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PTPN9 Gene

protein-coding   GIFtS: 60

GC15M052517
protein tyrosine phosphatase, non-receptor type 9
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
protein tyrosine phosphatase, non-receptor type 91 2     PTPMEG22
MEG21 2     tyrosine-protein phosphatase non-receptor type 92
Protein-tyrosine phosphatase MEG22 3     PTPase-MEG22
PTPase MEG22 3     EC 3.1.3.483

External Ids:    HGNC: 96611   Entrez Gene: 57802   Ensembl: ENSG000001694107   UniProtKB: P433783   

Export aliases for PTPN9 gene to outside databases

Previous GC identifers: GC15M071637 GC15M068850 GC15M073335 GC15M073475 GC15M073546 GC15M075759


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPN9:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic
cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with
yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion
through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be
involved in signaling events regulating phagocytosis. (provided by RefSeq)

UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378
Function: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of
the Golgi apparatus

Gene Wiki entry for PTPN9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPN9 gene promoter:
         FOXO1a   STAT5A   GCNF-2   GCNF-1   NF-1   YY1   LUN-1   ZID   Sox9   MyoD   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PTPN9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PTPN9 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q23

PTPN9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN9 gene location

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M052517:  view genomic region     (about GC identifiers)

Start:
52,517,713 bp from pter
End:
52,629,661 bp from pter
Size:
111,949 bases
Orientation:
minus strand

1 alternative location:
Chr15- 75,759,462-75,871,630     
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 9  
Size: 593 amino acids; 68020 Da
Subcellular location: Cytoplasm (Probable)
PDB structures from and Proteopedia :
2PA5 (3D)    
Secondary accessions: Q53XR9

Explore the universe of human proteins at neXtProt for PTPN9: NX_P43378 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002824.1  

    ENSEMBL proteins: 
    ENSP00000303554 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant PTPN9 Protein
    Sigma-Aldrich Proteins for PTPN9
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PTPN9
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for PTPN9 
    Novus Biologicals Proteins for PTPN9
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    About this table

    PTPN9 for ontologies           About GeneDecksing



    Antibodies for PTPN9: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for PTPN9
    R&D Systems Antibodies for PTPN9 (PTP-MEG2)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PTPN9 
    Browse antibodies at Epitomics

    Assays for PTPN9: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTPN9 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PTPN9 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PTPN9 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001251 CRAL-bd_TRIO_C
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Dual-sp/Tyr_phosphatase
     IPR011074 Sec14p-like_N

    Graphical View of Domain Structure for InterPro Entry P43378

    ProtoNet protein and cluster: P43378

    4 Blocks protein families:
    IPB000242 Protein tyrosine phosphatase signature
    IPB001071 Cellular retinaldehyde-binding protein signature
    IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
    IPB008273 Cellular retinaldehyde-binding/triple function


    UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily
    Similarity: Contains 1 CRAL-TRIO domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378
    Function: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of
    the Golgi apparatus
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Enzyme Number (IUBMB): EC 3.1.3.48 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PTPN9
    Sigma-Aldrich shRNA Panels and shRNA for PTPN9
    OriGene 29mer shRNA kits in GFP-retroviral vector: PTPN9
    OriGene shRNA RFP: PTPN9
    OriGene basic RS shRNA: PTPN9
    OriGene siRNA: PTPN9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTPN9 
    miRNA:Sigma-Aldrich microRNA Mimics for PTPN9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTPN9 
    8/16 SABiosciences Assays for microRNAs that regulate PTPN9 (see all 16):
    hsa-miR-328 hsa-miR-126 hsa-miR-181c hsa-miR-128 hsa-miR-944 hsa-miR-548a-3p hsa-miR-548g hsa-miR-1276

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PTPN9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PTPN9
    OriGene untagged cDNA clones in CMV expression vector (see all 3): PTPN9
    OriGene 3'-UTR clone: PTPN9 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PTPN9 
    Sino Biological Human cDNA Clone for PTPN9

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PTPN9 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725 protein tyrosine phosphatase activity IDA19167335
    GO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS1557404
    GO:0005515 protein binding IPI19167335
    GO:0016787 hydrolase activity IEA--
    GO:0016791 phosphatase activity ----
    About this table

    PTPN9 for ontologies           About GeneDecksing

    Animal Models: 14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ptpn9):

    behavior/neurologicalcardiovascular systemcellularcraniofacialembryogenesis
    growth/sizehematopoietic systemhomeostasis/metabolismimmune systemlethality-postnatal
    lethality-prenatal/perinatallimbs/digits/tailnervous systemskeleton

    PTPN9 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Array including PTPN9: PAHS-045A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN9

    3 Interacting proteins for PTPN9 (P433781, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GHRP109121, 2EBI-742898,EBI-286316 MINT-6797548 MINT-6797775
    GAB1Q134801EBI-742898,EBI-517684
    --Q7RTN42MINT-66307
    About this table

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470 protein dephosphorylation IEA--
    GO:0016311 dephosphorylation ----
    About this table

    PTPN9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PTPN9 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPN9
    3 Novoseek chemical compound relationships for PTPN9 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinaldehyde 82.1 1 15299870 (1)
    phosphatidylinositol 58.3 4 11711529 (1)
    tyrosine 48.3 8 11711529 (3), 1557404 (2), 14662869 (1), 19347325 (1) (see all 5)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PTPN9
    Sigma-Aldrich shRNA Panels and shRNA for PTPN9
    OriGene 29mer shRNA kits in GFP-retroviral vector: PTPN9
    OriGene shRNA RFP: PTPN9
    OriGene basic RS shRNA: PTPN9
    OriGene siRNA: PTPN9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTPN9 
    miRNA: Sigma-Aldrich microRNA Mimics for PTPN9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTPN9 
    8/16 SABiosciences Assays for microRNAs that regulate PTPN9 (see all 16):
    hsa-miR-328 hsa-miR-126 hsa-miR-181c hsa-miR-128 hsa-miR-944 hsa-miR-548a-3p hsa-miR-548g hsa-miR-1276
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PTPN9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PTPN9
    OriGene untagged cDNA clones in CMV expression vector (see all 3): PTPN9
    OriGene 3'-UTR Clone: PTPN9 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PTPN9 
    Primers: OriGene genome-wide validated SYBR primer pairs: PTPN9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PTPN9: PPH12669A

    REFSEQ mRNAs for PTPN9 gene: 

    NM_002833.2  

    Additional cDNA sequence: 

    AK126088.1 AL360201.1 BC010863.1 BC071574.1 BT007405.1 CR606925.1 M83738.1 

    21 DOTS entries:

    DT.100785572  DT.416479  DT.99932496  DT.95275990  DT.99973228  DT.100736878  DT.91995223  DT.121052866 
    DT.121052917  DT.207119  DT.92428239  DT.121052819  DT.75125478  DT.100698153  DT.92428236  DT.95305002 
    DT.100723295  DT.100819631  DT.121052922  DT.75185804  DT.91739539 

    24/188 AceView cDNA sequences (see all 188):

    BM801195 AI950192 AI419992 M83738 BX478608 AW138163 AW572418 AW468879 
    AW161220 CB528499 AI784154 BM967315 AA359978 BM727905 AI991947 AA045943 
    W67862 BU154770 AW183876 AW300748 BM803033 AI367760 BU608741 BQ024301 

    highest scoring ESTs for PTPN9:

    M83738 AI202869 AI253052 AI695945 AI950192 AI989610 AI990566 BE463921 BF222928 AI288909 

    Unigene Cluster for PTPN9:

    Protein tyrosine phosphatase, non-receptor type 9
    Hs.445775  [show with all ESTs]
    Unigene Representative Sequence: NM_002833


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000306726(uc002bal.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PTPN9 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching PTPN9 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1386_at2, 3 U95-A 1 0.81 1.00 1.00 1.00 M83738 1.00 0.90 0.95 1
    202958_at2, 3 U133-A 1 0.64 1.00 -- -- NM_002833 0.60 1.00 0.82 1
    202958_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    PTPN9 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PTPN9 gene expression
    PTPN9 gene electronic northern expression
    PTPN9 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.445775

    Expression variation in blood from EXPOLDB for PTPN9

    Primers: OriGene genome-wide validated SYBR primer pairs: PTPN9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PTPN9: PPH12669A
        SABiosciences Expression via Pathway-Focused PCR Array including PTPN9: PAHS-045A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PTPN9 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PTPN91   -- protein tyrosine phosphatase, non-receptor type 9 93.78(n)
    96.51(a)
    612991  XM_849318.1  XP_854411.1 
    chimpanzee
    (Pan troglodytes)
    PTPN91   -- protein tyrosine phosphatase, non-receptor type 9 94.32(n)
    93.42(a)
    737244  XM_001144390.1  XP_001144390.1 
    cow
    (Bos taurus)
    PTPN91   -- protein tyrosine phosphatase, non-receptor type 9 92.47(n)
    96.12(a)
    505220  XM_581476.3  XP_581476.3 
    rat
    (Rattus norvegicus)
    Ptpn91   -- protein tyrosine phosphatase, non-receptor type 9 91.91(n)
    97.13(a)
    266611  NM_001013040.1  NP_001013058.1 
    mouse
    (Mus musculus)
    Ptpn91 , 5 9 (30.70 cM)5
    protein tyrosine phosphatase, non-receptor type 91, 5 91.62(n)1
    97.3(a)1
    562941  NM_019651.21  NP_062625.21 
     AF0134905  AI5511515  (see all 11)
    About this table        Species with no ortholog for PTPN9

    ENSEMBL Gene Tree for PTPN9 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PTPN9 gene
    PTPN12  PTPRN2  PTPRN22  PTPN22  

    PTPN9 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/753 NCBI SNPs in PTPN9 are shown (see all 753)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs40755221,2
    C,F,A,H,75864335(+) ACCCTG/AAACAG 1 -- int119Minor allele frequency- A:0.45NS EA NA WA 1260
    rs42991171,2
    C,F,A,H,75789444(+) ATATTC/TATACT 1 -- int110Minor allele frequency- T:0.36NS EA NA WA 630
    rs43197321,2
    C,F,H75851565(+) cgtctG/Aagaag 1 -- int13Minor allele frequency- A:0.50NA 8
    rs43226271,2
    C,F,A,75810659(+) GACAGC/TGTGAG 1 -- int15Minor allele frequency- T:0.28NA 80
    rs43815651,2
    C,F,A75802154(+) accccG/Atctct 1 -- int13Minor allele frequency- A:0.50NA 6
    rs43935351,2
    C,F,H75851293(+) ccaccC/Tcgtct 1 -- int14Minor allele frequency- T:0.50NA 10
    rs44085071,2
    C,F,A,H75851644(+) catgaC/Tgacga 1 -- int13Minor allele frequency- T:0.50NA 8
    rs44292571,2
    --75803041(+) TCTAAA/TTTGGt 1 -- int10--------
    rs44307071,2
    C,F,A,H,75852784(+) AATGGC/TCATTC 1 -- int117Minor allele frequency- T:0.37NS EA NA WA 860
    rs45348001,2
    C75846221(+) CTCTTC/TCTGAA 1 -- int14Minor allele frequency- T:0.00NS EA 412
    About this table

    HapMap Linkage Disequilibrium images for PTPN9 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for PTPN9
         2 CNVs: 58736 102137
         1 Indel: 25562

    QIAGEN SeqTarget long-range PCR primers for resequencing PTPN9 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PTPN9 for disorders           About GeneDecksing

    OMIM: 600768

    1 PharmGKB disease relationship for PTPN9 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table


    Export disorders and mutations for PTPN9 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/21 PubMed articles for PTPN9 gene, integrated from 7 sources (see all 21):
    (articles sorted by number of sources associating them with PTPN9)
    1. Cloning and expression of a cytosolic megakaryocyte protein-tyrosine- phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p. (PubMed id 1557404)1, 2, 3, 7 Gu M.... Majerus P.W. (1992)
    2. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)1, 2 Barr A.J.... Knapp S. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides. (PubMed id 11711529)1, 7 Kruger J.M....Downey G.P. (2002)
    5. Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. (PubMed id 14662869)1, 7 Huynh H....Mustelin T. (2003)
    6. A genome-wide association study in 19 633 Japanese su bjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1 Okada Y....Kamatani N. (2010)
    7. Protein-tyrosine phosphatase PTPN9 negatively regulat es ErbB2 and epidermal growth factor receptor signaling in breast cancer cells. (PubMed id 20335174)1 Yuan T....Gu H. (2010)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    9. Association of protein-tyrosine phosphatase MEG2 via its Sec14p homology domain with vesicle-trafficking proteins. (PubMed id 17387180)1 Saito K....Mustelin T. (2007)
    10. Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. (PubMed id 16679294)1 Cho C.Y....Chanda S.K. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5780 HGNC: 9661 AceView: PTPN9 Ensembl:ENSG00000169410 euGenes: HUgn5780
    ECgene: PTPN9 H-InvDB: PTPN9

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for PTPN9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for PTPN9 gene:
    Search GeneIP for patents involving PTPN9

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
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     Predesigned and custom siRNAs for PTPN9 Antibodies for PTPN9
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     Regulatory tfbs in PTPN9 promoter
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     ELISAs and CLIAs for PTPN9
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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