Aliases &
Descriptions
for QSOX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| quiescin Q6 sulfhydryl oxidase 11 2 | | sulfhydryl oxidase 12 | | Quiescin Q61 3 | | FLJ348582 | | QSCN62 3 | | Q62 | | hQSOX2 3 | | EC 1.8.3.23 |
Export aliases for QSOX1 gene to outside databasesPrevious GC identifers: GC01P178391 GC01P180123 |
Summaries
for QSOX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for QSOX1:
This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families.The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggestingthat this gene plays an important role in growth regulation. Two transcript variants encoding two different isoformshave been found for this gene. (provided by RefSeq)
UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reductionof oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Infibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation
Gene Wiki entry for QSOX1 |
Genomic Views
for QSOX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for QSOX1
Other transcription factors
Search SABiosciences Chromatin IP Primers for QSOX1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for QSOX1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q24 Ensembl cytogenetic band: 1q25.2 HGNC cytogenetic band: 1q24QSOX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P151355: view genomic region
(about GC identifiers)
Start:
|
151,355,442 bp from pter |
End:
|
151,398,518 bp from pter |
Size:
|
43,077 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr1+ 180,123,968-180,180,667 |
RefSeq DNA sequence:- NC_000001.10 NT_004487.19
|
Proteins
for QSOX1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391 (See
protein sequence)Recommended Name: Sulfhydryl oxidase 1 precursor Size: 747 amino acids; 82578 Da
Cofactor: Binds 1 FAD per subunit (By similarity)
Subunit: Monomer (By similarity)
Subcellular location: Isoform 1: Golgi apparatus membrane; Single-pass membrane protein
Subcellular location: Isoform 2: Secreted, extracellular space. Note=Found in the extracellular medium of quiescentcells but is not found in proliferating cells
Miscellaneous: 'Quiescin Q6' means that it was the sixth clone to be found at a higher level of expression in quiescentfibroblasts
Sequence caution: Sequence=BAD92517.1; Type=Erroneous initiation;
PDB structure from  and Proteopedia  :3LLI (3D)
3LLK (3D)
Secondary accessions: Q59G29 Q5T2X0 Q8TDL6 Q8WVP4Alternative splicing: 2 isoforms: O00391-1 O00391-2 Explore the universe of human proteins at neXtProt for QSOX1: NX_O00391
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001004128.1 NP_002817.2
ENSEMBL proteins: ENSP00000375883 ENSP00000402170 ENSP00000356574 ENSP00000356572
Human Recombinant Proteins
5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7): About this table
QSOX1 for ontologies About GeneDecksing
Antibodies for QSOX1:
Assays for QSOX1: |
Protein
Domains/
Families
for QSOX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
QSOX1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O00391ProtoNet protein and cluster: O00391 2 Blocks protein families: IPB006662 Thioredoxin type domain IPB006863 Erv1/Alr
UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391Similarity: Belongs to the quiescin-sulfhydryl oxidase (QSOX) familySimilarity: Contains 1 ERV/ALR sulfhydryl oxidase domainSimilarity: Contains 1 thioredoxin domain |
Gene Function
for QSOX1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reductionof oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Infibroblasts, it may have tumor-suppressing capabilities being involved in growth regulationCatalytic activity: 4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)OInduction: Induced in quiescent cells just as fibroblasts begin to leave the proliferative cycle and enter quiescenceEnzyme Number (IUBMB): EC 1.8.3.2
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
QSOX1 for ontologies About GeneDecksing
|
Pathways & Interactions
for QSOX1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for QSOX1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QSOX1
1 Interacting protein for QSOX1 (O003912) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
QSOX1 for ontologies About GeneDecksing
|
Drugs & Compounds
for QSOX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for QSOX1
|
Transcripts
for QSOX1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for QSOX1 gene (2 alternative transcripts): NM_001004128.2 NM_002826.4 Additional cDNA sequence: AB209280.1 AF361868.1 AK290842.1 AK290887.1 AY358941.1 BC017692.1 BC100023.1 CR601148.1 CR613263.1 CR619667.1 U97276.2 24/40 DOTS entries (see all 40): DT.100829879 DT.99973359 DT.92440983 DT.100059508 DT.102840166 DT.86855929 DT.86841789 DT.97759904 DT.100724595 DT.101967478 DT.99968131 DT.102840180 DT.100691414 DT.121434083 DT.100053977 DT.102840170 DT.102840174 DT.102844889 DT.91750186 DT.92440981 DT.102840182 DT.100654003 DT.100654006 DT.100654010 24/1123 AceView cDNA sequences (see all 1123): CF131741 BM771315 CO245619 BM771903 CO394531 BM770704 BM988360 AA464152 U97276 CA489847 CR601148 BM989683 AA425481 F13473 CF125699 CO248497 CF131747 CF128268 AI678870 NM_002826 BQ684306 AI798888 CF132342 BM992865 Unigene Cluster for QSOX1: Quiescin Q6 sulfhydryl oxidase 1 Hs.518374 [show with all ESTs]Unigene Representative Sequence: NM_002826
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for QSOX1 (see all 9)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for QSOX1
5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000392029(uc001gob.1) ENST00000443059 ENST00000367602(uc001gny.2 uc001gnz.2 uc001goa.2 uc001goc.2 uc001god.3)
ENST00000367600 ENST00000484788
|
Expression
for QSOX1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| QSOX1 expression in normal and diseased human tissues
1 / 2 9 probe-sets matching QSOX1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 1257_s_at2
|
U95-A |
1 |
1.00 |
1.00 |
0.90 |
0.85 |
-- |
-- |
-- |
-- |
-- |
| 56644_at2
|
U95-C |
2 |
0.38 |
0.62 |
0.91 |
1.10 |
-- |
-- |
-- |
-- |
-- |
| 56685_at2
|
U95-C |
1 |
0.31 |
1.00 |
0.86 |
1.06 |
-- |
-- |
-- |
-- |
-- |
| 201482_at2
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 230523_at2
|
U133-B |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 226706_at2
|
U133-B |
2 |
0.27 |
0.75 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 201482_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 230523_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 226706_at2
|
U133Plus2 |
2 |
0.27 |
0.75 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
QSOX1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTTGATTCCC
SOURCE GeneReport for Unigene cluster: Hs.518374
UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain andkidney
SABiosciences Custom PCR Arrays for QSOX1
|
Orthologs
for QSOX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for QSOX1 gene from 5/10 species (see all 10)
About this table Species with no ortholog for QSOX1
ENSEMBL Gene Tree for QSOX1 (if available) |
Paralogs
for QSOX1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for QSOX1 gene
- QSOX22
QSOX1 for paralogs About GeneDecksing
|
Genomic Variants
for QSOX1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 1 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for QSOX1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for QSOX1
1 CNV: 4264 | | QIAGEN SeqTarget long-range PCR primers for resequencing QSOX1 |
|
Disorders & Mutations
for QSOX1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
QSOX1 for disorders About GeneDecksing
OMIM: 603120
2  Novoseek disease relationships for QSOX1 gene
About this table
Export disorders and mutations for QSOX1 gene to outside databases
|
Medical News
for QSOX1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for QSOX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/29 PubMed articles for QSOX1 gene, integrated from 7 sources (see all 29):
(articles sorted by number of sources associating them with QSOX1)- The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. (PubMed id 9878249)1, 2, 3, 7 Coppock D.L.... Gilleran S. (1998)
- Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. (PubMed id 10708601)1, 2, 7 Coppock D.L.... Cina-Poppe D.A. (2000)
- Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases. (PubMed id 10542195)1, 2, 7 Hoober K.L.... Thorpe C. (1999)
- Preferential gene expression in quiescent human lung fibroblasts. (PubMed id 8396966)1, 3, 7 Coppock D.L....Gilleran S. (1993)
- Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1. (PubMed id 17331072)1, 2 Chakravarthi S.... Bulleid N.J. (2007)
- Identification and expression of a new splicing variant of FAD- sulfhydryl oxidase in adult rat brain. (PubMed id 16806532)1, 2 Radom J.... Jouvenot M. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
|
External Searches for QSOX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing QSOX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing QSOX1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing QSOX1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for QSOX1 gene:
Search GeneIP for patents involving QSOX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for QSOX1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
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 |  |  |  | |
| |  | Search Tocris compounds for QSOX1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for QSOX1 |
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