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PTMA Gene

protein-coding   GIFtS: 55

GC02P232536
prothymosin, alpha
(Previous names: prothymosin, alpha (gene sequence 28) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TMSA)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
prothymosin, alpha1 2     OTTHUMP000002044282
TMSA2 3 5     prothymosin alpha2
prothymosin, alpha (gene sequence 28)1     OTTHUMP000002044332
prothymosin alpha protein2     OTTHUMP000002044272
gene sequence 282     MGC1048022
OTTHUMP000002044252     

External Ids:    HGNC: 96231   Entrez Gene: 57572   Ensembl: ENSG000001875147   UniProtKB: P064543   

Export aliases for PTMA gene to outside databases

Previous GC identifers: GC02P230632 GC02P231306 GC02P232775 GC02P232398 GC02P232281


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PTMA_HUMAN, P06454
Function: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections

Gene Wiki entry for PTMA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTMA gene promoter:
         STAT3   p53   Max1   c-Myc   Max   USF1   Sox9   Arnt   CUTL1   Nkx2-2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PTMA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PTMA 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

PTMA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTMA gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P232536:  view genomic region     (about GC identifiers)

Start:
232,571,605 bp from pter
End:
232,578,251 bp from pter
Size:
6,647 bases
Orientation:
plus strand

1 alternative location:
Chr2+ 224,415,419-224,421,126     
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PTMA_HUMAN, P06454 (See protein sequence)
Recommended Name: Prothymosin alpha  
Size: 111 amino acids; 12203 Da
Subcellular location: Nucleus
Secondary accessions: Q15249 Q15592
Alternative splicing: 2 isoforms:  P06454-1   P06454-2   

Explore the universe of human proteins at neXtProt for PTMA: NX_P06454 

Post-translational modifications:

  • Covalently linked to a small RNA of about 20 nucleotides (By similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001092755.1  NP_002814.3  


    ENSEMBL proteins: 
    ENSP00000400406 ENSP00000386645 ENSP00000386819 ENSP00000344547 ENSP00000387268 ENSP00000386519 
    ENSP00000387102 ENSP00000406903 ENSP00000392732 ENSP00000351703 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PTMA
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for PTMA 
    Novus Biologicals Proteins for PTMA
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    PTMA for ontologies           About GeneDecksing



    Antibodies for PTMA: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for PTMA
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PTMA 
    Novus Biologicals Antibodies for PTMA
    Browse antibodies at Epitomics

    Assays for PTMA: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTMA 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PTMA for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004931 Pro/parathymosin

    Graphical View of Domain Structure for InterPro Entry P06454

    ProtoNet protein and cluster: P06454

    1 Blocks protein family: IPB004931 Prothymosin/parathymosin

    UniProtKB/Swiss-Prot: PTMA_HUMAN, P06454
    Similarity: Belongs to the pro/parathymosin family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PTMA_HUMAN, P06454
    Function: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PTMA
    Sigma-Aldrich shRNA for PTMA
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): PTMA
    OriGene shRNA RFP (see all 3): PTMA
    OriGene basic RS shRNA (see all 3): PTMA
    OriGene siRNA (see all 2): PTMA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTMA 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTMA 
    4 SABiosciences Assays for microRNAs that regulate PTMA:
    hsa-miR-376b hsa-miR-548k hsa-miR-545 hsa-miR-376a

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PTMA
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PTMA
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PTMA
    OriGene 3'-UTR clone (see all 2): PTMA 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PTMA 
    Sino Biological Human cDNA Clone for PTMA

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PTMA 

    Genatlas biochemistry entry for PTMA:
    prothymosin alpha,widely expressed,abundant audic nuclear protein potential modulator of the interaction of histone 1
    with chromatin

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for PTMA 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTMA

    1 Interacting protein for PTMA (P064542) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SETQ011052MINT-50728 MINT-50726 MINT-50727
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription TAS10854063
    About this table

    PTMA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PTMA for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTMA
    10/22 Novoseek chemical compound relationships for PTMA gene (see all 22)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymalfasin 95.1 13 15992078 (2), 15546254 (2), 17275486 (2), 18020580 (1) (see all 10)
    lamivudine 65.9 27 19467157 (5), 16416004 (3), 16608033 (3), 15946554 (2) (see all 11)
    ifn-alpha 61.8 2 16640105 (1), 8687090 (1)
    entecavir 59.5 2 17087769 (1), 11871510 (1)
    adefovir 56.9 3 17087769 (1), 15546254 (1), 11871510 (1)
    emtricitabine 54.5 1 11871510 (1)
    ribavirin 53.7 11 20485665 (4), 15623184 (2), 12837162 (1), 14625884 (1) (see all 5)
    dacarbazine 47.1 3 7826907 (1), 10803720 (1), 20194853 (1)
    alanine 43.4 1 9537454 (1)
    amantadine 43 3 14625884 (1), 10603734 (1), 11945142 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PTMA
    Sigma-Aldrich shRNA for PTMA
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): PTMA
    OriGene shRNA RFP (see all 3): PTMA
    OriGene basic RS shRNA (see all 3): PTMA
    OriGene siRNA (see all 2): PTMA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTMA 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTMA 
    4 SABiosciences Assays for microRNAs that regulate PTMA:
    hsa-miR-376b hsa-miR-548k hsa-miR-545 hsa-miR-376a
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PTMA
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PTMA
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PTMA
    OriGene 3'-UTR Clone (see all 2): PTMA 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PTMA 
    Primers: OriGene genome-wide validated SYBR primer pairs: PTMA
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PTMA: PPH22315A

    REFSEQ mRNAs for PTMA gene (2 alternative transcripts): 

    NM_001099285.1  NM_002823.4  

    Additional cDNA sequence: 

    AF170294.1 AF348514.1 AF452640.1 AK223605.1 AK314106.1 AY169282.1 BC003510.1 BC013859.1 
    BC022433.1 BC034921.1 BC051265.1 BC066905.1 BC070480.1 BC071647.1 BC071732.1 BC071879.1 
    BC098420.1 CR592067.1 CR592101.1 CR592291.1 CR593816.1 CR594103.1 CR595284.1 CR599378.1 
    CR599711.1 CR599993.1 CR600163.1 CR601088.1 CR601616.1 CR602673.1 CR605128.1 CR610776.1 
    CR611351.1 CR611791.1 CR612313.1 CR612721.1 CR612758.1 CR616215.1 CR617850.1 CR619087.1 
    CR621405.1 CR621770.1 CR623382.1 CR623715.1 CR623981.1 CR624434.1 CR626005.1 M14483.1 
    M14630.1 M14794.1 M26708.1 

    24/124 DOTS entries (see all 124):

    DT.97868532  DT.100707850  DT.92473237  DT.100707854  DT.92473140  DT.95350608  DT.100707855  DT.100860759 
    DT.120998312  DT.120998355  DT.92473147  DT.95350637  DT.87017818  DT.120998435  DT.100638038  DT.92008110 
    DT.100707868  DT.92473157  DT.120998319  DT.95350656  DT.100707847  DT.92473127  DT.95319240  DT.100061224 

    24/3099 AceView cDNA sequences (see all 3099):

    BM785324 CB068051 BM423478 BQ083088 CR602673 AA670457 BM760778 BC066905 
    AI471009 BQ690968 BM844543 AI246210 BQ961830 BM917158 AA385946 BC071879 
    CA867345 BM752061 AW575411 BQ001843 AW475001 CR599711 BF718550 BI467277 

    highest scoring ESTs for PTMA:

    AA078898 AA081062 AA092920 AA111850 AA132556 AA158031 AA164672 AA165282 AA165283 AA165293 

    Unigene Cluster for PTMA:

    Prothymosin, alpha
    Hs.459927  [show with all ESTs]
    Unigene Representative Sequence: BM470466


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PTMA

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
    SP1:        -     -     -                                       
    SP2:                                                            
    SP3:                    -                                       
    SP4:                    -     -                                 

    About this scheme

    ECgene alternative splicing isoforms for PTMA
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466801 ENST00000448874 ENST00000409321 ENST00000409115(uc002vsb.3 uc010zmf.1)
    ENST00000341369(uc002vsc.3) ENST00000409405 ENST00000481928 ENST00000468027
    ENST00000409683 ENST00000410064 ENST00000412128 ENST00000440384 ENST00000467816
    ENST00000358839

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PTMA expression in normal and diseased human tissues

    1  / 2  / 3

    13 probe-sets matching PTMA gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38590_r_at2, 3 U95-A 3 1.00 0.83 0.95 1.12 M26708 1.00 0.80 0.91 1
    38589_i_at2, 3 U95-A 2 1.00 0.81 0.97 0.97 M26708 1.00 0.80 0.91 1
    58825_at2, 3 U95-C 1 0.31 1.00 0.96 0.91 AI701911 0.60 1.00 0.82 1
    200773_x_at2, 3 U133-A 3 1.00 0.77 -- -- NM_002823 0.60 1.00 0.82 1
    200772_x_at2, 3 U133-A 9 1.00 0.69 -- -- BF686442 0.60 0.83 0.73 1
    211921_x_at2, 3 U133-A 9 1.00 0.65 -- -- AF348514 0.80 0.88 0.84 1
    208549_x_at2, 3 U133-A 8 0.46 0.36 -- -- NM_016171 0.20 1.00 0.72 1
    216515_x_at2 U133-A 2 0.27 0.67 -- -- -- -- -- -- --
    200773_x_at2 U133Plus2 3 1.00 0.77 -- -- -- -- -- -- --
    200772_x_at2 U133Plus2 9 1.00 0.69 -- -- -- -- -- -- --
    211921_x_at2 U133Plus2 9 1.00 0.65 -- -- -- -- -- -- --
    208549_x_at2 U133Plus2 8 0.46 0.36 -- -- -- -- -- -- --
    216515_x_at2 U133Plus2 2 0.27 0.67 -- -- -- -- -- -- --
    About this table

    PTMA for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PTMA gene expression
    PTMA gene electronic northern expression
    PTMA gene sage expression
    About these images

    CGAP SAGE TAG: TCAGACGCAG

    SOURCE GeneReport for Unigene cluster: Hs.459927

    Expression variation in blood from EXPOLDB for PTMA

    Primers: OriGene genome-wide validated SYBR primer pairs: PTMA
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PTMA: PPH22315A
        SABiosciences Custom PCR Arrays for PTMA 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PTMA gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PTMA1   -- prothymosin, alpha (gene sequence 28) 92.79(n)
    99.1(a)
    610128  XM_860979.1  XP_866072.1 
    chimpanzee
    (Pan troglodytes)
    PTMA1   -- prothymosin, alpha 99.7(n)
    100(a)
    741861  XM_001158968.1  XP_001158968.1 
    cow
    (Bos taurus)
    PTMA1   -- prothymosin, alpha (gene sequence 28) 92.19(n)
    98.2(a)
    786336  XM_001253150.1  XP_001253151.1 
    rat
    (Rattus norvegicus)
    Ptma1   -- prothymosin alpha 92.19(n)
    95.5(a)
    29222  NM_021740.1  NP_068508.1 
    mouse
    (Mus musculus)
    Ptma1 , 5 1 (43.96 cM)5
    prothymosin alpha1, 5 91.89(n)1
    95.5(a)1
    192311  NM_008972.21  NP_032998.11 
     AK0205585  AK0379805  (see all 29)
    About this table        Species with no ortholog for PTMA

    ENSEMBL Gene Tree for PTMA (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PTMA gene
    LOC7280262  PTMS2  PTMAP52  

    PTMA for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/90 NCBI SNPs in PTMA are shown (see all 90)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs88681,2
    --232573301(+) CGCAGC/TCGCCT 1 -- ut511Minor allele frequency- T:0.50NA 2
    rs124151,2
    C,232573292(+) CTTGCT/CCGCCG 1 -- ut51 ese32Minor allele frequency- C:0.01MN NA 186
    rs133701,2
    --232573354(+) ATCGCC/TAGAGT 1 -- ut51 ese30--------
    rs8384401,2
    C,F,232572011(-) CACTTA/CGCTGT 1 -- ng5110Minor allele frequency- C:0.08EA NA MN NS WA 802
    rs10583151,2
    C,A,232573944(+) GGCCGC/GCGGTT 1 -- int12Minor allele frequency- G:0.38WA NA 52
    rs10583161,2
    --232574120(+) GTGCGC/TCGGGA 1 -- int10--------
    rs10598341,2
    --232576649(+) agaagA/Gggaag 2 E G ref1 mis10--------
    rs10606351,2
    --232577894(+) CTCGGA/GTGACC 1 -- ut310--------
    rs10647191,2
    --232576644(+) gacgaA/Cgaaga 2 E D ref1 mis10--------
    rs20604121,2
    C,A,232574504(-) AGAAAA/GAGCCA 1 -- int110Minor allele frequency- G:0.50EA NA WA 1800
    About this table

    HapMap Linkage Disequilibrium images for PTMA (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PTMA
         1 CNV: 3408

    QIAGEN SeqTarget long-range PCR primers for resequencing PTMA 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PTMA for disorders           About GeneDecksing

    OMIM: 188390

    10/30 Novoseek disease relationships for PTMA gene (see all 30)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis b chronic 78.3 41 10759236 (3), 16416004 (2), 14606705 (2), 16640105 (2) (see all 25)
    radiation sickness 60.7 1 1494642 (1)
    hepatitis b 60 17 15946554 (2), 17075991 (2), 9007707 (2), 12820143 (1) (see all 11)
    hepatitis c chronic 58.4 22 11529376 (3), 8873009 (3), 11380797 (2), 20485665 (2) (see all 13)
    hepatitis c 45.5 6 9537454 (1), 16307501 (1), 8873009 (1), 17600286 (1) (see all 6)
    hepatocellular carcinoma 41.6 9 15362772 (3), 9496515 (2), 16608033 (2), 15946554 (1) (see all 5)
    carcinoma lewis lung 38.6 1 17600290 (1)
    cirrhosis 35.1 1 10759236 (1)
    hepatoblastoma 34.7 1 9007707 (1)
    hepatitis chronic active 31 2 8873009 (1), 1452411 (1)
    About this table


    Export disorders and mutations for PTMA gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/229 PubMed articles for PTMA gene, integrated from 7 sources (see all 229):
    (articles sorted by number of sources associating them with PTMA)
    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Prothymosin alpha gene in humans: organization of its promoter region and localization to chromosome 2. (PubMed id 7916742)1, 2 Szabo P.... Horecker B.L. (1993)
    4. Phosphorylation of human and bovine prothymosin alpha in vivo. (PubMed id 8485135)1, 2 Sburlati A.R.... Berger S.L. (1993)
    5. The human prothymosin alpha gene family contains several processed pseudogenes lacking deleterious lesions. (PubMed id 1612591)1, 3 Manrow R.E....Berger S.L. (1992)
    6. The expression of prothymosin alpha gene in T lymphocytes and leukemic lymphoid cells is tied to lymphocyte proliferation. (PubMed id 2785990)1, 2 Gomez-Marquez J....Freire M. (1989)
    7. Isolation and partial sequencing of the human prothymosin alpha gene family. Evidence against export of the gene products. (PubMed id 2708378)1, 2 Eschenfeldt W.H.... Berger S.L. (1989)
    8. Human prothymosin alpha: amino acid sequence and immunologic properties. (PubMed id 3532956)1, 2 Pan L.X.... Horecker B.L. (1986)
    9. Molecular cloning of cDNA for human prothymosin alpha. (PubMed id 3466166)1, 2 Goodall G.J.... Horecker B.L. (1986)
    10. The human prothymosin alpha gene is polymorphic and induced upon growth stimulation: evidence using a cloned cDNA. (PubMed id 3467312)1, 2 Eschenfeldt W.H. and Berger S.L. (1986)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5757 HGNC: 9623 AceView: PTMA Ensembl:ENSG00000187514 euGenes: HUgn5757
    ECgene: PTMA H-InvDB: PTMA

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    ATLAS Chromosomes in Cancer entry for PTMA Genetics and Cytogenetics in Oncology and Haematology

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