Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



PVR Gene

protein-coding   GIFtS: 63

GC19P041579
poliovirus receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PVS)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
poliovirus receptor1 2     Tage41
PVS2 3 5     FLJ259462
Necl-51 2     nectin-like 52
HVED1 2     TAGE42
NECL51 2     CD155 antigen3
CD1551 2     NECL-53
Nectin-like protein 52 3     

External Ids:    HGNC: 97051   Entrez Gene: 58172   Ensembl: ENSG000000730087   UniProtKB: P151513   

Export aliases for PVR gene to outside databases

Previous GC identifers: GC19P045791 GC19P045538 GC19P049823 GC19P049839 GC19P045147


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PVR:
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The
external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular
domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves
as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: PVR_HUMAN, P15151
Function: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors:
CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature
immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and
IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and
PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may
trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating
tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in
axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network
through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde
transport


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PVR gene promoter:
         p53   Pax-5   SRF   NF-kappaB   NF-kappaB1   RelA   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PVR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PVR 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

PVR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PVR gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041579:  view genomic region     (about GC identifiers)

Start:
41,579,341 bp from pter
End:
41,601,754 bp from pter
Size:
22,414 bases
Orientation:
plus strand

1 alternative location:
Chr19+ 45,147,098-45,169,429     
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PVR_HUMAN, P15151 (See protein sequence)
Recommended Name: Poliovirus receptor precursor  
Size: 417 amino acids; 45303 Da
Subunit: Can form trans-heterodimers with PVRL3/nectin-3. The extracellular domain interacts with VTN, CD226 and CD96.
The cytoplasmic domain interacts with DYNLT1. Interacts with HHV-5 UL141. Interacts with poliovirus capsid composed of
VP1, VP2 and VP3, mainly through VP3. Binds with high affinity to TIGIT
Subcellular location: Isoform Alpha: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform Delta: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform Beta: Secreted
Subcellular location: Isoform Gamma: Secreted
Miscellaneous: The V-type domain is necessary and sufficient for virus binding and uptake
PDB structures from and Proteopedia :
1DGI (3D)    1NN8 (3D)    3EOW (3D)    3EPC (3D)    3EPD (3D)    3EPF (3D)    
Secondary accessions: B4DTS9 P15152 Q15267 Q15268 Q96BJ1
Alternative splicing: 4 isoforms:  P15151-1   P15151-2   P15151-3   P15151-4   

Explore the universe of human proteins at neXtProt for PVR: NX_P15151 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001129240.1  NP_001129241.1  NP_001129242.1  NP_006496.3  


    ENSEMBL proteins: 
    ENSP00000402060 ENSP00000187830 ENSP00000383907 ENSP00000385344 ENSP00000340870 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    R&D Systems Recombinant & Natural Proteins for PVR (CD155/PVR)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PVR
    GenScript Custom Purified and Recombinant Proteins Services for PVR 
    Novus Biologicals Proteins for PVR
    Novus Biologicals Lysate for PVR
    Sino Biological Recombinant Protein for PVR
    Browse ProSpec Recombinant Proteins

    5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005615 extracellular space TAS2170108
    GO:0005634 nucleus IDA18029348
    GO:0005730NOT nucleolus IDA18029348
    GO:0005737 cytoplasm TAS2170108
    About this table

    PVR for ontologies           About GeneDecksing



    Antibodies for PVR: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    R&D Systems Antibodies for PVR (CD155/PVR)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PVR 
    Novus Biologicals Antibodies for PVR
    Browse antibodies at Epitomics

    Assays for PVR: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PVR 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PVR 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PVR for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013162 CD80_C2-set
     IPR003596 Ig_V-set_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like

    Graphical View of Domain Structure for InterPro Entry P15151

    ProtoNet protein and cluster: P15151

    2 Blocks protein families:
    IPB003596 Immunoglobulin V-type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: PVR_HUMAN, P15151
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PVR_HUMAN, P15151
    Function: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors:
    CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature
    immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and
    IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and
    PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may
    trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating
    tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in
    axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network
    through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde
    transport
    Biophysicochemical properties: Kinetic parameters: KM=72 nM for VTN;
    Induction: Transcriptionally regulated by SHH

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Browse siRNA at Sigma-Aldrich
    Browse shRNA at Sigma-Aldrich
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): PVR
    OriGene shRNA RFP (see all 4): PVR
    OriGene basic RS shRNA (see all 4): PVR
    OriGene siRNA (see all 4): PVR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PVR 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PVR 
    Search SABiosciences for Assays for microRNAs that regulate PVR

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): PVR
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): PVR
    OriGene untagged cDNA clones in CMV expression vector: PVR
    OriGene 3'-UTR clone (see all 4): PVR 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PVR 
    Sino Biological Human cDNA Clone for PVR

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PVR 

    Genatlas biochemistry entry for PVR:
    poliovirus sensitivity,receptor

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618 viral receptor activity IEA--
    GO:0004872 receptor activity TAS2538245
    GO:0005515 protein binding IPI19011627
    GO:0050839 cell adhesion molecule binding IPI12913096
    About this table

    PVR for ontologies           About GeneDecksing

    Animal Models: 3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pvr):

    homeostasis/metabolismimmune systemtumorigenesis

    PVR for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    PVR for pathways           About GeneDecksing

    1 Kegg Pathway  (Kegg details for PVR):
        hsa04514 Cell adhesion molecules (CAMs)

        SABiosciences Pathway-Focused PCR Arrays including PVR: PAHS-095A PAHS-3401A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PVR

    5/8 Interacting proteins for PVR (P151512 ENSP000001878303) via UniProtKB, MINT, and/or STRING (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDH1P128302MINT-5224658
    TJP1Q071572MINT-5224586
    CD96ENSP000002832853STRING: ENSP00000283285
    SRCENSP000003626593STRING: ENSP00000362659
    PVRL3ENSP000003215143STRING: ENSP00000321514
    About this table

    5/11 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 11):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP12913096
    GO:0016337 cell-cell adhesion IEA--
    GO:0016477 cell migration IEA--
    GO:0034329 cell junction assembly TAS--
    GO:0034332 adherens junction organization TAS--
    About this table

    PVR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PVR


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Browse siRNA at Sigma-Aldrich
    Browse shRNA at Sigma-Aldrich
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): PVR
    OriGene shRNA RFP (see all 4): PVR
    OriGene basic RS shRNA (see all 4): PVR
    OriGene siRNA (see all 4): PVR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PVR 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PVR 
    Search SABiosciences for Assays for microRNAs that regulate PVR
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): PVR
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): PVR
    OriGene untagged cDNA clones in CMV expression vector: PVR
    OriGene 3'-UTR Clone (see all 4): PVR 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PVR 
    Primers: OriGene genome-wide validated SYBR primer pairs: PVR
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PVR: PPH13505A

    REFSEQ mRNAs for PVR gene (4 alternative transcripts): 

    NM_001135768.1  NM_001135769.1  NM_001135770.1  NM_006505.3  

    Additional cDNA sequence: 

    AK025949.1 AK094177.1 AK098812.1 AK290946.1 AK300349.1 BC015542.1 M24406.1 M24407.1 

    10 DOTS entries:

    DT.416566  DT.100783927  DT.75187267  DT.100783929  DT.91760736  DT.108862  DT.40263174  DT.91760729 
    DT.121481650  DT.95068821 

    24/329 AceView cDNA sequences (see all 329):

    AW079549 BX646992 BM743833 BM823693 F06714 F04991 AA650273 CO247073 
    CO396450 BE221800 BU684402 AI374885 CB147568 BQ233208 AA159556 BF724184 
    AA303931 M24407 BQ448049 AK094177 CD622813 BQ943688 AI193505 CA429918 

    highest scoring ESTs for PVR:

    AA086002 AA086109 AA099042 AA130783 AA130888 AA143796 AA148700 AA148701 AA150531 AA158739 

    Unigene Cluster for PVR:

    Poliovirus receptor
    Hs.171844  [show with all ESTs]
    Unigene Representative Sequence: NM_006505


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PVR

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                    -     -                                         -         
    SP2:                    -                                               -         
    SP3:                    -                                                         
    SP4:                                                                              
    SP5:                                                        -     -     -         

    About this scheme

    ECgene alternative splicing isoforms for PVR
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425690(uc010ejs.2) ENST00000187830 ENST00000406449 ENST00000403059
    ENST00000344956(uc002ozm.2 uc010xxb.1 uc010xxc.1 uc002ozn.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PVR expression in normal and diseased human tissues

    1  / 2  / 3

    14 probe-sets matching PVR gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    32699_s_at2, 3 U133-A 1 1.00 1.00 0.05 1.06 X64116 0.20 1.00 0.72 1
    32698_at2, 3 U95-A 1 1.00 1.00 0.95 0.70 X64116 0.20 1.00 0.72 1
    69681_at2, 3 U95-E 1 0.81 1.00 0.81 1.26 AI872476 0.20 0.50 0.38 1
    216283_s_at2, 3 U133-A 1 1.00 1.00 -- -- X64116 0.20 1.00 0.72 1
    212662_at2, 3 U133-A 1 1.00 1.00 -- -- BE615277 0.80 0.88 0.84 1
    32699_s_at2, 3 U133-A 1 1.00 1.00 -- -- X64116 0.20 1.00 0.72 1
    214444_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006505 0.60 0.83 0.73 1
    214443_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006505 0.60 0.83 0.73 1
    216283_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    212662_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    32699_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    214444_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    214443_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1556582_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    PVR for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PVR gene expression
    PVR gene electronic northern expression
    PVR gene sage expression
    About these images

    CGAP SAGE TAG: AACCACCCAG

    SOURCE GeneReport for Unigene cluster: Hs.171844

    Expression variation in blood from EXPOLDB for PVR

    Primers: OriGene genome-wide validated SYBR primer pairs: PVR
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PVR: PPH13505A
        SABiosciences Expression via Pathway-Focused PCR Arrays including PVR: PAHS-095A PAHS-3401A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PVR gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PVR1   -- poliovirus receptor 73.44(n)
    61.23(a)
    476439  XM_533645.2  XP_533645.2 
    chimpanzee
    (Pan troglodytes)
    PVR1   -- poliovirus receptor 98.32(n)
    97.84(a)
    744055  XM_001161582.1  XP_001161582.1 
    cow
    (Bos taurus)
    PVR1   -- poliovirus receptor 70.51(n)
    59.09(a)
    526865  XM_605244.3  XP_605244.3 
    mouse
    (Mus musculus)
    Pvr5 7 (9.95 cM) poliovirus receptor   -- U35836 
    About this table        Species with no ortholog for PVR

    ENSEMBL Gene Tree for PVR (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PVR gene
    CADM42  CADM32  PVRL22  CADM12  CADM22  PVRL42  PVRL12  PVRL32  

    PVR for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/321 NCBI SNPs in PVR are shown (see all 321)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs2037011,2
    C,A45152723(-) ttctgT/Cctcaa 3 -- int15Minor allele frequency- C:0.20NA WA 10
    rs2037021,2
    C,A,45151951(-) gaaaaG/Caaaac 3 -- int1 trp35Minor allele frequency- C:0.39NA EA WA 166
    rs2037031,2
    C,H45149993(-) gatctC/Ttgctc 3 -- int19Minor allele frequency- T:0.00NS EA NA WA 428
    rs2037041,2
    C,H45148684(-) atataC/Tacaaa 3 -- int10--------
    rs2037051,2
    --45148405(-) tatatA/Tatata 3 -- int10--------
    rs2037061,2
    --45155713(+) cagtgG/Tcacga 3 -- int10--------
    rs2037071,2
    C,A,45157488(+) ctgagG/Agagga 3 -- int1 trp33Minor allele frequency- A:0.33NA WA 6
    rs2037081,2
    C,F,A,45161139(+) ATGCCC/TTAGGA 6 L ref1 syn15Minor allele frequency- T:0.03MN NS EA 594
    rs2037091,2
    C,F,A,45161566(+) caaccA/Ttgtaa 3 -- int110Minor allele frequency- T:0.47NS EA NA WA 586
    rs2037101,2
    C,F,H,45162038(+) GGCATG/ATCCCG 4 /I /M ref1 mis1 int1 ese322Minor allele frequency- A:0.05EA NA NS WA 1134
    About this table

    HapMap Linkage Disequilibrium images for PVR (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PVR
         1 CNV: 0221

    QIAGEN SeqTarget long-range PCR primers for resequencing PVR 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PVR for disorders           About GeneDecksing

    OMIM: 173850

    9 Novoseek disease relationships for PVR gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polio 79 11 9188553 (1), 10777530 (1), 11597452 (1), 9203668 (1) (see all 11)
    pseudorabies 50.7 4 11255021 (1), 11454801 (1)
    paralysis 48.8 1 7476091 (1)
    malignant glioma 18.1 2 15279713 (1), 10841575 (1)
    tumors 15.3 19 15279713 (3), 15607800 (2), 15471548 (2), 19029379 (1) (see all 9)
    metastasis 0 2 14871893 (1), 17404872 (1)
    adenoma 0 3 11454801 (2), 11255021 (1)
    cancer 0 3 11454801 (1), 15471548 (1)
    immunodeficiency 0 1 11602758 (1)
    About this table

    Human Gene Mutation Database (HGMD): PVR
    Genetic Association Database (GAD): PVR
    Human Genome Epidemiology (HuGE) Navigator: PVR (8 documents)
    Tumor Gene Database (TGDB): PVR

    Export disorders and mutations for PVR gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/135 PubMed articles for PVR gene, integrated from 7 sources (see all 135):
    (articles sorted by number of sources associating them with PVR)
    1. The poliovirus receptor protein is produced both as membrane-bound and secreted forms. (PubMed id 2170108)1, 2, 3 Koike S.... Nomoto A. (1990)
    2. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). (PubMed id 15039383)1, 2, 7 Tahara-Hanaoka S.... Shibuya A. (2004)
    3. PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. (PubMed id 15607800)1, 2, 7 Pende D.... Moretta A. (2005)
    4. CD155/PVR plays a key role in cell motility during tumor cell invasion and migration. (PubMed id 15471548)1, 2, 7 Sloan K.E.... Jay D.G. (2004)
    5. CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). (PubMed id 15034010)1, 2, 7 Fuchs A.... Colonna M. (2004)
    6. The poliovirus receptor CD155 mediates cell-to-matrix contacts by specifically binding to vitronectin. (PubMed id 11437656)1, 2, 7 Lange R.... Bernhardt G. (2001)
    7. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. (PubMed id 15640804)1, 2, 7 Tomasec P.... Wilkinson G.W. (2005)
    8. Interaction of the poliovirus receptor with poliovirus. (PubMed id 10618374)1, 2, 7 He Y.... Rossmann M.G. (2000)
    9. N glycosylation of the virus binding domain is not essential for function of the human poliovirus receptor. (PubMed id 1331527)1, 2, 7 Zibert A. and Wimmer E. (1992)
    10. Functional domains of the poliovirus receptor. (PubMed id 1851992)1, 2, 7 Koike S.... Nomoto A. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5817 HGNC: 9705 AceView: PVRandCEAL1andLOC440536 Ensembl:ENSG00000073008 euGenes: HUgn5817
    ECgene: PVR Kegg: 5817 H-InvDB: PVR

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Protein Spotlighthttp://www.expasy.org/spotlight/back_issues/sptlt075.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for PVR gene:
    Search GeneIP for patents involving PVR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Browse siRNAs at Sigma-Aldrich Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Browse shRNAs at Sigma-Aldrich Browse microRNA Mimics at Sigma-Aldrich
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies for PVR (CD155/PVR)   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for PVR (CD155/PVR)  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PVR
     SeqTarget long-range PCR primers for resequencing PVR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PVR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PVR
     GenScript Custom Purified and Recombinant Proteins Services for PVR GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for PVR
     GenScript Custom Assay Services for PVR GenScript Custom Superior Antibodies Services for PVR
     GenScript Custom overexpressing Cell Line Services for PVR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PVR promoter
     Search Chromatin IP Primers for PVR
     RT2 qPCR Primer Assay for PVR
     GNC Network for PVR
     Search for Assays for microRNAs that regulate PVR
     SABiosciences PCR Arrays including PVR
     Search Tocris compounds for PVR
     Proteins and Antibodies for PVR
     cDNA Clones for PVR
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for PVR
     Proteins for PVR
     Lysates for PVR
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for PVR
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    PVR gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4