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PTGS1 Gene

protein-coding   GIFtS: 70

GC09P094748
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and
cyclooxygenase)1 2
     COX32 5
COX11 2 3 5     cyclooxygenase-12
PGHS-11 2 3     prostaglandin G/H synthase and cyclooxygenase2
PTGHS1 2     PGG/HS2
Prostaglandin H2 synthase 12 3     PHS12
COX-12 3     prostaglandin G/H synthase 12
PHS 12 3     Prostaglandin-endoperoxide synthase 13
PGH synthase 12 3     EC 1.14.99.13
PCOX12 5     Cyclooxygenase-13
PGHS12 5     

External Ids:    HGNC: 96041   Entrez Gene: 57422   Ensembl: ENSG000000953037   UniProtKB: P232193   

Export aliases for PTGS1 gene to outside databases

Previous GC identifers: GC09P116237 GC09P116779 GC09P118586 GC09P120509 GC09P122212 GC09P124173 GC09P125133


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGS1:
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin
biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1
and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes
PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs
such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis.
Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is
differentially regulated by relevant cytokines and growth factors. (provided by RefSeq)

UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219
Function: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically
transformed cells

summary for PTGS1:
Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is
expressed in cells in three isoforms: COX-1, COX-2 and COX-3. COX-1 (constitutive) and COX-2 (inducible)
isoforms catalyze the rate-limiting step of prostaglandin production and are the targets of non-steroidal
anti-inflammatory drugs. COX-3 does not appear to be involved in inflammatory processes, but seems to be
involved in pain and fever. COX-3 is thought to be derived through the retention of the highly structured G
+ C-rich intron 1 of the COX-1 gene.

Gene Wiki entry for PTGS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGS1 gene promoter:
         AP-1   c-Jun   c-Fos   Sp1   GCNF-1   GCNF-2   GATA-1   NF-kappaB   NF-kappaB1   NF-kappaB2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PTGS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32-q33.3   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q32-q33.3

PTGS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGS1 gene location

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P094748:  view genomic region     (about GC identifiers)

Start:
94,747,952 bp from pter
End:
94,772,697 bp from pter
Size:
24,746 bases
Orientation:
plus strand

1 alternative location:
Chr9+ 125,133,359-125,157,982     
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219 (See protein sequence)
Recommended Name: Prostaglandin G/H synthase 1 precursor  
Size: 599 amino acids; 68656 Da
Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity)
Subunit: Homodimer
Subcellular location: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral
membrane protein
Miscellaneous: This enzyme acts both as a dioxygenase and as a peroxidase
Miscellaneous: This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin
Sequence caution: Sequence=CAI14716.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K1V7 Q15122 Q5T7T6 Q5T7T7 Q5T7T8
Alternative splicing: 2 isoforms:  P23219-1   P23219-2   

Explore the universe of human proteins at neXtProt for PTGS1: NX_P23219 

REFSEQ proteins (2 alternative transcripts): 
NP_000953.2  NP_542158.1  


ENSEMBL proteins: 
ENSP00000362802 ENSP00000411606 ENSP00000354612 ENSP00000223423 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein: PTGS1
OriGene Protein Over-expression Lysate: PTGS1
GenScript Custom Purified and Recombinant Proteins Services for PTGS1 
Novus Biologicals Proteins for PTGS1
Novus Biologicals Lysates for PTGS1
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus ISS--
GO:0005635 nuclear envelope IEA--
GO:0005737 cytoplasm ISS--
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane TAS--
About this table

PTGS1 for ontologies           About GeneDecksing



Antibodies for PTGS1: 
Millipore Mono- and Polyclonal Antibodies for the study of PTGS1
Sigma-Aldrich Antibodies for PTGS1
R&D Systems Antibodies for PTGS1 (COX-1)
Cell Signaling Technology (CST) Antibodies for PTGS1  (Cox1)
OriGene Antibodies: PTGS1
GenScript Custom Superior Antibodies Services for PTGS1 
Novus Biologicals Antibodies for PTGS1
Epitomics antibodies for PTGS1

Assays for PTGS1: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript PTGS1-Activity-based Enzymatic Assay for Compound Screening 
Enzo Life Sciences assays for PTGS1
Uscn ELISAs and CLIAs for PTGS1 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTGS1 for domains           About GeneDecksing

5 InterPro domains/families:
 IPR000742 EGF_3
 IPR010255 Haem_peroxidase
 IPR019791 Haem_peroxidase_animal_sg
 IPR006210 EGF-like
 IPR002007 Haem_peroxidase_animal

Graphical View of Domain Structure for InterPro Entry P23219

ProtoNet protein and cluster: P23219

3 Blocks protein families:
IPB002007 Animal haem peroxidase signature
IPB006210 Type I EGF
IPB010255 Haem peroxidase


UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219
Similarity: Belongs to the prostaglandin G/H synthase family
Similarity: Contains 1 EGF-like domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219
Function: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically
transformed cells
Catalytic activity: Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O
Enzyme Number (IUBMB): EC 1.14.99.1 

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PTGS1
Sigma-Aldrich shRNA Panels and shRNA for PTGS1
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PTGS1
OriGene shRNA RFP (see all 2): PTGS1
OriGene basic RS shRNA (see all 2): PTGS1
OriGene siRNA (see all 2): PTGS1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTGS1 
miRNA:Sigma-Aldrich microRNA Mimics for PTGS1
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTGS1 
2 SABiosciences Assays for microRNAs that regulate PTGS1:
hsa-miR-22 hsa-miR-1299

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PTGS1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PTGS1
OriGene untagged cDNA clones in CMV expression vector (see all 2): PTGS1
OriGene 3'-UTR clone (see all 2): PTGS1 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): PTGS1 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for PTGS1 

Genatlas biochemistry entry for PTGS1:
prostaglandin G/H synthase 1,constitutively expressed in a wide range of tissues,acting first as a dioxygenase,then as
a peroxidase (lipocalin family,Kernel group),monomer,potent mediator of inflammation

5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

GO IDQualified GO termEvidencePubMed IDs
GO:0004601 peroxidase activity IEA--
GO:0004666 prostaglandin-endoperoxide synthase activity IDA1380156
GO:0005509 calcium ion binding ----
GO:0008289 lipid binding IEA--
GO:0016491 oxidoreductase activity IEA--
About this table

PTGS1 for ontologies           About GeneDecksing

Animal Models: 15/22 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptgs1) (see all 22):

behavior/neurologicalcardiovascular systemcellulardigestive/alimentaryendocrine/exocrine gland
growth/sizehematopoietic systemhomeostasis/metabolismimmune systemlethality-postnatal
lethality-prenatal/perinatallife span-post-weaning/agingmusclenervous systemother

PTGS1 for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


PTGS1 for pathways           About GeneDecksing

3 Millipore Pathways for PTGS1
    Prostaglandin 2 biosynthesis and metabolism FM
HETE and HPETE biosynthesis and metabolism
Neurophysiological process PGE2-induced pain processing

4 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  PTGS1
    Arachidonic Acid Metabolism
Ovarian Cancer Signaling
Eicosanoid Signaling
Endothelin-1 Signaling

2 Kegg Pathways  (Kegg details for PTGS1):
    hsa00590 Arachidonic acid metabolism
hsa01100 Metabolic pathways

UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219
Pathway: Lipid metabolism; prostaglandin biosynthesis

    SABiosciences Pathway-Focused PCR Arrays including PTGS1 (see all 6): PAHS-003A PAHS-024A  

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PTGS1
    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTGS1

5/38 Interacting proteins for PTGS1 (ENSP000003546123 P232192) via UniProtKB, MINT, and/or STRING (see all 38)

InteractantInteraction Details
GeneCardExternal ID(s)
CYP4F2ENSP000000119893STRING: ENSP00000221700 STRING: ENSP00000011989
ALOX12ENSP000002515353STRING: ENSP00000251535
ALOX15ENSP000002937613STRING: ENSP00000293761
ALOX5ENSP000003635123STRING: ENSP00000363512
CYP2B6ENSP000003246483STRING: ENSP00000324648
About this table

5/19 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 19):

GO IDQualified GO termEvidencePubMed IDs
GO:0001516 prostaglandin biosynthetic process ISS--
GO:0006629 lipid metabolic process NAS1907252
GO:0006633 fatty acid biosynthetic process IEA--
GO:0006692 prostanoid metabolic process TAS--
GO:0006693 prostaglandin metabolic process ----
About this table

PTGS1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

PTGS1 for compounds           About GeneDecksing

Sigma-Aldrich Small Molecules for PTGS1:
Small Molecule - Inhibitor
Enzo Life Sciences drugs & compounds for PTGS1

Compounds for PTGS1 available from Tocris Bioscience
CompoundAction CAS number
Tenidap NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3 [120210-48-2]
FR 122047 hydrochlorideCyclooxygenase (COX-1) inhibitor[130717-51-0]
PiroxicamCyclooxygenase (COX-1) inhibitor[36322-90-4]
(S)-(+)-IbuprofenCyclooxygenase inhibitor (COX-1 > COX-2)[51146-56-6]
SC 560Cyclooxygenase (COX-1) inhibitor[188817-13-2]
About this table


10/125 Novoseek chemical compound relationships for PTGS1 gene (see all 125)
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
prostaglandin 91 300 9461646 (4), 15035793 (3), 10609518 (2), 7947975 (2) (see all 99)
pge2 90.6 411 11809691 (4), 8872612 (3), 15963707 (3), 9779823 (3) (see all 99)
celecoxib 89.5 89 12152003 (2), 16952493 (2), 10664917 (2), 15498669 (2) (see all 62)
arachidonic acid 89.5 273 10358065 (5), 7737984 (4), 10551587 (3), 10206978 (3) (see all 99)
rofecoxib 89.5 72 10096266 (3), 11028250 (3), 11136272 (2), 10411562 (2) (see all 48)
aspirin 84.6 396 11717412 (5), 18753249 (5), 15041270 (4), 19152549 (4) (see all 99)
meloxicam 83.5 52 10381787 (3), 10812057 (3), 11874389 (3), 10340919 (2) (see all 32)
ns 398 82.8 16 10217458 (2), 9875720 (1), 11563332 (1), 16964399 (1) (see all 15)
prostaglandin-h2 82.3 34 17878511 (2), 8652509 (1), 10734173 (1), 11081405 (1) (see all 20)
valdecoxib 81.9 6 12644588 (1), 15494548 (1), 16519515 (1), 12466002 (1) (see all 5)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PTGS1
Sigma-Aldrich shRNA Panels and shRNA for PTGS1
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PTGS1
OriGene shRNA RFP (see all 2): PTGS1
OriGene basic RS shRNA (see all 2): PTGS1
OriGene siRNA (see all 2): PTGS1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTGS1 
miRNA: Sigma-Aldrich microRNA Mimics for PTGS1
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTGS1 
2 SABiosciences Assays for microRNAs that regulate PTGS1:
hsa-miR-22 hsa-miR-1299
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PTGS1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PTGS1
OriGene untagged cDNA clones in CMV expression vector (see all 2): PTGS1
OriGene 3'-UTR Clone (see all 2): PTGS1 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): PTGS1 
Primers: OriGene genome-wide validated SYBR primer pairs: PTGS1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for PTGS1: PPH01306A

REFSEQ mRNAs for PTGS1 gene (2 alternative transcripts): 

NM_000962.2  NM_080591.1  

Additional cDNA sequence: 

AF086438.1 AF129755.1 AJ420464.1 AK290022.1 AK295221.1 AK304403.1 AK308222.1 BC029840.1 
DQ180740.1 DQ180741.1 DQ180742.1 M59979.1 S36219.1 S36271.1 S78220.1 U63846.1 

12 DOTS entries:

DT.446317  DT.100767562  DT.121193472  DT.101957346  DT.100767557  DT.101982936  DT.121193484  DT.75197219 
DT.100767561  DT.100767556  DT.97797260  DT.91965381 

24/156 AceView cDNA sequences (see all 156):

AU279462 BQ014239 BF064148 AA630760 NM_000962 BM728404 BU733396 AA707736 
CD014048 AA345128 S36219 AI076274 N54739 NM_080591 AL709654 AI567867 
BM679302 AA635841 AI569876 BM990424 AL556508 BC029840 BF477437 AI885487 

highest scoring ESTs for PTGS1:

M59979 AA037294 AA278216 AI202433 AI424408 AI467819 AI740976 AI806507 AV734203 AV744257 

Unigene Cluster for PTGS1:

Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Hs.201978  [show with all ESTs]
Unigene Representative Sequence: NM_000962


GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PTGS1 (see all 8)

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d
SP1:                                                                                                                                    
SP2:                                -     -                                                                                             
SP3:                                -     -     -                                                     -                                 
SP4:                                -     -                       -                                                                     
SP5:                                -     -                                                                                             

About this scheme

ECgene alternative splicing isoforms for PTGS1
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000373698 ENST00000426608 ENST00000362012(uc011lys.1 uc010mwb.1 uc004bmf.1 uc004bmg.1 uc004bmh.1 uc011lyt.1)
ENST00000223423

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

PTGS1 expression in normal and diseased human tissues

1  / 2  / 3

10 probe-sets matching PTGS1 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
37969_at2, 3 U95-A 1 0.69 1.00 0.68 1.01 M59979 1.00 1.00 1.00 1
89844_at2, 3 U95-E 1 0.62 1.00 0.92 1.03 AI806507 0.80 1.00 0.91 1
215813_s_at2, 3 U133-A 1 1.00 1.00 -- -- S36219 0.80 1.00 0.91 1
205128_x_at2, 3 U133-A 1 0.91 1.00 -- -- NM_000962 0.60 1.00 0.82 1
238669_at2, 3 U133-B 1 0.82 1.00 -- -- BE613133 0.40 1.00 0.76 1
205127_at2, 3 U133-A 1 0.73 1.00 -- -- NM_000962 0.60 1.00 0.82 1
215813_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
205128_x_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
238669_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
205127_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
About this table

PTGS1 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
PTGS1 gene expression
PTGS1 gene electronic northern expression
PTGS1 gene sage expression
About these images

CGAP SAGE TAG: AAGCTAATAA

SOURCE GeneReport for Unigene cluster: Hs.201978

Expression variation in blood from EXPOLDB for PTGS1

Primers: OriGene genome-wide validated SYBR primer pairs: PTGS1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for PTGS1: PPH01306A
    SABiosciences Expression via Pathway-Focused PCR Arrays including PTGS1 (see all 6): PAHS-003A PAHS-024A  


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PTGS1 gene from 5/10 species (see all 10)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
PTGS11   -- prostaglandin-endoperoxide synthase 1 (prostaglandin more 89.55(n)
92.54(a)
403544  NM_001003023.1  NP_001003023.1 
chimpanzee
(Pan troglodytes)
PTGS11   -- prostaglandin-endoperoxide synthase 1 (prostaglandin more 99.12(n)
98.77(a)
464713  XM_520238.2  XP_520238.2 
cow
(Bos taurus)
PTGS11   -- prostaglandin-endoperoxide synthase 1 (prostaglandin more 88.65(n)
91.15(a)
282022  XM_864482.2  XP_869575.1 
rat
(Rattus norvegicus)
Ptgs11   -- prostaglandin-endoperoxide synthase 1 84.14(n)
86.93(a)
24693  NM_017043.1  NP_058739.1 
mouse
(Mus musculus)
Ptgs11 , 5 2 (24.19 cM)5
prostaglandin-endoperoxide synthase 11, 5 85.59(n)1
89.78(a)1
192241  NM_008969.31  NP_032995.11 
 AA8331465  AK0464575  (see all 21)
About this table        Species with no ortholog for PTGS1

ENSEMBL Gene Tree for PTGS1 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for PTGS1 gene
PTGS22  

PTGS1 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
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10/369 NCBI SNPs in PTGS1 are shown (see all 369)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs57871,2
--125140823(+) CATCCA/GAGAGA 4 Q R mis1 ref10--------
rs57881,2
C,F,H,125143792(+) TCTGGC/AAAGAT 4 /G syn1 ref1 ese320Minor allele frequency- A:0.26MN NA NS EA WA 1560
rs57891,2
C,F,125143973(+) ACAATC/ATGGAG 4 /M /L mis1 ref124Minor allele frequency- A:0.02NA MN NS EA 2194
rs57901,2
C125145976(+) AAGGCT/CGAGCA 4 /A syn1 ref1 ese35Minor allele frequency- C:0.00MN 404
rs57911,2
C,H125148791(+) GCTGAA/GATTTG 4 K R ref1 mis110Minor allele frequency- G:0.00MN NS EA 1006
rs57921,2
C,H125152507(+) ACCACA/GTCCTG 4 I V ref1 mis1 ese39Minor allele frequency- G:0.00MN NS EA 816
rs57931,2
C,H125152579(+) ACCGCA/GAGAGG 4 K E ref1 mis1 ese310Minor allele frequency- G:0.00MN NS EA 1002
rs57941,2
C,F,125152621(+) AGCTCG/ATAGGT 4 /I /V mis1 ref1 ese313Minor allele frequency- A:0.01MN NS EA 1238
rs57951,2
C,H125154942(+) TGGGGT/CTGACA 2 -- ut31 ese310Minor allele frequency- C:0.00MN NS EA 1004
rs57961,2
C125154984(+) AATATT/CGTGAT 2 -- ut31 ese310Minor allele frequency- C:0.00MN NS EA 1006
About this table

HapMap Linkage Disequilibrium images for PTGS1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PTGS1
     1 Indel: 47643

QIAGEN SeqTarget long-range PCR primers for resequencing PTGS1 

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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PTGS1 for disorders           About GeneDecksing

OMIM: 176805

10/93 Novoseek disease relationships for PTGS1 gene (see all 93)

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation 71.7 163 16982919 (3), 10628589 (2), 12733982 (2), 17270500 (2) (see all 99)
osteoarthritis 61.6 22 15337183 (2), 11041909 (2), 10719816 (1), 14752171 (1) (see all 16)
gastrointestinal complications 58.1 3 10377455 (1), 14602052 (1)
colon cancer 57 18 19258012 (4), 16091009 (2), 7780968 (2), 16984374 (2) (see all 12)
intestinal polyps 53.6 5 12941808 (3), 16984374 (1)
ulcer 53.2 28 16247187 (3), 11519793 (2), 17926541 (2), 11136275 (2) (see all 15)
nasal polyps 52.1 29 16517580 (4), 15921208 (4), 15480320 (2), 19132974 (2) (see all 11)
rheumatoid arthritis 51.8 11 10719816 (2), 15167967 (1), 10390126 (1), 10812057 (1) (see all 9)
polyps 50 31 12941808 (4), 11584208 (2), 11495083 (2), 19251796 (1) (see all 11)
arthritis 50 13 11550975 (2), 10193996 (1), 9714356 (1), 10225538 (1) (see all 10)
About this table

Human Gene Mutation Database (HGMD): PTGS1
Genetic Association Database (GAD): PTGS1
Human Genome Epidemiology (HuGE) Navigator: PTGS1 (65 documents)

Export disorders and mutations for PTGS1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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10/1479 PubMed articles for PTGS1 gene, integrated from 7 sources (see all 1479):
(articles sorted by number of sources associating them with PTGS1)
  1. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. (PubMed id 1907252)1, 2, 3 Funk C.D.... Fitzgerald G.A. (1991)
  2. Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. (PubMed id 2512924)1, 2, 3 Yokoyama C. and Tanabe T. (1989)
  3. Mutations within the cyclooxygenase-1 gene in aspirin non-responders with recurrence of stroke. (PubMed id 15041270)1, 4, 7 Hillarp A....Mattiasson I. (2003)
  4. Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis. (PubMed id 12192304)1, 2, 7 Scott B.T....Long G.L. (2002)
  5. Cyclooxygenase-1 gene polymorphisms in patients with different asthma phenotypes and atopy. (PubMed id 16055872)1, 4, 7 Shi J....Kedda M.A. (2005)
  6. A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. (PubMed id 16181776)1, 4 Wei J. and Hemmings G.P. (2005)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps. (PubMed id 15159324)1, 4 Ulrich C.M....Potter J.D. (2004)
  9. Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)1, 2 Goodman J.E.... Harris C.C. (2004)
  10. Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha. (PubMed id 1587858)1, 2 Diaz A.... Jimenez S.A. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5742 HGNC: 9604 AceView: PTGS1 Ensembl:ENSG00000095303 euGenes: HUgn5742
ECgene: PTGS1 Kegg: 5742 H-InvDB: PTGS1

(According to HUGE)
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  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
ATLAS Chromosomes in Cancer entry for PTGS1 Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPshttp://pga.gs.washington.edu/data/ptgs1/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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Patent Information for PTGS1 gene:
Search GeneIP for patents involving PTGS1

GeneCards and IP:
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 ELISAs and CLIAs for PTGS1
       

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