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QSOX2 Gene

protein-coding   GIFtS: 45

GC09M108562
quiescin Q6 sulfhydryl oxidase 2
(Previous name: quiescin Q6-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: QSCN6L1)
Products    

Aliases &
Descriptions
for QSOX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
quiescin Q6 sulfhydryl oxidase 21 2     Quiescin Q6-like protein 12 3
SOXN1 2 3 5     QSCN6L12 3
DKFZp762A20131 2     sulfhydryl oxidase 22
quiescin Q6-like 11 2     EC 1.8.3.23
Neuroblastoma-derived sulfhydryl oxidase2 3     

External Ids:    HGNC: 302491   Entrez Gene: 1697142   Ensembl: ENSG000001656617   UniProtKB: Q6ZRP73   

Export aliases for QSOX2 gene to outside databases

Previous GC identifers: GC09M138239 GC09M137879 GC09M139098


Summaries
for QSOX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for QSOX2:
QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization
of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 (PubMed
14633699)).(supplied by OMIM)

UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7
Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction
of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also
seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis


Genomic Views
for QSOX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for QSOX2
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for QSOX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for QSOX2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

QSOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QSOX2 gene location

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M108562:  view genomic region     (about GC identifiers)

Start:
 108,562,182 bp from pter
End:
 108,601,716 bp from pter
Size:
 39,535 bases
Orientation:
 minus strand

2 alternative locations:
Chr9-,PATCHES 139,137,322-139,137,687      Chr9- 139,098,179-139,137,687     
RefSeq DNA sequence:
NC_000009.11  NT_019501.13  

Proteins
for QSOX2 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7 (See protein sequence)
Recommended Name: Sulfhydryl oxidase 2 precursor  
Size: 698 amino acids; 77529 Da
Cofactor: Binds 1 FAD per subunit (Potential)
Subcellular location: Membrane; Single-pass membrane protein. Secreted. Cell membrane; Single-pass membrane protein
(Potential). Nucleus membrane; Single-pass membrane protein (Potential). Note=Seems to be predominantly targeted to
the nuclear and outer plasma membrane
Sequence caution: Sequence=BAC87262.1; Type=Erroneous initiation; Sequence=CAC85331.1; Type=Frameshift; Positions=354,
369, 616, 618;
Secondary accessions: A2CEE0 A6NLB0 Q5TB37 Q7Z7B6 Q86VV7 Q8N3G2

Explore the universe of human proteins at neXtProt for QSOX2: NX_Q6ZRP7 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_859052.3  

    ENSEMBL proteins: 
    ENSP00000374122 ENSP00000351536 ENSP00000389089 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for QSOX2 
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005634 nucleus IEA--
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
    GO:0031965 nuclear membrane IEA--
    About this table

    QSOX2 for ontologies           About GeneDecksing



    Antibodies for QSOX2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for QSOX2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for QSOX2 
    Browse antibodies at Epitomics

    Assays for QSOX2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for QSOX2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for QSOX2 

    Protein Domains/
    Families
    for QSOX2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    QSOX2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017905 ERV/ALR_sulphydryl_oxidase
     IPR012336 Thioredoxin-like_fold
     IPR012335 Thioredoxin_fold
     IPR006863 Evr1_Alr
     IPR013766 Thioredoxin_domain

    Graphical View of Domain Structure for InterPro Entry Q6ZRP7

    ProtoNet protein and cluster: Q6ZRP7

    2 Blocks protein families:
    IPB006662 Thioredoxin type domain
    IPB006863 Erv1/Alr


    UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7
    Similarity: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family
    Similarity: Contains 1 ERV/ALR sulfhydryl oxidase domain
    Similarity: Contains 1 thioredoxin domain


    Gene Function
    for QSOX2 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7
    Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction
    of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also
    seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis
    Catalytic activity: 4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)O
    Enzyme Number (IUBMB): EC 1.8.3.2 

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for QSOX2
    Sigma-Aldrich shRNA for QSOX2
    OriGene 29mer shRNA kits in GFP-retroviral vector: QSOX2
    OriGene shRNA RFP: QSOX2
    OriGene basic RS shRNA: QSOX2
    OriGene siRNA: QSOX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of QSOX2 
    miRNA:Sigma-Aldrich microRNA Mimics for QSOX2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of QSOX2 
    6 SABiosciences Assays for microRNAs that regulate QSOX2:
    hsa-miR-320a hsa-miR-320b hsa-miR-605 hsa-miR-320d hsa-miR-320c hsa-miR-664

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: QSOX2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: QSOX2
    OriGene untagged cDNA clones in CMV expression vector: QSOX2
    OriGene 3'-UTR clone: QSOX2 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for QSOX2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for QSOX2 

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491 oxidoreductase activity IEA--
    GO:0016972 thiol oxidase activity IEA--
    About this table

    QSOX2 for ontologies           About GeneDecksing


    Pathways & Interactions
    for QSOX2 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for QSOX2 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QSOX2

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045454 cell redox homeostasis IEA--
    GO:0055114 oxidation-reduction process IEA--
    About this table

    QSOX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for QSOX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    QSOX2 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for QSOX2
    3 Novoseek chemical compound relationships for QSOX2 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavin 66.1 2 19397338 (1), 15683237 (1)
    dithiothreitol 65.3 2 15568811 (1), 19409596 (1)
    h2o2 46.9 1 12202243 (1)
    About this table



    Transcripts
    for QSOX2 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for QSOX2
    Sigma-Aldrich shRNA for QSOX2
    OriGene 29mer shRNA kits in GFP-retroviral vector: QSOX2
    OriGene shRNA RFP: QSOX2
    OriGene basic RS shRNA: QSOX2
    OriGene siRNA: QSOX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of QSOX2 
    miRNA: Sigma-Aldrich microRNA Mimics for QSOX2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of QSOX2 
    6 SABiosciences Assays for microRNAs that regulate QSOX2:
    hsa-miR-320a hsa-miR-320b hsa-miR-605 hsa-miR-320d hsa-miR-320c hsa-miR-664
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: QSOX2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: QSOX2
    OriGene untagged cDNA clones in CMV expression vector: QSOX2
    OriGene 3'-UTR Clone: QSOX2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for QSOX2 
    Primers: OriGene genome-wide validated SYBR primer pairs: QSOX2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for QSOX2: PPH15632A

    REFSEQ mRNAs for QSOX2 gene: 

    NM_181701.3  

    Additional cDNA sequence: 

    AJ318051.1 AJ420461.1 AK128077.1 AK128750.1 AL834369.1 BC047604.2 CR601649.1 

    6 DOTS entries:

    DT.110458  DT.97836908  DT.97775695  DT.75100956  DT.40213602  DT.121194112 

    24/91 AceView cDNA sequences (see all 91):

    BE349598 BI492379 H08428 AI028313 CR601649 AI742021 AI309245 AI753180 
    AI280985 BE875636 BQ187181 AA514465 AA493143 AI304528 BQ894697 AI554061 
    AW662560 BG745598 BQ185744 BG180984 BM699256 BQ218767 BQ894531 AW873348 

    Unigene Cluster for QSOX2:

    Quiescin Q6 sulfhydryl oxidase 2
    Hs.657864  [show with all ESTs]
    Unigene Representative Sequence: AJ318051


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for QSOX2

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                            -     -                             -           -               
    SP2:                                                  -                             -           -               
    SP3:                                                                                -           -               
    SP4:                                                                                                            
    SP5:                    -     -                 -     -                                                         

    About this scheme

    ECgene alternative splicing isoforms for QSOX2
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389471 ENST00000358701(uc010nbi.2) ENST00000455222

    Expression
    for QSOX2 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    QSOX2 expression in normal and diseased human tissues

    1  / 2

    6 probe-sets matching QSOX2 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    61673_at2 U95-C 1 1.00 1.00 0.94 1.26 -- -- -- -- --
    75405_at2 U95-E 1 1.00 1.00 0.58 0.75 -- -- -- -- --
    227146_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --
    235239_at2 U133-B 1 0.82 1.00 -- -- -- -- -- -- --
    227146_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    235239_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    QSOX2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    QSOX2 gene expression
    QSOX2 gene electronic northern expression
    QSOX2 gene sage expression
    About these images

    CGAP SAGE TAG: GAAATGTCAG

    SOURCE GeneReport for Unigene cluster: Hs.657864

    UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7
    Tissue specificity: Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung,
    liver and skeletal muscles

    Primers: OriGene genome-wide validated SYBR primer pairs: QSOX2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for QSOX2: PPH15632A
        SABiosciences Custom PCR Arrays for QSOX2 


    Orthologs
    for QSOX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for QSOX2 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 QSOX21   -- quiescin Q6 sulfhydryl oxidase 2 80.17(n)
    77.87(a)    		 607571  XM_844307.1  XP_849400.1 
    chimpanzee
    (Pan troglodytes)    		 QSOX21   -- quiescin Q6 sulfhydryl oxidase 2 98.09(n)
    97.85(a)    		 464853  XM_520361.2  XP_520361.2 
    rat
    (Rattus norvegicus)    		 Qsox21   -- quiescin Q6 sulfhydryl oxidase 2 80.29(n)
    79.28(a)    		 681023  XM_001059980.1  XP_001059980.1 
    mouse
    (Mus musculus)    		 Qsox21 , 5 2 (18.45 cM)5
    		 quiescin Q6 sulfhydryl oxidase 21, 5 81.69(n)1
    82.57(a)1    		 2276381  NM_153559.21  NP_705787.11 
     AK0420365  AK1403245  (see all 11)
    chicken
    (Gallus gallus)    		 QSOX21   -- quiescin Q6 sulfhydryl oxidase 2 67.59(n)
    67.54(a)    		 417129  XM_415413.2  XP_415413.2 
    About this table        Species with no ortholog for QSOX2

    ENSEMBL Gene Tree for QSOX2 (if available)

    Paralogs
    for QSOX2 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for QSOX2 gene
    QSOX12  

    QSOX2 for paralogs           About GeneDecksing



    Genomic Variants
    for QSOX2 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/482 NCBI SNPs in QSOX2 are shown (see all 482)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs9124931,2
    		C,H,139110290(-) GGGGGC/TGTGAG 1 -- int15Minor allele frequency- T:0.00NA 12
    rs14752591,2
    		C,A,H,139109247(-) GCTGGC/TGTTTC 1 -- int14Minor allele frequency- T:0.21WA NA 56
    rs19245221,2
    		C,139126595(-) GGCCTC/TGTGGA 1 -- int15Minor allele frequency- T:0.10NA WA 10
    rs37801901,2
    		C,F,A,H,139099073(+) AAGCGA/GCAACA 1 -- ut3114Minor allele frequency- G:0.50NS EA NA WA 1054
    rs38111261,2
    		C,F,139099927(-) TGTTCG/CACACC 1 -- ut316Minor allele frequency- C:0.02EA NS WA 1968
    rs38111271,2
    		C,F139099600(-) AAAGCC/GCCCCC 1 -- ut314Minor allele frequency- G:0.01NS EA 418
    rs38243591,2
    		C,F,A,H,139105229(-) AGACCA/GTGTAA 1 -- int117Minor allele frequency- G:0.23EA NA NS WA 2668
    rs46331301,2
    		C139126672(+) TCCACG/AAGGCC 1 -- int12Minor allele frequency- A:0.50NA 4
    rs48419191,2
    		C139126569(+) TCCCCG/AGCTTG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs48421321,2
    		C,H,139125890(+) AAAGGC/TCTTCA 1 -- int17Minor allele frequency- T:0.00NA WA 16
    About this table

    HapMap Linkage Disequilibrium images for QSOX2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for QSOX2: --

    QIAGEN SeqTarget long-range PCR primers for resequencing QSOX2 

    Disorders & Mutations
    for QSOX2 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    QSOX2 for disorders           About GeneDecksing

    OMIM: 612860

    Human Genome Epidemiology (HuGE) Navigator: QSOX2 (1 document)

    Export disorders and mutations for QSOX2 gene to outside databases

    Medical News
    for QSOX2 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for QSOX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/41 PubMed articles for QSOX2 gene, integrated from 7 sources (see all 41):
    (articles sorted by number of sources associating them with QSOX2)
    1. Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/quiescin 6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells. (PubMed id 14633699)1, 2, 7 Wittke I....Schwab M. (2003)
    2. Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. (PubMed id 12176051)1, 3, 7 Thorpe C....Coppock D.L. (2002)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. A genome-wide association study in 19 633 Japanese su bjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1 Okada Y....Kamatani N. (2010)
    6. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010 Oct 14)
    7. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    8. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)

    External Searches for QSOX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing QSOX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 169714 HGNC: 30249 AceView: QSCN6L1 Ensembl:ENSG00000165661 euGenes: HUgn169714
    ECgene: QSOX2 H-InvDB: QSOX2

    Other Databases showing QSOX2 gene

    (According to HUGE)
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    Specialized Databases showing QSOX2 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    Intellectual Property
    for QSOX2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for QSOX2 gene:
    Search GeneIP for patents involving QSOX2

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    Products
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     ELISAs and CLIAs for QSOX2
           

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