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RGN Gene

protein-coding GIFtS: 55

GC0XP044651

regucalcin (senescence marker protein-30)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
regucalcin (senescence marker protein-30)¹ ²		SMP-30² ³
SMP30¹ ² ³ ⁵		regucalcin²
RC¹ ² ³		senescence marker protein-30²
Senescence marker protein 30² ³

External Ids:	HGNC: 9989¹	Entrez Gene: 9104²	Ensembl: ENSG00000130988⁷	UniProtKB: Q15493³

Export aliases for RGN gene to outside databases

Previous GC identifers: GC0XP045740 GC0XP045198 GC0XP045983 GC0XP046695 GC0XP046822 GC0XP046937

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGN:

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in

the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein

may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on

chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but

encoding the same protein. (provided by RefSeq)

UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493

Function: Calcium-binding protein which regulates Ca(2+) signaling by regulating Ca(2+)-dependent enzymatic activity in

the liver and kidney. Decrease of RGN leads to the dysregulation of calcium signaling in the aged liver (By

similarity)

Gene Wiki entry for RGN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RGN gene promoter:
         GR-alpha   GR-beta   CUTL1   C/EBPalpha   NF-1   GATA-2   GATA-3   GATA-1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)
         Other transcription factors

Search SABiosciences Chromatin IP Primers for RGN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RGN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.3

RGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGN gene location

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP044651: view genomic region (about GC identifiers)

Start:	44,651,176 bp from pter
End:	44,667,384 bp from pter
Size:	16,209 bases
Orientation:	plus strand

1 alternative location:

ChrX+ 46,937,775-46,952,712

RefSeq DNA sequence:

NC_000023.10 NT_079573.4

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493 (See protein sequence)

Recommended Name: Regucalcin

Size: 299 amino acids; 33253 Da

Subcellular location: Cytoplasm (By similarity)

PDB structure from and Proteopedia :

3G4E (3D)

3G4H (3D)

Secondary accessions: A4FTW1 A8K271 Q53FC9 Q5JRR5

Alternative splicing: 2 isoforms: Q15493-1 Q15493-2

Explore the universe of human proteins at neXtProt for RGN: NX_Q15493

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_004674.1 NP_690608.1

ENSEMBL proteins:

ENSP00000253303 ENSP00000338400 ENSP00000406568 ENSP00000380365

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: RGN
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	Novus Biologicals Proteins for RGN
	Novus Biologicals Lysates for RGN
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--

About this table

RGN for ontologies About GeneDecksing

Antibodies for RGN:

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	Browse antibodies at Epitomics

Assays for RGN:

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	GenScript Custom Assay Services for RGN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RGN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RGN for domains About GeneDecksing

4 InterPro domains/families:

IPR011042 6-blade_b-propeller_TolB-like

IPR005511 SMP-30

IPR008367 Regucalcin

IPR013658 SGL

Graphical View of Domain Structure for InterPro Entry Q15493

ProtoNet protein and cluster: Q15493

3 Blocks protein families:

IPB005511 Senescence marker protein-30 (SMP-30)

IPB008367 Regucalcin signature

IPB013658 SMP-30/Gluconolaconase/LRE-like region

UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493

Similarity: Belongs to the SMP-30/CGR1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: RGN_HUMAN, Q15493

Function: Calcium-binding protein which regulates Ca(2+) signaling by regulating Ca(2+)-dependent enzymatic activity in

the liver and kidney. Decrease of RGN leads to the dysregulation of calcium signaling in the aged liver (By

similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for RGN Sigma-Aldrich shRNA for RGN
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): RGN OriGene shRNA RFP (see all 2): RGN OriGene basic RS shRNA (see all 2): RGN OriGene siRNA (see all 2): RGN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RGN

miRNA:		Sigma-Aldrich microRNA Mimics for RGN Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RGN
		Search SABiosciences for Assays for microRNAs that regulate RGN

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): RGN OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): RGN OriGene untagged cDNA clones in CMV expression vector (see all 2): RGN OriGene 3'-UTR clone (see all 2): RGN Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): RGN
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for RGN

Genatlas biochemistry entry for RGN:

rat calcium binding protein (regucalcin) homolog

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	ISS	--
GO:0030234	enzyme regulator activity	IEA	--

About this table

RGN for ontologies About GeneDecksing

Animal Models: 1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Rgn):

liver/biliary system

RGN for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Pathway-Focused PCR Array including RGN: PAHS-094A

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RGN

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006874	cellular calcium ion homeostasis	ISS	--
GO:0032781	positive regulation of ATPase activity	ISS	--
GO:0050848	regulation of calcium-mediated signaling	ISS	--

About this table

RGN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

RGN for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RGN
7 Novoseek chemical compound relationships for RGN gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tabun	69.8	1	15247044 (1)
sarin	58	1	15247044 (1)
soman	55.4	1	15247044 (1)
deoxyribonucleic acid	36.9	2	15702226 (1)
ascorbic acid	28.2	9	17222174 (1), 19801822 (1)
calcium	27.7	33	18704329 (5), 9753637 (4), 10360682 (3), 8765750 (1) (see all 9)
superoxide	18.5	2	15902099 (1), 17569552 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for RGN Sigma-Aldrich shRNA for RGN
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): RGN OriGene shRNA RFP (see all 2): RGN OriGene basic RS shRNA (see all 2): RGN OriGene siRNA (see all 2): RGN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RGN

miRNA:		Sigma-Aldrich microRNA Mimics for RGN Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RGN
		Search SABiosciences for Assays for microRNAs that regulate RGN

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): RGN OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): RGN OriGene untagged cDNA clones in CMV expression vector (see all 2): RGN OriGene 3'-UTR Clone (see all 2): RGN Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): RGN

Primers:		OriGene genome-wide validated SYBR primer pairs: RGN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for RGN: PPH10080A

REFSEQ mRNAs for RGN gene (2 alternative transcripts):

NM_004683.4 NM_152869.2

Additional cDNA sequence:

AB028125.1 AB032064.1 AK223360.1 AK290136.1 BC050371.1 BC058880.1 BC073173.1 D31815.1

6 DOTS entries:

DT.100748481 DT.101980961 DT.99998879 DT.91742681 DT.99989586 DT.99999502

24/66 AceView cDNA sequences (see all 66):

AA349125 BC050371 BC058880 BM984993 D31815 CD106286 BC073173 NM_152869

CB161948 NM_004683 AI804699 BU949763 BF590441 BE348729 AW772220 CA433989

BU950067 BQ016185 AI767740 CB957212 AI354934 H49432 CA434067 BV204050

highest scoring ESTs for RGN:

D31815 AA349125 AI354934 AI628356 AI678127 AI767740 AI804678 AI804699 AV684485 AV685583

Unigene Cluster for RGN:

Regucalcin (senescence marker protein-30)

Hs.77854 [show with all ESTs]

Unigene Representative Sequence: NM_152869

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for RGN

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9
SP1:							-		-		-						-
SP2:																	-
SP3:							-		-		-						-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for RGN
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000352078 ENST00000469346 ENST00000336169 ENST00000475448 ENST00000457380

ENST00000397180(uc004dgz.1 uc004dha.1 uc010nho.1 uc010nhp.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

RGN expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching RGN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
942_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D31815	1.00	0.90	0.95	1
210751_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D31815	1.00	0.90	0.95	1
210751_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

RGN for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: CTGCTTTGGA

SOURCE GeneReport for Unigene cluster: Hs.77854

Expression variation in blood from EXPOLDB for RGN

Primers:		OriGene genome-wide validated SYBR primer pairs: RGN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for RGN: PPH10080A

SABiosciences Expression via Pathway-Focused PCR Array including RGN: PAHS-094A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RGN gene from 5/16 species (see all 16)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RGN¹	--	regucalcin (senescence marker protein-30)	89.63(n) 91.3(a)	480893 XM_538011.2 XP_538011.2
chimpanzee (Pan troglodytes)	RGN¹	--	regucalcin (senescence marker protein-30)	96.45(n) 94.26(a)	465598 XM_001141501.1 XP_001141501.1
rat (Rattus norvegicus)	Rgn¹	--	regucalcin (senescence marker protein-30)	86.85(n) 88.63(a)	25106 NM_031546.1 NP_113734.1
mouse (Mus musculus)	Rgn^{1 , 5}	X (16.04 cM)⁵	regucalcin^{1, 5}	86.51(n)¹ 88.63(a)¹	19733¹ NM_009060.2¹ NP_033086.1¹ AI265316⁵ AK146465⁵ (see all 9)
chicken (Gallus gallus)	RGN¹	--	regucalcin	73.47(n) 77.93(a)	395480 NM_204729.1 NP_990060.1

About this table Species with no ortholog for RGN

ENSEMBL Gene Tree for RGN (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs14312^1,2	C,F,O,H	46952398(+)	`GAATTC/TTGGGC`	1	--	ut3¹ ese³		6		MN NS EA NA	604
rs3814904^1,2	--	46937648(+)	`GGGACG/TGGGAC`	1	--	ng5¹		0	--	--	--	--
rs3814905^1,2	C	46937699(+)	`GCCGGA/GTCCCG`	1	--	ng5¹		0	--	--	--	--
rs4480242^1,2	C,F,A,H,	46952219(+)	`TTACTG/ACAAAT`	1	--	int¹		9		NS EA NA WA	424
rs4503212^1,2	C,F,A,H,	46941458(+)	`GGACCA/GTCTTT`	1	--	int¹		7		NS EA NA WA	424
rs4551488^1,2	C,A,H	46948159(+)	`aacccT/Cgtctc`	1	--	int¹		6		NA WA	10
rs4824418^1,2	C,A,H,	46944617(+)	`acagaA/Gaaaaa`	1	--	int¹		4		NA WA	6
rs4824599^1,2	C	46938229(+)	`CCCACC/TGGCTT`	1	--	int¹		0	--	--	--	--
rs5012957^1,2	C,F,A,H,	46952117(+)	`ATTATA/TAACTA`	1	--	int¹		8		NS EA NA WA	425
rs5905583^1,2	C,A,H	46941760(+)	`gctggG/Agtgca`	1	--	int¹		2		NA WA	3

About this table

HapMap Linkage Disequilibrium images for RGN (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RGN: --

QIAGEN SeqTarget long-range PCR primers for resequencing RGN

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RGN for disorders About GeneDecksing

OMIM: 300212

5 Novoseek disease relationships for RGN gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis	19.8	1	9059996 (1)
hepatocellular carcinoma	14.3	2	15358188 (1), 19801822 (1)
necrosis	0	1	15358188 (1)
tumors	0	4	19347872 (2), 16136218 (1), 15358188 (1)
cancer	0	1	19347872 (1)

About this table

Export disorders and mutations for RGN gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/51 PubMed articles for RGN gene, integrated from 7 sources (see all 51):
(articles sorted by number of sources associating them with RGN)

Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome. (PubMed id 7548213)^{1, 2, 3, 7} Fujita T....Maruyama N. (1995)
Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin. (PubMed id 10677570)^{1, 2, 7} Misawa H. and Yamaguchi M. (2000)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Expression and structure of senescence marker protein-30 (SMP30) and its biological significance. (PubMed id 10360682)^{1, 7} Fujita T....Maruyama N. (1999)
Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells. (PubMed id 15358188)^{1, 7} Matsuyama S....Sato N. (2004)
Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells. (PubMed id 15714273)^{1, 7} Ishigami A....Maruyama N. (2005)
Hepatic senescence marker protein-30 is involved in t he progression of nonalcoholic fatty liver disease. (PubMed id 19946731)^{1, 7} Park H....Okanoue T. (2010)
Regucalcin is under-expressed in human breast and pro state cancers: Effect of sex steroid hormones. (PubMed id 19347872)^{1, 7} Maia C....Socorro S. (2009)
Senescence marker protein 30 in acute liver failure: validation of a mass spectrometry proteomics assay. (PubMed id 18507831)^{1, 7} Lv S....Wei L. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9104	HGNC: 9989	AceView: RGN	Ensembl:ENSG00000130988	euGenes: HUgn9104
ECgene: RGN	H-InvDB: RGN

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for RGN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for RGN gene:
Search GeneIP for patents involving RGN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RGN		Antibodies for RGN
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	Lentivirus-delivered shRNAs for RGN		microRNA Mimics for RGN
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
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	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
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	feedback

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	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RGN
	SeqTarget long-range PCR primers for resequencing RGN
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RGN
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RGN

	GenScript Custom Purified and Recombinant Proteins Services for RGN		GenScript cDNA clones with any tag delivered in your preferred vector for RGN
	GenScript Custom Assay Services for RGN		GenScript Custom Superior Antibodies Services for RGN
	GenScript Custom overexpressing Cell Line Services for RGN		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RGN promoter
	Search Chromatin IP Primers for RGN
	RT² qPCR Primer Assay for RGN
	GNC Network for RGN
	Search for Assays for microRNAs that regulate RGN
	SABiosciences PCR Arrays including RGN

Search Tocris compounds for RGN

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for RGN
	Proteins for RGN
	Lysates for RGN

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for RGN

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

RGN gene at Home site.

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RGN Gene

protein-coding GIFtS: 55

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Export list of displayed genes

RGN Gene

protein-coding GIFtS: 55

Aliases & Descriptionsfor RGN gene

Summariesfor RGN gene

Genomic Viewsfor RGN gene

Proteinsfor RGN gene

Protein Domains/Familiesfor RGN gene

Gene Functionfor RGN gene

Pathways & Interactionsfor RGN gene

Drugs & Compoundsfor RGN gene

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Expression for RGN gene

Orthologsfor RGN gene

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Genome Databases showing RGN gene

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Specialized Databases showing RGN gene

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Aliases &
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for RGN gene

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for RGN gene

Genomic Views
for RGN gene

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for RGN gene

Protein Domains/
Families
for RGN gene

Gene Function
for RGN gene

Pathways & Interactions
for RGN gene

Drugs & Compounds
for RGN gene

Transcripts
for RGN gene

Expression
for RGN gene

Orthologs
for RGN gene

Paralogs
for RGN gene

Genomic Variants
for RGN gene

Disorders & Mutations
for RGN gene

Medical News
for RGN gene

Publications
for RGN gene

Intellectual Property
for RGN gene

Products
for RGN gene