Aliases &
Descriptions
for QTRT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| queuine tRNA-ribosyltransferase 11 2 | | FP32352 | | TGT1 2 3 5 | | queuine tRNA-ribosyltransferase2 | | Guanine insertion enzyme2 3 | | EC 2.4.2.293 | | tRNA-guanine transglycosylase2 3 | | TGUT3 |
Export aliases for QTRT1 gene to outside databasesPrevious GC identifers: GC19P010674 GC19P010675 GC19P010676 GC19P010812 |
Summaries
for QTRT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for QTRT1:
tRNA-guanine transglycosylase (TGT; EC 2.4.2.29) synthesizes queuosine (Q), which is found in tRNAs that recognize NAUand NAC codons, encoding tyr, asn, asp, and his. Prokaryotic TGT is a single protein of 43 kD. In contrast, mammalianTGT appears to be a heterodimer consisting of a 60-kD subunit (USP14; MIM 607274) and a 43-kD catalytic subunit(QTRT1) (Deshpande and Katze, 2001 (PubMed 11255023)).(supplied by OMIM)
UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0Function: Interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine forthe guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming thehypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (Bysimilarity)
|
Genomic Views
for QTRT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the QTRT1 gene promoter:
NRSF form 2 NRSF form 1 AP-1 SREBP-1a SREBP-1b SREBP-1c HOXA9B Meis-1 SRF TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for QTRT1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for QTRT1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3QTRT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P010389: view genomic region
(about GC identifiers)
Start:
|
10,389,232 bp from pter |
End:
|
10,401,116 bp from pter |
Size:
|
11,885 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr19+ 10,812,112-10,824,040 |
RefSeq DNA sequence:- NC_000019.9 NT_011295.11
|
Proteins
for QTRT1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0 (See
protein sequence)Recommended Name: Queuine tRNA-ribosyltransferase Size: 403 amino acids; 44048 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with QTRTD1 (By similarity)
Subcellular location: Cytoplasm (By similarity). Mitochondrion (By similarity). Nucleus (By similarity). Note=Weaklyassociates with mitochondria, possibly via QTRTD1 (By similarity)
Sequence caution: Sequence=AAH15350.1; Type=Erroneous initiation;
Secondary accessions: Q96BQ4 Q9BXQ9Explore the universe of human proteins at neXtProt for QTRT1: NX_Q9BXR0
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_112486.1
ENSEMBL proteins: ENSP00000250237 ENSP00000389126
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
QTRT1 for ontologies About GeneDecksing
Antibodies for QTRT1:
Assays for QTRT1: |
Protein
Domains/
Families
for QTRT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
QTRT1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BXR0ProtoNet protein and cluster: Q9BXR0 1 Blocks protein family: IPB002616 Queuine/other tRNA-ribosyltransferase
UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0Similarity: Belongs to the queuine tRNA-ribosyltransferase family |
Gene Function
for QTRT1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0Function: Interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine forthe guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming thehypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (Bysimilarity)Catalytic activity: [tRNA]-guanine + queuine = [tRNA]-queuine + guanineEnzyme Number (IUBMB): EC 2.4.2.29
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
QTRT1 for ontologies About GeneDecksing
|
Pathways & Interactions
for QTRT1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0Pathway: tRNA modification; tRNA-queuosine biosynthesis SABiosciences Custom Pathway-Focused PCR Arrays for QTRT1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QTRT1
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
QTRT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for QTRT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
QTRT1 for compounds About GeneDecksing
 Browse Tocris compounds for QTRT1
8  Novoseek chemical compound relationships for QTRT1 gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| queuine |
95.9 |
12 |
20354154 (2), 12877882 (1), 7630726 (1), 15246567 (1) (see all 6) |
| trna guanine |
94.5 |
2 |
7630726 (1), 12581659 (1) |
| 7-deazaguanine |
86.1 |
1 |
9369241 (1) |
| trna |
71.1 |
12 |
1378304 (2), 11134952 (2), 16206323 (1), 7630726 (1) (see all 5) |
| guanine |
69.8 |
19 |
20354154 (3), 12877882 (2), 1378304 (2), 11255023 (2) (see all 8) |
| anticodon |
57.8 |
1 |
7630726 (1) |
| guanosine |
47.3 |
2 |
15246567 (1) |
| nucleoside |
42.7 |
4 |
11134952 (1), 15246567 (1) |
About this table
|
Transcripts
for QTRT1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for QTRT1 gene: NM_031209.2 Additional cDNA sequence: AF302783.1 AF302784.1 AF302785.1 AF370379.1 AK055216.1 AK057877.1 AK225173.1 AK294166.1 AK314308.1 BC015350.1 CR602960.1 CR614822.1 CR614899.1 20 DOTS entries: DT.100027084 DT.121465724 DT.442457 DT.100699569 DT.100652329 DT.121465619 DT.121465708 DT.100027083 DT.100796387 DT.100796386 DT.40316301 DT.97845567 DT.121465747 DT.97798801 DT.121465660 DT.121465665 DT.121465685 DT.121465738 DT.121465706 DT.91997349 24/186 AceView cDNA sequences (see all 186): BF939611 AK055216 BU621033 BQ929911 BM719390 BM511883 BM747043 BX423123 BX113603 AI366116 BM460709 F27177 BM756341 CR614822 AI492206 BE207231 AA378418 AF302784 BQ643095 BU634015 CR602960 BF447204 BE327879 AL138461
 highest scoring ESTs for QTRT1:AA514559 AA649522 AA827574 AF302783 AF302784 AI015010 AI366116 AI433680 AI492206 AI571124 Unigene Cluster for QTRT1: Queuine tRNA-ribosyltransferase 1 Hs.631638 [show with all ESTs]Unigene Representative Sequence: BM467261
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000250237(uc002mpr.2) ENST00000421333
|
Expression
for QTRT1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| QTRT1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching QTRT1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 78349_at2, 3
|
U95-E |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
AA514559 |
0.80 |
1.00 |
0.91 |
1 |
| 221270_s_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
NM_031209 |
0.60 |
1.00 |
0.82 |
1 |
| 221270_s_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
QTRT1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TACGGGGATC
SOURCE GeneReport for Unigene cluster: Hs.631638
SABiosciences Custom PCR Arrays for QTRT1
|
Orthologs
for QTRT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for QTRT1 gene from 5/17 species (see all 17)
About this table Species with no ortholog for QTRT1
ENSEMBL Gene Tree for QTRT1 (if available) |
Paralogs
for QTRT1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for QTRT1 gene
- QTRTD12
QTRT1 for paralogs About GeneDecksing
Pseudogenes
- 1 related pseudogene
|
Genomic Variants
for QTRT1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for QTRT1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for QTRT1
1 CNV: 5086 | | QIAGEN SeqTarget long-range PCR primers for resequencing QTRT1 |
|
Disorders & Mutations
for QTRT1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
QTRT1 for disorders About GeneDecksing
OMIM: 609615
1 Novoseek disease relationship for QTRT1 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
0 |
2 |
11134952 (1), 15246567 (1) |
About this table
Export disorders and mutations for QTRT1 gene to outside databases
|
Medical News
for QTRT1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for QTRT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/27 PubMed articles for QTRT1 gene, integrated from 7 sources (see all 27):
(articles sorted by number of sources associating them with QTRT1)- Characterization of cDNA encoding the human tRNA-guanine transglycosylase (TGT) catalytic subunit. (PubMed id 11255023)1, 2, 7 Deshpande K.L. and Katze J.R. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of the human tRNA-guanine transglyco sylase: confirmation of the heterodimeric subunit structure. (PubMed id 20354154)1, 7 Chen Y.C....Garcia G.A. (2010)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)1 Suzuki Y.... Sugano S. (1997)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
- Increased expression of queuosine synthesizing enzyme, tRNA-guanine transglycosylase, and queuosine levels in tRNA of leukemic cells. (PubMed id 11134952)7 Ishiwata S....Mizugaki M. (2001)
|
External Searches for QTRT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing QTRT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing QTRT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing QTRT1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for QTRT1 gene:
Search GeneIP for patents involving QTRT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for QTRT1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for QTRT1 |
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 | | | ELISAs and CLIAs for QTRT1 |
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