Aliases &
Descriptions
for RAB3A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| RAB3A, member RAS oncogene family1 2 | | ras-related protein Rab-3A2 | | RAS-associated protein RAB3A2 |
Export aliases for RAB3A gene to outside databasesPrevious GC identifers: GC19M018801 GC19M018699 GC19M018152 GC19M018168 GC19M018307 |
Summaries
for RAB3A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336Function: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role inneurotransmitter release by regulating membrane flow in the nerve terminal
Gene Wiki entry for RAB3A |
Genomic Views
for RAB3A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB3A gene promoter:
SREBP-1b SREBP-1a SREBP-1c Arnt GCNF-2 GCNF-1 AREB6 RORalpha1 NRSF form 2 NRSF form 1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB3A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RAB3A  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.2RAB3A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M017871: view genomic region
(about GC identifiers)
Start:
|
17,871,059 bp from pter |
End:
|
17,878,307 bp from pter |
Size:
|
7,249 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr19- 18,307,594-18,314,839 |
RefSeq DNA sequence:- NC_000019.9 NT_011295.11
|
Proteins
for RAB3A gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336 (See
protein sequence)Recommended Name: Ras-related protein Rab-3A Size: 220 amino acids; 24984 Da
Subunit: Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interactswith the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 andSGSM3 (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: A8K0J4 Q9NYE1Explore the universe of human proteins at neXtProt for RAB3A: NX_P20336
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002857.1
ENSEMBL proteins: ENSP00000222256
Human Recombinant Proteins
5/11 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 11): About this table
RAB3A for ontologies About GeneDecksing
Antibodies for RAB3A:
Assays for RAB3A: |
Protein
Domains/
Families
for RAB3A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB3A for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P20336ProtoNet protein and cluster: P20336 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336Similarity: Belongs to the small GTPase superfamily. Rab family |
Gene Function
for RAB3A gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336Function: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role inneurotransmitter release by regulating membrane flow in the nerve terminal
Genatlas biochemistry entry for RAB3A:RAB3A,Ras oncogene superfamily member,expressed synaptic vesicles, involved in calcium regulated exocytosis,expressedin parathyroid chief cells4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
RAB3A for ontologies About GeneDecksing
Animal Models: 7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Rab3a):
RAB3A for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAB3A gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for RAB3A
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB3A
5/21 Interacting proteins for RAB3A (ENSP000002222563) via UniProtKB, MINT, and/or STRING (see all 21)About this table
5/21 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 21): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003016 | respiratory system process |
IEA | -- | | GO:0006886 | intracellular protein transport |
-- | -- | | GO:0006913 | nucleocytoplasmic transport |
-- | -- | | GO:0007005 | mitochondrion organization |
IEA | -- | | GO:0007165 | signal transduction |
-- | -- |
About this table
RAB3A for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB3A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
RAB3A for compounds About GeneDecksing
 Browse Tocris compounds for RAB3A
5  Novoseek chemical compound relationships for RAB3A gene
About this table
|
Transcripts
for RAB3A gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for RAB3A gene: NM_002866.4 Additional cDNA sequence: AF254795.1 AF498931.1 AK289559.1 AK293467.1 BC011782.2 M28210.1 5 DOTS entries: DT.444206 DT.100653326 DT.100668937 DT.40110695 DT.95301547 24/124 AceView cDNA sequences (see all 124): BQ898770 BI917111 BX419052 BU739142 BC011782 CA309409 CD615936 AW163583 AA364643 AW205498 BM673547 AW205866 AW160374 AL534649 BM926739 NM_002866 BP360364 BX442130 BG819310 T28069 BX444435 CF147395 BM544182 BM703383
 highest scoring ESTs for RAB3A:M28210 AF254795 AI879002 AW961221 BC011782 BE265314 BE791798 BE792476 BG395376 BG819310 Unigene Cluster for RAB3A: RAB3A, member RAS oncogene family Hs.27744 [show with all ESTs]Unigene Representative Sequence: NM_002866
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB3A
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for RAB3A
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000464076 ENST00000481914 ENST00000222256(uc002nie.2)
|
Expression
for RAB3A gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| RAB3A expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching RAB3A gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 620_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.90 |
0.68 |
M28210 |
1.00 |
1.00 |
1.00 |
1 |
| 57558_at2, 3
|
U95-B |
1 |
0.56 |
1.00 |
0.98 |
1.34 |
AA988241 |
0.80 |
0.80 |
0.80 |
1 |
| 204974_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
AA988241 |
0.80 |
0.80 |
0.80 |
1 |
| 204974_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
RAB3A for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACAACACTAC
SOURCE GeneReport for Unigene cluster: Hs.27744
Expression variation in blood from EXPOLDB for RAB3A UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336Tissue specificity: Specifically expressed in brain
SABiosciences Custom PCR Arrays for RAB3A
|
Orthologs
for RAB3A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB3A gene from 5/10 species (see all 10)
About this table Species with no ortholog for RAB3A
ENSEMBL Gene Tree for RAB3A (if available) |
Paralogs
for RAB3A gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for RAB3A gene
- RAB3B2 RAB442 RAB3D2 RAB3C2
RAB3A for paralogs About GeneDecksing
|
Genomic Variants
for RAB3A gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RAB3A
2 CNVs: 5093 58863 | | QIAGEN SeqTarget long-range PCR primers for resequencing RAB3A |
|
Disorders & Mutations
for RAB3A gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB3A for disorders About GeneDecksing
OMIM: 179490
2 Novoseek disease relationships for RAB3A gene
About this table
Human Genome Epidemiology (HuGE) Navigator: RAB3A (1 document)
Tumor Gene Database (TGDB): RAB3A
Export disorders and mutations for RAB3A gene to outside databases
|
Medical News
for RAB3A gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RAB3A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/96 PubMed articles for RAB3A gene, integrated from 7 sources (see all 96):
(articles sorted by number of sources associating them with RAB3A)- Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. (PubMed id 7991565)1, 2, 7 Farnsworth C.C.... Glomset J.A. (1994)
- Isoprenoid modification of rab proteins terminating in CC or CXC motifs. (PubMed id 1648736)1, 2, 7 Khosravi-Far R.... Der C.J. (1991)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND. (PubMed id 10574328)1, 2 Sullivan M.... Houslay M.D. (1999)
- Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A. (PubMed id 7532276)1, 3 Brondyk W.H....Macara I.G. (1995)
- The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PubMed id 2501306)1, 2 Zahraoui A.... Tavitian A. (1989)
- Chromosome mapping of the human ras-related rab3A gene to 19p13.2. (PubMed id 2687157)1, 3 Rousseau-Merck M.F....Berger R. (1989)
- Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A. (PubMed id 10025402)1, 7 Ostermeier C. and Brunger A.T. (1999)
- Membrane-permeant Rab3A triggers acrosomal exocytosis in living human sperm. (PubMed id 17625073)1, 7 Lopez C.I....Mayorga L.S. (2007)
|
External Searches for RAB3A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing RAB3A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB3A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB3A gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAB3A gene:
Search GeneIP for patents involving RAB3A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB3A gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 | Antibodies & Assays for RAB3A |
| | | | Search Tocris compounds for RAB3A |
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 | | | ELISAs and CLIAs for RAB3A |
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