Aliases &
Descriptions
for RAB15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| RAB15, member RAS onocogene family1 2 | | ras-related protein Rab-152 | | RAB15, member RAS oncogene family2 |
Export aliases for RAB15 gene to outside databasesPrevious GC identifers: GC14M059207 GC14M063402 GC14M064482 GC14M065412 |
Summaries
for RAB15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RAB15_HUMAN, P59190Function: May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerveterminal (By similarity)
Gene Wiki entry for RAB15 |
Genomic Views
for RAB15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB15 gene promoter:
CHOP-10 C/EBPalpha Chx10 Nkx2-2 SRF LUN-1 Lmo2 TGIF RREB-1 AREB6
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB15
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RAB15  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q23.3 Ensembl cytogenetic band: 14q23.3 HGNC cytogenetic band: 14q23.2RAB15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M045582: view genomic region
(about GC identifiers)
Start:
|
45,582,156 bp from pter |
End:
|
45,608,228 bp from pter |
Size:
|
26,073 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr14- 65,412,532-65,438,875 |
RefSeq DNA sequence:- NC_000014.8 NT_026437.12
|
Proteins
for RAB15 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: RAB15_HUMAN, P59190 (See
protein sequence)Recommended Name: Ras-related protein Rab-15 Size: 212 amino acids; 24391 Da
Subunit: The GTP bound form of RAB15 interacts with REP15
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: Q86TX7 Q8IW89Alternative splicing: 2 isoforms: P59190-1 P59190-2 Explore the universe of human proteins at neXtProt for RAB15: NX_P59190
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_941959.1
ENSEMBL proteins: ENSP00000267512 ENSP00000393414
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- | | GO:0005886 | plasma membrane |
IEA | -- |
About this table
RAB15 for ontologies About GeneDecksing
Antibodies for RAB15:
Assays for RAB15: |
Protein
Domains/
Families
for RAB15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB15 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P59190ProtoNet protein and cluster: P59190 4 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB002041 GTP-binding nuclear protein Ran IPB003577 Ras small GTPase IPB003578 Ras small GTPase
UniProtKB/Swiss-Prot: RAB15_HUMAN, P59190Similarity: Belongs to the small GTPase superfamily. Rab family |
Gene Function
for RAB15 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: RAB15_HUMAN, P59190Function: May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerveterminal (By similarity)
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
RAB15 for ontologies About GeneDecksing
|
Pathways & Interactions
for RAB15 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
RAB15 for pathways About GeneDecksing
2  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for RAB15
SABiosciences Custom Pathway-Focused PCR Arrays for RAB15
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for RAB15
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB15
5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006886 | intracellular protein transport |
-- | -- | | GO:0006913 | nucleocytoplasmic transport |
-- | -- | | GO:0007165 | signal transduction |
-- | -- | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- |
About this table
RAB15 for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for RAB15
|
Transcripts
for RAB15 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for RAB15 gene: NM_198686.2 Additional cDNA sequence: BC014511.1 BC040679.2 BX248046.1 BX640825.1 10 DOTS entries: DT.91655154 DT.100715880 DT.454380 DT.92426949 DT.100790904 DT.100714529 DT.97816418 DT.95242640 DT.95257083 DT.100715879 24/120 AceView cDNA sequences (see all 120): CB158366 BX093757 CB044182 BG057625 BM975016 BX647017 CA424721 CK300190 BX119534 BX248046 BX397019 AI554311 AW027845 BM128186 BM551913 BQ220195 BU849866 BE295607 BG703353 BF966292 NM_198686 BG766350 BF966846 BQ188717
 highest scoring ESTs for RAB15:AA582932 BC040679 AA010873 AA010997 AA380204 AA503244 AA563578 AA568367 AA568687 AA975748 Unigene Cluster for RAB15: RAB15, member RAS onocogene family Hs.512492 [show with all ESTs]Unigene Representative Sequence: NM_198686
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB15
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for RAB15
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000267512(uc010aqk.2 uc001xhz.2) ENST00000426039 ENST00000436278
|
Expression
for RAB15 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| RAB15 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching RAB15 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 59697_at2, 3
|
U133-B |
1 |
0.69 |
1.00 |
0.98 |
1.06 |
AA582932 |
0.80 |
1.00 |
0.91 |
1 |
| 42831_at2, 3
|
U95-B |
1 |
0.50 |
1.00 |
0.99 |
0.94 |
AI201843 |
0.40 |
1.00 |
0.76 |
1 |
| 59697_at2, 3
|
U133-A |
1 |
0.69 |
1.00 |
-- |
-- |
AA582932 |
0.80 |
1.00 |
0.91 |
1 |
| 221810_at2, 3
|
U133-A |
1 |
0.64 |
1.00 |
-- |
-- |
AA631242 |
0.40 |
1.00 |
0.76 |
1 |
| 59697_at2
|
U133Plus2 |
1 |
0.69 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 221810_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
RAB15 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TCTTGAGGCC
SOURCE GeneReport for Unigene cluster: Hs.512492
SABiosciences Custom PCR Arrays for RAB15
|
Orthologs
for RAB15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB15 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
mouse
(Mus musculus) |
Rab155 |
12 (33.73 cM) |
RAB15, member RAS oncogene family |
-- |
BY237353 |
About this table Species with no ortholog for RAB15
ENSEMBL Gene Tree for RAB15 (if available) |
Paralogs
for RAB15 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for RAB15 gene
- RAB102 RAB8A2 RAB40AL2 RAB40B2 RAB8B2 RAB40A2 RAB40C2 RAB132
RAB15 for paralogs About GeneDecksing
|
Genomic Variants
for RAB15 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for RAB15
5 CNVs: 7038 76660 87249 76661 66653 | | QIAGEN SeqTarget long-range PCR primers for resequencing RAB15 |
|
Disorders & Mutations
for RAB15 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB15 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: RAB15 (8 documents)
Export disorders and mutations for RAB15 gene to outside databases
|
Medical News
for RAB15 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RAB15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/19 PubMed articles for RAB15 gene, integrated from 7 sources (see all 19):
(articles sorted by number of sources associating them with RAB15)- Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment. (PubMed id 16195351)1, 2 Strick D.J. and Elferink L.A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911)1, 3 Pereira-Leal J.B. and Seabra M.C. (2001)
- Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
- PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1 Hosgood H.D....Lan Q. (2009)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
|
External Searches for RAB15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAB15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB15 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAB15 gene:
Search GeneIP for patents involving RAB15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB15 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for RAB15 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for RAB15 |
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