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RGN Gene

protein-coding   GIFtS: 55

GC0XP044651
regucalcin (senescence marker protein-30)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
regucalcin (senescence marker protein-30)1 2     SMP-302 3
SMP301 2 3 5     regucalcin2
RC1 2 3     senescence marker protein-302
Senescence marker protein 302 3     

External Ids:    HGNC: 99891   Entrez Gene: 91042   Ensembl: ENSG000001309887   UniProtKB: Q154933   

Export aliases for RGN gene to outside databases

Previous GC identifers: GC0XP045740 GC0XP045198 GC0XP045983 GC0XP046695 GC0XP046822 GC0XP046937


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGN:
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in
the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein
may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on
chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but
encoding the same protein. (provided by RefSeq)

UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493
Function: Calcium-binding protein which regulates Ca(2+) signaling by regulating Ca(2+)-dependent enzymatic activity in
the liver and kidney. Decrease of RGN leads to the dysregulation of calcium signaling in the aged liver (By
similarity)

Gene Wiki entry for RGN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGN gene promoter:
         GR-alpha   GR-beta   CUTL1   C/EBPalpha   NF-1   GATA-2   GATA-3   GATA-1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for RGN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RGN 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.3

RGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGN gene location

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP044651:  view genomic region     (about GC identifiers)

Start:
44,651,176 bp from pter
End:
44,667,384 bp from pter
Size:
16,209 bases
Orientation:
plus strand

1 alternative location:
ChrX+ 46,937,775-46,952,712     
RefSeq DNA sequence:
NC_000023.10  NT_079573.4  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493 (See protein sequence)
Recommended Name: Regucalcin  
Size: 299 amino acids; 33253 Da
Subcellular location: Cytoplasm (By similarity)
PDB structure from and Proteopedia :
3G4E (3D)    3G4H (3D)    
Secondary accessions: A4FTW1 A8K271 Q53FC9 Q5JRR5
Alternative splicing: 2 isoforms:  Q15493-1   Q15493-2   

Explore the universe of human proteins at neXtProt for RGN: NX_Q15493 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_004674.1  NP_690608.1  


    ENSEMBL proteins: 
    ENSP00000253303 ENSP00000338400 ENSP00000406568 ENSP00000380365 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: RGN
    GenScript Custom Purified and Recombinant Proteins Services for RGN 
    Novus Biologicals Proteins for RGN
    Novus Biologicals Lysates for RGN
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus ISS--
    GO:0005737 cytoplasm ISS--
    About this table

    RGN for ontologies           About GeneDecksing



    Antibodies for RGN: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RGN
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for RGN 
    Novus Biologicals Antibodies for RGN
    Browse antibodies at Epitomics

    Assays for RGN: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RGN 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RGN 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RGN for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011042 6-blade_b-propeller_TolB-like
     IPR005511 SMP-30
     IPR008367 Regucalcin
     IPR013658 SGL

    Graphical View of Domain Structure for InterPro Entry Q15493

    ProtoNet protein and cluster: Q15493

    3 Blocks protein families:
    IPB005511 Senescence marker protein-30 (SMP-30)
    IPB008367 Regucalcin signature
    IPB013658 SMP-30/Gluconolaconase/LRE-like region


    UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493
    Similarity: Belongs to the SMP-30/CGR1 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493
    Function: Calcium-binding protein which regulates Ca(2+) signaling by regulating Ca(2+)-dependent enzymatic activity in
    the liver and kidney. Decrease of RGN leads to the dysregulation of calcium signaling in the aged liver (By
    similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for RGN
    Sigma-Aldrich shRNA for RGN
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): RGN
    OriGene shRNA RFP (see all 2): RGN
    OriGene basic RS shRNA (see all 2): RGN
    OriGene siRNA (see all 2): RGN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RGN 
    miRNA:Sigma-Aldrich microRNA Mimics for RGN
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RGN 
    Search SABiosciences for Assays for microRNAs that regulate RGN

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): RGN
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): RGN
    OriGene untagged cDNA clones in CMV expression vector (see all 2): RGN
    OriGene 3'-UTR clone (see all 2): RGN 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): RGN 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for RGN 

    Genatlas biochemistry entry for RGN:
    rat calcium binding protein (regucalcin) homolog

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509 calcium ion binding ISS--
    GO:0030234 enzyme regulator activity IEA--
    About this table

    RGN for ontologies           About GeneDecksing

    Animal Models: 1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rgn):

    liver/biliary system

    RGN for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Array including RGN: PAHS-094A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGN

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874 cellular calcium ion homeostasis ISS--
    GO:0032781 positive regulation of ATPase activity ISS--
    GO:0050848 regulation of calcium-mediated signaling ISS--
    About this table

    RGN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    RGN for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGN
    7 Novoseek chemical compound relationships for RGN gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tabun 69.8 1 15247044 (1)
    sarin 58 1 15247044 (1)
    soman 55.4 1 15247044 (1)
    deoxyribonucleic acid 36.9 2 15702226 (1)
    ascorbic acid 28.2 9 17222174 (1), 19801822 (1)
    calcium 27.7 33 18704329 (5), 9753637 (4), 10360682 (3), 8765750 (1) (see all 9)
    superoxide 18.5 2 15902099 (1), 17569552 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for RGN
    Sigma-Aldrich shRNA for RGN
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): RGN
    OriGene shRNA RFP (see all 2): RGN
    OriGene basic RS shRNA (see all 2): RGN
    OriGene siRNA (see all 2): RGN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RGN 
    miRNA: Sigma-Aldrich microRNA Mimics for RGN
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RGN 
    Search SABiosciences for Assays for microRNAs that regulate RGN
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): RGN
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): RGN
    OriGene untagged cDNA clones in CMV expression vector (see all 2): RGN
    OriGene 3'-UTR Clone (see all 2): RGN 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): RGN 
    Primers: OriGene genome-wide validated SYBR primer pairs: RGN
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for RGN: PPH10080A

    REFSEQ mRNAs for RGN gene (2 alternative transcripts): 

    NM_004683.4  NM_152869.2  

    Additional cDNA sequence: 

    AB028125.1 AB032064.1 AK223360.1 AK290136.1 BC050371.1 BC058880.1 BC073173.1 D31815.1 

    6 DOTS entries:

    DT.100748481  DT.101980961  DT.99998879  DT.91742681  DT.99989586  DT.99999502 

    24/66 AceView cDNA sequences (see all 66):

    AA349125 BC050371 BC058880 BM984993 D31815 CD106286 BC073173 NM_152869 
    CB161948 NM_004683 AI804699 BU949763 BF590441 BE348729 AW772220 CA433989 
    BU950067 BQ016185 AI767740 CB957212 AI354934 H49432 CA434067 BV204050 

    highest scoring ESTs for RGN:

    D31815 AA349125 AI354934 AI628356 AI678127 AI767740 AI804678 AI804699 AV684485 AV685583 

    Unigene Cluster for RGN:

    Regucalcin (senescence marker protein-30)
    Hs.77854  [show with all ESTs]
    Unigene Representative Sequence: NM_152869


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RGN

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -     -     -                 -                           
    SP2:                                                  -                           
    SP3:                    -     -     -                 -     -                     
    SP4:                                                                              
    SP5:                                                                              

    About this scheme

    ECgene alternative splicing isoforms for RGN
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000352078 ENST00000469346 ENST00000336169 ENST00000475448 ENST00000457380
    ENST00000397180(uc004dgz.1 uc004dha.1 uc010nho.1 uc010nhp.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    RGN expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching RGN gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    942_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 D31815 1.00 0.90 0.95 1
    210751_s_at2, 3 U133-A 1 1.00 1.00 -- -- D31815 1.00 0.90 0.95 1
    210751_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    RGN for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    RGN gene expression
    RGN gene electronic northern expression
    RGN gene sage expression
    About these images

    CGAP SAGE TAG: CTGCTTTGGA

    SOURCE GeneReport for Unigene cluster: Hs.77854

    Expression variation in blood from EXPOLDB for RGN

    Primers: OriGene genome-wide validated SYBR primer pairs: RGN
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for RGN: PPH10080A
        SABiosciences Expression via Pathway-Focused PCR Array including RGN: PAHS-094A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for RGN gene from 5/16 species (see all 16)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RGN1   -- regucalcin (senescence marker protein-30) 89.63(n)
    91.3(a)
    480893  XM_538011.2  XP_538011.2 
    chimpanzee
    (Pan troglodytes)
    RGN1   -- regucalcin (senescence marker protein-30) 96.45(n)
    94.26(a)
    465598  XM_001141501.1  XP_001141501.1 
    rat
    (Rattus norvegicus)
    Rgn1   -- regucalcin (senescence marker protein-30) 86.85(n)
    88.63(a)
    25106  NM_031546.1  NP_113734.1 
    mouse
    (Mus musculus)
    Rgn1 , 5 X (16.04 cM)5
    regucalcin1, 5 86.51(n)1
    88.63(a)1
    197331  NM_009060.21  NP_033086.11 
     AI2653165  AK1464655  (see all 9)
    chicken
    (Gallus gallus)
    RGN1   -- regucalcin 73.47(n)
    77.93(a)
    395480  NM_204729.1  NP_990060.1 
    About this table        Species with no ortholog for RGN

    ENSEMBL Gene Tree for RGN (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/89 NCBI SNPs in RGN are shown (see all 89)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs143121,2
    C,F,O,H46952398(+) GAATTC/TTGGGC 1 -- ut31 ese36Minor allele frequency- T:0.10MN NS EA NA 604
    rs38149041,2
    --46937648(+) GGGACG/TGGGAC 1 -- ng510--------
    rs38149051,2
    C46937699(+) GCCGGA/GTCCCG 1 -- ng510--------
    rs44802421,2
    C,F,A,H,46952219(+) TTACTG/ACAAAT 1 -- int19Minor allele frequency- A:0.33NS EA NA WA 424
    rs45032121,2
    C,F,A,H,46941458(+) GGACCA/GTCTTT 1 -- int17Minor allele frequency- G:0.29NS EA NA WA 424
    rs45514881,2
    C,A,H46948159(+) aacccT/Cgtctc 1 -- int16Minor allele frequency- C:0.10NA WA 10
    rs48244181,2
    C,A,H,46944617(+) acagaA/Gaaaaa 1 -- int14Minor allele frequency- G:0.17NA WA 6
    rs48245991,2
    C46938229(+) CCCACC/TGGCTT 1 -- int10--------
    rs50129571,2
    C,F,A,H,46952117(+) ATTATA/TAACTA 1 -- int18Minor allele frequency- T:0.33NS EA NA WA 425
    rs59055831,2
    C,A,H46941760(+) gctggG/Agtgca 1 -- int12Minor allele frequency- A:0.33NA WA 3
    About this table

    HapMap Linkage Disequilibrium images for RGN (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RGN: --

    QIAGEN SeqTarget long-range PCR primers for resequencing RGN 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RGN for disorders           About GeneDecksing

    OMIM: 300212

    5 Novoseek disease relationships for RGN gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis 19.8 1 9059996 (1)
    hepatocellular carcinoma 14.3 2 15358188 (1), 19801822 (1)
    necrosis 0 1 15358188 (1)
    tumors 0 4 19347872 (2), 16136218 (1), 15358188 (1)
    cancer 0 1 19347872 (1)
    About this table


    Export disorders and mutations for RGN gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/51 PubMed articles for RGN gene, integrated from 7 sources (see all 51):
    (articles sorted by number of sources associating them with RGN)
    1. Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome. (PubMed id 7548213)1, 2, 3, 7 Fujita T....Maruyama N. (1995)
    2. Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin. (PubMed id 10677570)1, 2, 7 Misawa H. and Yamaguchi M. (2000)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Expression and structure of senescence marker protein-30 (SMP30) and its biological significance. (PubMed id 10360682)1, 7 Fujita T....Maruyama N. (1999)
    6. Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells. (PubMed id 15358188)1, 7 Matsuyama S....Sato N. (2004)
    7. Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells. (PubMed id 15714273)1, 7 Ishigami A....Maruyama N. (2005)
    8. Hepatic senescence marker protein-30 is involved in t he progression of nonalcoholic fatty liver disease. (PubMed id 19946731)1, 7 Park H....Okanoue T. (2010)
    9. Regucalcin is under-expressed in human breast and pro state cancers: Effect of sex steroid hormones. (PubMed id 19347872)1, 7 Maia C....Socorro S. (2009)
    10. Senescence marker protein 30 in acute liver failure: validation of a mass spectrometry proteomics assay. (PubMed id 18507831)1, 7 Lv S....Wei L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9104 HGNC: 9989 AceView: RGN Ensembl:ENSG00000130988 euGenes: HUgn9104
    ECgene: RGN H-InvDB: RGN

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for RGN gene:
    Search GeneIP for patents involving RGN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for RGN Antibodies for RGN
     Super-pooled esiRNAs for RGN Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for RGN microRNA Mimics for RGN
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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     Antibodies   Cell Culture Products  
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     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
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     Fluorogenic Cell Assay Kits
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RGN
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     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RGN
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     GenScript Custom Purified and Recombinant Proteins Services for RGN GenScript cDNA clones with any tag delivered in your preferred vector for RGN
     GenScript Custom Assay Services for RGN GenScript Custom Superior Antibodies Services for RGN
     GenScript Custom overexpressing Cell Line Services for RGN CloneReady with Over 120,000 Genes
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     Search for Antibodies & Assays

     Regulatory tfbs in RGN promoter
     Search Chromatin IP Primers for RGN
     RT2 qPCR Primer Assay for RGN
     GNC Network for RGN
     Search for Assays for microRNAs that regulate RGN
     SABiosciences PCR Arrays including RGN
     Search Tocris compounds for RGN
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     Proteins for RGN
     Lysates for RGN
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for RGN
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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