Aliases &
Descriptions
for RGS6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| regulator of G-protein signaling 61 2 | | regulator of G protein signalling 62 | | regulator of G-protein signalling 61 2 | | GTPase activating protein2 | | S9142 3 | | GAP2 | | H_DJ0283M22.12 | | WUGSC:H_DJ0283M22.12 | | regulator of G protein signaling 62 | | MGC1421322 | | H_DJ1108A12.12 | | WUGSC:H_DJ1108A12.12 | | DKFZp313G12412 | | FLJ435522 | | G protein signaling 6 regulator2 | | |
Export aliases for RGS6 gene to outside databasesPrevious GC identifers: GC14P069904 GC14P066195 GC14P070389 GC14P071469 GC14P072399 |
Summaries
for RGS6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RGS6:
Members of the RGS (regulator of G protein signaling) family, such as RGS6, modulate G protein function by activatingthe intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits (Seki et al., 1999 (PubMed10083744)).(supplied by OMIM)
UniProtKB/Swiss-Prot: RGS6_HUMAN, P49758Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby drivingthem into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer
Gene Wiki entry for RGS6 |
Genomic Views
for RGS6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RGS6 gene promoter:
POU3F2 ATF-2 Pax-6 ATF6 XBP-1 RORalpha2 E4BP4 Meis-1 MEF-2A FOXL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RGS6
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.2 HGNC cytogenetic band: 14q24.3RGS6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P052566: view genomic region
(about GC identifiers)
Start:
|
52,566,447 bp from pter |
End:
|
53,199,765 bp from pter |
Size:
|
633,319 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr14+ 72,431,509-73,033,237 |
RefSeq DNA sequence:- NC_000014.8 NT_026437.12
|
Proteins
for RGS6 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: RGS6_HUMAN, P49758 (See
protein sequence)Recommended Name: Regulator of G-protein signaling 6 Size: 472 amino acids; 54423 Da
Subunit: Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of theheterodimer formed with Gbeta5 (By similarity)
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein
Sequence caution: Sequence=AAC42001.1; Type=Frameshift; Positions=Several;
PDB structures from  and Proteopedia  :2ES0 (3D)
Secondary accessions: O75576 O75577 Q8TE13 Q8TE14 Q8TE15 Q8TE16 Q8TE17 Q8TE18 Q8TE19 Q8TE20 Q8TE21Q8TE22 Q9UDS8 Q9UDT0 Q9Y245 Q9Y647Alternative splicing: 11 isoforms: P49758-4 P49758-2 P49758-3 P49758-5 P49758-6 P49758-7 P49758-8 P49758-9 P49758-10 P49758-11 P49758-12 Explore the universe of human proteins at neXtProt for RGS6: NX_P49758
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004287.3
ENSEMBL proteins: ENSP00000385243 ENSP00000383953 ENSP00000347699 ENSP00000341199 ENSP00000384612 ENSP00000384218 ENSP00000412144 ENSP00000411555
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
RGS6 for ontologies About GeneDecksing
Antibodies for RGS6:
Assays for RGS6: |
Protein
Domains/
Families
for RGS6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RGS6 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P49758ProtoNet protein and cluster: P49758 3 Blocks protein families: IPB000342 Regulator of G-protein signalling (RGS) protein signature IPB000591 Pleckstrin putative G-protein interacting domain IPB001770 Gamma G-protein (transducin) signature
UniProtKB/Swiss-Prot: RGS6_HUMAN, P49758Similarity: Contains 1 DEP domainSimilarity: Contains 1 G protein gamma domainSimilarity: Contains 1 RGS domain |
Gene Function
for RGS6 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: RGS6_HUMAN, P49758Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby drivingthem into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer
Genatlas biochemistry entry for RGS6:negative regulator of G protein signaling 6,functioning as GTPase-activating protein for G protein alpha i and qsubunits,ubiquitously expressed3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004871 | signal transducer activity |
IEA | -- | | GO:0005096 | GTPase activator activity |
ISS | -- | | GO:0019904 | protein domain specific binding |
-- | -- |
About this table
RGS6 for ontologies About GeneDecksing
|
Pathways & Interactions
for RGS6 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for RGS6
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGS6
1 Interacting protein for RGS6 (ENSP000003476993) via UniProtKB, MINT, and/or STRINGAbout this table
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor protein signaling pathway |
-- | -- | | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway |
NAS | -- | | GO:0009968 | negative regulation of signal transduction |
IEA | -- | | GO:0023034 | intracellular signaling pathway |
-- | -- | | GO:0045666 | positive regulation of neuron differentiation |
-- | -- |
About this table
RGS6 for ontologies About GeneDecksing
|
Drugs & Compounds
for RGS6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for RGS6
|
Transcripts
for RGS6 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for RGS6 gene: NM_004296.4 Additional cDNA sequence: AB209462.1 AF073920.2 AF073921.1 AF107619.1 AF107620.1 AF156932.1 AK125540.1 AK294486.1 AK294895.1 AK302319.1 AK310463.1 AK313481.1 AY309097.1 AY309098.1 AY309099.1 AY309100.1 BC104877.1 BC113572.1 BC143699.1 BX537512.1 L40394.1 10 DOTS entries: DT.455181 DT.101981204 DT.452449 DT.91732544 DT.91732546 DT.101981205 DT.40299115 DT.120793288 DT.75142740 DT.95306069 24/38 AceView cDNA sequences (see all 38): NM_004296 AA351873 AA321084 BX108984 AF073921 AI187394 CF456329 AF107620 AF073920 BF980050 AF156932 AW014027 AA883187 BM908076 BG772886 AF107619 AI201062 BX501394 AY309097 AA694278 AI201067 AY309100 R39325 AY309098
 highest scoring ESTs for RGS6:AF073920 AA321084 AA694278 AA725313 AA883187 AF073921 AF107619 AF107620 AF156932 AI201062 Unigene Cluster for RGS6: Regulator of G-protein signaling 6 Hs.509872 [show with all ESTs]Unigene Representative Sequence: NM_004296
GeneLoc Exon Structure
8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000404301(uc010arg.2 uc010ttp.1) ENST00000402788 ENST00000355512
ENST00000343854(uc001xmz.1) ENST00000407322 ENST00000406236 ENST00000434263
ENST00000453330(uc010ttn.1 uc001xna.3 uc001xmx.3 uc010tto.1 uc001xmy.3)
|
Expression
for RGS6 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| RGS6 expression in normal and diseased human tissues
1 / 2 / 3 10 probe-sets matching RGS6 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 39656_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.99 |
1.02 |
AF073920 |
1.00 |
1.00 |
1.00 |
1 |
| 52713_at2
|
U95-B |
1 |
0.69 |
1.00 |
0.81 |
1.04 |
-- |
-- |
-- |
-- |
-- |
| 211448_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AF107619 |
0.80 |
1.00 |
0.91 |
1 |
| 210270_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AF156932 |
0.80 |
1.00 |
0.91 |
1 |
| 236726_at2
|
U133-B |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 214538_x_at2, 3
|
U133-A |
1 |
0.64 |
1.00 |
-- |
-- |
AF073921 |
0.80 |
1.00 |
0.91 |
1 |
| 211448_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 210270_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 236726_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 214538_x_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
RGS6 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTGGTACAGT
SOURCE GeneReport for Unigene cluster: Hs.509872
Expression variation in blood from EXPOLDB for RGS6 SABiosciences Custom PCR Arrays for RGS6
|
Orthologs
for RGS6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RGS6 gene from 5/11 species (see all 11)
About this table Species with no ortholog for RGS6
ENSEMBL Gene Tree for RGS6 (if available) |
Paralogs
for RGS6 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for RGS6 gene
- RGS172 RGS112 RGS192 RGS72 RGS202 RGS92
RGS6 for paralogs About GeneDecksing
|
Genomic Variants
for RGS6 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 14 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for RGS6 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for RGS6
4 CNVs: 3054 58685 38307 87265
2 Indels: 63014 10705 | | QIAGEN SeqTarget long-range PCR primers for resequencing RGS6 |
|
Disorders & Mutations
for RGS6 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RGS6 for disorders About GeneDecksing
OMIM: 603894
Human Gene Mutation Database (HGMD): RGS6
Genetic Association Database (GAD): RGS6
Human Genome Epidemiology (HuGE) Navigator: RGS6 (10 documents)
Export disorders and mutations for RGS6 gene to outside databases
|
Medical News
for RGS6 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RGS6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/25 PubMed articles for RGS6 gene, integrated from 7 sources (see all 25):
(articles sorted by number of sources associating them with RGS6)- Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants. (PubMed id 12761221)1, 2, 7 Chatterjee T.K.... Fisher R.A. (2003)
- Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. (PubMed id 10521509)1, 2, 7 Posner B.A.... Harris B.A. (1999)
- A functional polymorphism in RGS6 modulates the risk of bladder cancer. (PubMed id 15375002)1, 4 Berman D.M....Wu X. (2004)
- RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP 1 transcriptional repressor activity. (PubMed id 14734556)1, 3 Liu Z. and Fisher R.A. (2004)
- Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. (PubMed id 10339615)1, 2 Snow B.E.... Siderovski D.P. (1999)
- The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3. (PubMed id 10083744)1, 3 Seki N....Saito T. (1999)
- Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)1, 2 Sherrington R....Holman K. (1995)
- Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins. (PubMed id 12761220)1, 7 Chatterjee T.K. and Fisher R.A. (2003)
- A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. (PubMed id 16691626)1, 7 Gu J....Berman D.M. (2006)
- Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
|
External Searches for RGS6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RGS6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RGS6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RGS6 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RGS6 gene:
Search GeneIP for patents involving RGS6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RGS6 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
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| | | |
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 |  |  |  | |
| |  | Search Tocris compounds for RGS6 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for RGS6 |
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