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RBM11 Gene

protein-coding   GIFtS: 45

GC21P000958
RNA binding motif protein 11
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase, and/or 9Nature:405,311-319 and CroW21)
About This Section

Aliases & Descriptions
RNA binding motif protein 111 2
RNA-binding motif protein 112 3
putative RNA-binding protein 112
putative gene, RNA binding motif protein 11 like9

External Ids:    HGNC: 98971   Entrez Gene: 540332   Ensembl: ENSG000001852727   UniProtKB: P570523   

Export aliases for RBM11 gene to outside databases

Previous GC identifers: GC21P012252 GC21P014510 GC21P015588


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for RBM11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBM11 gene promoter:
         CUTL1   POU3F2 (N-Oct-5a)   POU3F2   POU3F2 (N-Oct-5b)   Pax-6   FOXD1   C/EBPalpha   Cart-1   FOXC1   oct-B2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for RBM11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RBM11 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q11   Ensembl cytogenetic band:  21q11.2   HGNC cytogenetic band: 21q11
Nature(405: 311-319) cytogenetic band:   21q11
RBM11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM11 gene location
GeneLoc gene densities for chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P000958:   GeneLoc Nature:405,311-319
Start:
958,833 bp from pter       1,252,617 bp from centromere
End:
971,058 bp from pter 1,263,937 bp from centromere
Size:
12,226 bases 11,321 bases
Orientation:
plus strand plus strand

1 alternative location:
Chr21+ 15,588,451-15,600,693     
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  

genomic clones: P98L15 P90B5


(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RBM11_HUMAN, P57052 (See protein sequence)
Recommended Name: Putative RNA-binding protein 11  
Size: 281 amino acids; 32179 Da
Sequence caution: Sequence=AAH30196.2; Type=Erroneous initiation; Sequence=AAL82535.1; Type=Frameshift; Positions=33;
Sequence=BAC03638.1; Type=Frameshift; Positions=33;
PDB structures from and Proteopedia :
2YWK (3D)    
Secondary accessions: Q6YNC2 Q8NBA1 Q8NFF6
Alternative splicing: 2 isoforms:  P57052-1   P57052-2   

Explore the universe of human proteins at neXtProt for RBM11: NX_P57052 

REFSEQ proteins: NP_658983.3  

ENSEMBL proteins: 
ENSP00000333170 ENSP00000383421 


Human Recombinant Proteins 
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Antibodies for RBM11: 
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Browse antibodies at Epitomics

Assays for RBM11: 
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Browse ELISAs at Sigma-Aldrich
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Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for RBM11 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for RBM11 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RBM11 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR000504 RRM_dom
 IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry P57052

ProtoNet protein and cluster: P57052

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: RBM11_HUMAN, P57052
Similarity: Contains 1 RRM (RNA recognition motif) domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for RBM11
Sigma-Aldrich shRNA for RBM11
OriGene 29mer shRNA kits in GFP-retroviral vector: RBM11
OriGene shRNA RFP: RBM11
OriGene basic RS shRNA: RBM11
OriGene siRNA: RBM11
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RBM11 
miRNA:Sigma-Aldrich microRNA Mimics for RBM11
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RBM11 
2 SABiosciences Assays for microRNAs that regulate RBM11:
hsa-miR-9 hsa-miR-590-3p

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: RBM11
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: RBM11
OriGene untagged cDNA clones in CMV expression vector (see all 2): RBM11
OriGene 3'-UTR clone: RBM11 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for RBM11 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for RBM11 

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0003676 nucleic acid binding ----
GO:0003723 RNA binding IEA--
About this table

RBM11 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for RBM11 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM11

2 Interacting proteins for RBM11 (P570522) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
PCBP1Q153652MINT-2873675
RHOXF2Q9BQY42MINT-66154
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RBM11


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for RBM11
Sigma-Aldrich shRNA for RBM11
OriGene 29mer shRNA kits in GFP-retroviral vector: RBM11
OriGene shRNA RFP: RBM11
OriGene basic RS shRNA: RBM11
OriGene siRNA: RBM11
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RBM11 
miRNA: Sigma-Aldrich microRNA Mimics for RBM11
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RBM11 
2 SABiosciences Assays for microRNAs that regulate RBM11:
hsa-miR-9 hsa-miR-590-3p
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: RBM11
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: RBM11
OriGene untagged cDNA clones in CMV expression vector (see all 2): RBM11
OriGene 3'-UTR Clone: RBM11 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for RBM11 
Primers: OriGene genome-wide validated SYBR primer pairs: RBM11
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for RBM11: PPH15951A

REFSEQ mRNAs for RBM11 gene: 

NM_144770.3  

Additional cDNA sequence: 

AF519623.1 AK091331.1 AY077695.1 BC030196.1 

5 DOTS entries:

DT.95262633  DT.100745049  DT.91704104  DT.436113  DT.95237154 

24 AceView cDNA sequences:

BC030196 AL596989 NM_144770 BX281687 BX104385 BQ186146 BX950891 AY077695 
BX950892 BI913079 CB153254 AX746917 BI603848 AF519623 AK091331 BG706195 
AL041993 BI753557 AA639269 N63517 D61628 N94835 BG541166 AA737090 

highest scoring ESTs for RBM11:

AA639269 AA737090 AF519623 AK091331 AL041993 AY077695 BC030196 BG541166 BG706195 BI603848 

Unigene Cluster for RBM11:

RNA binding motif protein 11
Hs.283828  [show with all ESTs]
Unigene Representative Sequence: BC030196


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for RBM11

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1:                                -                                       
SP2:                                -           -                           
SP3:              -                 -           -                           
SP4:              -     -           -           -                           
SP5:              -                                                         

About this scheme

ECgene alternative splicing isoforms for RBM11
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000330599 ENST00000461088 ENST00000495055 ENST00000475864 ENST00000468788
ENST00000400577 ENST00000468643(uc002yjo.3 uc002yjn.3 uc002yjp.3)


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

RBM11 expression in normal and diseased human tissues

1  / 2  / 3

2 probe-sets matching RBM11 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
232549_at2, 3 U133-B 1 1.00 1.00 -- -- N94835 0.80 1.00 0.91 1
232549_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
RBM11 gene expression
RBM11 gene electronic northern expression
RBM11 gene sage expression
About these images

CGAP SAGE TAG: TTGCCTAGCA

SOURCE GeneReport for Unigene cluster: Hs.283828

UniProtKB/Swiss-Prot: RBM11_HUMAN, P57052
Tissue specificity: Expressed in brain, hippocampus, prefrontal cortex, cerebellum, spinal cord, testis, mammary gland,
spleen and kidney. Also expressed in fetal brain

Primers: OriGene genome-wide validated SYBR primer pairs: RBM11
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for RBM11: PPH15951A
    SABiosciences Custom PCR Arrays for RBM11 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RBM11 gene from 5/8 species (see all 8)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
RBM111   -- RNA binding motif protein 11 85.22(n)
79.03(a)
478383  XM_535558.2  XP_535558.1 
chimpanzee
(Pan troglodytes)
RBM111   -- RNA binding motif protein 11 99.2(n)
98.8(a)
473914  XM_531391.2  XP_531391.2 
cow
(Bos taurus)
RBM111   -- RNA binding motif protein 11 85.4(n)
80.99(a)
539474  NM_001040567.1  NP_001035657.1 
rat
(Rattus norvegicus)
Rbm111   -- RNA binding motif protein 11 75.81(n)
67.74(a)
288321  XM_221731.4  XP_221731.4 
mouse
(Mus musculus)
Rbm111 , 5 16 (43.22 cM)5
RNA binding motif protein 111, 5 76.08(n)1
65.32(a)1
2243441  NM_198302.21  NP_938044.11 
 AK0392975  BB3331005  (see all 8)
About this table        Species with no ortholog for RBM11

ENSEMBL Gene Tree for RBM11 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for RBM11 gene
RBM72  

RBM11 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/198 NCBI SNPs in RBM11 are shown (see all 198)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 21 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs1088851,2
C,F,A,H,15589940(-) AACCTA/GAAAGT 1 -- int18Minor allele frequency- G:0.22EA NS NA WA 388
rs3672491,2
C,F,A,H,15597894(-) ATATAC/TGTTGG 1 -- int110Minor allele frequency- T:0.27NS EA NA WA 634
rs3676201,2
C,F,A,H,15597802(-) ACTGTA/TGATTA 1 -- int19Minor allele frequency- T:0.15EA NS NA WA 394
rs3677181,2
C,F,A,H,15597717(-) AATTAA/TGATTT 1 -- int19Minor allele frequency- T:0.14EA NS NA WA 382
rs3725551,2
C,F,A,H,15595111(-) GAGATG/AGGGAA 1 -- int113Minor allele frequency- A:0.20NS EA NA WA 494
rs3726491,2
C,H,15595031(-) TGTTAA/GCTGAC 1 -- int17Minor allele frequency- G:0.20NA EA WA 218
rs3753701,2
C,F,A,H,15595581(-) TTTGGG/AGACAT 1 -- int16Minor allele frequency- A:0.19NA EA WA 216
rs3772971,2
C,F,A,15597345(-) tcatgC/Tctcag 1 -- int14Minor allele frequency- T:0.15NA EA WA 164
rs3782801,2
C,F,A,15593495(+) GGTAAT/GTTTAA 1 -- int16Minor allele frequency- G:0.20NA EA WA 216
rs3797241,2
C,F,15596683(-) AAAACC/TACTAT 1 -- int113Minor allele frequency- T:0.10NS EA NA WA 968
About this table

HapMap Linkage Disequilibrium images for RBM11 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for RBM11: --

QIAGEN SeqTarget long-range PCR primers for resequencing RBM11 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10 PubMed articles for RBM11 gene integrated from 7 sources:
(articles sorted by number of sources associating them with RBM11)
  1. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PubMed id 12036298)1, 2, 3 Gardiner K....Davisson M. (2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms. (PubMed id 12909339)1, 2 Brun M.-E.... De Sario A. (2003)
  5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
  6. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
  7. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
  8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 54033 HGNC: 9897 AceView: RBM11 Ensembl:ENSG00000185272 euGenes: HUgn54033
ECgene: RBM11 H-InvDB: RBM11

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for RBM11 gene:
Search GeneIP for patents involving RBM11

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RBM11
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RBM11
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 ELISAs and CLIAs for RBM11
       

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