Aliases &
Descriptions
for RDH14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| retinol dehydrogenase 14 (all-trans/9-cis/11-cis)1 2 | | short chain dehydrogenase/reductase family 7C, member 42 | | PAN21 2 3 | | pancreas protein 22 | | retinol dehydrogenase 14 (all-trans and 9-cis)1 2 | | retinol dehydrogenase 142 | | SDR7C41 2 | | EC 1.1.1.-3 | | Alcohol dehydrogenase PAN22 3 | | |
Export aliases for RDH14 gene to outside databasesPrevious GC identifers: GC02M018670 GC02M018703 GC02M018720 GC02M018658 GC02M018659 GC02M018600 |
Summaries
for RDH14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RDH14_HUMAN, Q9HBH5Function: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinalreductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected
Gene Wiki entry for RDH14 |
Genomic Views
for RDH14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RDH14 gene promoter:
RP58 POU2F1 Nkx6-1 MRF-2 AP-2gamma AP-2alphaA SRF HNF-1A CUTL1 MEF-2A
Other transcription factors
Search SABiosciences Chromatin IP Primers for RDH14
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RDH14  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p24.2 Ensembl cytogenetic band: 2p24.2 HGNC cytogenetic band: 2p24.2RDH14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M018601: view genomic region
(about GC identifiers)
Start:
|
18,511,154 bp from pter |
End:
|
18,517,127 bp from pter |
Size:
|
5,974 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr2- 18,735,989-18,741,946 |
RefSeq DNA sequence:- NC_000002.11 NT_015926.15
|
Proteins
for RDH14 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: RDH14_HUMAN, Q9HBH5 (See
protein sequence)Recommended Name: Retinol dehydrogenase 14 Size: 336 amino acids; 36865 DaExplore the universe of human proteins at neXtProt for RDH14: NX_Q9HBH5
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_065956.1
ENSEMBL proteins: ENSP00000370648
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
RDH14 for ontologies About GeneDecksing
Antibodies for RDH14:
Assays for RDH14: |
Protein
Domains/
Families
for RDH14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RDH14 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HBH5ProtoNet protein and cluster: Q9HBH5 2 Blocks protein families: IPB002198 Short-chain dehydrogenase/reductase SDR IPB002347 Glucose/ribitol dehydrogenase family signature
UniProtKB/Swiss-Prot: RDH14_HUMAN, Q9HBH5Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family |
Gene Function
for RDH14 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: RDH14_HUMAN, Q9HBH5Function: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinalreductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detectedEnzyme Number (IUBMB): EC 1.1.1.-
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005488 | binding |
IEA | -- | | GO:0016491 | oxidoreductase activity |
IEA | -- |
About this table
RDH14 for ontologies About GeneDecksing
|
Pathways & Interactions
for RDH14 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
RDH14 for pathways About GeneDecksing
1  Millipore Pathway for RDH14
2  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for RDH14
SABiosciences Custom Pathway-Focused PCR Arrays for RDH14
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for RDH14
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RDH14
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008152 | metabolic process |
-- | -- | | GO:0055114 | oxidation-reduction process |
IEA | -- |
About this table
RDH14 for ontologies About GeneDecksing
|
Drugs & Compounds
for RDH14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for RDH14
|
Transcripts
for RDH14 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for RDH14 gene: NM_020905.3 Additional cDNA sequence: AF237952.1 AK023625.1 AK314994.1 AY358511.1 BC009830.2 CR597110.1 CR598421.1 CR598793.1 CR612704.1 CR619475.1 4 DOTS entries: DT.312418 DT.97839857 DT.91981067 DT.100746307 24/136 AceView cDNA sequences (see all 136): BC009830 AI383883 CR598421 AI570292 BU838555 AI910921 AV688583 CR612704 AA864535 BU608953 NM_033253 AI041525 AK057444 AA926945 AA774597 AI570797 BX112465 AK097848 N76631 AI954386 BM548950 BM142623 AF352326 AI085960
 highest scoring ESTs for RDH14:AF237952 AI309334 AY358511 BC009830 BE870533 BG759199 BX421596 CD242285 CF146616 CB988129 Unigene Cluster for RDH14: Retinol dehydrogenase 14 (all-trans/9-cis/11-cis) Hs.726345 [show with all ESTs]Unigene Representative Sequence: AK023625
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381249(uc002rcx.3) ENST00000468071
|
Expression
for RDH14 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| RDH14 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching RDH14 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 51185_at2, 3
|
U95-B |
1 |
0.44 |
1.00 |
1.00 |
1.00 |
AI309334 |
0.80 |
0.88 |
0.84 |
1 |
| 222203_s_at2, 3
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
AK023625 |
0.60 |
0.83 |
0.73 |
1 |
| 222203_s_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
RDH14 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GCCAAAGTGT
SOURCE GeneReport for Unigene cluster: Hs.726345
UniProtKB/Swiss-Prot: RDH14_HUMAN, Q9HBH5Tissue specificity: Expressed in brain, kidney, pancreas and placenta
SABiosciences Custom PCR Arrays for RDH14
|
Orthologs
for RDH14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RDH14 gene from 5/11 species (see all 11)
About this table Species with no ortholog for RDH14
ENSEMBL Gene Tree for RDH14 (if available) |
Paralogs
for RDH14 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for RDH14 gene
- RDH132 RDH122 RDH112
RDH14 for paralogs About GeneDecksing
|
Genomic Variants
for RDH14 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for RDH14 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RDH14
2 CNVs: 89518 8365 | | QIAGEN SeqTarget long-range PCR primers for resequencing RDH14 |
|
Disorders & Mutations
for RDH14 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RDH14 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: RDH14 (1 document)
Export disorders and mutations for RDH14 gene to outside databases
|
Medical News
for RDH14 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RDH14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/16 PubMed articles for RDH14 gene, integrated from 7 sources (see all 16):
(articles sorted by number of sources associating them with RDH14)- Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. (PubMed id 12226107)1, 2, 3 Haeseleer F.... Palczewski K. (2002)
- The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues. (PubMed id 12435598)1, 7 Belyaeva O.V. and Kedishvili N.Y. (2002)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17362836)1 Schymick J.C....Traynor B.J. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
|
External Searches for RDH14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RDH14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RDH14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RDH14 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RDH14 gene:
Search GeneIP for patents involving RDH14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RDH14 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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