Aliases &
Descriptions
for RAB10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| RAB10, member RAS oncogene family1 2 | | GTP-binding protein RAB102 | | ras-related protein Rab-102 | | ras-related GTP-binding protein2 |
Export aliases for RAB10 gene to outside databasesPrevious GC identifers: GC02P026178 GC02P026349 GC02P026231 GC02P026168 GC02P026256 |
Summaries
for RAB10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAB10:
RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic andendocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 (PubMed 9918381)).(supplied byOMIM)
UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026Function: May be involved in vesicular trafficking and neurotransmitter release
Gene Wiki entry for RAB10 |
Genomic Views
for RAB10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB10 gene promoter:
STAT1beta STAT1 STAT1alpha STAT2 STAT3 STAT4 STAT6 STAT5A STAT5B GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB10
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RAB10  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3RAB10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P025993: view genomic region
(about GC identifiers)
Start:
|
25,993,019 bp from pter |
End:
|
26,096,921 bp from pter |
Size:
|
103,903 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr2+ 26,256,976-26,360,323 |
RefSeq DNA sequence:- NC_000002.11 NT_022184.15
|
Proteins
for RAB10 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026 (See
protein sequence)Recommended Name: Ras-related protein Rab-10 Size: 200 amino acids; 22541 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: O88386 Q6IA52 Q9D7X6 Q9H0T3Explore the universe of human proteins at neXtProt for RAB10: NX_P61026
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057215.3
ENSEMBL proteins: ENSP00000264710
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
RAB10 for ontologies About GeneDecksing
Antibodies for RAB10:
Assays for RAB10: |
Protein
Domains/
Families
for RAB10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB10 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P61026ProtoNet protein and cluster: P61026 4 Blocks protein families: IPB002041 GTP-binding nuclear protein Ran IPB003577 Ras small GTPase IPB003578 Ras small GTPase IPB006688 ADP-ribosylation factor
UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026Similarity: Belongs to the small GTPase superfamily. Rab family |
Gene Function
for RAB10 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026Function: May be involved in vesicular trafficking and neurotransmitter release
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
RAB10 for ontologies About GeneDecksing
|
Pathways & Interactions
for RAB10 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for RAB10
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB10
5 Interacting proteins for RAB10 (P610261, 2) via UniProtKB, MINT, and/or STRINGAbout this table
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006886 | intracellular protein transport |
-- | -- | | GO:0006913 | nucleocytoplasmic transport |
-- | -- | | GO:0007165 | signal transduction |
-- | -- | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- |
About this table
RAB10 for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for RAB10
|
Transcripts
for RAB10 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for RAB10 gene: NM_016131.4 Additional cDNA sequence: AF086917.1 AF091032.1 AF106681.1 AF297660.1 AF498945.1 AK023223.1 AK025136.1 AL136650.1 BC000896.1 CR457303.1 CR606343.1 CR606383.1 CR615601.1 CR623312.1 23 DOTS entries: DT.419913 DT.95351212 DT.100845459 DT.92455495 DT.100845450 DT.100845453 DT.70102743 DT.95282215 DT.100774101 DT.100845452 DT.100845458 DT.100845456 DT.120977613 DT.120977629 DT.120977685 DT.40249961 DT.92455457 DT.92455488 DT.95373709 DT.100696537 DT.91945989 DT.95373710 DT.95373712 24/614 AceView cDNA sequences (see all 614): BM992610 AA373366 AW026273 BM741900 AA360801 BM999316 CR606383 AI753213 AI288253 AI523512 AW468983 BM738365 AI421506 BU739650 BQ002826 BE896006 BM982179 BM989220 CR615601 AI452841 BG390246 AI337889 T34846 AI038945
 highest scoring ESTs for RAB10:AI979258 AA004503 AA004504 AA037328 AA039234 AA039341 AA040197 AA040842 AA064719 AA069181 Unigene Cluster for RAB10: RAB10, member RAS oncogene family Hs.467960 [show with all ESTs]Unigene Representative Sequence: NM_016131
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB10
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for RAB10
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000473035 ENST00000462003 ENST00000264710(uc002rgv.2) ENST00000495146
|
Expression
for RAB10 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| RAB10 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching RAB10 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 52273_s_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.94 |
1.14 |
AI979258 |
1.00 |
1.00 |
1.00 |
1 |
| 49068_at2, 3
|
U95-C |
1 |
0.81 |
1.00 |
0.93 |
0.86 |
AI031674 |
0.80 |
1.00 |
0.91 |
1 |
| 222980_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AL136650 |
0.80 |
0.88 |
0.84 |
1 |
| 222981_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
BC000896 |
0.80 |
0.88 |
0.84 |
1 |
| 222980_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 222981_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
RAB10 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AGTTTTATTT
SOURCE GeneReport for Unigene cluster: Hs.467960
SABiosciences Custom PCR Arrays for RAB10
|
Orthologs
for RAB10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB10 gene from 5/13 species (see all 13)
About this table Species with no ortholog for RAB10
ENSEMBL Gene Tree for RAB10 (if available) |
Paralogs
for RAB10 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for RAB10 gene
- RAB8A2 RAB40AL2 RAB152 RAB40B2 RAB8B2 RAB40A2 RAB40C2 RAB132
RAB10 for paralogs About GeneDecksing
|
Genomic Variants
for RAB10 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for RAB10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RAB10
1 CNV: 7261 | | QIAGEN SeqTarget long-range PCR primers for resequencing RAB10 |
|
Disorders & Mutations
for RAB10 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB10 for disorders About GeneDecksing
OMIM: 612672
Human Genome Epidemiology (HuGE) Navigator: RAB10 (1 document)
Export disorders and mutations for RAB10 gene to outside databases
|
Medical News
for RAB10 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RAB10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/21 PubMed articles for RAB10 gene, integrated from 7 sources (see all 21):
(articles sorted by number of sources associating them with RAB10)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag. (PubMed id 7688123)1, 3 Chen Y.T....Moore H.P. (1993)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Rab10 regulates phagosome maturation and its overexpr ession rescues Mycobacterium-containing phagosomes maturation. (PubMed id 20028485)1 Cardoso C.M....Vieira O.V. (2010)
- Alternative splicing in class v myosins determines association with rab10. (PubMed id 19008234)1 Roland J.T....Goldenring J.R. (2009)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for RAB10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAB10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB10 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAB10 gene:
Search GeneIP for patents involving RAB10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB10 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
 | Antibodies & Assays for RAB10 |
| | | | Search Tocris compounds for RAB10 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for RAB10 |
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