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PTX3 Gene

protein-coding   GIFtS: 59

GC03P154550
pentraxin 3, long
(Previous names: pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor, alpha-induced protein 5, pentraxin-related gene, rapidly induced by IL-1 beta )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TNFAIP5)
Products    

Aliases &
Descriptions
for PTX3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
pentraxin 3, long1 2     TNFAIP52 3
TSG-141 2 3     pentaxin-related gene, rapidly induced by IL-1 beta1
tumor necrosis factor, alpha-induced protein 51 2     pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor,
alpha-induced protein 52
pentraxin-related gene, rapidly induced by IL-1 beta1 2     pentraxin-32
Pentaxin-related protein PTX32 3     tumor necrosis factor-inducible protein TSG-142
Tumor necrosis factor-inducible gene 14 protein2 3     pentraxin-related protein PTX32
Tumor necrosis factor alpha-induced protein 52 3     TSG143
TNF alpha-induced protein 52 3     

External Ids:    HGNC: 96921   Entrez Gene: 58062   Ensembl: ENSG000001636617   UniProtKB: P260223   

Export aliases for PTX3 gene to outside databases

Previous GC identifers: GC03P154190 GC03P158101 GC03P158436 GC03P158475 GC03P158637 GC03P157154


Summaries
for PTX3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PTX3_HUMAN, P26022
Function: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance
of self-components and female fertility (By similarity)

Gene Wiki entry for PTX3

Genomic Views
for PTX3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTX3 gene promoter:
         NF-kappaB1   NF-kappaB   c-Rel   Pax-6   Sox9   FOXJ2 (long isoform)   Hlf   POU2F2 (Oct-2.1)   Oct-B1   oct-B2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PTX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PTX3 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25   Ensembl cytogenetic band:  3q25.32   HGNC cytogenetic band: 3q25

PTX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTX3 gene location

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P154550:  view genomic region     (about GC identifiers)

Start:
 154,550,694 bp from pter
End:
 154,557,531 bp from pter
Size:
 6,838 bases
Orientation:
 plus strand

1 alternative location:
Chr3+ 157,154,578-157,161,417     
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  

Proteins
for PTX3 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: PTX3_HUMAN, P26022 (See protein sequence)
Recommended Name: Pentraxin-related protein PTX3 precursor  
Size: 381 amino acids; 41976 Da
Subunit: Homooctamer; disulfide-linked. Binds to C1q (By similarity)
Subcellular location: Secreted
Secondary accessions: B2R6T6 Q38M82

Explore the universe of human proteins at neXtProt for PTX3: NX_P26022 

Post-translational modifications:

  • Glycosylated (Probable)1


    • REFSEQ proteins: NP_002843.2  

    ENSEMBL proteins: 
    ENSP00000295927 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    R&D Systems Recombinant & Natural Proteins for PTX3 (Pentraxin 3/TSG-14)
    Enzo Life Sciences proteins for PTX3
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for PTX3 
    Novus Biologicals Proteins for PTX3
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PTX3

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    About this table

    PTX3 for ontologies           About GeneDecksing



    Antibodies for PTX3: 
    Millipore Mono- and Polyclonal Antibodies for the study of PTX3
    Sigma-Aldrich Antibody Arrays and Antibodies for PTX3
    R&D Systems Antibodies for PTX3 (Pentraxin 3/TSG-14)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PTX3 
    Novus Biologicals Antibodies for PTX3
    Browse antibodies at Epitomics

    Assays for PTX3: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    R&D Systems ELISAs for PTX3 (Pentraxin 3/TSG-14)
    GenScript Custom Assay Services for PTX3 
    Enzo Life Sciences assays for PTX3
    Uscn ELISAs and CLIAs for PTX3 

    Protein Domains/
    Families
    for PTX3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTX3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013320 ConA-like_subgrp
     IPR001759 Pentaxin
     IPR008985 ConA-like_lec_gl

    Graphical View of Domain Structure for InterPro Entry P26022

    ProtoNet protein and cluster: P26022

    1 Blocks protein family: IPB001759 Pentaxin

    UniProtKB/Swiss-Prot: PTX3_HUMAN, P26022
    Similarity: Contains 1 pentaxin domain


    Gene Function
    for PTX3 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PTX3_HUMAN, P26022
    Function: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance
    of self-components and female fertility (By similarity)
    Induction: By IL1B/interleukin-1 beta and TNF

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for PTX3
    Sigma-Aldrich shRNA for PTX3
    OriGene 29mer shRNA kits in GFP-retroviral vector: PTX3
    OriGene shRNA RFP: PTX3
    OriGene basic RS shRNA: PTX3
    OriGene siRNA: PTX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTX3 
    miRNA:Sigma-Aldrich microRNA Mimics for PTX3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTX3 
    7 SABiosciences Assays for microRNAs that regulate PTX3:
    hsa-miR-224 hsa-miR-655 hsa-miR-802 hsa-miR-29c hsa-miR-29a hsa-miR-410 hsa-miR-29b

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PTX3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PTX3
    OriGene untagged cDNA clones in CMV expression vector: PTX3
    OriGene 3'-UTR clone: PTX3 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PTX3 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for PTX3 

    Genatlas biochemistry entry for PTX3:
    pentaxin 3,acute phase reactant,induced by IL1B,in endothelial,hepatic,fibroblastic cells

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001872 zymosan binding IEA--
    About this table

    PTX3 for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ptx3):

    endocrine/exocrine glandimmune systemreproductive systemrespiratory system

    PTX3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PTX3 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    PTX3 for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  PTX3
        Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

        SABiosciences Pathway-Focused PCR Arrays including PTX3: PAHS-032A PAHS-3803A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PTX3
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTX3

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001878 response to yeast IEA--
    GO:0006954 inflammatory response TAS1429570
    GO:0008228 opsonization IEA--
    GO:0045429 positive regulation of nitric oxide biosynthetic process IEA--
    GO:0050766 positive regulation of phagocytosis IEA--
    About this table

    PTX3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTX3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PTX3 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTX3
    10 Novoseek chemical compound relationships for PTX3 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ccl3 36.3 2 20298930 (1), 19414540 (1), 20215499 (1)
    actinomycin d 25.2 4 9119472 (1), 16339571 (1), 7949102 (1)
    cycloheximide 23.8 3 9119472 (1), 16339571 (1), 7949102 (1)
    anti-fungal 8.87 4 16840729 (1), 17277044 (1), 19131771 (1)
    dexamethasone 8.33 4 7523502 (2), 16461742 (1), 7949102 (1)
    cholesterol 3.42 8 19238513 (2), 15262177 (1), 15324368 (1), 18571180 (1) (see all 5)
    nitric oxide 0 2 17533181 (2)
    tyrosine 0 1 17460897 (1)
    creatinine 0 2 17380301 (1), 15477419 (1)
    dopamine 0 1 15536184 (1)
    About this table



    Transcripts
    for PTX3 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for PTX3
    Sigma-Aldrich shRNA for PTX3
    OriGene 29mer shRNA kits in GFP-retroviral vector: PTX3
    OriGene shRNA RFP: PTX3
    OriGene basic RS shRNA: PTX3
    OriGene siRNA: PTX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTX3 
    miRNA: Sigma-Aldrich microRNA Mimics for PTX3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTX3 
    7 SABiosciences Assays for microRNAs that regulate PTX3:
    hsa-miR-224 hsa-miR-655 hsa-miR-802 hsa-miR-29c hsa-miR-29a hsa-miR-410 hsa-miR-29b
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PTX3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PTX3
    OriGene untagged cDNA clones in CMV expression vector: PTX3
    OriGene 3'-UTR Clone: PTX3 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PTX3 
    Primers: OriGene genome-wide validated SYBR primer pairs: PTX3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PTX3: PPH01105A

    REFSEQ mRNAs for PTX3 gene: 

    NM_002852.3  

    Additional cDNA sequence: 

    AK312705.1 BC027887.1 BC039733.1 CR593354.1 CR605317.1 CR606073.1 CR612979.1 CR612981.1 
    M31166.1 X63053.1 X63613.1 

    3 DOTS entries:

    DT.311828  DT.100709433  DT.100777112 

    24/126 AceView cDNA sequences (see all 126):

    BQ574679 AI952606 CB528977 CR612979 CD366496 AI141490 CR612981 AA343499 
    AW163320 BU681636 AA301817 BQ014604 BM970998 CA446598 BU680522 BQ015128 
    BU623796 CR606073 CR593354 CR605317 BQ001175 CA448395 CB110430 BU622869 

    highest scoring ESTs for PTX3:

    M31166 AA216121 AA301817 AA302014 AA304615 AA343499 AA344970 AI080546 AI082514 AI383040 

    Unigene Cluster for PTX3:

    Pentraxin 3, long
    Hs.591286  [show with all ESTs]
    Unigene Representative Sequence: NM_002852


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PTX3

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              

    About this scheme

    ECgene alternative splicing isoforms for PTX3
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000295927(uc003fbl.3)

    Expression
    for PTX3 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PTX3 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching PTX3 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1491_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M31166 1.00 1.00 1.00 1
    206157_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002852 0.60 1.00 0.82 1
    206157_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    PTX3 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PTX3 gene expression
    PTX3 gene electronic northern expression
    PTX3 gene sage expression
    About these images

    CGAP SAGE TAG: GTGCTTTCAG

    SOURCE GeneReport for Unigene cluster: Hs.591286

    Expression variation in blood from EXPOLDB for PTX3

    Primers: OriGene genome-wide validated SYBR primer pairs: PTX3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PTX3: PPH01105A
        SABiosciences Expression via Pathway-Focused PCR Arrays including PTX3: PAHS-032A PAHS-3803A 


    Orthologs
    for PTX3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for PTX3 gene from 5/6 species (see all 6)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 PTX31   -- pentraxin-related gene, rapidly induced by IL-1 beta 99.21(n)
    98.43(a)    		 460807  XM_516838.2  XP_516838.2 
    cow
    (Bos taurus)    		 PTX31   -- pentraxin-related gene, rapidly induced by IL-1 beta 87.46(n)
    82.11(a)    		 541148  NM_001076259.1  NP_001069727.1 
    rat
    (Rattus norvegicus)    		 Ptx31   -- pentraxin related gene 83.38(n)
    81.63(a)    		 689388  XM_001068884.1  XP_001068884.1 
    mouse
    (Mus musculus)    		 Ptx31 , 5 3 (30.25 cM)5
    		 pentraxin related gene1, 5 84.69(n)1
    82.15(a)1    		 192881  NM_008987.31  NP_033013.31 
     AA9604465  AI6078045  (see all 14)
    chicken
    (Gallus gallus)    		 PTX31   -- pentraxin-related gene, rapidly induced by IL-1 beta 66.23(n)
    58.47(a)    		 548626  NM_001017413.1  NP_001017413.1 
    About this table        Species with no ortholog for PTX3

    ENSEMBL Gene Tree for PTX3 (if available)

    Paralogs
    for PTX3 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PTX3 gene
    APCS2  NPTX22  CRP2  CBX62  PTX42  NPTX12  NPTXR2  

    PTX3 for paralogs           About GeneDecksing



    Genomic Variants
    for PTX3 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PTX3
         1 CNV: 3459
    QIAGEN SeqTarget long-range PCR primers for resequencing PTX3 

    Disorders & Mutations
    for PTX3 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTX3 for disorders           About GeneDecksing

    OMIM: 602492

    10/19 Novoseek disease relationships for PTX3 gene (see all 19)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 64 69 17828584 (2), 18045580 (2), 19164811 (2), 17380301 (2) (see all 44)
    response acute phase 62.5 6 16380821 (1), 15262177 (1), 15324368 (1), 16951703 (1) (see all 5)
    necrosis 44 27 1429570 (1), 7679696 (1), 9079634 (1), 15673302 (1) (see all 22)
    atherosclerosis 40.8 22 19238513 (5), 17380301 (2), 12006411 (2), 19729861 (1) (see all 11)
    preeclampsia 40.3 15 16647920 (5), 16816069 (3), 19544202 (2), 20374043 (1) (see all 7)
    atherosclerotic plaque 31.2 1 18220316 (1)
    bacterial infections 28.8 4 15977234 (1), 17277044 (1), 11404378 (1)
    shock septic 26.3 4 20119647 (1), 11445697 (1), 15226367 (1)
    autoimmunity 24.7 6 18614204 (3), 16380821 (1), 16166594 (1)
    acute myocardial infarction 22.3 7 10931803 (2), 17095712 (1), 12006411 (1), 12006390 (1) (see all 5)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: PTX3 (15 documents)

    Export disorders and mutations for PTX3 gene to outside databases

    Medical News
    for PTX3 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for PTX3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/178 PubMed articles for PTX3 gene, integrated from 7 sources (see all 178):
    (articles sorted by number of sources associating them with PTX3)
    1. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. (PubMed id 1429570)1, 2, 3, 7 Breviario F.... Introna M. (1992)
    2. TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. (PubMed id 7679696)1, 2, 7 Lee G.W.... Vilcek J. (1993)
    3. Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins. (PubMed id 7523502)1, 2, 7 Lee G.W.... Vilcek J. (1994)
    4. Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity. (PubMed id 12763682)1, 2, 7 Mantovani A.... Bottazzi B. (2003)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. IL-1 inducible genes in human umbilical vein endothelial cells. (PubMed id 8131794)1, 2 Introna M....Mantovani A. (1993)
    7. Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes. (PubMed id 7949102)1, 7 Alles V.V....Mantovani A. (1994)
    8. Pentraxin 3 is elevated in haemodialysis patients and is associated with cardiovascular disease. (PubMed id 17496115)1, 7 Boehme M....Schindler R. (2007)
    9. Increased serum pentraxin 3 in patients with systemic sclerosis. (PubMed id 19273457)1, 7 Iwata Y....Sato S. (2009)
    10. Cell-specific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells. (PubMed id 18703503)1, 7 Doni A....Mantovani A. (2008)

    External Searches for PTX3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTX3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5806 HGNC: 9692 AceView: PTX3 Ensembl:ENSG00000163661 euGenes: HUgn5806
    ECgene: PTX3 H-InvDB: PTX3

    Other Databases showing PTX3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTX3 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for PTX3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PTX3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for PTX3 gene:
    Search GeneIP for patents involving PTX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PTX3 gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for PTX3 Antibodies for PTX3
     Super-pooled esiRNAs for PTX3 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for PTX3 microRNA Mimics for PTX3
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies for PTX3 (Pentraxin 3/TSG-14)   Cell Culture Products  
     ELISAs for PTX3 (Pentraxin 3/TSG-14)   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for PTX3 (Pentraxin 3/TSG-14)  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PTX3
     SeqTarget long-range PCR primers for resequencing PTX3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PTX3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PTX3
     GenScript Custom Purified and Recombinant Proteins Services for PTX3 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for PTX3
     GenScript Custom Assay Services for PTX3 GenScript Custom Superior Antibodies Services for PTX3
     GenScript Custom overexpressing Cell Line Services for PTX3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PTX3 promoter
     Search Chromatin IP Primers for PTX3
     RT2 qPCR Primer Assay for PTX3
     GNC Network for PTX3
     Assays for microRNAs that regulate PTX3
     SABiosciences PCR Arrays including PTX3
     Search Tocris compounds for PTX3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Assays/Proteins for PTX3
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for PTX3
     Proteins for PTX3
     Browse antibodies at Epitomics
     Recombinant Protein for PTX3

     ELISAs and CLIAs for PTX3
           

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