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PTPN18 Gene

protein-coding   GIFtS: 59

GC02P123403
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)1 2     PTP-HSCF2
BDP11 2 3 5     OTTHUMP000002045182
Brain-derived phosphatase2 3     EC 3.1.3.483
tyrosine-protein phosphatase non-receptor type 182     

External Ids:    HGNC: 96491   Entrez Gene: 264692   Ensembl: ENSG000000721357   UniProtKB: Q999523   

Export aliases for PTPN18 gene to outside databases

Previous GC identifers: GC02M128348 GC02M129897 GC02P131018 GC02P131206 GC02P130829 GC02P131113


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPN18:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic
cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein
interaction domain, and may be related to protein intracellular half-live. This protein can differentially
dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to
regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952
Function: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in
tumor tissues

Gene Wiki entry for PTPN18

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPN18 gene promoter:
         RFX1   TGIF   Pax-2   CUTL1   XBP-1   CP1C   NF-Y   NF-YA   CP1A   POU2F1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PTPN18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PTPN18 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21

PTPN18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN18 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P123403:  view genomic region     (about GC identifiers)

Start:
123,403,555 bp from pter
End:
123,422,890 bp from pter
Size:
19,336 bases
Orientation:
plus strand

1 alternative location:
Chr2+ 131,113,580-131,132,982     
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 18  
Size: 460 amino acids; 50482 Da
Subunit: Interacts with PSTPIP1 (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity)
PDB structures from and Proteopedia :
2OC3 (3D)    
Secondary accessions: Q53P42

Explore the universe of human proteins at neXtProt for PTPN18: NX_Q99952 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001135842.1  NP_055184.2  


    ENSEMBL proteins: 
    ENSP00000411750 ENSP00000387031 ENSP00000310092 ENSP00000406853 ENSP00000175756 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for PTPN18 
    Novus Biologicals Protein for PTPN18
    Novus Biologicals Lysate for PTPN18
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    About this table

    PTPN18 for ontologies           About GeneDecksing



    Antibodies for PTPN18: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for PTPN18
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PTPN18 
    Novus Biologicals Antibody for PTPN18
    Browse antibodies at Epitomics

    Assays for PTPN18: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTPN18 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PTPN18 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PTPN18 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Dual-sp/Tyr_phosphatase

    Graphical View of Domain Structure for InterPro Entry Q99952

    ProtoNet protein and cluster: Q99952

    1 Blocks protein family: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952
    Function: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in
    tumor tissues
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Enzyme Number (IUBMB): EC 3.1.3.48 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PTPN18
    Sigma-Aldrich shRNA Panels and shRNA for PTPN18
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): PTPN18
    OriGene shRNA RFP (see all 3): PTPN18
    OriGene basic RS shRNA (see all 3): PTPN18
    OriGene siRNA (see all 2): PTPN18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTPN18 
    miRNA:Sigma-Aldrich microRNA Mimics for PTPN18
    Sigma-Aldrich microRNA target validation systems for PTPN18 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTPN18 
    2 SABiosciences Assays for microRNAs that regulate PTPN18:
    hsa-miR-125a-5p hsa-miR-125b

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PTPN18
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PTPN18
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PTPN18
    OriGene 3'-UTR clone (see all 2): PTPN18 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PTPN18 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PTPN18 

    Genatlas biochemistry entry for PTPN18:
    protein tyrosine phosphatase,non-receptor type 18,expressed in brain,colon and several tumor-derived cell lines

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725 protein tyrosine phosphatase activity ----
    GO:0004726 non-membrane spanning protein tyrosine phosphatase activity IEA--
    GO:0005515 protein binding IEA--
    GO:0016787 hydrolase activity IEA--
    GO:0016791 phosphatase activity ----
    About this table

    PTPN18 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for PTPN18 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PTPN18

    1 Interacting protein for PTPN18 (ENSP000001757563) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSTPIP1ENSP000003689143STRING: ENSP00000368914
    About this table

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470 protein dephosphorylation IEA--
    GO:0016311 dephosphorylation ----
    About this table

    PTPN18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPN18


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PTPN18
    Sigma-Aldrich shRNA Panels and shRNA for PTPN18
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): PTPN18
    OriGene shRNA RFP (see all 3): PTPN18
    OriGene basic RS shRNA (see all 3): PTPN18
    OriGene siRNA (see all 2): PTPN18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTPN18 
    miRNA: Sigma-Aldrich microRNA Mimics for PTPN18
    Sigma-Aldrich microRNA target validation systems for PTPN18 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTPN18 
    2 SABiosciences Assays for microRNAs that regulate PTPN18:
    hsa-miR-125a-5p hsa-miR-125b
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PTPN18
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PTPN18
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PTPN18
    OriGene 3'-UTR Clone (see all 2): PTPN18 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PTPN18 
    Primers: OriGene genome-wide validated SYBR primer pairs: PTPN18
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PTPN18: PPH14466A

    REFSEQ mRNAs for PTPN18 gene (2 alternative transcripts): 

    NM_001142370.1  NM_014369.3  

    Additional cDNA sequence: 

    AK297884.1 AK303804.1 BC024280.1 BC041562.1 BC052800.1 CR609214.1 CR616748.1 CR623157.1 
    X79568.1 

    24/28 DOTS entries (see all 28):

    DT.415969  DT.100751707  DT.92455428  DT.97859241  DT.100775592  DT.92455407  DT.91875410  DT.120981520 
    DT.429645  DT.95313577  DT.306615  DT.95343851  DT.95306663  DT.100746051  DT.91700098  DT.91860968 
    DT.95306684  DT.120980897  DT.120981444  DT.92455403  DT.100733576  DT.120981108  DT.121610570  DT.40282072 

    24/284 AceView cDNA sequences (see all 284):

    BM724913 BU619831 AA931499 CA427181 AA524210 AA702095 AA775582 CK822863 
    BM480121 BQ102255 BE793556 CA443644 BQ436608 BM789073 CR608379 BX107629 
    CA390912 AI445719 BM015920 BQ086140 BU507872 AA568882 AW403522 AA323185 

    highest scoring ESTs for PTPN18:

    X79568 AA292316 AA430687 AI910153 AL572275 AL574171 AL581670 BC024280 BC041562 BC052800 

    Unigene Cluster for PTPN18:

    Protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
    Hs.726000  [show with all ESTs]
    Unigene Representative Sequence: NM_014369


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN18 (see all 9)

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16 ^
    SP1:                                                                    -                                                                                       
    SP2:                                                                                                                                                            
    SP3:                    -                                                                                                                                       
    SP4:                    -     -     -     -     -                                                                                                               
    SP5:                                                                                                              -     -     -                                 

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      

    About this scheme

    ECgene alternative splicing isoforms for PTPN18
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428843 ENST00000409022 ENST00000462321 ENST00000489215 ENST00000495400
    ENST00000347849 ENST00000479295 ENST00000460992 ENST00000481492 ENST00000483617
    ENST00000464576 ENST00000420717 ENST00000490812 ENST00000490137 ENST00000462996
    ENST00000175756(uc002trd.2 uc002trc.2 uc002trb.2 uc002tre.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PTPN18 expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching PTPN18 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33453_at2, 3 U95-A 1 1.00 1.00 0.99 1.11 AI400326 0.40 1.00 0.76 1
    160041_at2, 3 U95-A 1 0.94 1.00 0.94 0.89 X79568 1.00 1.00 1.00 1
    213521_at2, 3 U133-A 1 0.91 1.00 -- -- AW575379 0.40 1.00 0.76 1
    203555_at2, 3 U133-A 1 0.73 1.00 -- -- NM_014369 0.60 1.00 0.82 1
    213521_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    203555_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    1569552_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    About this table

    PTPN18 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PTPN18 gene expression
    PTPN18 gene electronic northern expression
    PTPN18 gene sage expression
    About these images

    CGAP SAGE TAG: GGAAAGTGAC

    SOURCE GeneReport for Unigene cluster: Hs.726000

    Expression variation in blood from EXPOLDB for PTPN18

    UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952
    Tissue specificity: Expressed in brain, colon and several tumor-derived cell lines

    Primers: OriGene genome-wide validated SYBR primer pairs: PTPN18
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PTPN18: PPH14466A
        SABiosciences Custom PCR Arrays for PTPN18 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PTPN18 gene from 5/6 species (see all 6)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    cow
    (Bos taurus)
    PTPN181   -- protein tyrosine phosphatase, non-receptor type 18 more 82.53(n)
    79.74(a)
    617215  XM_001249788.1  XP_001249789.1 
    rat
    (Rattus norvegicus)
    Ptpn181   -- protein tyrosine phosphatase, non-receptor type 18 79.2(n)
    76.11(a)
    301333  NM_001013111.1  NP_001013129.1 
    mouse
    (Mus musculus)
    Ptpn181 , 5 1 (13.25 cM)5
    protein tyrosine phosphatase, non-receptor type 181, 5 80.75(n)1
    77.43(a)1
    192531  NM_011206.21  NP_035336.21 
     AI6434425  AK1443535  (see all 11)
    zebrafish
    (Danio rerio)
    zgc:1131051   -- zgc:113105 52.03(n)
    45.5(a)
    541324  NM_001013452.1  NP_001013470.1 
    worm
    (Caenorhabditis elegans)
    C17H12.33 IV(6794148-6795367) protein-tyrosine phosphatase 34(a)   --
    About this table        Species with no ortholog for PTPN18

    ENSEMBL Gene Tree for PTPN18 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PTPN18 gene
    PTPN142  PTPN212  PTPN222  PTPN122  

    PTPN18 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/220 NCBI SNPs in PTPN18 are shown (see all 220)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs10436791,2
    --131127778(+) ATGGGC/TTTCAG 2 -- int11Minor allele frequency- T:0.00MN 184
    rs11273631,2
    --131132948(-) cacagG/Tgaaca 2 -- ut310--------
    rs15182891,2
    C,F,A,131127950(-) GAGCAA/GGAGCT 2 -- int12Minor allele frequency- G:0.12MN WA 234
    rs15182901,2
    C,A131127949(-) AGCAAAG/C    
       
    /G/GC
    AGCTG
    2 -- int11MN 184
    rs15335651,2
    C,F,131128498(-) TGGAGT/CGTGGA 4 /T ref1 syn1 ese311Minor allele frequency- C:0.14EA NA MN NS 794
    rs15335661,2
    C,A,131128204(-) GCCTGT/CATCGT 2 -- int13Minor allele frequency- C:0.00EA NA 54
    rs15335671,2
    C,F,131128201(-) TGTATC/TGTACC 2 -- int12Minor allele frequency- T:0.12MN WA 234
    rs22717841,2
    C,F,131129679(-) CTCGCT/CTCTGT 2 -- int11Minor allele frequency- C:0.11EA 1298
    rs37391221,2
    C,F,131131525(-) TCTGTG/ATATCT 2 -- ut31 ese310Minor allele frequency- A:0.15EA NA NS WA 2202
    rs37391231,2
    C,F,131131424(-) GGGCTC/GTGTTT 2 -- ut31 ese37Minor allele frequency- G:0.15EA NS WA 2052
    About this table

    HapMap Linkage Disequilibrium images for PTPN18 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for PTPN18
         4 CNVs: 3393 53632 2408 8387

    QIAGEN SeqTarget long-range PCR primers for resequencing PTPN18 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PTPN18 for disorders           About GeneDecksing

    OMIM: 606587

    1 PharmGKB disease relationship for PTPN18 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table


    Export disorders and mutations for PTPN18 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/24 PubMed articles for PTPN18 gene, integrated from 7 sources (see all 24):
    (articles sorted by number of sources associating them with PTPN18)
    1. Characterization of the PEST family protein tyrosine phosphatase BDP1. (PubMed id 8950995)1, 2, 3, 7 Kim Y.W.... Ullrich A. (1996)
    2. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)1, 2 Zhang Y.... White F.M. (2005)
    3. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)1, 2 Tao W.A.... Aebersold R. (2005)
    4. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)2 Barr A.J.... Knapp S. (2009)
    5. An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. (PubMed id 19534553)2 Heibeck T.H.... Qian W.-J. (2009)
    6. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107)2 Rikova K....Comb M.J. (2007)
    7. Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. (PubMed id 17389395)2 Wolf-Yadlin A.... White F.M. (2007)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    9. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    10. Substrate-trapping techniques in the identification of cellular PTP targets. (PubMed id 15588985)1 Blanchetot C....Tremblay M.L. (2005)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26469 HGNC: 9649 AceView: PTPN18 Ensembl:ENSG00000072135 euGenes: HUgn26469
    ECgene: PTPN18 H-InvDB: PTPN18

    (According to HUGE)
    About This Section
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for PTPN18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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