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RELA Gene

protein-coding   GIFtS: 67

GC11M061748
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
(Previous name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NFKB3)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
v-rel reticuloendotheliosis viral oncogene homolog A (avian)1 2     v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of
kappa light polypeptide gene enhancer in B-cells 3 (p65))2
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 31 2 3     transcription factor p652
NFKB32 3 5     v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa
light polypeptide gene enhancer in B-cells 3, p652
p651 2     MGC1317742
Nuclear factor NF-kappa-B p65 subunit2 3     

External Ids:    HGNC: 99551   Entrez Gene: 59702   Ensembl: ENSG000001730397   UniProtKB: Q042063   

Export aliases for RELA gene to outside databases

Previous GC identifers: GC11M067936 GC11M067102 GC11M065671 GC11M065196 GC11M065172 GC11M065178 GC11M065421


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RELA:
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB
complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by
I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm.
Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258)
marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated
NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime
or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).(supplied
by OMIM)

UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206
Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in
many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis.
NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB,
NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The
dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for
different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations
act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of
post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors
or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the
NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by
I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active
NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are
transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of
IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the
interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the
NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1

Gene Wiki entry for RELA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RELA gene promoter:
         AP-1   C/EBPbeta   HNF-4alpha2   c-Jun   c-Fos   c-Rel   GATA-2   Sp1   COUP-TF1   STAT3   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for RELA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RELA 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

RELA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RELA gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M061748:  view genomic region     (about GC identifiers)

Start:
61,748,056 bp from pter
End:
61,757,436 bp from pter
Size:
9,381 bases
Orientation:
minus strand

1 alternative location:
Chr11- 65,421,070-65,430,443     
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206 (See protein sequence)
Recommended Name: Transcription factor p65  
Size: 551 amino acids; 60219 Da
Subunit: Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-c-Rel complex. Homodimer;
component of the NF-kappa-B p65-p65 complex. Component of the NF-kappa-B p65-p52 complex. May interact with ETHE1.
Binds AES and TLE1. Interacts with TP53BP2. Binds to and is phosphorylated by the activated form of either RPS6KA4 or
RPS6KA5. Interacts with ING4 and this interaction may be indirect. Interacts with CARM1, USP48 and UNC5CL. Interacts
with IRAK1BP1 (By similarity).Interacts with NFKBID (By similarity). Interacts with NFKBIA. Interacts with GSK3B.
Interacts with NFKBIB (By similarity). Interacts with NFKBIE. Interacts with NFKBIZ (By similarity). Part of a 70-90
kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HDAC3; HDAC3 mediates
the deacetylation of RELA. Interacts with HDAC1; the interaction requires non-phosphorylated RELA. Interacts with CBP;
the interaction requires phosphorylated RELA. Interacts (phosphorylated at 'Thr-254') with PIN1; the interaction
inhibits p65 binding to NFKBIA. Interacts with SOCS1. Interacts with UXT. Interacts with MTDH and PHF11. Interacts
with ARRB2. Interacts with human respiratory syncytial virus (HRSV) protein M2-1. Interacts with NFKBIA (when
phosphorylated), the interaction is direct; phosphorylated NFKBIA is part of a SCF(BTRC)-like complex lacking CUL1.
Interacts with RNF25. Interacts (via C-terminus) with DDX1
Subcellular location: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed
to an inhibitor (I-kappa-B). Colocalized with RELA in the nucleus upon TNF-alpha induction
PDB structures from and Proteopedia :
1NFI (3D)    2O61 (3D)    3GUT (3D)    
Secondary accessions: Q6GTV1 Q6SLK1
Alternative splicing: 4 isoforms:  Q04206-1   Q04206-2   Q04206-3   Q04206-4   

Explore the universe of human proteins at neXtProt for RELA: NX_Q04206 

Post-translational modifications:

  • Ubiquitinated, leading to its proteosomal degradation. Degradation is required for termination of NF-kappa-B response1
  • Phosphorylation on 'Ser-536' stimulates acetylation on 'Lys-310' and interaction with CBP; the phosphorylated and
  • acetylated forms show enhanced transcriptional activity1
  • Reversibly acetylated; the acetylation seems to be mediated by CBP, the deacetylation by HDAC3. Acetylation at
  • 'Lys-122' enhances DNA binding and impairs association with NFKBIA. Acetylation at 'Lys-310' is required for full
    transcriptional activity in the absence of effects on DNA binding and NFKBIA association. Acetylation can also lower
    DNA-binding and results in nuclear export1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001138610.1  NP_068810.3  


    ENSEMBL proteins: 
    ENSP00000384273 ENSP00000311508 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for RELA
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for RELA
    OriGene Purified Protein: RELA
    OriGene Protein Over-expression Lysate: RELA
    GenScript Purified and Recombinant Proteins for RELA 
    Novus Biologicals Proteins for RELA
    Novus Biologicals Lysate for RELA
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA19058135
    GO:0005654 nucleoplasm TAS--
    GO:0005667 transcription factor complex IDA12048232
    GO:0005737 cytoplasm IDA3140380
    GO:0005829 cytosol TAS--
    About this table

    RELA for ontologies           About GeneDecksing



    Antibodies for RELA: 
    Millipore Mono- and Polyclonal Antibodies for the study of RELA
    Sigma-Aldrich Antibodies for RELA
    R&D Systems Antibodies for RELA
    Cell Signaling Technology (CST) Antibodies for RELA  (NF-KappaB p65)
    OriGene Antibodies (see all 4): RELA
    GenScript Superior Antibodies for RELA 
    Novus Biologicals Antibodies for RELA
    Epitomics antibodies for RELA

    Assays for RELA: 
    Millipore Kits and Assays for the Analysis of RELA
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RELA 
    Cell Signaling Technology (CST) Sandwich ELISA Kits for RELA (NF-KappaB p65)
    Enzo Life Sciences assays for RELA
    Uscn ELISAs and CLIAs for RELA 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RELA for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR014756 Ig_E-set
     IPR008967 p53-like_TF_DNA-bd
     IPR002909 IPT_TIG_rcpt
     IPR013783 Ig-like_fold
     IPR000451 NF_Rel_dor

    Graphical View of Domain Structure for InterPro Entry Q04206

    ProtoNet protein and cluster: Q04206

    3 Blocks protein families:
    IPB000451 NF-kappa-B/Rel/dorsal family
    IPB002909 Cell surface receptor IPT/TIG
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206
    Similarity: Contains 1 RHD (Rel-like) domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: TF65_HUMAN, Q04206
    Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in
    many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis.
    NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB,
    NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The
    dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for
    different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations
    act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of
    post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors
    or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the
    NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by
    I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active
    NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are
    transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of
    IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the
    interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the
    NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1

    Inhib.
    RNA:
        
    Millipore RNAi Products for the Analysis of RELA Gene knock-down
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for RELA
    Sigma-Aldrich shRNA Panels and shRNA for RELA
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): RELA
    OriGene shRNA RFP (see all 2): RELA
    OriGene basic RS shRNA (see all 2): RELA
    OriGene siRNA (see all 2): RELA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RELA 
    miRNA:Sigma-Aldrich microRNA Mimics for RELA
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RELA 
    Search SABiosciences for Assays for microRNAs that regulate RELA

    Gene
    Editing:
    Sigma-Aldrich CompoZr Knockout ZFN for RELA 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): RELA
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): RELA
    OriGene untagged cDNA clones in CMV expression vector: RELA
    OriGene 3'-UTR clone (see all 2): RELA 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for RELA 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for RELA 

    Genatlas biochemistry entry for RELA:
    nuclear transcription factor of kappa light chain enhancer in B cells,3 (p65),NF-kappa B/REL family

    5/19 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 19):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IDA15790681
    GO:0003682 chromatin binding IDA19058135
    GO:0003700 sequence-specific DNA binding transcription factor activity IDA12048232
    GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity IDA3091258
    GO:0005515 protein binding IPI15140884
    About this table

    RELA for ontologies           About GeneDecksing

    Animal Models: 15/21 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Rela) (see all 21):

    cardiovascular systemcellulardigestive/alimentaryembryogenesisendocrine/exocrine gland
    growth/sizehematopoietic systemhomeostasis/metabolismimmune systemlethality-postnatal
    lethality-prenatal/perinatallife span-post-weaning/aginglimbs/digits/tailliver/biliary systemmuscle

    RELA for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    RELA for pathways           About GeneDecksing

    5/50 Millipore Pathways for RELA (see all 50)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Development TGF-beta receptor signaling
    Immune response IL-1 signaling pathway
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5/92 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  RELA (see all 92)
        Renin-Angiotensin Signaling
    Estrogen-Dependent Breast Cancer Signaling
    Atherosclerosis Signaling
    IL-6 Signaling
    Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

    1 Cell Signaling Technology (CST) Pathway for RELA
        NF-kB Signaling

    5/24 Kegg Pathways  (Kegg details for RELA) (see all 24):
        hsa04010 MAPK signaling pathway
    hsa04062 Chemokine signaling pathway
    hsa04210 Apoptosis
    hsa04620 Toll-like receptor signaling pathway
    hsa04621 NOD-like receptor signaling pathway

        SABiosciences Pathway-Focused PCR Arrays including RELA (see all 7): PAHS-018A PAHS-025A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for RELA
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RELA

    5/305 Interacting proteins for RELA (Q042061, 2 ENSP000003115083) via UniProtKB, MINT, and/or STRING (see all 305)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198381, 2, ENSP000002265743EBI-73886,EBI-300010 MINT-47911 MINT-6178467 MINT-48923 MINT-47891 MINT-6178544 MINT-48559 MINT-6178520 MINT-48686 STRING: ENSP00000226574
    RELQ048641, 2, ENSP000002950253EBI-73886,EBI-307352 MINT-48934 MINT-47835 MINT-6178520 MINT-6178544 STRING: ENSP00000295025
    CHUKO151111, 2, ENSP000003594243EBI-73886,EBI-81249 MINT-50107 MINT-48896 MINT-48009 STRING: ENSP00000359424
    NFKBIAP259631, 2, ENSP000002167973EBI-73886,EBI-307386 MINT-48917 MINT-47847 STRING: ENSP00000216797
    NFKBIBQ156531, 2, ENSP000003129883EBI-73886,EBI-352889 MINT-47871 MINT-48919 STRING: ENSP00000312988
    About this table

    5/50 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 50):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889 liver development IEA--
    GO:0001942 hair follicle development IEA--
    GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006355 regulation of transcription, DNA-dependent ----
    GO:0006916 anti-apoptosis IDA10747850
    About this table

    RELA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    RELA for compounds           About GeneDecksing

    Sigma-Aldrich Small Molecules for RELA:
    Small Molecule - Antagonist
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RELA
    9 Novoseek chemical compound relationships for RELA gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxycholic acid 22.2 4 14726307 (2), 15876188 (1)
    daunorubicin 10.2 5 16424027 (2), 15053878 (1)
    okadaic acid 7.19 2 11591705 (1)
    lysine 4.5 3 19262565 (3)
    paraffin 1.35 2 15112579 (1), 15484295 (1)
    oxygen 0 2 16919261 (1), 19706715 (1)
    calcium 0 1 16556680 (1)
    testosterone 0 1 8798655 (1)
    serine 0 8 19706715 (3)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Millipore RNAi Products for the Analysis of RELA Gene knock-down
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for RELA
    Sigma-Aldrich shRNA Panels and shRNA for RELA
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): RELA
    OriGene shRNA RFP (see all 2): RELA
    OriGene basic RS shRNA (see all 2): RELA
    OriGene siRNA (see all 2): RELA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RELA 
    miRNA: Sigma-Aldrich microRNA Mimics for RELA
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RELA 
    Search SABiosciences for Assays for microRNAs that regulate RELA
    Clones: Sigma-Aldrich FLAG tag genes for RELA
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): RELA
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): RELA
    OriGene untagged cDNA clones in CMV expression vector: RELA
    OriGene 3'-UTR Clone (see all 2): RELA 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for RELA 
    Primers: OriGene genome-wide validated SYBR primer pairs: RELA
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for RELA: PPH01812A

    REFSEQ mRNAs for RELA gene (2 alternative transcripts): 

    NM_001145138.1  NM_021975.3  

    Additional cDNA sequence: 

    AK303262.1 AK308020.1 AK308478.1 BC011603.1 BC014095.2 BC033522.1 BC069248.1 BC110830.1 
    CR590105.1 CR598825.1 CR605571.1 CR615054.1 L19067.1 M62399.1 U33838.1 U88316.1 

    24/31 DOTS entries (see all 31):

    DT.91765826  DT.453518  DT.120691756  DT.100828990  DT.91713615  DT.100828991  DT.100706889  DT.95168124 
    DT.95168121  DT.95168127  DT.91765829  DT.95168119  DT.91765817  DT.95168120  DT.120691718  DT.120691732 
    DT.91765812  DT.99942709  DT.102830297  DT.120691721  DT.120691754  DT.120691767  DT.120691701  DT.120691720 

    24/513 AceView cDNA sequences (see all 513):

    BM916512 AU143705 BM918609 BQ879245 BU501297 BP355398 AI668775 BP338125 
    BF108432 BQ437947 BQ433161 BM917161 AA287356 BU617515 BU180728 NM_021975 
    CA488197 AI241350 BE208001 BI000249 CB242015 H96570 CR590105 AW848518 

    highest scoring ESTs for RELA:

    AA227250 AI241350 AL531207 AL702070 AU099013 AU121812 AU124990 AU125193 AU131718 AU143705 

    Unigene Cluster for RELA:

    V-rel reticuloendotheliosis viral oncogene homolog A (avian)
    Hs.502875  [show with all ESTs]
    Unigene Representative Sequence: BC110830


    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RELA (see all 14)

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^
    SP1:                                      -                       -     -                                                                                       
    SP2:              -     -     -           -                       -     -                                                                                       
    SP3:                                      -                       -     -                                         -     -     -     -     -     -               
    SP4:              -                       -                       -     -                                                                                       
    SP5:                                                              -     -                                                                                       

    ExUns: 12
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      

    About this scheme

    ECgene alternative splicing isoforms for RELA
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406246(uc001ofg.2 uc010ron.1 uc009yqr.2 uc001ofe.2 uc001off.2)
    ENST00000308639(uc009yqs.1 uc001ofh.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    RELA expression in normal and diseased human tissues

    1  / 2  / 3

    8 probe-sets matching RELA gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1271_g_at2, 3 U95-A 1 1.00 1.00 0.71 1.07 L19067 0.60 1.00 0.82 1
    36645_at2, 3 U95-A 1 0.94 1.00 0.69 1.10 L19067 0.60 1.00 0.82 1
    1045_s_at2, 3 U95-A 1 0.94 1.00 0.80 0.63 U33838 0.80 1.00 0.91 1
    1295_at2, 3 U95-A 1 0.75 1.00 0.87 1.21 L19067 0.60 1.00 0.82 1
    201783_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_021975 0.60 1.00 0.82 1
    209878_s_at2, 3 U133-A 1 1.00 1.00 -- -- M62399 0.80 1.00 0.91 1
    201783_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    209878_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    RELA for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    RELA gene expression
    RELA gene electronic northern expression
    RELA gene sage expression
    About these images

    CGAP SAGE TAG: GCTGAAGGAA

    SOURCE GeneReport for Unigene cluster: Hs.502875

    Expression variation in blood from EXPOLDB for RELA

    Primers: OriGene genome-wide validated SYBR primer pairs: RELA
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for RELA: PPH01812A
        SABiosciences Expression via Pathway-Focused PCR Arrays including RELA (see all 7): PAHS-018A PAHS-025A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for RELA gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RELA1   -- v-rel reticuloendotheliosis viral oncogene homolog more 90.99(n)
    93.33(a)
    483729  XM_540850.2  XP_540850.2 
    chimpanzee
    (Pan troglodytes)
    RELA1   -- v-rel reticuloendotheliosis viral oncogene homolog more 99.76(n)
    99.64(a)
    466665  XM_001170057.1  XP_001170057.1 
    cow
    (Bos taurus)
    RELA1   -- v-rel reticuloendotheliosis viral oncogene homolog more 90.64(n)
    92.48(a)
    508233  XM_584983.3  XP_584983.2 
    rat
    (Rattus norvegicus)
    Rela1   -- v-rel reticuloendotheliosis viral oncogene homolog more 87.77(n)
    90.69(a)
    309165  NM_199267.2  NP_954888.1 
    mouse
    (Mus musculus)
    Rela1 , 5 19 (4.34 cM)5
    v-rel reticuloendotheliosis viral oncogene homolog more1, 5 86.96(n)1
    89.03(a)1
    196971  NM_009045.41  NP_033071.11 
     AF1993715  AK0894895  (see all 28)
    About this table        Species with no ortholog for RELA

    ENSEMBL Gene Tree for RELA (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for RELA gene
    NFKB12  REL2  NFKB22  RELB2  

    RELA for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/117 NCBI SNPs in RELA are shown (see all 117)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs93781,2
    --65421188(-) TAAGAG/TTGGGG 2 -- ut311Minor allele frequency- T:0.00MN 184
    rs97251,2
    C,F,65421476(-) AAAGCC/TTTATC 2 -- ut312Minor allele frequency- T:0.02MN WA 234
    rs7320721,2
    C,F,65427568(-) ACACCC/TGCACC 2 -- int119Minor allele frequency- T:0.04MN NS EA NA 3102
    rs10496421,2
    C65421623(-) GGAGCA/TGGGGA 2 -- ut310--------
    rs10497281,2
    C,F,A,65421117(-) TTGGAC/GTCTTG 2 -- ut31 ese312Minor allele frequency- G:0.01NS EA 1148
    rs11089221,2
    C,65423930(+) GACAAC/TCTCAT 2 -- int19Minor allele frequency- T:0.04NA EA NS 818
    rs11447921,2
    C,65423082(+) gcccaA/Ggagtc 2 -- int112Minor allele frequency- G:0.12MN NS EA NA WA 622
    rs11514931,2
    C,H,65424061(+) tgacaC/Tatatt 2 -- int17Minor allele frequency- T:0.00NA WA 18
    rs23063651,2
    C,F,H,65427346(+) TCTGCG/ACTGGG 2 -- int115Minor allele frequency- A:0.28NS EA NA 984
    rs23756761,2
    --65427191(-) CCACTA/C/GCAAGG 8 -- mis1 ref10--------
    About this table

    HapMap Linkage Disequilibrium images for RELA (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RELA: --

    Search QIAGEN SeqTarget long-range PCR primers for resequencing for RELA 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RELA for disorders           About GeneDecksing

    OMIM: 164014

    10/17 Novoseek disease relationships for RELA gene (see all 17)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    reticuloendotheliosis 66.3 4 16556680 (1), 20332460 (1), 17151784 (1), 17804543 (1)
    necrosis 47.1 10 15876188 (2), 17413040 (1), 12881425 (1), 7852340 (1) (see all 8)
    tumors 41.6 31 16424027 (4), 10467400 (2), 9047386 (2), 17413040 (1) (see all 18)
    inflammation 36.4 4 14691478 (1), 19128834 (1), 19957349 (1), 12509469 (1)
    colorectal tumors 28 4 15112579 (2), 15484295 (2)
    leukemia t-cell 23.3 1 17804543 (1)
    breast cancer 16.1 5 11114727 (2), 12897145 (1), 16408291 (1), 9724088 (1)
    cancer 6.37 12 19345327 (2), 19664134 (2), 20001340 (2), 11591705 (1) (see all 9)
    carcinoma renal cell 5.68 1 10685665 (1)
    melanoma 1.51 13 11775058 (4), 11591705 (3), 8530498 (1)
    About this table

    Genetic Association Database (GAD): RELA
    Human Genome Epidemiology (HuGE) Navigator: RELA (19 documents)

    Export disorders and mutations for RELA gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/736 PubMed articles for RELA gene, integrated from 7 sources (see all 736):
    (articles sorted by number of sources associating them with RELA)
    1. The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription. (PubMed id 19058135)1, 2, 7 Ishaq M....Guo D. (2009)
    2. Duration of nuclear NF-kappaB action regulated by reversible acetylation. (PubMed id 11533489)1, 2, 7 Chen L.F.... Greene W.C. (2001)
    3. A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. (PubMed id 9315679)1, 2, 7 Li Z. and Nabel G.J. (1997)
    4. Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. (PubMed id 15775976)1, 2, 7 Rocha S.... Perkins N.D. (2005)
    5. Identification of a ZU5 and death domain-containing inhibitor of NF- kappaB. (PubMed id 14769797)1, 2, 7 Zhang J.... Shu H.-B. (2004)
    6. UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome. (PubMed id 17620405)1, 2 Sun S.... Wang C. (2007)
    7. Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. (PubMed id 16214042)1, 2 Tzimas C....Hatzivassiliou E.G. (2006)
    8. IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. (PubMed id 16477006)1, 2 Song Y.J....Cahir-McFarland E. (2006)
    9. Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. (PubMed id 16497732)1, 2 Miao F.... Natarajan R. (2006)
    10. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. (PubMed id 16452207)1, 2 Emdad L....Fisher P.B. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5970 HGNC: 9955 AceView: RELA Ensembl:ENSG00000173039 euGenes: HUgn5970
    ECgene: RELA Kegg: 5970 H-InvDB: RELA

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for RELA Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/rela/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for RELA gene:
    Search GeneIP for patents involving RELA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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