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Aliases & Descriptionsfor PTPRCAP gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions protein tyrosine phosphatase, receptor type, C-associated protein1 2 protein tyrosine phosphatase receptor type C-associated protein2 LPAP1 2 3 5 MGC1386022 CD45-AP1 2 3 protein tyrosine phosphatase, receptor type, c polypeptide-associated protein2 Lymphocyte phosphatase-associated phosphoprotein2 3 MGC1386032 CD45-associated protein2 3 CD45 associated protein2 PTPRC-associated protein2 3
Export aliases for PTPRCAP gene to outside databases Previous GC identifers: GC11P069666 GC11M068899 GC11M067452 GC11M066978 GC11M066959 GC11M067202
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Summariesfor PTPRCAP gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for PTPRCAP : The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. (provided by RefSeq) Gene Wiki entry for PTPRCAP
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Genomic Viewsfor PTPRCAP gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PTPRCAP gene promoter: LUN-1 GATA-1 NF-1 SREBP-1b SREBP-1a SREBP-1c Chx10 CREB deltaCREB CUTL1 Other transcription factors Search SABiosciences Chromatin IP Primers for PTPRCAP Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q13.3 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.2 PTPRCAP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M063531: view genomic region
(about GC identifiers )
Start:
63,531,031 bp from pter
End:
63,533,330 bp from pter
Size:
2,300 bases
Orientation:
minus strand
1 alternative location : Chr 11- 67,202,981-67,205,538
RefSeq DNA sequence: NC_000011.9 NT_167190.1
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Proteinsfor PTPRCAP gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: PTCA_HUMAN, Q14761 (See
protein sequence )Recommended Name: Protein tyrosine phosphatase receptor type C-associated protein Size : 206 amino acids; 21196 Da
Subunit : Interacts with CD45/PTPRC
Subcellular location : Membrane; Single-pass membrane protein (Potential)
Secondary accessions : B2R512 O00643 Q6I9S6Explore the universe of human proteins at neXtProt for PTPRCAP: NX_Q14761 Post-translational modifications:
Phosphorylated on tyrosine residues1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_005599.1 ENSEMBL proteins: ENSP00000325589 Human Recombinant Proteins 2 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
PTPRCAP for ontologies About GeneDecksing Antibodies for PTPRCAP: Assays for PTPRCAP:
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Protein
Domains/ Familiesfor PTPRCAP gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
PTPRCAP for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q14761 ProtoNet protein and cluster: Q14761
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Gene Functionfor PTPRCAP gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section Genatlas biochemistry entry for PTPRCAP :phosphotyrosine phosphatase,receptor-type 1,CD45,(PTPRC) associated protein,32kDa Animal Models: 3 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ptprcap) :
PTPRCAP for phenotypes About GeneDecksing
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Pathways & Interactionsfor PTPRCAP gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for PTPRCAP SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPRCAP 1 Interacting protein for PTPRCAP (Q14761 2 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (GO ID links to tree view) :
About this table
PTPRCAP for ontologies About GeneDecksing
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Drugs & Compoundsfor PTPRCAP gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section
PTPRCAP for compounds About GeneDecksing Browse Tocris compounds for PTPRCAP 1 Novoseek chemical compound relationship for PTPRCAP gene
About this table
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Transcriptsfor PTPRCAP gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for PTPRCAP gene: NM_005608.2
Additional cDNA sequence: AK312022.1 BC113859.1 BC114467.1 CR457429.1 CR592526.1 CR622472.1 X81422.1
6 DOTS entries : DT.450682 DT.100749777 DT.95344808 DT.100829736 DT.120735481 DT.100749779
24/629 AceView cDNA sequences (see all 629 ):
BE207040 BX339802 AW406588 BM707785 CR612430 CR613163 BQ438264 BQ434901 BM558555 AI127109 BI518865 BX439712 CR603235 BQ063990 BQ056672 BI870906 BI834220 BM021452 CR615750 BU500758 AI150761 BM848557 BI766109 BQ954286
highest scoring ESTs for PTPRCAP :AA215523 AA305662 AA481613 AL561116 AW404387 AW404685 AW406570 BE268293 BE268411 BE268428 Unigene Cluster for PTPRCAP:
Protein tyrosine phosphatase, receptor type, C-associated protein Hs.155975 [show with all ESTs ] Unigene Representative Sequence: BQ051978 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000326294 (uc001oli.1 )
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Expression for PTPRCAP gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section PTPRCAP expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching PTPRCAP gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
32070_at2 , 3
U95-A
1
0.69
1.00
1.00
1.00
X97267
0.20
1.00
0.72
1
204960_at2 , 3
U133-A
1
0.82
1.00
--
--
NM_005608
0.60
1.00
0.82
1
204960_at2
U133Plus2
1
0.82
1.00
--
--
--
--
--
--
--
About this table
PTPRCAP for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TGTACCCCGC SOURCE GeneReport for Unigene cluster: Hs.155975 Expression variation in blood from EXPOLDB for PTPRCAP
SABiosciences Custom PCR Arrays for PTPRCAP
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Orthologsfor PTPRCAP gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for PTPRCAP gene from 5 species
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
PTPRCAP1
--
protein tyrosine phosphatase, receptor type, C-associated more
79.94(n) 75.24(a)
611830 XM_849549.1 XP_854642.1
chimpanzee (Pan troglodytes)
PTPRCAP1
--
protein tyrosine phosphatase, receptor type, C-associated more
99.35(n) 99.51(a)
451369 XM_508595.2 XP_508595.2
cow (Bos taurus)
PTPRCAP1
--
protein tyrosine phosphatase, receptor type, C-associated more
76.73(n) 72.77(a)
618341 NM_001046618.1 NP_001040083.1
rat (Rattus norvegicus)
Ptprcap1
--
protein tyrosine phosphatase, receptor type, C-associated more
75.17(n) 68.88(a)
499300 NM_001024289.1 NP_001019460.1
mouse (Mus musculus)
Ptprcap1 , 5
19 (3.86 cM) 5
protein tyrosine phosphatase, receptor type, C polypeptide-associated more 1, 5
72.93(n) 1 65.99(a) 1
19265 1 NM_016933.3 1 NP_058629.2 1 AA265746 5 AI323196 5 (see all 16 )
About this table Species with no ortholog for PTPRCAP ENSEMBL Gene Tree for PTPRCAP (if available)
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Paralogsfor PTPRCAP gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section --
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Genomic Variantsfor PTPRCAP gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 11 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for PTPRCAP (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for PTPRCAP: --
QIAGEN SeqTarget long-range PCR primers for resequencing PTPRCAP
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Disorders & Mutationsfor PTPRCAP gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
PTPRCAP for disorders About GeneDecksing
OMIM: 601577 Human Gene Mutation Database (HGMD) : PTPRCAP Human Genome Epidemiology (HuGE) Navigator: PTPRCAP (1 document)Export disorders and mutations for PTPRCAP gene to outside databases
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Medical Newsfor PTPRCAP gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor PTPRCAP gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/20 PubMed articles for PTPRCAP gene, integrated from 7 sources (see all 20 ): (articles sorted by number of sources associating them with PTPRCAP) Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45. (PubMed id 8537410) 1 , 2 , 7 Bruyns E....Schraven B. (1995) LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes. (PubMed id 7961877) 1 , 2 , 7 Schraven B....Meuer S. (1994) Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes. (PubMed id 8954783) 1 , 2 , 7 Bruyns E.... Schraven B. (1996) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 2 Mayya V.... Han D.K. (2009) A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expr ession. (PubMed id 20019842) 1 Ju H....Kang C. (2009) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005) PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients. (PubMed id 15372250) 1 Cocco E....Marrosu M.G. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) 77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link. (PubMed id 12595907) 1 Vogel A....Manns M.P. (2003)
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External Searches for PTPRCAP gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing PTPRCAP gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing PTPRCAP gene
(According to HUGE )
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Specialized Databases showing PTPRCAP gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for PTPRCAP gene: Search GeneIP for patents involving PTPRCAP GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor PTPRCAP gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for PTPRCAP
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