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Aliases &
Descriptions
for PTCH2 gene

Summaries
for PTCH2 gene

Genomic Views
for PTCH2 gene

Proteins
for PTCH2 gene

Protein Domains/
Families
for PTCH2 gene

Gene Function
for PTCH2 gene

Pathways & Interactions
for PTCH2 gene

Drugs & Compounds
for PTCH2 gene

Transcripts
for PTCH2 gene

Expression
for PTCH2 gene

Orthologs
for PTCH2 gene

Paralogs
for PTCH2 gene

Genomic Variants
for PTCH2 gene

Disorders & Mutations
for PTCH2 gene

Medical News
for PTCH2 gene

Publications
for PTCH2 gene

Intellectual Property
for PTCH2 gene

Products
for PTCH2 gene