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RAD51 Gene

protein-coding   GIFtS: 70

GC15P017834
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
(Previous name: RAD51 (S. cerevisiae) homolog (E coli RecA homolog) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: RAD51A, RECA)
Products    

Aliases &
Descriptions
for RAD51 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)1 2     DNA repair protein RAD51 homolog 12
RECA2 3 5     RecA, E. coli, homolog of2
RAD51A2 3 5     BRCA1/BRCA2-containing complex, subunit 52
HsT169301 2     HRAD512
BRCC51 2     RecA-like protein2
HsRad511 2     recombination protein A2
RAD51 homolog A2 3     hRAD513
RAD51 (S. cerevisiae) homolog (E coli RecA homolog)1     HsRAD513

External Ids:    HGNC: 98171   Entrez Gene: 58882   Ensembl: ENSG000000511807   UniProtKB: Q066093   

Export aliases for RAD51 gene to outside databases

Previous GC identifers: GC15P036354 GC15P033883 GC15P038566 GC15P038703 GC15P038774 GC15P040987


Summaries
for RAD51 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAD51:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to
bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and
repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles
in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which
may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular
localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key
event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609
Function: May participate in a common DNA damage response pathway associated with the activation of homologous
recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent
ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments

Gene Wiki entry for RAD51

Genomic Views
for RAD51 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAD51 gene promoter:
         C/EBPbeta   NF-kappaB1   p53   POU2F1   NF-kappaB   Arnt   AhR   Nkx3-1   Nkx3-1 v1   Nkx3-1 v2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for RAD51

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q15.1

RAD51 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD51 gene location

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P017834:  view genomic region     (about GC identifiers)

Start:
 17,834,870 bp from pter
End:
 17,872,189 bp from pter
Size:
 37,320 bases
Orientation:
 plus strand

1 alternative location:
Chr15+ 40,987,358-41,024,356     
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  

Proteins
for RAD51 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609 (See protein sequence)
Recommended Name: DNA repair protein RAD51 homolog 1  
Size: 339 amino acids; 36966 Da
Subunit: Interacts with BRCA1, BRCA2 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and
RAD54B. Part of a complex with RAD51C and RAD51B. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1/CHK1, and
this may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer (By similarity).
Interacts with OBFC2B. Interacts with RPA1. Interacts with PALB2
Subcellular location: Nucleus. Note=Colocalizes with RAD51AP1 to multiple nuclear foci upon induction of DNA damage
PDB structure from and Proteopedia :
1B22 (3D)    1N0W (3D)    
Secondary accessions: B2R8T6 Q6FHX9 Q9BV60
Alternative splicing: 2 isoforms:  Q06609-1   Q06609-2   

Explore the universe of human proteins at neXtProt for RAD51: NX_Q06609 

Post-translational modifications:

  • Phosphorylated. Phosphorylation of Thr-309 by CHEK1/CHK1 may enhance association with chromatin at sites of DNA damage
    • and promote DNA repair by homologous recombination1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (4 alternative transcripts): 
    NP_001157741.1  NP_001157742.1  NP_002866.2  NP_597994.3  


    ENSEMBL proteins: 
    ENSP00000410197 ENSP00000372087 ENSP00000406602 ENSP00000267868 ENSP00000372088 ENSP00000413974 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: RAD51
    GenScript Custom Purified and Recombinant Proteins Services for RAD51 
    Novus Biologicals Protein for RAD51
    Novus Biologicals Lysates for RAD51
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000793 condensed chromosome ISS--
    GO:0000794 condensed nuclear chromosome ISS--
    GO:0000800 lateral element ----
    GO:0005634 nucleus ISS--
    GO:0005654 nucleoplasm EXP12606939
    About this table

    RAD51 for ontologies           About GeneDecksing



    Antibodies for RAD51: 
    Millipore Mono- and Polyclonal Antibodies for the study of RAD51
    Sigma-Aldrich Antibodies for RAD51
    Browse R&D Systems for Antibodies
    OriGene Antibodies: RAD51
    GenScript Superior Antibodies for RAD51 
    Novus Biologicals Antibodies for RAD51
    Epitomics antibodies for RAD51

    Assays for RAD51: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAD51 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RAD51 

    Protein Domains/
    Families
    for RAD51 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAD51 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
     IPR020587 RecA_monomer-monomer_interface
     IPR020588 DNA_recomb_RecA/RadB_ATP-bd
     IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
     IPR016467 DNA_recomb/repair_RecA-like

    Graphical View of Domain Structure for InterPro Entry Q06609

    ProtoNet protein and cluster: Q06609

    2 Blocks protein families:
    IPB003583 Helix-hairpin-helix DNA-binding
    IPB013632 Rad51


    UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609
    Similarity: Belongs to the recA family. RAD51 subfamily
    Similarity: Contains 1 HhH domain


    Gene Function
    for RAD51 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609
    Function: May participate in a common DNA damage response pathway associated with the activation of homologous
    recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent
    ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments

    Inhib.
    RNA:            		Millipore RNAi Products for the Analysis of RAD51 Gene knock-down
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for RAD51
    Sigma-Aldrich shRNA Panels and shRNA for RAD51
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): RAD51
    OriGene shRNA RFP (see all 4): RAD51
    OriGene basic RS shRNA (see all 4): RAD51
    OriGene siRNA (see all 4): RAD51
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RAD51 
    miRNA:Sigma-Aldrich microRNA Mimics for RAD51
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RAD51 
    1 SABiosciences Assays for microRNA that regulate RAD51:
    hsa-miR-758

    Gene
    Editing:    		Sigma-Aldrich CompoZr Knockout ZFN for RAD51 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): RAD51
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): RAD51
    OriGene untagged cDNA clones in CMV expression vector (see all 2): RAD51
    OriGene 3'-UTR clone (see all 4): RAD51 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for RAD51 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for RAD51 

    Genatlas biochemistry entry for RAD51:
    yeast (S cerevisiae) RAD51 homolog A,colocalizing with RPA heterotrimeric ssDNA binding protein,complexing with
    phosphorylated BRCA1,BRCA2 and RAD52 for DNA repair of double strand breaks through homologous recombination,also
    involved in immunoglobulin switch recombination,not mutated ,deleted in breast cancer with poor prognosis,uncommonly
    associated with parathyroid tumorigenesis

    5/12 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 12):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003677 DNA binding ----
    GO:0003684 damaged DNA binding IEA--
    GO:0003690 double-stranded DNA binding IDA7988572
    GO:0003697 single-stranded DNA binding IDA7988572
    About this table

    RAD51 for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rad51):

    cellularembryogenesisgrowth/sizelethality-prenatal/perinatal

    RAD51 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RAD51 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    RAD51 for pathways           About GeneDecksing

    2 Millipore Pathways for RAD51
        Meiosis
    DNA damage Role of Brca1 and Brca2 in DNA repair

    5/6 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  RAD51 (see all 6)
        Purine Metabolism
    Hereditary Breast Cancer Signaling
    ATM Signaling
    Pancreatic Adenocarcinoma Signaling
    Role of BRCA1 in DNA Damage Response

    1 Cell Signaling Technology (CST) Pathway for RAD51
        Cell Cycle Control: G2/M DNA Damage Checkpoint

    3 Kegg Pathways  (Kegg details for RAD51):
        hsa03440 Homologous recombination
    hsa05200 Pathways in cancer
    hsa05212 Pancreatic cancer

        SABiosciences Pathway-Focused PCR Arrays including RAD51 (see all 4): PAHS-020A PAHS-029A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for RAD51
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD51

    5/30 Interacting proteins for RAD51 (ENSP000003720883 Q066091, 2) via UniProtKB, MINT, and/or STRING (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA2P515871, 2STRING: ENSP00000369497 EBI-297202,EBI-79792 MINT-4980488 MINT-4980408 MINT-4980796 MINT-4980567 MINT-4980473 MINT-4980518 MINT-4980502
    TP53P046371STRING: ENSP00000269305 EBI-297202,EBI-366083
    RAD51CO435022STRING: ENSP00000336701 MINT-2736051 MINT-2736074 MINT-2736012
    ABL1P005192STRING: ENSP00000361423 MINT-7034009
    DMC1Q145652STRING: ENSP00000216024 MINT-4980408
    About this table

    5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724 double-strand break repair via homologous recombination TAS12427746
    GO:0000730 DNA recombinase assembly TAS--
    GO:0006259 DNA metabolic process ----
    GO:0006268 DNA unwinding involved in replication IDA7988572
    GO:0006281 DNA repair TAS--
    About this table

    RAD51 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAD51 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    RAD51 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAD51
    10/62 Novoseek chemical compound relationships for RAD51 gene (see all 62)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atpgammas 83 49 9201926 (3), 9718317 (3), 1507222 (2), 8325858 (2) (see all 31)
    adenosine 5'-o-(3-thiotriphosphate) 79.9 18 2195545 (1), 7882996 (1), 8045304 (1), 2188972 (1) (see all 15)
    5-formyl-2'-deoxyuridine 74.4 6 12836321 (2), 11562961 (1), 12903258 (1), 14611842 (1)
    atp 67.7 210 11342134 (6), 9012806 (4), 9201926 (4), 15719060 (4) (see all 87)
    mitomycin c 62.4 15 11684015 (1), 16825569 (1), 20042515 (1), 10373565 (1) (see all 12)
    adp 47.8 43 12758082 (4), 11839740 (3), 15123651 (3), 16624636 (2) (see all 21)
    inosine triphosphate 46.3 8 1606138 (3), 1606139 (2)
    methylmethanesulfonate 46.1 6 9560268 (3), 18375193 (1), 7892263 (1)
    amp-pnp 42.6 3 19622740 (2), 9718317 (1)
    rpa 2 41.8 1 15326288 (1)
    About this table



    Transcripts
    for RAD51 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Millipore RNAi Products for the Analysis of RAD51 Gene knock-down
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for RAD51
    Sigma-Aldrich shRNA Panels and shRNA for RAD51
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): RAD51
    OriGene shRNA RFP (see all 4): RAD51
    OriGene basic RS shRNA (see all 4): RAD51
    OriGene siRNA (see all 4): RAD51
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RAD51 
    miRNA: Sigma-Aldrich microRNA Mimics for RAD51
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RAD51 
    1 SABiosciences Assays for microRNA that regulate RAD51:
    hsa-miR-758
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): RAD51
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): RAD51
    OriGene untagged cDNA clones in CMV expression vector (see all 2): RAD51
    OriGene 3'-UTR Clone (see all 4): RAD51 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for RAD51 
    Primers: OriGene genome-wide validated SYBR primer pairs: RAD51
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for RAD51: PPH00942A

    REFSEQ mRNAs for RAD51 gene (4 alternative transcripts): 

    NM_001164269.1  NM_001164270.1  NM_002875.4  NM_133487.3  

    Additional cDNA sequence: 

    AK131299.1 AK291969.1 AK303089.1 AK313503.1 AY425955.1 AY608888.1 BC001459.2 BT019705.1 
    CR536559.1 CR594665.1 CR606487.1 CR619182.1 CR622784.1 CR626167.1 D13804.1 D14134.1 
    EU362635.1 

    10 DOTS entries:

    DT.209091  DT.95254199  DT.121050424  DT.95254169  DT.92452043  DT.95085123  DT.91749880  DT.100777886 
    DT.121050426  DT.95254167 

    24/118 AceView cDNA sequences (see all 118):

    BX494877 BM810067 AU100170 BM791694 BM808716 CR606487 CR536559 AY608888 
    AW363521 BM910438 BG474115 AI347079 CR594665 BU164989 BU624430 BC001459 
    CR619182 BQ424388 AU107551 BE280848 CR626167 CR622784 BE262785 BX364160 

    highest scoring ESTs for RAD51:

    D14134 AA568782 AA873056 AI347079 AK131299 AL526587 AL526641 AL563755 AW006523 AW103435 

    Unigene Cluster for RAD51:

    RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
    Hs.631709  [show with all ESTs]
    Unigene Representative Sequence: NM_133487


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAD51

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:                    -     -                             -                                                   
    SP2:                          -                 -     -                                                         
    SP3:                          -                 -     -     -                                                   
    SP4:                          -                                                                                 
    SP5:                                                                                                            

    About this scheme

    ECgene alternative splicing isoforms for RAD51
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450111 ENST00000382642 ENST00000423169 ENST00000267868(uc001zmi.3 uc010bbw.2 uc001zmk.3 uc001zmm.1)
    ENST00000382643(uc010bbx.2 uc001zml.3 uc001zmn.1) ENST00000435604


    Expression
    for RAD51 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    RAD51 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching RAD51 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1872_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 D14134 1.00 1.00 1.00 1
    205024_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002875 0.60 1.00 0.82 1
    205023_at2, 3 U133-A 1 0.91 1.00 -- -- D14134 1.00 1.00 1.00 1
    205024_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    205023_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    RAD51 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    RAD51 gene expression
    RAD51 gene electronic northern expression
    RAD51 gene sage expression
    About these images

    CGAP SAGE TAG: GTGCCTTAGG

    SOURCE GeneReport for Unigene cluster: Hs.631709

    Expression variation in blood from EXPOLDB for RAD51

    UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609
    Tissue specificity: Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and
    ovary. Weakly expressed in breast

    Primers: OriGene genome-wide validated SYBR primer pairs: RAD51
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for RAD51: PPH00942A
        SABiosciences Expression via Pathway-Focused PCR Arrays including RAD51 (see all 4): PAHS-020A PAHS-029A  


    Orthologs
    for RAD51 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for RAD51 gene from 5/23 species (see all 23)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 RAD511   -- RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 94.2(n)
    99.12(a)    		 403568  NM_001003043.1  NP_001003043.1 
    chimpanzee
    (Pan troglodytes)    		 RAD511   -- RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 99.8(n)
    100(a)    		 453339  XM_510313.2  XP_510313.1 
    cow
    (Bos taurus)    		 RAD511   -- RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 93.22(n)
    99.41(a)    		 514749  NM_001046179.1  NP_001039644.1 
    rat
    (Rattus norvegicus)    		 Rad511   -- RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 91.45(n)
    99.41(a)    		 499870  XM_575211.2  XP_575211.1 
    mouse
    (Mus musculus)    		 Rad511 , 5 2 (59.92 cM)5
    		 RAD51 homolog (S. cerevisiae)1, 5 91.05(n)1
    98.82(a)1    		 193611  NM_011234.31  NP_035364.11 
     AI4512345  AK0112425  (see all 19)
    About this table        Species with no ortholog for RAD51

    ENSEMBL Gene Tree for RAD51 (if available)

    Paralogs
    for RAD51 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for RAD51 gene
    RAD51L32  RAD51L12  RAD51C2  

    RAD51 for paralogs           About GeneDecksing



    Genomic Variants
    for RAD51 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/436 NCBI SNPs in RAD51 are shown (see all 436)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs9576031,2
    		C,F,A,H,41009668(-) AATGAC/TGCTAA 4 -- int1112Minor allele frequency- T:0.17NS EA PA EU CA WA NA 7114
    rs10567421,2
    		H41023293(+) TCTGCA/CAAATC 12 K Q P ref1 mis15Minor allele frequency- C:0.00MN NS EA 588
    rs18013201,2
    		C,F,40987528(+) AGCCAG/CGGGCG 6 -- ut51 int117Minor allele frequency- C:0.14MN NS EA NA WA 1586
    rs18013211,2
    		C,F,40987565(+) GCCACC/G/TCCCGC 6 -- ut51 int1 ese39MN NS NA 712
    rs18042691,2
    		--41021736(+) ACCGCC/TCTTTA 12 A ref1 syn10--------
    rs22298761,2
    		F41021833(+) ATGAGT/ATTGGT 11 /I /F mis1 ref1 int11Minor allele frequency- A:0.25MN 44
    rs23045791,2
    		C,F,O,40991153(+) ACCCAA/GATTAG 4 -- int120Minor allele frequency- G:0.09EA NA NS WA 3292
    rs24125461,2
    		C,F,A,41006523(+) CATCCA/GTCATT 4 -- int119Minor allele frequency- G:0.44NS EA NA WA 1206
    rs24125471,2
    		C,F,A,41012695(+) tcagaA/Caagca 4 -- int117Minor allele frequency- C:0.40NS EA NA WA 974
    rs24125481,2
    		C,F,41012792(+) atccaC/Tccaca 4 -- int110Minor allele frequency- T:0.38NA NS EA WA 468
    About this table

    HapMap Linkage Disequilibrium images for RAD51 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RAD51
         2 CNVs: 102087 3959

    QIAGEN SeqTarget long-range PCR primers for resequencing RAD51 

    Disorders & Mutations
    for RAD51 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAD51 for disorders           About GeneDecksing

    OMIM: 179617   disorders: 114480  

    UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609

  • Defects in RAD51 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy
    • originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive
    ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous.
    Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than
    one locus can be involved in different families or even in the same case

    10/26 Novoseek disease relationships for RAD51 gene (see all 26)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fanconis anemia 66.7 7 12239151 (1), 12483114 (1)
    bloom syndrome 64.4 4 12975363 (1), 10767546 (1), 19632996 (1), 15143192 (1)
    ataxia telangiectasia 50.6 2 15135073 (1), 9315668 (1)
    breast cancer 50.3 94 16762046 (7), 18974064 (6), 12673366 (5), 17707537 (3) (see all 42)
    germ-line mutation 47.4 2 20002770 (1), 10463575 (1)
    ovarian cancer 38.9 10 11535547 (3), 16005565 (2), 10197592 (1), 16165098 (1) (see all 5)
    cancer 37.9 40 19106292 (4), 20002770 (2), 15150571 (2), 18618591 (2) (see all 27)
    tumors 27.2 63 16596227 (5), 11782381 (5), 16234517 (4), 18243065 (3) (see all 32)
    bilateral breast cancer 26.3 2 17666788 (1), 10807537 (1)
    chromosomal aberrations 24.7 2 11283264 (1), 16511829 (1)
    About this table

    Human Gene Mutation Database (HGMD): RAD51
    Genetic Association Database (GAD): RAD51
    Human Genome Epidemiology (HuGE) Navigator: RAD51 (99 documents)

    Export disorders and mutations for RAD51 gene to outside databases

    Medical News
    for RAD51 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for RAD51 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/709 PubMed articles for RAD51 gene, integrated from 7 sources (see all 709):
    (articles sorted by number of sources associating them with RAD51)
    1. A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers. (PubMed id 11535547)1, 2, 4, 7 Wang W.W.... Struewing J.P. (2001)
    2. Cloning and sequence of the human RecA-like gene cDNA. (PubMed id 8479919)1, 2, 3 Yoshimura Y.... Matsushiro A. (1993)
    3. Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. (PubMed id 8358431)1, 2, 3 Shinohara A.... Ogawa T. (1993)
    4. A novel human rad54 homologue, Rad54B, associates with Rad51. (PubMed id 10851248)1, 2, 7 Tanaka K....Miyagawa K. (2000)
    5. Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA. (PubMed id 7988572)1, 2, 7 Benson F.E.... West S.C. (1994)
    6. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. (PubMed id 9192668)1, 2, 7 Mizuta R.... Alt F.W. (1997)
    7. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. (PubMed id 15665856)1, 2, 7 Soerensen C.S.... Helleday T. (2005)
    8. Polymorphisms of the BRCA2 and RAD51 genes in breast cancer. (PubMed id 16261408)1, 4, 7 Sliwinski T....Blasiak J. (2005)
    9. Polymorphisms of DNA repair genes and risk of glioma. (PubMed id 15313891)1, 4, 7 Wang L.E....Wei Q. (2004)
    10. Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia. (PubMed id 15102670)1, 4, 7 Seedhouse C....Russell N. (2004)

    External Searches for RAD51 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing RAD51 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5888 HGNC: 9817 AceView: RAD51 Ensembl:ENSG00000051180 euGenes: HUgn5888
    ECgene: RAD51 Kegg: 5888 H-InvDB: RAD51

    Other Databases showing RAD51 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAD51 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for RAD51 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad51/

    Intellectual Property
    for RAD51 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for RAD51 gene:
    Search GeneIP for patents involving RAD51

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RAD51 gene

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    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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     ELISAs and CLIAs for RAD51
           

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