Aliases &
Descriptions
for PTGS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase andcyclooxygenase)1 2 | | COX32 5 | | COX11 2 3 5 | | cyclooxygenase-12 | | PGHS-11 2 3 | | prostaglandin G/H synthase and cyclooxygenase2 | | PTGHS1 2 | | PGG/HS2 | | Prostaglandin H2 synthase 12 3 | | PHS12 | | COX-12 3 | | prostaglandin G/H synthase 12 | | PHS 12 3 | | Prostaglandin-endoperoxide synthase 13 | | PGH synthase 12 3 | | EC 1.14.99.13 | | PCOX12 5 | | Cyclooxygenase-13 | | PGHS12 5 | | |
Export aliases for PTGS1 gene to outside databasesPrevious GC identifers: GC09P116237 GC09P116779 GC09P118586 GC09P120509 GC09P122212 GC09P124173 GC09P125133 |
Summaries
for PTGS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PTGS1:
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandinbiosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodesPTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugssuch as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis.Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts isdifferentially regulated by relevant cytokines and growth factors. (provided by RefSeq)
UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219Function: May play an important role in regulating or promoting cell proliferation in some normal and neoplasticallytransformed cells
 summary
for PTGS1: Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is
expressed in cells in three isoforms: COX-1, COX-2 and COX-3. COX-1 (constitutive) and COX-2 (inducible)
isoforms catalyze the rate-limiting step of prostaglandin production and are the targets of non-steroidal
anti-inflammatory drugs. COX-3 does not appear to be involved in inflammatory processes, but seems to be
involved in pain and fever. COX-3 is thought to be derived through the retention of the highly structured G
+ C-rich intron 1 of the COX-1 gene.
Gene Wiki entry for PTGS1 |
Genomic Views
for PTGS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PTGS1 gene promoter:
AP-1 c-Jun c-Fos Sp1 GCNF-1 GCNF-2 GATA-1 NF-kappaB NF-kappaB1 NF-kappaB2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PTGS1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q32-q33.3 Ensembl cytogenetic band: 9q33.2 HGNC cytogenetic band: 9q32-q33.3PTGS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P094748: view genomic region
(about GC identifiers)
Start:
|
94,747,952 bp from pter |
End:
|
94,772,697 bp from pter |
Size:
|
24,746 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr9+ 125,133,359-125,157,982 |
RefSeq DNA sequence:- NC_000009.11 NT_008470.19
|
Proteins
for PTGS1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219 (See
protein sequence)Recommended Name: Prostaglandin G/H synthase 1 precursor Size: 599 amino acids; 68656 Da
Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity)
Subunit: Homodimer
Subcellular location: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheralmembrane protein
Miscellaneous: This enzyme acts both as a dioxygenase and as a peroxidase
Miscellaneous: This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin
Sequence caution: Sequence=CAI14716.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K1V7 Q15122 Q5T7T6 Q5T7T7 Q5T7T8Alternative splicing: 2 isoforms: P23219-1 P23219-2 Explore the universe of human proteins at neXtProt for PTGS1: NX_P23219
REFSEQ proteins (2 alternative transcripts):
NP_000953.2 NP_542158.1
ENSEMBL proteins: ENSP00000362802 ENSP00000411606 ENSP00000354612 ENSP00000223423
Human Recombinant Proteins
5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9): About this table
PTGS1 for ontologies About GeneDecksing
Antibodies for PTGS1:
Assays for PTGS1: |
Protein
Domains/
Families
for PTGS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PTGS1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P23219ProtoNet protein and cluster: P23219 3 Blocks protein families: IPB002007 Animal haem peroxidase signature IPB006210 Type I EGF IPB010255 Haem peroxidase
UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219Similarity: Belongs to the prostaglandin G/H synthase familySimilarity: Contains 1 EGF-like domain |
Gene Function
for PTGS1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219Function: May play an important role in regulating or promoting cell proliferation in some normal and neoplasticallytransformed cellsCatalytic activity: Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)OEnzyme Number (IUBMB): EC 1.14.99.1
Genatlas biochemistry entry for PTGS1:prostaglandin G/H synthase 1,constitutively expressed in a wide range of tissues,acting first as a dioxygenase,then asa peroxidase (lipocalin family,Kernel group),monomer,potent mediator of inflammation5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8): About this table
PTGS1 for ontologies About GeneDecksing
Animal Models: 15/22 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ptgs1) (see all 22):
PTGS1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PTGS1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
PTGS1 for pathways About GeneDecksing
3  Millipore Pathways for PTGS1
4  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for PTGS1
2  Kegg Pathways (Kegg details for PTGS1):
UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219Pathway: Lipid metabolism; prostaglandin biosynthesis SABiosciences Pathway-Focused PCR Arrays including PTGS1 (see all 6): PAHS-003A PAHS-024A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PTGS1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTGS1
5/38 Interacting proteins for PTGS1 (ENSP000003546123 P232192) via UniProtKB, MINT, and/or STRING (see all 38) About this table
5/19 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 19): About this table
PTGS1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PTGS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
PTGS1 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for PTGS1 |
Compounds for PTGS1 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Tenidap | NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3 | [120210-48-2] | | FR 122047 hydrochloride | Cyclooxygenase (COX-1) inhibitor | [130717-51-0] | | Piroxicam | Cyclooxygenase (COX-1) inhibitor | [36322-90-4] | | (S)-(+)-Ibuprofen | Cyclooxygenase inhibitor (COX-1 > COX-2) | [51146-56-6] | | SC 560 | Cyclooxygenase (COX-1) inhibitor | [188817-13-2] |
About this table
10/125  Novoseek chemical compound relationships for PTGS1 gene (see all 125)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| prostaglandin |
91 |
300 |
9461646 (4), 15035793 (3), 10609518 (2), 7947975 (2) (see all 99) |
| pge2 |
90.6 |
411 |
11809691 (4), 8872612 (3), 15963707 (3), 9779823 (3) (see all 99) |
| celecoxib |
89.5 |
89 |
12152003 (2), 16952493 (2), 10664917 (2), 15498669 (2) (see all 62) |
| arachidonic acid |
89.5 |
273 |
10358065 (5), 7737984 (4), 10551587 (3), 10206978 (3) (see all 99) |
| rofecoxib |
89.5 |
72 |
10096266 (3), 11028250 (3), 11136272 (2), 10411562 (2) (see all 48) |
| aspirin |
84.6 |
396 |
11717412 (5), 18753249 (5), 15041270 (4), 19152549 (4) (see all 99) |
| meloxicam |
83.5 |
52 |
10381787 (3), 10812057 (3), 11874389 (3), 10340919 (2) (see all 32) |
| ns 398 |
82.8 |
16 |
10217458 (2), 9875720 (1), 11563332 (1), 16964399 (1) (see all 15) |
| prostaglandin-h2 |
82.3 |
34 |
17878511 (2), 8652509 (1), 10734173 (1), 11081405 (1) (see all 20) |
| valdecoxib |
81.9 |
6 |
12644588 (1), 15494548 (1), 16519515 (1), 12466002 (1) (see all 5) |
About this table
|
Transcripts
for PTGS1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PTGS1 gene (2 alternative transcripts): NM_000962.2 NM_080591.1 Additional cDNA sequence: AF086438.1 AF129755.1 AJ420464.1 AK290022.1 AK295221.1 AK304403.1 AK308222.1 BC029840.1 DQ180740.1 DQ180741.1 DQ180742.1 M59979.1 S36219.1 S36271.1 S78220.1 U63846.1 12 DOTS entries: DT.446317 DT.100767562 DT.121193472 DT.101957346 DT.100767557 DT.101982936 DT.121193484 DT.75197219 DT.100767561 DT.100767556 DT.97797260 DT.91965381 24/156 AceView cDNA sequences (see all 156): AU279462 BQ014239 BF064148 AA630760 NM_000962 BM728404 BU733396 AA707736 CD014048 AA345128 S36219 AI076274 N54739 NM_080591 AL709654 AI567867 BM679302 AA635841 AI569876 BM990424 AL556508 BC029840 BF477437 AI885487
 highest scoring ESTs for PTGS1:M59979 AA037294 AA278216 AI202433 AI424408 AI467819 AI740976 AI806507 AV734203 AV744257 Unigene Cluster for PTGS1: Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Hs.201978 [show with all ESTs]Unigene Representative Sequence: NM_000962
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PTGS1 (see all 8)
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | · | 14d |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PTGS1
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373698 ENST00000426608 ENST00000362012(uc011lys.1 uc010mwb.1 uc004bmf.1 uc004bmg.1 uc004bmh.1 uc011lyt.1)
ENST00000223423
|
Expression
for PTGS1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PTGS1 expression in normal and diseased human tissues
1 / 2 / 3 10 probe-sets matching PTGS1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 37969_at2, 3
|
U95-A |
1 |
0.69 |
1.00 |
0.68 |
1.01 |
M59979 |
1.00 |
1.00 |
1.00 |
1 |
| 89844_at2, 3
|
U95-E |
1 |
0.62 |
1.00 |
0.92 |
1.03 |
AI806507 |
0.80 |
1.00 |
0.91 |
1 |
| 215813_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
S36219 |
0.80 |
1.00 |
0.91 |
1 |
| 205128_x_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_000962 |
0.60 |
1.00 |
0.82 |
1 |
| 238669_at2, 3
|
U133-B |
1 |
0.82 |
1.00 |
-- |
-- |
BE613133 |
0.40 |
1.00 |
0.76 |
1 |
| 205127_at2, 3
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
NM_000962 |
0.60 |
1.00 |
0.82 |
1 |
| 215813_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 205128_x_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 238669_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 205127_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PTGS1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AAGCTAATAA
SOURCE GeneReport for Unigene cluster: Hs.201978
Expression variation in blood from EXPOLDB for PTGS1 SABiosciences Expression via Pathway-Focused PCR Arrays including PTGS1 (see all 6): PAHS-003A PAHS-024A
|
Orthologs
for PTGS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PTGS1 gene from 5/10 species (see all 10)
About this table Species with no ortholog for PTGS1
ENSEMBL Gene Tree for PTGS1 (if available) |
Paralogs
for PTGS1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PTGS1 gene
- PTGS22
PTGS1 for paralogs About GeneDecksing
|
Genomic Variants
for PTGS1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 9 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PTGS1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PTGS1
1 Indel: 47643 | | QIAGEN SeqTarget long-range PCR primers for resequencing PTGS1 |
|
Disorders & Mutations
for PTGS1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PTGS1 for disorders About GeneDecksing
OMIM: 176805
10/93 Novoseek disease relationships for PTGS1 gene (see all 93)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammation |
71.7 |
163 |
16982919 (3), 10628589 (2), 12733982 (2), 17270500 (2) (see all 99) |
| osteoarthritis |
61.6 |
22 |
15337183 (2), 11041909 (2), 10719816 (1), 14752171 (1) (see all 16) |
| gastrointestinal complications |
58.1 |
3 |
10377455 (1), 14602052 (1) |
| colon cancer |
57 |
18 |
19258012 (4), 16091009 (2), 7780968 (2), 16984374 (2) (see all 12) |
| intestinal polyps |
53.6 |
5 |
12941808 (3), 16984374 (1) |
| ulcer |
53.2 |
28 |
16247187 (3), 11519793 (2), 17926541 (2), 11136275 (2) (see all 15) |
| nasal polyps |
52.1 |
29 |
16517580 (4), 15921208 (4), 15480320 (2), 19132974 (2) (see all 11) |
| rheumatoid arthritis |
51.8 |
11 |
10719816 (2), 15167967 (1), 10390126 (1), 10812057 (1) (see all 9) |
| polyps |
50 |
31 |
12941808 (4), 11584208 (2), 11495083 (2), 19251796 (1) (see all 11) |
| arthritis |
50 |
13 |
11550975 (2), 10193996 (1), 9714356 (1), 10225538 (1) (see all 10) |
About this table
Human Gene Mutation Database (HGMD): PTGS1
Genetic Association Database (GAD): PTGS1
Human Genome Epidemiology (HuGE) Navigator: PTGS1 (65 documents)
Export disorders and mutations for PTGS1 gene to outside databases
|
Medical News
for PTGS1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PTGS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/1479 PubMed articles for PTGS1 gene, integrated from 7 sources (see all 1479):
(articles sorted by number of sources associating them with PTGS1)- Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. (PubMed id 1907252)1, 2, 3 Funk C.D.... Fitzgerald G.A. (1991)
- Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. (PubMed id 2512924)1, 2, 3 Yokoyama C. and Tanabe T. (1989)
- Mutations within the cyclooxygenase-1 gene in aspirin non-responders with recurrence of stroke. (PubMed id 15041270)1, 4, 7 Hillarp A....Mattiasson I. (2003)
- Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis. (PubMed id 12192304)1, 2, 7 Scott B.T....Long G.L. (2002)
- Cyclooxygenase-1 gene polymorphisms in patients with different asthma phenotypes and atopy. (PubMed id 16055872)1, 4, 7 Shi J....Kedda M.A. (2005)
- A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. (PubMed id 16181776)1, 4 Wei J. and Hemmings G.P. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps. (PubMed id 15159324)1, 4 Ulrich C.M....Potter J.D. (2004)
- Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)1, 2 Goodman J.E.... Harris C.C. (2004)
- Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha. (PubMed id 1587858)1, 2 Diaz A.... Jimenez S.A. (1992)
|
External Searches for PTGS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PTGS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PTGS1 gene
(According to HUGE)
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Specialized Databases showing PTGS1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for PTGS1 gene:
Search GeneIP for patents involving PTGS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PTGS1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
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 | Antibodies & Assays for PTGS1 (Cox1) |
| | | | Tocris compounds for PTGS1 |
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