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QKI Gene

protein-coding GIFtS: 59

GC06P161274

quaking homolog, KH domain RNA binding (mouse)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
quaking homolog, KH domain RNA binding (mouse)¹ ²		hqkI²
QK3¹ ²		RNA binding protein HQK²
Hqk² ³		QK1²
protein quaking²		QK²
homolog of mouse quaking QKI (KH domain RNA binding protein)²		HKQ³
DKFZp586I0923²		HqkI³

External Ids:	HGNC: 21100¹	Entrez Gene: 9444²	Ensembl: ENSG00000112531⁷	UniProtKB: Q96PU8³

Export aliases for QKI gene to outside databases

Previous GC identifers: GC06P163188 GC06P163709 GC06P163689 GC06P163728 GC06P163806 GC06P163755 GC06P163835

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for QKI:

QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a

200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1

(MIM 601516) (Chen and Richard, 1998 (PubMed 9671495)). QKI proteins regulate RNA splicing, export of target RNAs from

the nucleus, translation of proteins, and RNA stability (Lauriat et al., 2008 (PubMed 17918747)).(supplied by OMIM)

UniProtKB/Swiss-Prot: QKI_HUMAN, Q96PU8

Function: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA

core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to

protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and

maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates

in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG

pre-mRNA. Acts as a translational repressor (By similarity)

Gene Wiki entry for QKI

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the QKI gene promoter:
         Max   c-Myc   MEF-2A   CUTL1   HNF-1A   FOXJ2 (long isoform)   Max1   Arnt   AhR   SREBP-1a
         Other transcription factors

Search SABiosciences Chromatin IP Primers for QKI

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for QKI

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q26 Ensembl cytogenetic band: 6q26 HGNC cytogenetic band: 6q26

QKI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QKI gene location

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P161274: view genomic region (about GC identifiers)

Start:	161,274,469 bp from pter
End:	161,453,987 bp from pter
Size:	179,519 bases
Orientation:	plus strand

1 alternative location:

Chr6+ 163,835,675-163,994,896

RefSeq DNA sequence:

NC_000006.11 NT_025741.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: QKI_HUMAN, Q96PU8 (See protein sequence)

Recommended Name: Protein quaking

Size: 341 amino acids; 37671 Da

Subunit: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 (By similarity)

Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity)

Sequence caution: Sequence=AAF63412.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA; Sequence=AAF63415.1;

Type=Miscellaneous discrepancy; Note=Chimeric cDNA; Sequence=AAF63416.1; Type=Miscellaneous discrepancy; Note=Chimeric

cDNA; Sequence=BAB55032.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q2I375 Q5MJQ1 Q969L9 Q96EJ3 Q96KA3 Q96PU6 Q96PU7 Q9P0X6 Q9P0X7 Q9P0X8 Q9P0X9

Q9P0Y0 Q9P0Y1

Alternative splicing: 9 isoforms: Q96PU8-1 Q96PU8-2 Q96PU8-3 Q96PU8-4 Q96PU8-5 Q96PU8-6 Q96PU8-7 Q96PU8-8

Q96PU8-9

Explore the universe of human proteins at neXtProt for QKI: NX_Q96PU8

Post-translational modifications:

Methylated by PRMT1 (By similarity)¹

Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity,

affecting transport and/or stabilization of MBP mRNA (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_006766.1 NP_996735.1 NP_996736.1 NP_996737.1

ENSEMBL proteins:

ENSP00000354951 ENSP00000408382 ENSP00000408775 ENSP00000355094 ENSP00000375976 ENSP00000354867

ENSP00000275262 ENSP00000375973

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 3): QKI OriGene Protein Over-expression Lysate (see all 4): QKI
	GenScript Custom Purified and Recombinant Proteins Services for QKI
	Novus Biologicals Proteins for QKI
	Novus Biologicals Lysates for QKI
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IDA	18029348

About this table

QKI for ontologies About GeneDecksing

Antibodies for QKI:

	Millipore Mono- and Polyclonal Antibodies for the study of QKI
	Sigma-Aldrich Antibodies for QKI
	Browse R&D Systems for Antibodies
	OriGene Antibodies: QKI
	GenScript Superior Antibodies for QKI
	Novus Biologicals Antibodies for QKI
	Browse antibodies at Epitomics

Assays for QKI:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for QKI
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for QKI

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

QKI for domains About GeneDecksing

2 InterPro domains/families:

IPR018111 KH_type_1_subgr

IPR004087 KH

Graphical View of Domain Structure for InterPro Entry Q96PU8

ProtoNet protein and cluster: Q96PU8

2 Blocks protein families:

IPB004087 KH domain

IPB004088 KH

UniProtKB/Swiss-Prot: QKI_HUMAN, Q96PU8

Similarity: Contains 1 KH domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: QKI_HUMAN, Q96PU8

Function: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA

core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to

protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and

maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates

in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG

pre-mRNA. Acts as a translational repressor (By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for QKI Sigma-Aldrich shRNA for QKI
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): QKI OriGene shRNA RFP (see all 5): QKI OriGene basic RS shRNA (see all 5): QKI OriGene siRNA (see all 5): QKI
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of QKI

miRNA:		Sigma-Aldrich microRNA Mimics for QKI Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of QKI
		8/41 SABiosciences Assays for microRNAs that regulate QKI (see all 41):
		hsa-miR-199a-3p hsa-miR-15a hsa-miR-30d hsa-miR-30a hsa-miR-424 hsa-miR-133a hsa-miR-208b hsa-miR-208a

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): QKI OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): QKI OriGene untagged cDNA clones in CMV expression vector (see all 4): QKI OriGene 3'-UTR clone: QKI Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for QKI
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for QKI

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	16713569
GO:0017124	SH3 domain binding	IEA	--

About this table

QKI for ontologies About GeneDecksing

Animal Models: 13 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Qk):

behavior/neurological	cardiovascular system	embryogenesis	growth/size	hearing/vestibular/ear
hematopoietic system	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging
limbs/digits/tail	nervous system	reproductive system

QKI for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for QKI

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for QKI

5/22 Interacting proteins for QKI (Q96PU8^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HNRNPK	P61978¹^,²	EBI-945792,EBI-304185 MINT-2855592 MINT-2859777
PCBP1	Q15365¹^,²	EBI-945792,EBI-946095 MINT-2866427 MINT-2856312
PTBP1	P26599¹^,²	EBI-945792,EBI-350540 MINT-2855611 MINT-2862237
ENSG00000100320	O43251¹^,²	EBI-945792,EBI-746056 MINT-2855630 MINT-2871304
FOX1	Q9NWB1¹^,²	EBI-945792,EBI-945906 MINT-2855822 MINT-2866408

About this table

5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001570	vasculogenesis	IEA	--
GO:0006397	mRNA processing	IEA	--
GO:0006417	regulation of translation	IEA	--
GO:0006810	transport	IEA	--
GO:0007275	multicellular organismal development	IEA	--

About this table

QKI for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for QKI

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for QKI Sigma-Aldrich shRNA for QKI
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): QKI OriGene shRNA RFP (see all 5): QKI OriGene basic RS shRNA (see all 5): QKI OriGene siRNA (see all 5): QKI
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of QKI

miRNA:		Sigma-Aldrich microRNA Mimics for QKI Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of QKI
		8/41 SABiosciences Assays for microRNAs that regulate QKI (see all 41):
		hsa-miR-199a-3p hsa-miR-15a hsa-miR-30d hsa-miR-30a hsa-miR-424 hsa-miR-133a hsa-miR-208b hsa-miR-208a

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): QKI OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): QKI OriGene untagged cDNA clones in CMV expression vector (see all 4): QKI OriGene 3'-UTR Clone: QKI Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for QKI

Primers:		OriGene genome-wide validated SYBR primer pairs: QKI Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for QKI: PPH12882A

REFSEQ mRNAs for QKI gene (4 alternative transcripts):

NM_006775.2 NM_206853.2 NM_206854.2 NM_206855.2

Additional cDNA sequence:

AB067798.1 AB067799.1 AB067800.1 AB067801.1 AF272349.1 AJ420502.1 AK027309.1 AK055085.1

AK074562.1 AK096701.1 AK295235.1 AK308784.1 AL050218.1 AY780788.1 BC008190.1 BC012222.1

BC019917.2 CR611372.1 CR626096.1 DQ323998.1

24/33 DOTS entries (see all 33):

DT.454551 DT.101973994 DT.95256589 DT.100798534 DT.121644952 DT.444196 DT.100798531 DT.206927

DT.212668 DT.100798536 DT.97781562 DT.426724 DT.100798532 DT.121391671 DT.92439646 DT.100798527

DT.121391768 DT.95137009 DT.100798529 DT.91641735 DT.92439628 DT.100889285 DT.121391627 DT.121391760

24/580 AceView cDNA sequences (see all 580):

AI745294 AL120142 F11381 BU508110 AA478104 BE644914 CA429064 BX499838

BM985026 F09727 AV645609 AL596541 BE466275 NM_206853 AW050497 CD640090

AA742313 CA416068 AI373478 AF272349 BF665855 CB145848 NM_006775 AW236382

highest scoring ESTs for QKI:

AA002101 AA002102 AA090044 AA102572 AA149507 AA215424 AA255504 AA279636 AA280004 AA284979

Unigene Cluster for QKI:

Quaking homolog, KH domain RNA binding (mouse)

Hs.510324 [show with all ESTs]

Unigene Representative Sequence: NM_206855

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for QKI (see all 10)

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11a	·	11b	^	12a	·	12b
SP1:							-						-																		-		-		-
SP2:							-						-
SP3:							-						-												-
SP4:																									-						-		-		-
SP5:													-		-																-		-		-

About this scheme

ECgene alternative splicing isoforms for QKI
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361758 ENST00000424802 ENST00000453779(uc003quj.2) ENST00000361752(uc003qui.2)

ENST00000392130 ENST00000361195 ENST00000275262(uc003quf.2 uc003qug.2 uc003quh.2)

ENST00000392127(uc003que.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

QKI expression in normal and diseased human tissues

¹ / ² / ³

26 probe-sets matching QKI gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
74289_at²^{, 3}	U95-D	1	1.00	1.00	0.91	0.85	AW009668	0.40	1.00	0.76	1
39760_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.20	AL031781	0.20	1.00	0.72	1
45656_at²^{, 3}	U95-B	1	0.88	1.00	0.88	1.16	AI633884	0.40	1.00	0.76	1
66100_s_at²^{, 3}	U95-C	1	0.81	1.00	0.93	0.89	AW016430	0.80	1.00	0.91	1
60826_at²	U95-C	1	0.75	1.00	0.94	1.21	--	--	--	--	--
39759_at²^{, 3}	U95-A	1	0.69	1.00	0.21	1.08	AL031781	0.20	1.00	0.72	1
86251_at*²^{, 3}	U95-E	1	0.38	1.00	0.56	0.73	AA935633	0.40	1.00	0.76	1
212636_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL031781	0.20	1.00	0.72	1
212263_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI114716	0.80	1.00	0.91	1
228540_at²^{, 3}	U133-B	1	0.91	1.00	--	--	BE218313	0.20	1.00	0.72	1
236154_at²	U133-B	1	0.91	1.00	--	--	--	--	--	--	--
212265_at²^{, 3}	U133-A	1	0.82	1.00	--	--	AL031781	0.20	1.00	0.72	1
214541_s_at²^{, 3}	U133-A	1	0.64	1.00	--	--	AF142418	0.40	1.00	0.76	1
214543_x_at²^{, 3}	U133-A	1	0.64	1.00	--	--	AF142421	0.40	1.00	0.76	1
212262_at²^{, 3}	U133-A	1	0.55	1.00	--	--	AA149639	0.60	1.00	0.82	1
241938_at*²^{, 3}	U133-B	1	0.55	1.00	--	--	AA935633	0.40	1.00	0.76	1
212636_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212263_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555154_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228540_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
236154_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
212265_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--
214541_s_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--
214543_x_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--
212262_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--
241938_at*²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--

About this table

QKI for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: TTGTTTGTAA

SOURCE GeneReport for Unigene cluster: Hs.510324

Expression variation in blood from EXPOLDB for QKI

UniProtKB/Swiss-Prot: QKI_HUMAN, Q96PU8

Tissue specificity: Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients

Primers:		OriGene genome-wide validated SYBR primer pairs: QKI Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for QKI: PPH12882A

SABiosciences Custom PCR Arrays for QKI

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for QKI gene from 5/11 species (see all 11)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	QKI¹	--	quaking homolog, KH domain RNA binding (mouse)	95.96(n) 99.33(a)	606754 XM_850463.1 XP_855556.1
cow (Bos taurus)	QKI¹	--	quaking homolog, KH domain RNA binding (mouse)	95.8(n) 100(a)	493722 NM_001007817.1 NP_001007818.1
rat (Rattus norvegicus)	Qk¹	--	quaking	95.6(n) 99.4(a)	499022 XM_574316.2 XP_574316.2
mouse (Mus musculus)	Qk^{1 , 5}	17 (7.75 cM)⁵	quaking^{1, 5}	96.03(n)¹ 100(a)¹	19317¹ NM_021881.1¹ NP_068681.1¹ AA183896⁵ AA210530⁵ (see all 46)
chicken (Gallus gallus)	QKI¹	--	quaking homolog, KH domain RNA binding (mouse)	89.62(n) 97.81(a)	374204 NM_204310.1 NP_989641.1

About this table Species with no ortholog for QKI

ENSEMBL Gene Tree for QKI (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for QKI gene

KHDRBS2² SF1² KHDRBS1² KHDRBS3²

QKI for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs140777^1,2	--	163865584(-)	`TTTTA-/ATTA NNNGA`	4	--	int¹		0	--	--	--	--
rs140781^1,2	--	163842596(-)	`CTCAA-/TCAA ATACA`	4	--	int¹		0	--	--	--	--
rs140782^1,2	--	163887483(+)	`TCTTG-/AGAA AGAAC`	4	--	int¹		0	--	--	--	--
rs715020^1,2	C,O,A,H,	163986482(-)	`TCTTAC/TTCATT`	6	--	int¹ ut3¹ ese³		16		MN NS EA NA	2484
rs721190^1,2	C,F,A,H,	163920117(-)	`gtgtaA/Gaactg`	4	--	int¹		13		NS EA NA WA	556
rs721191^1,2	C,F,O,A,H,	163920254(-)	`AATTAC/TTTTTA`	4	--	int¹		94		NS EA PA EU CA WA NA	4644
rs724826^1,2	C,A,	163938594(-)	`tgctcG/Acctat`	4	--	int¹		6		NA	82
rs724827^1,2	--	163938496(-)	`CTCCAG/TCCTGA`	4	--	int¹		0	--	--	--	--
rs783136^1,2	C,F,A,	163847606(+)	`GCcccG/Atcaac`	4	--	int¹		11		NS EA NA WA	674
rs783137^1,2	C,F,A,H,	163847852(+)	`gctagC/Ttgctt`	4	--	int¹		15		NS EA NA WA	692

About this table

HapMap Linkage Disequilibrium images for QKI (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for QKI
2 CNVs: 3651 69648

QIAGEN SeqTarget long-range PCR primers for resequencing QKI

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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QKI for disorders About GeneDecksing

OMIM: 609590

Human Gene Mutation Database (HGMD): QKI
Human Genome Epidemiology (HuGE) Navigator: QKI (1 document)

Export disorders and mutations for QKI gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/39 PubMed articles for QKI gene, integrated from 7 sources (see all 39):
(articles sorted by number of sources associating them with QKI)

Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia. (PubMed id 16641098)^{1, 2} Aberg K.... Jazin E. (2006)
Human QKI, a new candidate gene for schizophrenia involved in myelination. (PubMed id 16342280)^{1, 2} Aeberg K.... Jazin E. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Expression of Hqk encoding a KH RNA binding protein is altered in human glioma. (PubMed id 11856480)^{1, 2} Li Z.Z.... Abe K. (2002)
The STAR protein QKI-6 is a translational repressor. (PubMed id 10535969)^{1, 3} Saccomanno L....Goodwin E.B. (1999)
Characterization of QKI gene expression, genetics, an d epigenetics in suicide victims with major depressive disorder. (PubMed id 19545858)^{1, 7} Klempan T.A....Turecki G. (2009)
The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia. (PubMed id 17012699)^{1, 7} Haroutunian V....Davis K.L. (2006)
RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer. (PubMed id 19686745)¹ Yang G....Lu Z. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9444	HGNC: 21100	AceView: QKI	Ensembl:ENSG00000112531	euGenes: HUgn9444
ECgene: QKI	H-InvDB: QKI

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for QKI gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for QKI gene:
Search GeneIP for patents involving QKI

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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