Aliases &
Descriptions
for PTPN9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| protein tyrosine phosphatase, non-receptor type 91 2 | | PTPMEG22 | | MEG21 2 | | tyrosine-protein phosphatase non-receptor type 92 | | Protein-tyrosine phosphatase MEG22 3 | | PTPase-MEG22 | | PTPase MEG22 3 | | EC 3.1.3.483 |
Export aliases for PTPN9 gene to outside databasesPrevious GC identifers: GC15M071637 GC15M068850 GC15M073335 GC15M073475 GC15M073546 GC15M075759 |
Summaries
for PTPN9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PTPN9:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitoticcycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity withyeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretionthrough the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to beinvolved in signaling events regulating phagocytosis. (provided by RefSeq)
UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378Function: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions ofthe Golgi apparatus
Gene Wiki entry for PTPN9 |
Genomic Views
for PTPN9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PTPN9 gene promoter:
FOXO1a STAT5A GCNF-2 GCNF-1 NF-1 YY1 LUN-1 ZID Sox9 MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for PTPN9
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PTPN9  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q24.2 Ensembl cytogenetic band: 15q24.2 HGNC cytogenetic band: 15q23PTPN9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M052517: view genomic region
(about GC identifiers)
Start:
|
52,517,713 bp from pter |
End:
|
52,629,661 bp from pter |
Size:
|
111,949 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr15- 75,759,462-75,871,630 |
RefSeq DNA sequence:- NC_000015.9 NT_010194.17
|
Proteins
for PTPN9 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378 (See
protein sequence)Recommended Name: Tyrosine-protein phosphatase non-receptor type 9 Size: 593 amino acids; 68020 Da
Subcellular location: Cytoplasm (Probable)
PDB structures from  and Proteopedia  :2PA5 (3D)
Secondary accessions: Q53XR9Explore the universe of human proteins at neXtProt for PTPN9: NX_P43378
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002824.1
ENSEMBL proteins: ENSP00000303554
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
About this table
PTPN9 for ontologies About GeneDecksing
Antibodies for PTPN9:
Assays for PTPN9: |
Protein
Domains/
Families
for PTPN9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PTPN9 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P43378ProtoNet protein and cluster: P43378 4 Blocks protein families: IPB000242 Protein tyrosine phosphatase signature IPB001071 Cellular retinaldehyde-binding protein signature IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) IPB008273 Cellular retinaldehyde-binding/triple function
UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamilySimilarity: Contains 1 CRAL-TRIO domainSimilarity: Contains 1 tyrosine-protein phosphatase domain |
Gene Function
for PTPN9 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378Function: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions ofthe Golgi apparatusCatalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateEnzyme Number (IUBMB): EC 3.1.3.48
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
PTPN9 for ontologies About GeneDecksing
Animal Models: 14 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ptpn9):
PTPN9 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PTPN9 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Array including PTPN9: PAHS-045A
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN9
3 Interacting proteins for PTPN9 (P433781, 2) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006470 | protein dephosphorylation |
IEA | -- | | GO:0016311 | dephosphorylation |
-- | -- |
About this table
PTPN9 for ontologies About GeneDecksing
|
Drugs & Compounds
for PTPN9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
PTPN9 for compounds About GeneDecksing
 Browse Tocris compounds for PTPN9
3  Novoseek chemical compound relationships for PTPN9 gene
About this table
|
Transcripts
for PTPN9 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PTPN9 gene: NM_002833.2 Additional cDNA sequence: AK126088.1 AL360201.1 BC010863.1 BC071574.1 BT007405.1 CR606925.1 M83738.1 21 DOTS entries: DT.100785572 DT.416479 DT.99932496 DT.95275990 DT.99973228 DT.100736878 DT.91995223 DT.121052866 DT.121052917 DT.207119 DT.92428239 DT.121052819 DT.75125478 DT.100698153 DT.92428236 DT.95305002 DT.100723295 DT.100819631 DT.121052922 DT.75185804 DT.91739539 24/188 AceView cDNA sequences (see all 188): BM801195 AI950192 AI419992 M83738 BX478608 AW138163 AW572418 AW468879 AW161220 CB528499 AI784154 BM967315 AA359978 BM727905 AI991947 AA045943 W67862 BU154770 AW183876 AW300748 BM803033 AI367760 BU608741 BQ024301
 highest scoring ESTs for PTPN9:M83738 AI202869 AI253052 AI695945 AI950192 AI989610 AI990566 BE463921 BF222928 AI288909 Unigene Cluster for PTPN9: Protein tyrosine phosphatase, non-receptor type 9 Hs.445775 [show with all ESTs]Unigene Representative Sequence: NM_002833
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000306726(uc002bal.2)
|
Expression
for PTPN9 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PTPN9 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching PTPN9 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 1386_at2, 3
|
U95-A |
1 |
0.81 |
1.00 |
1.00 |
1.00 |
M83738 |
1.00 |
0.90 |
0.95 |
1 |
| 202958_at2, 3
|
U133-A |
1 |
0.64 |
1.00 |
-- |
-- |
NM_002833 |
0.60 |
1.00 |
0.82 |
1 |
| 202958_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PTPN9 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.445775
Expression variation in blood from EXPOLDB for PTPN9 SABiosciences Expression via Pathway-Focused PCR Array including PTPN9: PAHS-045A
|
Orthologs
for PTPN9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PTPN9 gene from 5/9 species (see all 9)
About this table Species with no ortholog for PTPN9
ENSEMBL Gene Tree for PTPN9 (if available) |
Paralogs
for PTPN9 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PTPN9 gene
- PTPN12 PTPRN2 PTPRN22 PTPN22
PTPN9 for paralogs About GeneDecksing
|
Genomic Variants
for PTPN9 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 15 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PTPN9 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PTPN9
2 CNVs: 58736 102137
1 Indel: 25562 | | QIAGEN SeqTarget long-range PCR primers for resequencing PTPN9 |
|
Disorders & Mutations
for PTPN9 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PTPN9 for disorders About GeneDecksing
OMIM: 600768
1 PharmGKB disease relationship for PTPN9 geneAbout this table
Export disorders and mutations for PTPN9 gene to outside databases
|
Medical News
for PTPN9 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PTPN9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/21 PubMed articles for PTPN9 gene, integrated from 7 sources (see all 21):
(articles sorted by number of sources associating them with PTPN9)- Cloning and expression of a cytosolic megakaryocyte protein-tyrosine- phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p. (PubMed id 1557404)1, 2, 3, 7 Gu M.... Majerus P.W. (1992)
- Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)1, 2 Barr A.J.... Knapp S. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides. (PubMed id 11711529)1, 7 Kruger J.M....Downey G.P. (2002)
- Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. (PubMed id 14662869)1, 7 Huynh H....Mustelin T. (2003)
- A genome-wide association study in 19 633 Japanese su bjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1 Okada Y....Kamatani N. (2010)
- Protein-tyrosine phosphatase PTPN9 negatively regulat es ErbB2 and epidermal growth factor receptor signaling in breast cancer cells. (PubMed id 20335174)1 Yuan T....Gu H. (2010)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Association of protein-tyrosine phosphatase MEG2 via its Sec14p homology domain with vesicle-trafficking proteins. (PubMed id 17387180)1 Saito K....Mustelin T. (2007)
- Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. (PubMed id 16679294)1 Cho C.Y....Chanda S.K. (2006)
|
External Searches for PTPN9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PTPN9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PTPN9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PTPN9 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PTPN9 gene:
Search GeneIP for patents involving PTPN9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PTPN9 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
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