Aliases &
Descriptions
for PTMA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| prothymosin, alpha1 2 | | OTTHUMP000002044282 | | TMSA2 3 5 | | prothymosin alpha2 | | prothymosin, alpha (gene sequence 28)1 | | OTTHUMP000002044332 | | prothymosin alpha protein2 | | OTTHUMP000002044272 | | gene sequence 282 | | MGC1048022 | | OTTHUMP000002044252 | | |
Export aliases for PTMA gene to outside databasesPrevious GC identifers: GC02P230632 GC02P231306 GC02P232775 GC02P232398 GC02P232281 |
Summaries
for PTMA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PTMA_HUMAN, P06454Function: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections
Gene Wiki entry for PTMA |
Genomic Views
for PTMA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PTMA gene promoter:
STAT3 p53 Max1 c-Myc Max USF1 Sox9 Arnt CUTL1 Nkx2-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PTMA
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PTMA  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1PTMA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P232536: view genomic region
(about GC identifiers)
Start:
|
232,571,605 bp from pter |
End:
|
232,578,251 bp from pter |
Size:
|
6,647 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr2+ 224,415,419-224,421,126 |
RefSeq DNA sequence:- NC_000002.11 NT_005403.17
|
Proteins
for PTMA gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PTMA_HUMAN, P06454 (See
protein sequence)Recommended Name: Prothymosin alpha Size: 111 amino acids; 12203 Da
Subcellular location: Nucleus
Secondary accessions: Q15249 Q15592Alternative splicing: 2 isoforms: P06454-1 P06454-2 Explore the universe of human proteins at neXtProt for PTMA: NX_P06454
Post-translational modifications:
Covalently linked to a small RNA of about 20 nucleotides (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001092755.1 NP_002814.3
ENSEMBL proteins: ENSP00000400406 ENSP00000386645 ENSP00000386819 ENSP00000344547 ENSP00000387268 ENSP00000386519 ENSP00000387102 ENSP00000406903 ENSP00000392732 ENSP00000351703
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
About this table
PTMA for ontologies About GeneDecksing
Antibodies for PTMA:
Assays for PTMA: |
Protein
Domains/
Families
for PTMA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PTMA for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P06454ProtoNet protein and cluster: P06454 1 Blocks protein family: IPB004931 Prothymosin/parathymosin
UniProtKB/Swiss-Prot: PTMA_HUMAN, P06454Similarity: Belongs to the pro/parathymosin family |
Gene Function
for PTMA gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PTMA_HUMAN, P06454Function: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections
Genatlas biochemistry entry for PTMA:prothymosin alpha,widely expressed,abundant audic nuclear protein potential modulator of the interaction of histone 1with chromatin |
Pathways & Interactions
for PTMA gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for PTMA
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTMA
1 Interacting protein for PTMA (P064542) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): About this table
PTMA for ontologies About GeneDecksing
|
Drugs & Compounds
for PTMA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
PTMA for compounds About GeneDecksing
 Browse Tocris compounds for PTMA
10/22  Novoseek chemical compound relationships for PTMA gene (see all 22)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| thymalfasin |
95.1 |
13 |
15992078 (2), 15546254 (2), 17275486 (2), 18020580 (1) (see all 10) |
| lamivudine |
65.9 |
27 |
19467157 (5), 16416004 (3), 16608033 (3), 15946554 (2) (see all 11) |
| ifn-alpha |
61.8 |
2 |
16640105 (1), 8687090 (1) |
| entecavir |
59.5 |
2 |
17087769 (1), 11871510 (1) |
| adefovir |
56.9 |
3 |
17087769 (1), 15546254 (1), 11871510 (1) |
| emtricitabine |
54.5 |
1 |
11871510 (1) |
| ribavirin |
53.7 |
11 |
20485665 (4), 15623184 (2), 12837162 (1), 14625884 (1) (see all 5) |
| dacarbazine |
47.1 |
3 |
7826907 (1), 10803720 (1), 20194853 (1) |
| alanine |
43.4 |
1 |
9537454 (1) |
| amantadine |
43 |
3 |
14625884 (1), 10603734 (1), 11945142 (1) |
About this table
|
Transcripts
for PTMA gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PTMA gene (2 alternative transcripts): NM_001099285.1 NM_002823.4 Additional cDNA sequence: AF170294.1 AF348514.1 AF452640.1 AK223605.1 AK314106.1 AY169282.1 BC003510.1 BC013859.1 BC022433.1 BC034921.1 BC051265.1 BC066905.1 BC070480.1 BC071647.1 BC071732.1 BC071879.1 BC098420.1 CR592067.1 CR592101.1 CR592291.1 CR593816.1 CR594103.1 CR595284.1 CR599378.1 CR599711.1 CR599993.1 CR600163.1 CR601088.1 CR601616.1 CR602673.1 CR605128.1 CR610776.1 CR611351.1 CR611791.1 CR612313.1 CR612721.1 CR612758.1 CR616215.1 CR617850.1 CR619087.1 CR621405.1 CR621770.1 CR623382.1 CR623715.1 CR623981.1 CR624434.1 CR626005.1 M14483.1 M14630.1 M14794.1 M26708.1 24/124 DOTS entries (see all 124): DT.97868532 DT.100707850 DT.92473237 DT.100707854 DT.92473140 DT.95350608 DT.100707855 DT.100860759 DT.120998312 DT.120998355 DT.92473147 DT.95350637 DT.87017818 DT.120998435 DT.100638038 DT.92008110 DT.100707868 DT.92473157 DT.120998319 DT.95350656 DT.100707847 DT.92473127 DT.95319240 DT.100061224 24/3099 AceView cDNA sequences (see all 3099): BM785324 CB068051 BM423478 BQ083088 CR602673 AA670457 BM760778 BC066905 AI471009 BQ690968 BM844543 AI246210 BQ961830 BM917158 AA385946 BC071879 CA867345 BM752061 AW575411 BQ001843 AW475001 CR599711 BF718550 BI467277
 highest scoring ESTs for PTMA:AA078898 AA081062 AA092920 AA111850 AA132556 AA158031 AA164672 AA165282 AA165283 AA165293 Unigene Cluster for PTMA: Prothymosin, alpha Hs.459927 [show with all ESTs]Unigene Representative Sequence: BM470466
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for PTMA
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PTMA
14 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000466801 ENST00000448874 ENST00000409321 ENST00000409115(uc002vsb.3 uc010zmf.1)
ENST00000341369(uc002vsc.3) ENST00000409405 ENST00000481928 ENST00000468027
ENST00000409683 ENST00000410064 ENST00000412128 ENST00000440384 ENST00000467816
ENST00000358839
|
Expression
for PTMA gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PTMA expression in normal and diseased human tissues
1 / 2 / 3 13 probe-sets matching PTMA gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 38590_r_at2, 3
|
U95-A |
3 |
1.00 |
0.83 |
0.95 |
1.12 |
M26708 |
1.00 |
0.80 |
0.91 |
1 |
| 38589_i_at2, 3
|
U95-A |
2 |
1.00 |
0.81 |
0.97 |
0.97 |
M26708 |
1.00 |
0.80 |
0.91 |
1 |
| 58825_at2, 3
|
U95-C |
1 |
0.31 |
1.00 |
0.96 |
0.91 |
AI701911 |
0.60 |
1.00 |
0.82 |
1 |
| 200773_x_at2, 3
|
U133-A |
3 |
1.00 |
0.77 |
-- |
-- |
NM_002823 |
0.60 |
1.00 |
0.82 |
1 |
| 200772_x_at2, 3
|
U133-A |
9 |
1.00 |
0.69 |
-- |
-- |
BF686442 |
0.60 |
0.83 |
0.73 |
1 |
| 211921_x_at2, 3
|
U133-A |
9 |
1.00 |
0.65 |
-- |
-- |
AF348514 |
0.80 |
0.88 |
0.84 |
1 |
| 208549_x_at2, 3
|
U133-A |
8 |
0.46 |
0.36 |
-- |
-- |
NM_016171 |
0.20 |
1.00 |
0.72 |
1 |
| 216515_x_at2
|
U133-A |
2 |
0.27 |
0.67 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 200773_x_at2
|
U133Plus2 |
3 |
1.00 |
0.77 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 200772_x_at2
|
U133Plus2 |
9 |
1.00 |
0.69 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 211921_x_at2
|
U133Plus2 |
9 |
1.00 |
0.65 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 208549_x_at2
|
U133Plus2 |
8 |
0.46 |
0.36 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 216515_x_at2
|
U133Plus2 |
2 |
0.27 |
0.67 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PTMA for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TCAGACGCAG
SOURCE GeneReport for Unigene cluster: Hs.459927
Expression variation in blood from EXPOLDB for PTMA SABiosciences Custom PCR Arrays for PTMA
|
Orthologs
for PTMA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PTMA gene from 5/8 species (see all 8)
About this table Species with no ortholog for PTMA
ENSEMBL Gene Tree for PTMA (if available) |
Paralogs
for PTMA gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PTMA gene
- LOC7280262 PTMS2 PTMAP52
PTMA for paralogs About GeneDecksing
|
Genomic Variants
for PTMA gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PTMA (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PTMA
1 CNV: 3408 | | QIAGEN SeqTarget long-range PCR primers for resequencing PTMA |
|
Disorders & Mutations
for PTMA gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PTMA for disorders About GeneDecksing
OMIM: 188390
10/30 Novoseek disease relationships for PTMA gene (see all 30)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hepatitis b chronic |
78.3 |
41 |
10759236 (3), 16416004 (2), 14606705 (2), 16640105 (2) (see all 25) |
| radiation sickness |
60.7 |
1 |
1494642 (1) |
| hepatitis b |
60 |
17 |
15946554 (2), 17075991 (2), 9007707 (2), 12820143 (1) (see all 11) |
| hepatitis c chronic |
58.4 |
22 |
11529376 (3), 8873009 (3), 11380797 (2), 20485665 (2) (see all 13) |
| hepatitis c |
45.5 |
6 |
9537454 (1), 16307501 (1), 8873009 (1), 17600286 (1) (see all 6) |
| hepatocellular carcinoma |
41.6 |
9 |
15362772 (3), 9496515 (2), 16608033 (2), 15946554 (1) (see all 5) |
| carcinoma lewis lung |
38.6 |
1 |
17600290 (1) |
| cirrhosis |
35.1 |
1 |
10759236 (1) |
| hepatoblastoma |
34.7 |
1 |
9007707 (1) |
| hepatitis chronic active |
31 |
2 |
8873009 (1), 1452411 (1) |
About this table
Export disorders and mutations for PTMA gene to outside databases
|
Medical News
for PTMA gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PTMA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/229 PubMed articles for PTMA gene, integrated from 7 sources (see all 229):
(articles sorted by number of sources associating them with PTMA)- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prothymosin alpha gene in humans: organization of its promoter region and localization to chromosome 2. (PubMed id 7916742)1, 2 Szabo P.... Horecker B.L. (1993)
- Phosphorylation of human and bovine prothymosin alpha in vivo. (PubMed id 8485135)1, 2 Sburlati A.R.... Berger S.L. (1993)
- The human prothymosin alpha gene family contains several processed pseudogenes lacking deleterious lesions. (PubMed id 1612591)1, 3 Manrow R.E....Berger S.L. (1992)
- The expression of prothymosin alpha gene in T lymphocytes and leukemic lymphoid cells is tied to lymphocyte proliferation. (PubMed id 2785990)1, 2 Gomez-Marquez J....Freire M. (1989)
- Isolation and partial sequencing of the human prothymosin alpha gene family. Evidence against export of the gene products. (PubMed id 2708378)1, 2 Eschenfeldt W.H.... Berger S.L. (1989)
- Human prothymosin alpha: amino acid sequence and immunologic properties. (PubMed id 3532956)1, 2 Pan L.X.... Horecker B.L. (1986)
- Molecular cloning of cDNA for human prothymosin alpha. (PubMed id 3466166)1, 2 Goodall G.J.... Horecker B.L. (1986)
- The human prothymosin alpha gene is polymorphic and induced upon growth stimulation: evidence using a cloned cDNA. (PubMed id 3467312)1, 2 Eschenfeldt W.H. and Berger S.L. (1986)
|
External Searches for PTMA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PTMA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PTMA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PTMA gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PTMA gene:
Search GeneIP for patents involving PTMA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PTMA gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
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| | |
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| |  | Search Tocris compounds for PTMA |
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