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PTPRCAP Gene

protein-coding   GIFtS: 53

GC11M063531
protein tyrosine phosphatase, receptor type, C-associated protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
protein tyrosine phosphatase, receptor type, C-associated protein1 2     protein tyrosine phosphatase receptor type C-associated protein2
LPAP1 2 3 5     MGC1386022
CD45-AP1 2 3     protein tyrosine phosphatase, receptor type, c polypeptide-associated protein2
Lymphocyte phosphatase-associated phosphoprotein2 3     MGC1386032
CD45-associated protein2 3     CD45 associated protein2
PTPRC-associated protein2 3     

External Ids:    HGNC: 96671   Entrez Gene: 57902   Ensembl: ENSG000002134027   UniProtKB: Q147613   

Export aliases for PTPRCAP gene to outside databases

Previous GC identifers: GC11P069666 GC11M068899 GC11M067452 GC11M066978 GC11M066959 GC11M067202


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPRCAP:
The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine
phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required
for the stable expression of this protein. (provided by RefSeq)

Gene Wiki entry for PTPRCAP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPRCAP gene promoter:
         LUN-1   GATA-1   NF-1   SREBP-1b   SREBP-1a   SREBP-1c   Chx10   CREB   deltaCREB   CUTL1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PTPRCAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

PTPRCAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRCAP gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M063531:  view genomic region     (about GC identifiers)

Start:
63,531,031 bp from pter
End:
63,533,330 bp from pter
Size:
2,300 bases
Orientation:
minus strand

1 alternative location:
Chr11- 67,202,981-67,205,538     
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PTCA_HUMAN, Q14761 (See protein sequence)
Recommended Name: Protein tyrosine phosphatase receptor type C-associated protein  
Size: 206 amino acids; 21196 Da
Subunit: Interacts with CD45/PTPRC
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B2R512 O00643 Q6I9S6

Explore the universe of human proteins at neXtProt for PTPRCAP: NX_Q14761 

Post-translational modifications:

  • Phosphorylated on tyrosine residues1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005599.1  

    ENSEMBL proteins: 
    ENSP00000325589 


    Human Recombinant Proteins 
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    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IDA11390434
    GO:0016021 integral to membrane IEA--
    About this table

    PTPRCAP for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PTPRCAP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR016553 Tyr_Pase_rcpt_C-assoc_CD45-AP

    Graphical View of Domain Structure for InterPro Entry Q14761

    ProtoNet protein and cluster: Q14761


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
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    Search SABiosciences for Assays for microRNAs that regulate PTPRCAP

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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    OriGene GFP tagged cDNA clones in CMV expression vector: PTPRCAP
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    Cell
    Lines:
      
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    Genatlas biochemistry entry for PTPRCAP:
    phosphotyrosine phosphatase,receptor-type 1,CD45,(PTPRC) associated protein,32kDa
    Animal Models: 3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ptprcap):
    hematopoietic systemimmune systemnormal

    PTPRCAP for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for PTPRCAP 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPRCAP

    1 Interacting protein for PTPRCAP (Q147612) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --Q5JR012MINT-64176
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952 defense response TAS7961877
    About this table

    PTPRCAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PTPRCAP for compounds           About GeneDecksing

    Sigma-Aldrich Small Molecules for PTPRCAP:
    Small Molecule - Inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPRCAP
    1 Novoseek chemical compound relationship for PTPRCAP gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 49 14 7961877 (2), 8954783 (1), 9533446 (1), 7499298 (1) (see all 5)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for PTPRCAP
    Sigma-Aldrich shRNA for PTPRCAP
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    OriGene basic RS shRNA: PTPRCAP
    OriGene siRNA: PTPRCAP
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    miRNA: Browse microRNA Mimics at Sigma-Aldrich
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    Search SABiosciences for Assays for microRNAs that regulate PTPRCAP
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PTPRCAP
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PTPRCAP
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    Primers: OriGene genome-wide validated SYBR primer pairs: PTPRCAP
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    SABiosciences RT2 qPCR Primer Assay for PTPRCAP: PPH02163A

    REFSEQ mRNAs for PTPRCAP gene: 

    NM_005608.2  

    Additional cDNA sequence: 

    AK312022.1 BC113859.1 BC114467.1 CR457429.1 CR592526.1 CR622472.1 X81422.1 

    6 DOTS entries:

    DT.450682  DT.100749777  DT.95344808  DT.100829736  DT.120735481  DT.100749779 

    24/629 AceView cDNA sequences (see all 629):

    BE207040 BX339802 AW406588 BM707785 CR612430 CR613163 BQ438264 BQ434901 
    BM558555 AI127109 BI518865 BX439712 CR603235 BQ063990 BQ056672 BI870906 
    BI834220 BM021452 CR615750 BU500758 AI150761 BM848557 BI766109 BQ954286 

    highest scoring ESTs for PTPRCAP:

    AA215523 AA305662 AA481613 AL561116 AW404387 AW404685 AW406570 BE268293 BE268411 BE268428 

    Unigene Cluster for PTPRCAP:

    Protein tyrosine phosphatase, receptor type, C-associated protein
    Hs.155975  [show with all ESTs]
    Unigene Representative Sequence: BQ051978


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000326294(uc001oli.1)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PTPRCAP expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching PTPRCAP gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    32070_at2, 3 U95-A 1 0.69 1.00 1.00 1.00 X97267 0.20 1.00 0.72 1
    204960_at2, 3 U133-A 1 0.82 1.00 -- -- NM_005608 0.60 1.00 0.82 1
    204960_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    PTPRCAP for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PTPRCAP gene expression
    PTPRCAP gene electronic northern expression
    PTPRCAP gene sage expression
    About these images

    CGAP SAGE TAG: TGTACCCCGC

    SOURCE GeneReport for Unigene cluster: Hs.155975

    Expression variation in blood from EXPOLDB for PTPRCAP

    Primers: OriGene genome-wide validated SYBR primer pairs: PTPRCAP
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PTPRCAP: PPH02163A
        SABiosciences Custom PCR Arrays for PTPRCAP 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PTPRCAP gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PTPRCAP1   -- protein tyrosine phosphatase, receptor type, C-associated more 79.94(n)
    75.24(a)
    611830  XM_849549.1  XP_854642.1 
    chimpanzee
    (Pan troglodytes)
    PTPRCAP1   -- protein tyrosine phosphatase, receptor type, C-associated more 99.35(n)
    99.51(a)
    451369  XM_508595.2  XP_508595.2 
    cow
    (Bos taurus)
    PTPRCAP1   -- protein tyrosine phosphatase, receptor type, C-associated more 76.73(n)
    72.77(a)
    618341  NM_001046618.1  NP_001040083.1 
    rat
    (Rattus norvegicus)
    Ptprcap1   -- protein tyrosine phosphatase, receptor type, C-associated more 75.17(n)
    68.88(a)
    499300  NM_001024289.1  NP_001019460.1 
    mouse
    (Mus musculus)
    Ptprcap1 , 5 19 (3.86 cM)5
    protein tyrosine phosphatase, receptor type, C polypeptide-associated more1, 5 72.93(n)1
    65.99(a)1
    192651  NM_016933.31  NP_058629.21 
     AA2657465  AI3231965  (see all 16)
    About this table        Species with no ortholog for PTPRCAP

    ENSEMBL Gene Tree for PTPRCAP (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10 NCBI SNPs in PTPRCAP are shown
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs122951451,2
    --67203791(+) CAGCAA/GCATCC 2 L ref1 syn10--------
    rs127870211,2
    C,A,67204342(+) TAGGAA/GACGGG 1 -- int16Minor allele frequency- G:0.42NA EA WA 168
    rs359812061,2
    --67204891(+) ATGGG-/GTGCTG 1 -- int10--------
    rs609695941,2
    C,F,67203442(+) CTTCCC/TCAGGG 2 E G mis1 ref11Minor allele frequency- T:0.03NA 72
    rs617317721,2
    C67203608(+) CAGCGC/TGGCAC 2 T A mis1 ref10--------
    rs675016571,2
    C,67204255(+) CTTTTT/CCCTTC 1 -- int14Minor allele frequency- C:0.31NA WA 126
    rs714577761,2
    --67204066(+) GCCTGG/AGGCCT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs744583651,2
    C,67204151(+) CTCACC/TGTGCT 1 -- int11Minor allele frequency- T:0.02WA 50
    rs800007831,2
    C,F,67204451(+) AGGAGG/ATTGCT 1 -- int11Minor allele frequency- A:0.10WA 50
    rs1175457301,2
    67204084(+) GGCTGG/TTCCCT 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for PTPRCAP (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PTPRCAP: --

    QIAGEN SeqTarget long-range PCR primers for resequencing PTPRCAP 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PTPRCAP for disorders           About GeneDecksing

    OMIM: 601577

    Human Gene Mutation Database (HGMD): PTPRCAP
    Human Genome Epidemiology (HuGE) Navigator: PTPRCAP (1 document)

    Export disorders and mutations for PTPRCAP gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/20 PubMed articles for PTPRCAP gene, integrated from 7 sources (see all 20):
    (articles sorted by number of sources associating them with PTPRCAP)
    1. Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45. (PubMed id 8537410)1, 2, 7 Bruyns E....Schraven B. (1995)
    2. LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes. (PubMed id 7961877)1, 2, 7 Schraven B....Meuer S. (1994)
    3. Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes. (PubMed id 8954783)1, 2, 7 Bruyns E.... Schraven B. (1996)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    6. A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expr ession. (PubMed id 20019842)1 Ju H....Kang C. (2009)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    8. PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients. (PubMed id 15372250)1 Cocco E....Marrosu M.G. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. 77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link. (PubMed id 12595907)1 Vogel A....Manns M.P. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5790 HGNC: 9667 AceView: PTPRCAPandCORO1B Ensembl:ENSG00000213402 euGenes: HUgn5790
    ECgene: PTPRCAP H-InvDB: PTPRCAP

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for PTPRCAP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for PTPRCAP gene:
    Search GeneIP for patents involving PTPRCAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     RT2 qPCR Primer Assay for PTPRCAP
     GNC Network for PTPRCAP
     Search for Assays for microRNAs that regulate PTPRCAP
     SABiosciences Custom PCR Arrays for PTPRCAP
     Search Tocris compounds for PTPRCAP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Lysates for PTPRCAP
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for PTPRCAP
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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